Alpha galactosidase C-terminal beta sandwich
CDP-alcohol phosphatidyltransferase C-terminal
Cytochrome b561 bacterial/Ni-hydrogenase
Glycoside-hydrolase family GH114 TIM-barrel domain-containing protein
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Biopterin-dependent aromatic amino acid hydroxylase family profile
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
NADH:ubiquinone oxidoreductase chain 4 N-terminal
Large ribosomal subunit protein uL6 alpha-beta
Chalcone isomerase domain-containing protein
Sphingolipid delta4-desaturase N-terminal
TonB-dependent receptor-like beta-barrel
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Lysozyme inhibitor LprI N-terminal domain-containing protein
RNA 2-O ribose methyltransferase substrate binding
Putative auto-transporter adhesin head GIN
Putative auto-transporter adhesin head GIN domain-containing protein
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Tryptophan synthase beta chain-like PALP
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Sialate O-acetylesterase domain-containing protein
Polymerase/histidinol phosphatase N-terminal
Thymidylate synthase/dCMP hydroxymethylase
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Aminoacyl-transfer RNA synthetases class-II family profile
Gfo/Idh/MocA-like oxidoreductase N-terminal
2-oxoisovalerate dehydrogenase E1 alpha subunit N-terminal
Major facilitator superfamily (MFS) profile
Ribosomal RNA adenine methylase transferase N-terminal
Exonuclease VII large subunit C-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Glucosamine/galactosamine-6-phosphate isomerase
Heme-copper oxidase subunit III family profile
Pyridine nucleotide-disulphide oxidoreductase dimerisation
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Small ribosomal subunit protein uS4 N-terminal
S-adenosylmethionine-dependent methyltransferase
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
LPXTG cell wall anchor domain-containing protein
Alpha-D-phosphohexomutase alpha/beta/alpha
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Could play a key role in the communication between the regulatory and the substrate sites
Electron transfer via tryptophanyl radical
Outer membrane protein assembly factor BamD
Important for interaction with partner proteins
Prokaryotic-type class I peptide chain release factors
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Nucleophile; methyl group acceptor from either O6-methylguanine or O4-methylthymine
Nucleophile; methyl group acceptor from methylphosphotriester
Saccharopine dehydrogenase-like C-terminal
Cysteine sulfenic acid (-SOH) intermediate
Spore coat protein U domain-containing protein
Invasion associated locus B (IalB) protein
Glycosyl transferase family 3 N-terminal
PHA accumulation regulator DNA-binding N-terminal
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Schiff-base intermediate with substrate; via pyruvic acid
3-keto-disaccharide hydrolase domain-containing protein
Polysaccharide biosynthesis protein CapD-like
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Nitrite/Sulfite reductase ferredoxin-like
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Aconitase A/isopropylmalate dehydratase small subunit swivel
YbaK/aminoacyl-tRNA synthetase-associated
Prepilin type IV endopeptidase peptidase
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS
Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS domain-containing protein
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Quercetin 2,3-dioxygenase C-terminal cupin
Phosphatidate phosphatase APP1 catalytic
NAD(P) transhydrogenase alpha subunit C-terminal
Pyrroline-5-carboxylate reductase dimerisation
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Penicillin-binding protein transpeptidase
Membrane fusion protein biotin-lipoyl like
Extradiol ring-cleavage dioxygenase LigAB LigA subunit
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Shikimate dehydrogenase substrate binding N-terminal
Required for zinc-mediated homotetramerization and catalytic activity
TRAP C4-dicarboxylate transport system permease DctM subunit
N-end rule aminoacyl transferase C-terminal
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Poly-beta-hydroxybutyrate polymerase N-terminal
Reversibly protonated during proton transport
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Beta-barrel assembly machine subunit BamF
Glycosyl transferase family 28 C-terminal
Polysaccharide biosynthesis protein C-terminal
Pyridoxamine 5'-phosphate oxidase putative
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Glycerophosphoryl diester phosphodiesterase membrane
Large ribosomal subunit protein uL2 C-terminal
RNA binding; important for wobble base 34 recognition
Peptidase S9 prolyl oligopeptidase catalytic
Peptide methionine sulphoxide reductase MsrA
Histidine-specific methyltransferase SAM-dependent
Type VI secretion system IcmF C-terminal
Resolvase/invertase-type recombinase catalytic
4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase-like C-terminal
Thiolase-like protein type 1 additional C-terminal
Membrane-bound lysozyme-inhibitor of c-type lysozyme
Ribose-phosphate pyrophosphokinase N-terminal
D-glutamate N-acetyltransferase-like C-terminal
D-glutamate N-acetyltransferase-like N-terminal
Signal transduction histidine kinase dimerisation/phosphoacceptor
Bacterial type II secretion system protein E
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Protein O-mannosyl-transferase C-terminal four TM
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Endoribonuclease L-PSP/chorismate mutase-like
NADH:flavin oxidoreductase/NADH oxidase N-terminal
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
General stress protein FMN-binding split barrel
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Polysaccharide chain length determinant N-terminal
Pseudouridine synthase I TruA alpha/beta
Signal recognition particle SRP54 helical bundle
Translation elongation factor P/YeiP central
Prolyl 3,4-dihydroxylase TPA1/OFD1 N-terminal
Signal transduction histidine kinase internal region
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Cytochrome c-type biogenesis protein CcmF C-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Tetrahydrodipicolinate-N-succinyltransferase chain A
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Glycosyltransferase family 28 N-terminal
RNA polymerase sigma factor 70 region 4 type 2
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Small-conductance mechanosensitive channel
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Polypeptide-transport-associated ShlB-type
Coenzyme F420 hydrogenase/dehydrogenase beta subunit C-terminal
Coenzyme F420 hydrogenase/dehydrogenase beta subunit N-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
RND efflux pump membrane fusion protein barrel-sandwich
tRNA pseudouridylate synthase B C-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Terminase large subunit gp17-like C-terminal
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Positions MEP for the nucleophilic attack
Phosphoribosylformylglycinamidine synthase linker
Methionyl-tRNA synthetase anticodon-binding
Interaction with polymerase core subunit RpoC
Heat-inducible transcription repressor HrcA C-terminal
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Peptide methionine sulfoxide reductase MsrA
DNA-directed DNA polymerase family A palm
DNA replication/recombination mediator RecO N-terminal
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
SUF system FeS cluster assembly SufBD N-terminal
Release factor glutamine methyltransferase N-terminal
PEP-CTERM sorting domain-containing protein
Bacterial bifunctional deaminase-reductase C-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Important for beta-aspartyl-AMP intermediate formation
ATP synthase F1 complex delta/epsilon subunit N-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Bacterial extracellular solute-binding protein
Alanyl-transfer RNA synthetases family profile
Endolytic peptidoglycan transglycosylase RlpA
RlpA-like protein double-psi beta-barrel
Could be important to modulate the pK values of the two catalytic cysteine residues
Glycosyltransferase subfamily 4-like N-terminal
Alpha-glycerophosphate oxidase C-terminal
Beta-lactamase hydrolase-like protein phosphatase-like
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Superoxide dismutase copper/zinc binding
Glucose-methanol-choline oxidoreductase N-terminal
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
L,D-transpeptidase catalytic domain-containing protein
DNA mismatch repair proteins mutS family
Carbamoyl-phosphate synthase small subunit N-terminal
PhoD-like phosphatase metallophosphatase
Large ribosomal subunit protein uL15/eL18
Survival protein SurE-like phosphatase/nucleotidase
Chromosomal replication initiator protein DnaA
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Helix-hairpin-helix DNA-binding motif class 1
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Plays an important role in substrate specificity
Bacterial sensory transduction regulator
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Outer membrane protein beta-barrel domain-containing protein
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
Mandelate racemase/muconate lactonizing enzyme C-terminal
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Pili assembly chaperone N-terminal domain-containing protein
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal