Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Probable dihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit
Polysaccharide biosynthesis protein C-terminal
Damage-control phosphatase ARMT1-like metal-binding
Thiamine pyrophosphate enzyme TPP-binding
Putative HTH-type transcriptional regulatory protein TK0539
tRNA N6-adenosine threonylcarbamoyltransferase
Pyruvate ferredoxin oxidoreductase beta subunit C-terminal
2,3-bisphosphoglycerate-independent phosphoglycerate mutase
Digeranylgeranylglyceryl phosphate synthase
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
Decreases efficiency of the inhibition by CoA.
Decreases efficiency of the inhibition by CoA. Inhibition shows no time-dependency.
Phosphate import ATP-binding protein PstB
Plays an important role in substrate specificity
Quinolinate phosphoribosyl transferase N-terminal
Major facilitator superfamily (MFS) profile
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
GMP synthase [glutamine-hydrolyzing] subunit A
Dinitrogenase iron-molybdenum cofactor biosynthesis
Pyruvoyl-dependent arginine decarboxylase subunit alpha
Pyruvoyl-dependent arginine decarboxylase subunit beta
GMP synthase [glutamine-hydrolyzing] subunit B
Alpha-D-phosphohexomutase alpha/beta/alpha
Ribosome maturation protein SDO1/SBDS C-terminal
Ribosome maturation protein SDO1/SBDS N-terminal
Ribosome maturation protein SDO1/SBDS central
Pyruvate/ketoisovalerate oxidoreductase catalytic
DNA-directed RNA polymerase subunit Rpo5
Na+/H+ antiporter MnhB subunit-related protein
5-methylthioadenosine/S-adenosylhomocysteine deaminase
DNA-directed RNA polymerase subunit Rpo12
Probable glycine cleavage system H protein
tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase 1
Peptidase S9 prolyl oligopeptidase catalytic
tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase 2
Nicotinate phosphoribosyltransferase C-terminal
Quinolinate phosphoribosyl transferase C-terminal
3-isopropylmalate dehydratase small subunit
Probable cobalamin biosynthesis protein CobD
Transcription regulator AsnC/Lrp ligand binding
Glycosyltransferase subfamily 4-like N-terminal
Probable Brix domain-containing ribosomal biogenesis protein
DNA-directed RNA polymerase subunit Rpo10
Coenzyme A biosynthesis bifunctional protein CoaBC
Phosphopantothenoylcysteine decarboxylase
Myo-inositol-1-phosphate synthase GAPDH-like
SUF system FeS cluster assembly SufBD N-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
Pyruvate phosphate dikinase AMP/ATP-binding
Translation initiation factor 2 subunit beta
NADH:ubiquinone oxidoreductase-like 20kDa subunit
HTH-type transcriptional regulator TrmBL2
Probable inosine/xanthosine triphosphatase
ADP-dependent glucose/glucosamine kinase
Aspartate carbamoyltransferase regulatory chain
Indolepyruvate oxidoreductase subunit IorB
Translation initiation factor 2 subunit gamma
Expected to impair oligomerization. Alters compaction of DNA on nucleosome-like structures. Delays adaptation to a sulfur-free medium due to impaired transcriptional activation of genes required for growth on a sulfur-free medium.
1,4-alpha-glucan branching enzyme TK1436
DNA-directed RNA polymerase subunit Rpo1C
3-isopropylmalate dehydratase large subunit
Phosphoadenosine phosphosulphate reductase
Glutamyl-tRNA(Gln) amidotransferase subunit E
Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase
Replication factor C small subunit, 1st part
Replication factor C small subunit, 2nd part
DNA repair and recombination protein RadB
Involved in ionization of N3 of dUMP, leading to its activation
tRNA (guanine(9)-/adenine(9)-N1)-methyltransferase
SAM-dependent methyltransferase TRM5/TYW2-type
Pyridoxal 5'-phosphate synthase subunit PdxT
3-phosphoshikimate 1-carboxyvinyltransferase
DNA polymerase II large subunit, 1st part
DNA polymerase II large subunit, 2nd part
DNA-directed RNA polymerase subunit Rpo11
Molybdate/tungstate transport system permease protein WtpB
Phosphoribosylformylglycinamidine cyclo-ligase
Aldehyde ferredoxin oxidoreductase N-terminal
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Digeranylgeranylglycerophospholipid reductase
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Fructose-1,6-bisphosphate aldolase/phosphatase
Proton acceptor; for FBP phosphatase activity
Proton donor/acceptor; for FBP aldolase activity
Schiff-base intermediate with DHAP; for FBP aldolase activity
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
Resolvase/invertase-type recombinase catalytic
Solute-binding protein family 3/N-terminal
Decrease in activity and in thermostability. Large decrease in activity; forms dimers; when associated with S-66 and S-69.
Large decrease in activity and in thermostability. Large decrease in activity; forms dimers; when associated with S-63 and S-69.
Slight decrease in activity; no change in thermostability. Large decrease in activity; forms dimers; when associated with S-63 and S-66.
Schiff-base intermediate with dihydroxyacetone-P
NAD(P)H sulfur oxidoreductase (CoA-dependent)
Translation initiation factor 2 subunit alpha
Probable transposase IS891/IS1136/IS1341
Removed in mature form; by autocatalysis
DNA repair and recombination protein RadA, 1st part
DNA repair and recombination protein RadA, 2nd part
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Protein-glutamate methylesterase/protein-glutamine glutaminase
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Probable glycine dehydrogenase (decarboxylating) subunit 2
Uncharacterized serpin-like protein TK1782
Docks into pockets in the proteasome alpha-ring to cause gate opening
Probable cyclic pyranopterin monophosphate synthase
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Indolepyruvate oxidoreductase subunit IorA
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
tRNA (pseudouridine(54)-N(1))-methyltransferase
Decreases affinities for both ATP and pantoate.
Displays a defect in dimer assembly. Does not affect Km for ATP but the affinity for pantoate decreases dramatically.
Does not affect kinetics toward ATP but decreases affinity for pantoate.
Does not affect kinetics toward ATP but significantly decreases affinity for pantoate.
Molybdate/tungstate-binding protein WtpA
Putative [LysW]-lysine/[LysW]-ornithine hydrolase
Pyridoxal 5'-phosphate synthase subunit PdxS
Schiff-base intermediate with D-ribose 5-phosphate
Alanyl-transfer RNA synthetases family profile
Signal recognition particle 19 kDa protein
Adenosylcobinamide-GDP ribazoletransferase
DNA double-strand break repair Rad50 ATPase
Tryptophan synthase beta chain-like PALP
6-hydroxymethylpterin diphosphokinase MptE-like
Signal recognition particle 54 kDa protein
Nascent polypeptide-associated complex protein
Cysteine sulfenic acid (-SOH) intermediate
S-adenosyl-l-methionine hydroxide adenosyltransferase C-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase N-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
Bifunctional IPC transferase and DIPP synthase
Cyclic 2,3-diphosphoglycerate synthetase
N-(5'-phosphoribosyl)anthranilate isomerase
Phosphoribosylformylglycinamidine synthase subunit PurQ
Saccharopine dehydrogenase-like C-terminal
3-methyl-2-oxobutanoate hydroxymethyltransferase
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Membrane protein 6-pyruvoyl-tetrahydropterin synthase-related
N(4)-bis(aminopropyl)spermidine synthase
NADH:ubiquinone oxidoreductase 30kDa subunit
Schiff-base intermediate with acetaldehyde
Nicotinamide-nucleotide adenylyltransferase
Imidazole glycerol phosphate synthase subunit HisF
DNA-directed RNA polymerase subunit 2 hybrid-binding
Pyruvate/ketoisovalerate oxidoreductases common subunit gamma
Bacterial type II secretion system protein E
Probable 6-oxopurine nucleoside phosphorylase
Glycoside hydrolase family 57 N-terminal
Formate-dependent phosphoribosylglycinamide formyltransferase
Tungsten-containing aldehyde ferredoxin oxidoreductase
UPF0173 metal-dependent hydrolase TK0141
Probable molybdenum cofactor guanylyltransferase
Glyceraldehyde-3-phosphate dehydrogenase
Putative transcriptional regulatory protein TK2151
Glutamyl-tRNA(Gln) amidotransferase subunit D
Aspartate/homoserine dehydrogenase NAD-binding
Impairs molecular assembly. 60-fold decrease in catalytic activity.
5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase
Probable glycine dehydrogenase (decarboxylating) subunit 1
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Gains the ability to form Asp-tRNA(Asn) in vitro, and is impaired in its ability to synthesize Asp-tRNA(Asp) due to a 8-fold decrease in affinity for tRNA(Asp).
Gains the ability to form Asp-tRNA(Asn) in vitro. Only 2-fold decrease in catalytic efficiency for Asp-tRNA(Asp) synthesis.
Phenylalanine--tRNA ligase alpha subunit
Methylated-DNA--protein-cysteine methyltransferase
Ribosomal RNA small subunit methyltransferase Nep1
Putative [LysW]-L-2-aminoadipate/[LysW]-L-glutamate phosphate reductase
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
DNA-directed RNA polymerase subunit Rpo6
Phosphoribosylformylglycinamidine synthase subunit PurL
tRNA (guanine(26)-N(2))-dimethyltransferase
Forms homodimers. Shows almost wild-type activity.
Geranylgeranylglyceryl phosphate synthase
Mannose-6-phosphate isomerase type II C-terminal
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Sugar fermentation stimulation protein C-terminal
Greatly reduced enzymatic activity. Greatly reduced enzymatic activity; when associated with the deletion of the beta-jelly roll domain of the mature domain.
Loss of activity. Greatly destabilized; when associated with the deletion of the calcium-binding form of the beta-jelly roll domain of the mature domain.
Imidazole glycerol phosphate synthase subunit HisH
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Peptidase A24A-predicted C-terminal archaea
O-(5'-phospho-DNA)-tyrosine intermediate
Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)
DNA mismatch repair proteins mutS family
Polyribonucleotide 5'-hydroxyl-kinase TK1956
Probable ribosomal RNA small subunit methyltransferase A