NADH:flavin oxidoreductase/NADH oxidase N-terminal
DNA primase/polymerase bifunctional N-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Membrane transport protein MMPL domain-containing protein
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Major facilitator superfamily (MFS) profile
CD-NTase-associated protein 12/Pycsar effector protein TIR
Ionotropic glutamate receptor C-terminal
Solute-binding protein family 3/N-terminal
Reversibly protonated during proton transport
Peptidase M1 membrane alanine aminopeptidase
Peptidase S8/S53 domain-containing protein
Cytochrome bc1 complex Rieske iron-sulfur subunit
Ricin B lectin domain-containing protein
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
SMP-30/Gluconolactonase/LRE-like region domain-containing protein
Tryptophan synthase beta chain-like PALP
Bacterial bifunctional deaminase-reductase C-terminal
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Nitrile hydratase alpha /Thiocyanate hydrolase gamma
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
RNA polymerase sigma factor 70 region 4 type 2
Helix-hairpin-helix DNA-binding motif class 1
Schiff-base intermediate with D-ribose 5-phosphate
Pyridoxamine 5'-phosphate oxidase putative
PknH-like extracellular domain-containing protein
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Lysyl-tRNA synthetase N-terminal transmembrane region
Phosphatidylglycerol lysyltransferase C-terminal
Transposase IS116/IS110/IS902 C-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
Bacterial Ig-like domain-containing protein
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Terminase large subunit gp17-like C-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
DNA replication/recombination mediator RecO N-terminal
Alpha-glycerophosphate oxidase C-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Transition state stabilizer; via amide nitrogen
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Probable subtilase-type protease inhibitor
Glycosyltransferase subfamily 4-like N-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Penicillin-binding protein transpeptidase
Mycothiol-dependent maleylpyruvate isomerase metal-binding
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Gram-positive cocci surface proteins LPxTG domain-containing protein
Interaction with polymerase core subunit RpoC
Pyruvate dehydrogenase E1 component middle
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Mandelate racemase/muconate lactonizing enzyme C-terminal
Transcription regulator AsnC/Lrp ligand binding
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Cytochrome b561 bacterial/Ni-hydrogenase
Type VII secretion system protein EssD-like
Large ribosomal subunit protein uL6 alpha-beta
DnaJ homologue subfamily C member 28 conserved
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Cytochrome C biogenesis protein transmembrane
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Cell wall-active antibiotics response LiaF-like C-terminal
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Glycine cleavage T-protein C-terminal barrel
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Cell envelope-related transcriptional attenuator
Peptidoglycan binding-like domain-containing protein
Beta-hexosaminidase bacterial type N-terminal
Ribosomal RNA adenine methylase transferase N-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Polymerase/histidinol phosphatase N-terminal
Release factor glutamine methyltransferase N-terminal
Glycosyltransferase family 28 N-terminal
Large ribosomal subunit protein uL15/eL18
Cytochrome bc1 complex cytochrome c subunit
Shikimate dehydrogenase substrate binding N-terminal
Resolvase/invertase-type recombinase catalytic
Important for substrate specificity; cannot use PPi as phosphoryl donor
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Metallo-beta-lactamase domain-containing protein
Removed in mature form; by autocatalysis
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Gly-cisPro motif, important for rejection of L-amino acids
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Exonuclease VII large subunit C-terminal
Phosphocysteine intermediate; for EIIB activity
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
L,D-transpeptidase catalytic domain-containing protein
Carbohydrate-binding/sugar hydrolysis domain-containing protein
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
SUF system FeS cluster assembly SufBD N-terminal
AB hydrolase-1 domain-containing protein
Chitosanase (Glycosyl hydrolase group 75)
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)
Calcineurin-like phosphoesterase domain-containing protein
MmyB-like transcription regulator ligand binding
Glycoside hydrolase family 42 N-terminal
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Methionyl-tRNA synthetase anticodon-binding
Tetracyclin repressor-like C-terminal group 31
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Heme-copper oxidase subunit III family profile
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
RNA 2-O ribose methyltransferase substrate binding
Acetylserotonin O-methyltransferase dimerisation
Involved in allosteric activation by GTP
Protein-arginine deiminase C-terminal domain-containing protein
Proteinase inhibitor I42 chagasin domain-containing protein
Acyltransferase MbtK/IucB-like conserved
Could play a key role in the communication between the regulatory and the substrate sites
Important for beta-aspartyl-AMP intermediate formation
Thiopeptide-type bacteriocin biosynthesis
Polynucleotide kinase-phosphatase C-terminal
Polynucleotide kinase-phosphatase ligase
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-99)
Squalene cyclase C-terminal domain-containing protein
Glycosyl transferase family 28 C-terminal
Endoribonuclease L-PSP/chorismate mutase-like
Erythromycin biosynthesis protein CIII-like central
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
TIGR04222 domain-containing membrane protein
Putative amidase domain-containing protein
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Prokaryotic-type class I peptide chain release factors
DNA-directed RNA polymerase RpoA/D/Rpb3-type
3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold
PhoD-like phosphatase metallophosphatase
SGNH hydrolase-type esterase domain-containing protein
Ribose-phosphate pyrophosphokinase N-terminal
YbaK/aminoacyl-tRNA synthetase-associated
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
Subtilisin inhibitor domain-containing protein
DNA-directed DNA polymerase family A palm
Prepilin type IV endopeptidase peptidase
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Alanyl-transfer RNA synthetases family profile
Electron transfer via tryptophanyl radical
Membrane insertase YidC/Oxa/ALB C-terminal
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
6-phosphogluconate dehydrogenase C-terminal
Glycosyl hydrolase family 98 putative carbohydrate-binding module
Peptidase S9 prolyl oligopeptidase catalytic
Transglycosylase SLT domain-containing protein
Glycosyl hydrolase family 95 N-terminal domain-containing protein
NADH:ubiquinone oxidoreductase-like 20kDa subunit
S-adenosyl-L-homocysteine hydrolase NAD binding
Peptidase C39-like domain-containing protein
ABC-type glycine betaine transport system substrate-binding
Integral membrane protein YccS N-terminal
Schiff-base intermediate with substrate; via pyruvic acid
Molybdopterin cofactor biosynthesis C (MoaC)
Glycerophosphoryl diester phosphodiesterase family protein
Nicotinate phosphoribosyltransferase N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Plays an important role in substrate specificity
Styrene monooxygenase StyA putative substrate binding
Nitrite/Sulfite reductase ferredoxin-like
Elongation factor G-binding protein C-terminal treble-clef zinc-finger
dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase
Translation elongation factor P/YeiP central
Capsule synthesis protein CapA domain-containing protein
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Aromatic amino acid beta-eliminating lyase/threonine aldolase
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
N,N-dimethylformamidase beta subunit-like C-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Polysaccharide chain length determinant N-terminal
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Threonine/serine exporter-like N-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
Streptomyces killer toxin-like beta/gamma crystallin domain-containing protein
Pyrroline-5-carboxylate reductase catalytic N-terminal
ABC transporter substrate-binding protein PnrA-like
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
Cobalamin-independent methionine synthase MetE N-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Positions MEP for the nucleophilic attack
Peptide methionine sulphoxide reductase MsrA
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Bacterial type II secretion system protein E
Phosphoribosylformylglycinamidine synthase linker
NADH:ubiquinone oxidoreductase 30kDa subunit
Large ribosomal subunit protein bL12 C-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
NIF system FeS cluster assembly NifU N-terminal
tRNA pseudouridine synthase II TruB subfamily 2 C-terminal
tRNA pseudouridylate synthase B C-terminal
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Inosine/uridine-preferring nucleoside hydrolase
Putative oxidoreductase/dehydrogenase Rossmann-like
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Microcin J25-processing protein McjB C-terminal
Sporulation transcription regulator WhiA N-terminal
4'-phosphopantetheinyl transferase N-terminal
Essential for prephenate dehydratase activity
Aconitase A/isopropylmalate dehydratase small subunit swivel
Gram-positive cocci surface proteins LPxTG
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
vWA-MoxR associated protein middle region 0
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Glycoside-hydrolase family GH114 TIM-barrel
Glucosamine/galactosamine-6-phosphate isomerase
Myo-inositol-1-phosphate synthase GAPDH-like
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
Glutathionylspermidine synthase pre-ATP-grasp-like
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Proton acceptor; for glutaminase activity
NADH-rubredoxin oxidoreductase C-terminal
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
N-acetylneuraminic acid synthase N-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Large ribosomal subunit protein uL2 C-terminal
Gamma-glutamylcyclotransferase AIG2-like
Right handed beta helix domain-containing protein
Involved in ionization of N3 of dUMP, leading to its activation
Sodium/calcium exchanger membrane region
Small ribosomal subunit protein uS4 N-terminal
Glycosyl transferase family 3 N-terminal
Lactate utilization protein B C-terminal
Phosphomannose isomerase type I catalytic
Transposase IS204/IS1001/IS1096/IS1165 DDE
Transposase IS204/IS1001/IS1096/IS1165 zinc-finger
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Molybdenum cofactor biosynthesis protein F N-terminal
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
Putative glycogen debranching enzyme N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Histidine-specific methyltransferase SAM-dependent
Quercetin 2,3-dioxygenase C-terminal cupin
Cytochrome b/b6 N-terminal region profile
Peptidoglycan recognition protein family
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Polysaccharide lyase 8 N-terminal alpha-helical
Polysaccharide lyase family 8 C-terminal
Saccharopine dehydrogenase-like C-terminal
Anthranilate synthase component I N-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Could be important to modulate the pK values of the two catalytic cysteine residues
Gp5/Type VI secretion system Vgr protein OB-fold
Erythromycin biosynthesis protein CIII-like central domain-containing protein
ATP synthase F1 complex delta/epsilon subunit N-terminal
Adaptive response protein AidB N-terminal
Damage-control phosphatase ARMT1-like metal-binding
O-(5'-phospho-DNA)-tyrosine intermediate
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Protein O-mannosyl-transferase C-terminal four TM
Cysteine sulfenic acid (-SOH) intermediate
Bifunctional glucose-6-phosphate/mannose-6-phosphate isomerase C-terminal
Pseudouridine synthase I TruA alpha/beta
Schiff-base intermediate with substrate; via topaquinone
Outer membrane protein beta-barrel domain-containing protein
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Lon proteolytic domain-containing protein
Phosphotransferase system enzyme I N-terminal
Type ISP restriction-modification enzyme LLaBIII C-terminal specificity
NIF system FeS cluster assembly NifU C-terminal
Cytochrome oxidase subunit II copper A binding
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Heat-inducible transcription repressor HrcA C-terminal