Thymidylate synthase/dCMP hydroxymethylase
RNA polymerase sigma factor 70 region 4 type 2
NIF system FeS cluster assembly NifU C-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Polymerase/histidinol phosphatase N-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
RNA binding; important for wobble base 34 recognition
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
RND efflux pump membrane fusion protein barrel-sandwich
Peptidase M1 membrane alanine aminopeptidase
DNA mismatch repair proteins mutS family
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Aminoacyl-transfer RNA synthetases class-II family profile
3-keto-disaccharide hydrolase domain-containing protein
Glycosyltransferase subfamily 4-like N-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Signal transduction histidine kinase internal region
SUF system FeS cluster assembly SufBD N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Tryptophan synthase beta chain-like PALP
Lipocalin-like domain-containing protein
Putative auto-transporter adhesin head GIN
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Polysaccharide biosynthesis protein C-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
TonB-dependent receptor-like beta-barrel
Carboxypeptidase-like regulatory domain-containing protein
Major facilitator superfamily (MFS) profile
Outer membrane protein beta-barrel domain-containing protein
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Secretion system C-terminal sorting domain-containing protein
Gliding motility-associated C-terminal domain-containing protein
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Pseudouridine synthase I TruA alpha/beta
Phosphatidic acid phosphatase type 2/haloperoxidase
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Membrane fusion protein biotin-lipoyl like
N6 adenine-specific DNA methyltransferase N-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
O-(5'-phospho-DNA)-tyrosine intermediate
Tetratricopeptide TPR_1 repeat-containing protein
N-sulphoglucosamine sulphohydrolase C-terminal
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Surface lipoprotein of Spirochaetales order
DNA-directed DNA polymerase family A palm
DNA topoisomerase I catalytic core eukaryotic-type
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Peptide methionine sulphoxide reductase MsrA
Pyrroline-5-carboxylate reductase catalytic N-terminal
Type I restriction modification DNA specificity
Small ribosomal subunit protein uS4 N-terminal
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Large ribosomal subunit protein uL2 C-terminal
Nicotinamide phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Polysaccharide biosynthesis protein CapD-like
Mandelate racemase/muconate lactonizing enzyme C-terminal
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Molybdopterin cofactor biosynthesis C (MoaC)
CarboxypepD_reg-like domain-containing protein
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Pyrrolo-quinoline quinone repeat-containing protein
Dihydrodipicolinate reductase N-terminal
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
NADH:ubiquinone oxidoreductase intermediate-associated protein 30
ATP synthase F1 complex delta/epsilon subunit N-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Receptor L-domain domain-containing protein
Glycoside-hydrolase family GH114 TIM-barrel
Beta-lactamase-inhibitor-like PepSY-like domain-containing protein
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Beta-xylosidase C-terminal Concanavalin A-like
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Pyruvate phosphate dikinase AMP/ATP-binding
Glucosamine/galactosamine-6-phosphate isomerase
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Important for interaction with partner proteins
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Ysc84 actin-binding domain-containing protein
Ribose-phosphate pyrophosphokinase N-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Peptidase S9 prolyl oligopeptidase catalytic
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Penicillin-binding protein transpeptidase
Heme-copper oxidase subunit III family profile
Cytochrome C biogenesis protein transmembrane
Thiol:disulfide interchange protein DsbD N-terminal
RNA 2-O ribose methyltransferase substrate binding
Sodium/calcium exchanger membrane region
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Glycine cleavage T-protein C-terminal barrel
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Homogentisate 1,2-dioxygenase N-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Beta-lactamase class A catalytic domain-containing protein
Histidine-specific methyltransferase SAM-dependent
Glycoamylase-like domain-containing protein
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Alpha-glycerophosphate oxidase C-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Anthranilate synthase component I N-terminal
Cysteine sulfenic acid (-SOH) intermediate
Urease accessory protein UreH-like transmembrane
Alpha-D-phosphohexomutase alpha/beta/alpha
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Polysaccharide chain length determinant N-terminal
Mandelate racemase/muconate lactonizing enzyme N-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Important for beta-aspartyl-AMP intermediate formation
Inosine/uridine-preferring nucleoside hydrolase
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Aconitase A/isopropylmalate dehydratase small subunit swivel
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Electron transfer via tryptophanyl radical
Pyrroline-5-carboxylate reductase dimerisation
6-phosphogluconate dehydrogenase C-terminal
Dihydrodipicolinate reductase C-terminal
ATP-grasp fold succinyl-CoA synthetase-type
Reversibly protonated during proton transport
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Transcription elongation factor GreA/GreB C-terminal
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Survival protein SurE-like phosphatase/nucleotidase
Membrane insertase YidC/Oxa/ALB C-terminal
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Transcription elongation factor GreA/GreB N-terminal
Blue (type 1) copper domain-containing protein
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Cell division protein FtsQ/DivIB C-terminal
Beta-hexosaminidase bacterial type N-terminal
Aspartate/homoserine dehydrogenase NAD-binding
Plays an important role in substrate specificity
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Shikimate dehydrogenase substrate binding N-terminal
Putative beta-lactamase-inhibitor-like PepSY-like
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Prokaryotic-type class I peptide chain release factors
Right handed beta helix domain-containing protein
Cation-transporting P-type ATPase C-terminal
Cation-transporting P-type ATPase N-terminal
Type 1 periplasmic binding fold superfamily protein
Helix-hairpin-helix DNA-binding motif class 1
Gp5/Type VI secretion system Vgr protein OB-fold
Phosphoribosylglycinamide synthetase C-domain
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
S-adenosyl-l-methionine hydroxide adenosyltransferase C-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase N-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Glycosyl transferase family 3 N-terminal
Inner membrane protein YgaP-like transmembrane
Chromosomal replication initiator DnaA C-terminal
PhoD-like phosphatase metallophosphatase
Transposase IS116/IS110/IS902 C-terminal
Superoxide dismutase copper/zinc binding
Nitrite/Sulfite reductase ferredoxin-like
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Large ribosomal subunit protein uL6 alpha-beta
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Bacterial DNA polymerase III alpha subunit NTPase
DNA polymerase helix-hairpin-helix motif
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Na(+)-translocating NADH-quinone reductase subunit A C-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
UDP N-acetylglucosamine O-acyltransferase C-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
SusE outer membrane protein domain-containing protein
Gliding motility protein SprA N-terminal
Translation elongation factor P/YeiP central
Integral membrane protein YccS N-terminal
Lysidine-tRNA(Ile) synthetase C-terminal
Carbohydrate-binding domain-containing protein
Phospholipase/carboxylesterase/thioesterase domain-containing protein
Large ribosomal subunit protein bL9 C-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Type I restriction enzyme R protein N-terminal
Glycoside hydrolase family 31 N-terminal
Gliding motility-associated protein GldM C-terminal
Gliding motility-associated protein GldM N-terminal
Glycosyl hydrolase-like 10 domain-containing protein
Peptidase M10A and M12B matrixin and adamalysin
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Tetrahydrodipicolinate-N-succinyltransferase chain A
Biopterin-dependent aromatic amino acid hydroxylase family profile
Large ribosomal subunit protein uL15/eL18
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Bacterial transcription activator effector binding
Nicotinic acid mononucleotide adenyltransferase
Aromatic amino acid beta-eliminating lyase/threonine aldolase
NADH-rubredoxin oxidoreductase C-terminal
Saccharopine dehydrogenase-like C-terminal
Plays an important role in maintaining the position of the catalytic nucleophile
tRNA pseudouridylate synthase B C-terminal
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Type IX secretion system protein PorV domain-containing protein
Alanyl-transfer RNA synthetases family profile
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
ATP-dependent DNA helicase RecG C-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Schiff-base intermediate with substrate; via pyruvic acid
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Important for catalytic activity and assists the phosphoryl transfer reaction to Asp8 by balancing charge and orienting the reacting groups
LPS export ABC transporter periplasmic protein LptC
Transposase IS204/IS1001/IS1096/IS1165 DDE
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Outer membrane lipoprotein-sorting protein
DNA replication/recombination mediator RecO N-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Alpha-L-glutamate ligase-related protein ATP-grasp
Gly-cisPro motif, important for rejection of L-amino acids
Phosphoinositide phospholipase C, Ca2+-dependent
Moybdenum cofactor oxidoreductase dimerisation