Essential for prephenate dehydratase activity
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Organic solvent tolerance-like N-terminal
RND efflux pump membrane fusion protein barrel-sandwich
Gp5/Type VI secretion system Vgr protein OB-fold
Glycosyltransferase subfamily 4-like N-terminal
Putative oxidoreductase/dehydrogenase Rossmann-like
NADH:flavin oxidoreductase/NADH oxidase N-terminal
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Ysc84 actin-binding domain-containing protein
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Major facilitator superfamily (MFS) profile
Small ribosomal subunit protein uS4 N-terminal
Peptidase M1 membrane alanine aminopeptidase
ATP synthase F1 complex delta/epsilon subunit N-terminal
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
RNA polymerase sigma factor 70 region 4 type 2
Outer membrane protein beta-barrel domain-containing protein
Tryptophan synthase beta chain-like PALP
Important for interaction with partner proteins
Could play a key role in the communication between the regulatory and the substrate sites
Tetrahydrodipicolinate-N-succinyltransferase chain A
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Large ribosomal subunit protein uL6 alpha-beta
Oligogalacturonate lyase domain-containing protein
TonB-dependent receptor-like beta-barrel
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Heme-copper oxidase subunit III family profile
Glucosamine/galactosamine-6-phosphate isomerase
Alginate lyase domain-containing protein
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Oxidoreductase molybdopterin-binding domain-containing protein
Beta-hexosaminidase eukaryotic type N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Beta-hexosaminidase bacterial type N-terminal
Cytochrome b561 bacterial/Ni-hydrogenase
Glycosyl transferase family 3 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Activator of Hsp90 ATPase homologue 1-like C-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
RNA 2-O ribose methyltransferase substrate binding
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Soil-associated protein, TIGR03435 family
Peptidase S9 prolyl oligopeptidase catalytic
Prepilin type IV endopeptidase peptidase
Polysaccharide biosynthesis protein C-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Large ribosomal subunit protein uL2 C-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
NIF system FeS cluster assembly NifU N-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Alpha-glycerophosphate oxidase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Alpha galactosidase C-terminal beta sandwich
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Phosphoesterase PA-phosphatase related protein
Thioredoxin-like fold domain-containing protein
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Type 2A encapsulin shell protein SrpI-like
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Phosphoadenosine phosphosulphate reductase
Carboxypeptidase regulatory-like domain-containing protein
Aminoacyl-transfer RNA synthetases class-II family profile
Membrane insertase YidC/Oxa/ALB C-terminal
Lipocalin-like domain-containing protein
N6 adenine-specific DNA methyltransferase N-terminal
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Polysaccharide lyase 8 N-terminal alpha-helical
Polysaccharide lyase family 8 C-terminal
Glycine cleavage T-protein C-terminal barrel
Glucose-methanol-choline oxidoreductase C-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Transition state stabilizer; via amide nitrogen
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Alanyl-transfer RNA synthetases family profile
AB hydrolase-1 domain-containing protein
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
O-(5'-phospho-DNA)-tyrosine intermediate
6-phosphogluconate dehydrogenase C-terminal
Signal transduction histidine kinase internal region
Aconitase A/isopropylmalate dehydratase small subunit swivel
Bacterial bifunctional deaminase-reductase C-terminal
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Chromosomal replication initiator DnaA C-terminal
Moves into active site upon enzyme activation, plays a role in electron transfer
Alpha-L-rhamnosidase six-hairpin glycosidase
Bacterial alpha-L-rhamnosidase N-terminal
Glycosyl-hydrolase family 116 N-terminal
Glycosyl-hydrolase family 116 catalytic region
Release factor glutamine methyltransferase N-terminal
Cytochrome b/b6 N-terminal region profile
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Endoribonuclease L-PSP/chorismate mutase-like
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Molybdopterin cofactor biosynthesis C (MoaC)
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
Peptide methionine sulphoxide reductase MsrA
Anthranilate synthase component I N-terminal
DNA-directed DNA polymerase family A palm
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Important for beta-aspartyl-AMP intermediate formation
Polymerase/histidinol phosphatase N-terminal
Calcium-dependent phosphoinositide phospholipase C
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Plays an important role in substrate specificity
SMP-30/Gluconolaconase/LRE-like region-containing protein
Cation-transporting P-type ATPase N-terminal
Pyruvate dehydrogenase E1 component middle
Penicillin-binding protein transpeptidase
40-residue YVTN family beta-propeller repeat protein
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
DNA replication/recombination mediator RecO N-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Mandelate racemase/muconate lactonizing enzyme C-terminal
Proton acceptor; for glutaminase activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-91)
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Membrane fusion protein biotin-lipoyl like
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Mannose-6-phosphate isomerase type II C-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Myo-inositol-1-phosphate synthase GAPDH-like
Polynucleotide kinase-phosphatase C-terminal
Polynucleotide kinase-phosphatase ligase
Gamma-butyrobetaine hydroxylase-like N-terminal
Translation elongation factor P/YeiP central
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Outer membrane lipoprotein-sorting protein
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Type IV secretion system coupling protein TraD DNA-binding
1,4-alpha-glucan branching enzyme C-terminal
Glycoside hydrolase family 57 N-terminal
Outer membrane lipoprotein carrier protein LolA
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Glycosyl hydrolase family 30 beta sandwich
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
4'-phosphopantetheinyl transferase N-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Inosine/uridine-preferring nucleoside hydrolase
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:ubiquinone/plastoquinone oxidoreductase chloroplast chain 5 C-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Prolyl 3,4-dihydroxylase TPA1/OFD1 N-terminal
Alginate export domain-containing protein
Superoxide dismutase copper/zinc binding
Pyridoxamine 5'-phosphate oxidase putative
Gfo/Idh/MocA-like oxidoreductase bacterial type C-terminal
Formiminotransferase C-terminal subdomain
Formiminotransferase N-terminal subdomain
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
Putative regulatory protein FmdB Zinc ribbon
Pectate lyase superfamily protein domain-containing protein
NADH:ubiquinone oxidoreductase 30kDa subunit
Beta-xylosidase C-terminal Concanavalin A-like
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
DNA mismatch repair proteins mutS family
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Glycoside hydrolase GH146 substrate-binding
Glycoside hydrolase GH146 substrate-binding domain-containing protein
Biopterin-dependent aromatic amino acid hydroxylase family profile
Bacterial type II secretion system protein E
Nitrite/Sulfite reductase ferredoxin-like
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
O-(phosphoribosyl dephospho-coenzyme A)serine
Alpha-N-acetylglucosaminidase C-terminal
Alpha-N-acetylglucosaminidase N-terminal
Alpha-N-acetylglucosaminidase tim-barrel
Signal transduction histidine kinase osmosensitive K+ channel sensor N-terminal
RNA binding; important for wobble base 34 recognition
Antitoxin Xre/MbcA/ParS-like toxin-binding
Glycoside hydrolase family 31 N-terminal
Cytochrome P460 domain-containing protein
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Membrane protein 6-pyruvoyl-tetrahydropterin synthase-related
Formamidopyrimidine-DNA glycosylase catalytic
Putative adhesin domain-containing protein
Bacteriophage tail tape measure C-terminal
SGNH hydrolase-type esterase domain-containing protein
Probable endolytic peptidoglycan transglycosylase RlpA
RlpA-like protein double-psi beta-barrel
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
Peptide methionine sulfoxide reductase MsrA
Polysaccharide chain length determinant N-terminal
Glycine zipper domain-containing protein
Large ribosomal subunit protein uL15/eL18
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Glucose-methanol-choline oxidoreductase N-terminal
YbaK/aminoacyl-tRNA synthetase-associated
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Transposase IS116/IS110/IS902 C-terminal
Nucleophile; methyl group acceptor from either O6-methylguanine or O4-methylthymine
Nucleophile; methyl group acceptor from methylphosphotriester
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Pseudouridine synthase I TruA alpha/beta
N-acetylneuraminic acid synthase N-terminal
Glycoside hydrolase family 42 N-terminal
Glycosyl-hydrolase 97 C-terminal oligomerisation
Helix-hairpin-helix DNA-binding motif class 1
TonB-dependent receptor-like beta-barrel domain-containing protein
Phage terminase large subunit N-terminal
Thiol:disulfide interchange protein DsbD N-terminal
N-sulphoglucosamine sulphohydrolase C-terminal
Bacterial OB-fold domain-containing protein
Large ribosomal subunit protein uL30-like ferredoxin-like fold
NADH:ubiquinone oxidoreductase chain 4 N-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Could be important to modulate the pK values of the two catalytic cysteine residues
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Trigger factor ribosome-binding bacterial
YVTN beta-propeller repeat-containing protein
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Phospholipase C/D domain-containing protein
Interaction with polymerase core subunit RpoC
Glutathionylspermidine synthase pre-ATP-grasp-like
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
UDP N-acetylglucosamine O-acyltransferase C-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Membrane iron-sulfur containing protein FtrD-like
Pyrroline-5-carboxylate reductase dimerisation
Outer membrane lipoprotein BamD-like domain-containing protein
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Abnormal spindle-like microcephaly-associated protein ASH
Histidine-specific methyltransferase SAM-dependent
Pyrimidine nucleoside phosphorylase C-terminal