Ribonucleotide reductase large subunit C-terminal
Ribonucleotide reductase large subunit N-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Signal transduction histidine kinase osmosensitive K+ channel sensor N-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
TonB-dependent receptor-like beta-barrel
YbaK/aminoacyl-tRNA synthetase-associated
Glycine cleavage T-protein C-terminal barrel
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Glucosamine/galactosamine-6-phosphate isomerase
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Glycosyltransferase subfamily 4-like N-terminal
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
RNA polymerase sigma factor 70 region 4 type 2
Tryptophan synthase beta chain-like PALP
Pyruvate phosphate dikinase AMP/ATP-binding
Could be important to modulate the pK values of the two catalytic cysteine residues
Polysaccharide chain length determinant N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Translation elongation factor P/YeiP central
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Major facilitator superfamily (MFS) profile
NADH:ubiquinone oxidoreductase 30kDa subunit
TtsA-like Glycoside hydrolase family 108
Plays an important role in substrate specificity
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Alpha-D-phosphohexomutase alpha/beta/alpha
tRNA pseudouridylate synthase B C-terminal
N-acetylneuraminic acid synthase N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Saccharopine dehydrogenase-like C-terminal
Alanyl-transfer RNA synthetases family profile
Carbamoyl-phosphate synthase small subunit N-terminal
Type I restriction enzyme R protein N-terminal
Lipocalin-like domain-containing protein
Outer membrane protein beta-barrel domain-containing protein
Large ribosomal subunit protein uL2 C-terminal
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Phosphoadenosine phosphosulphate reductase
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
ATP synthase F1 complex delta/epsilon subunit N-terminal
Chromosomal replication initiator DnaA C-terminal
Beta-hexosaminidase bacterial type N-terminal
Beta-xylosidase C-terminal Concanavalin A-like
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Solute-binding protein family 3/N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Ribose-phosphate pyrophosphokinase N-terminal
Pseudouridine synthase I TruA alpha/beta
Haem-binding uptake Tiki superfamily ChaN
Haem-binding uptake Tiki superfamily ChaN domain-containing protein
N6 adenine-specific DNA methyltransferase N-terminal
Thymidylate synthase/dCMP hydroxymethylase
Glycosyl-hydrolase 97 C-terminal oligomerisation
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Beta-lactamase-inhibitor-like PepSY-like domain-containing protein
UDP-glucose/GDP-mannose dehydrogenase C-terminal
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Essential for prephenate dehydratase activity
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Aspartate carbamoyltransferase regulatory subunit C-terminal
Aspartate carbamoyltransferase regulatory subunit N-terminal
Membrane fusion protein biotin-lipoyl like
RND efflux pump membrane fusion protein barrel-sandwich
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Signal transduction histidine kinase internal region
O-(3'-phospho-DNA)-tyrosine intermediate
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Resolvase/invertase-type recombinase catalytic
N-sulphoglucosamine sulphohydrolase C-terminal
Proton acceptor; for glutaminase activity
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Prokaryotic-type class I peptide chain release factors
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Penicillin-binding protein transpeptidase
AB hydrolase-1 domain-containing protein
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Outer membrane lipoprotein-sorting protein
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Putative carbohydrate metabolism domain-containing protein
Important for beta-aspartyl-AMP intermediate formation
Peptidase S9 prolyl oligopeptidase catalytic
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Cation-transporting P-type ATPase N-terminal
Polysaccharide biosynthesis protein CapD-like
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Phosphomannose isomerase type I catalytic
Important for autoinhibition of adenylyltransferase activity
SUF system FeS cluster assembly SufBD N-terminal
Bacterial toxin RNase RnlA/LsoA N-terminal
Bacterial toxin RNase RnlA/LsoA N-terminal repeated
Pesticidal crystal protein Cry22Aa Ig-like
RNA 2-O ribose methyltransferase substrate binding
Major fimbrial subunit protein N-terminal domain-containing protein
Outer membrane lipoprotein carrier protein LolA
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Glycoside hydrolase 123 C-terminal domain-containing protein
RNA binding; important for wobble base 34 recognition
Polysaccharide biosynthesis protein C-terminal
CobB/CobQ-like glutamine amidotransferase
Peptide methionine sulfoxide reductase MsrA
Peptide methionine sulphoxide reductase MsrA
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Reversibly protonated during proton transport
Polymerase/histidinol phosphatase N-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
DNA mismatch repair proteins mutS family
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
UDP N-acetylglucosamine O-acyltransferase C-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Phosphoethanolamine transferase N-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Lysidine-tRNA(Ile) synthetase C-terminal
Biotin biosynthesis bifunctional protein BioAB
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Trigger factor ribosome-binding bacterial
Positions MEP for the nucleophilic attack
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Glycogen debranching enzyme bacterial and archaeal type N-terminal
Putative acyltransferase ACT14924-like acyltransferase
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Threonine/serine exporter-like N-terminal
Glycosyl hydrolase family 30 beta sandwich
Ribosomal RNA adenine methylase transferase N-terminal
Large ribosomal subunit protein uL15/eL18
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Shikimate dehydrogenase substrate binding N-terminal
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Bacterial bifunctional deaminase-reductase C-terminal
Formiminotransferase C-terminal subdomain
Formiminotransferase N-terminal subdomain
Pyruvate/ketoisovalerate oxidoreductase catalytic
Carbohydrate-binding domain-containing protein
Meso-diaminopimelate D-dehydrogenase C-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Exonuclease VII large subunit C-terminal
4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase
Putative auto-transporter adhesin head GIN
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Major fimbrial subunit protein N-terminal
Schiff-base intermediate with substrate; via pyruvic acid
Malonyl-[acyl-carrier protein] O-methyltransferase
Membrane insertase YidC/Oxa/ALB C-terminal
Putative auto-transporter adhesin head GIN domain-containing protein
Mandelate racemase/muconate lactonizing enzyme C-terminal
Carboxypeptidase-like regulatory domain-containing protein
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
DNA replication/recombination mediator RecO N-terminal
Arginine decarboxylase C-terminal helical
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Glycoside hydrolase family 57 N-terminal
Alpha-L-glutamate ligase-related protein ATP-grasp
Glycoside hydrolase 123 N-terminal domain-containing protein
Peptidoglycan recognition protein family
Cysteine sulfenic acid (-SOH) intermediate
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Sodium/calcium exchanger membrane region
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
ABC transporter substrate-binding protein PnrA-like
Alpha-N-acetylglucosaminidase C-terminal
Alpha-N-acetylglucosaminidase N-terminal
Alpha-N-acetylglucosaminidase tim-barrel
Small ribosomal subunit protein uS4 N-terminal
Large ribosomal subunit protein uL6 alpha-beta
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Methylguanine DNA methyltransferase ribonuclease-like
Na(+)-translocating NADH-quinone reductase subunit A C-terminal
DNA-directed DNA polymerase family A palm
Glycosyl hydrolase-like 10 domain-containing protein
Important for catalytic activity against all substrates
Important for catalytic activity against dermatan sulfate substrate
Peptidase M43 pregnancy-associated plasma-A
Helix-hairpin-helix DNA-binding motif class 1
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Flavodoxin-like domain-containing protein
Fibrobacter succinogenes major paralogous
Protein glutaminase domain-containing protein
5-glutamyl coenzyme A thioester intermediate
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
Myo-inositol-1-phosphate synthase GAPDH-like
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Glycosyl transferase family 3 N-terminal
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
Arabinogalactan endo-beta-1,4-galactanase
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Important for substrate specificity; cannot use PPi as phosphoryl donor
ATPsynthase alpha/beta subunit N-terminal extension
Anthranilate synthase component I N-terminal
Phosphatidylglycerol lysyltransferase C-terminal
Survival protein SurE-like phosphatase/nucleotidase
6-phosphogluconate dehydrogenase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Ribosome maturation factor RimP N-terminal
Gly-cisPro motif, important for rejection of L-amino acids