4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase-like C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
L,D-transpeptidase catalytic domain-containing protein
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Biopterin-dependent aromatic amino acid hydroxylase family profile
Polymerase/histidinol phosphatase N-terminal
Metallo-beta-lactamase domain-containing protein
Mediates proton transfer from the outer aqueous phase to the interior of the protein; involved in linking H(+) and Cl(-) transport
Mediates proton transfer from the protein to the inner aqueous phase
ABC-type glycine betaine transport system substrate-binding
Phosphoethanolamine transferase N-terminal
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Membrane fusion protein biotin-lipoyl like
Tryptophan synthase beta chain-like PALP
Peptide methionine sulphoxide reductase MsrA
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Outer membrane protein assembly factor BamB
Plays an important role in discriminating NADH against NADPH
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Mandelate racemase/muconate lactonizing enzyme C-terminal
Penicillin-binding protein transpeptidase
Major facilitator superfamily (MFS) profile
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Sugar fermentation stimulation protein C-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
N6 adenine-specific DNA methyltransferase N-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Glycosyltransferase subfamily 4-like N-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Survival protein SurE-like phosphatase/nucleotidase
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Urease accessory protein UreH-like transmembrane
Glycosyl transferase family 3 N-terminal
TRAP C4-dicarboxylate transport system permease DctM subunit
Aminoacyl-transfer RNA synthetases class-II family profile
7 transmembrane helices usually fused to an inactive transglutaminase
Inactive transglutaminase fused to 7 transmembrane helices
D-glutamate N-acetyltransferase-like C-terminal
D-glutamate N-acetyltransferase-like N-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
DNA polymerase III subunit delta C-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Alpha-glycerophosphate oxidase C-terminal
Acyl-CoA dehydrogenase C-terminal bacterial-type
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Bacterial OB-fold domain-containing protein
Could play a key role in the communication between the regulatory and the substrate sites
Small ribosomal subunit protein uS4 N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Periplasmic binding protein/LacI sugar binding
The binding site for the sugar molecule has not yet been established, but C-87 may be involved
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Cob(I)alamin adenosyltransferase N-terminal
Ribosomal RNA adenine methylase transferase N-terminal
Menaquinone biosynthesis protein MenD middle
DNA mismatch repair MutH/Type II restriction enzyme Sau3AI
Glucosamine/galactosamine-6-phosphate isomerase
NADH-rubredoxin oxidoreductase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Na(+)-translocating NADH-quinone reductase subunit A C-terminal
Capsule biosynthesis GfcC-like C-terminal
Capsule biosynthesis GfcC-like N-terminal
Reversibly protonated during proton transport
Sodium/calcium exchanger membrane region
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Replication initiator protein RctB central region
Schiff-base intermediate with acetaldehyde
Extradiol ring-cleavage dioxygenase LigAB LigA subunit
Solute-binding protein family 3/N-terminal
Flagellar motor switch protein FliN-like C-terminal
TonB-dependent receptor-like beta-barrel
Cytochrome c-type biogenesis protein CcmF C-terminal
Glycosyl-hydrolase family 116 N-terminal
Glycosyl-hydrolase family 116 catalytic region
Pyruvate phosphate dikinase AMP/ATP-binding
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Involved in allosteric activation by GTP
Erythronate-4-phosphate dehydrogenase dimerisation
Periplasmic nitrate reductase, electron transfer subunit
Outer membrane protein assembly factor BamA
Phosphoadenosine phosphosulphate reductase
O-(3'-phospho-DNA)-tyrosine intermediate
Outer membrane protein OmpA-like transmembrane
Outer membrane protein OmpA-like transmembrane domain-containing protein
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Homogentisate 1,2-dioxygenase N-terminal
Phosphocysteine intermediate; for EIIB activity
Chitobiase/beta-hexosaminidases N-terminal
YbaK/aminoacyl-tRNA synthetase-associated
Pseudouridine synthase I TruA alpha/beta
HTH-type transcriptional regulator MT1864/Rv1816-like C-terminal
Cytochrome b561 bacterial/Ni-hydrogenase
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Transposase IS116/IS110/IS902 C-terminal
Outer-membrane lipoprotein Wza C-terminal
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
RNA polymerase sigma factor 70 region 4 type 2
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Important for substrate binding and specificity
Disulphide bond isomerase DsbC/G N-terminal
Ion-translocating oxidoreductase complex subunit G
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Molybdopterin cofactor biosynthesis C (MoaC)
Alanyl-transfer RNA synthetases family profile
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Interacts with tRNA; defines subfamily-specific binding signature
Haem-binding uptake Tiki superfamily ChaN
Haem-binding uptake Tiki superfamily ChaN domain-containing protein
RND efflux pump membrane fusion protein barrel-sandwich
Beta-hexosaminidase bacterial type N-terminal
Dinitrogenase iron-molybdenum cofactor biosynthesis
Large ribosomal subunit protein uL2 C-terminal
Phosphomannose isomerase type I catalytic
Phosphomannose isomerase type I helical insertion
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Transposon Tn7 transposition protein TnsD C-terminal
Magnesium transporter MgtE intracellular
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Putative beta-barrel assembly-enhancing protease
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Bacterial type II secretion system protein E
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Putative Flp pilus-assembly TadG-like N-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Saccharopine dehydrogenase-like C-terminal
Type II secretion system protein GspI C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Translation elongation factor P/YeiP central
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Flagellar Assembly Protein A N-terminal region
Prokaryotic-type class I peptide chain release factors
Gamma-glutamylcyclotransferase AIG2-like
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Gp5/Type VI secretion system Vgr protein OB-fold
Bacterial collagen-like protein middle domain-containing protein
Poly-beta-hydroxybutyrate polymerase N-terminal
Inner membrane protein YgaP-like transmembrane
Threonine/serine exporter-like N-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
ATP synthase F1 complex delta/epsilon subunit N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Methylamine/Aralkylamine dehydrogenase light chain C-terminal
Tryptophylquinone 6'-substrate hemiaminal intermediate
Solitary outer membrane autotransporter beta-barrel
Large ribosomal subunit protein uL6 alpha-beta
Peptide methionine sulfoxide reductase MsrA
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Important for beta-aspartyl-AMP intermediate formation
Virulence factor membrane-bound polymerase C-terminal
Integral membrane protein YccS N-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
6-phosphogluconate dehydrogenase C-terminal
Flagellar hook-length control protein-like C-terminal
Signal transduction histidine kinase internal region
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
DNA-directed DNA polymerase family A palm
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Outer membrane protein beta-barrel domain-containing protein
Thymidylate synthase/dCMP hydroxymethylase
DnaJ homologue subfamily C member 28 conserved
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Anthranilate synthase component I N-terminal
Polysaccharide chain length determinant N-terminal
DNA-binding and helicase activity, interacts with RecC
Nuclease activity, interacts with RecD and RecA
Interaction with polymerase core subunit RpoC
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Appears to be important in orienting the phosphate for catalysis
Gfo/Idh/MocA-like oxidoreductase C-terminal
Sodium symporter small subunit predicted
Translocation and assembly module subunit TamA
Curli production assembly/transport component CsgG
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
Polysaccharide biosynthesis protein CapD-like
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Activator of Hsp90 ATPase homologue 1-like C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
CobB/CobQ-like glutamine amidotransferase
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Quercetin 2,3-dioxygenase C-terminal cupin
Type III secretion system flagellar brake protein YcgR PilZN
ABC transporter substrate-binding protein
FAD-dependent cmnm(5)s(2)U34 oxidoreductase
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
UDP N-acetylglucosamine O-acyltransferase C-terminal
RNA methyltransferase SpoU/TrmH type C-terminal
Polypeptide-transport-associated ShlB-type
Chromosomal replication initiator DnaA C-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
4'-phosphopantetheinyl transferase N-terminal
NIF system FeS cluster assembly NifU C-terminal
Flagellar assembly protein FliH/Type III secretion system HrpE
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Pyridoxamine 5'-phosphate oxidase putative
Positions MEP for the nucleophilic attack
Lipopolysaccharide export system protein LptA
Organic solvent tolerance-like N-terminal
Involved in tetramerization or stability of the tetramer
DNA replication/recombination mediator RecO N-terminal
Plays an important role in substrate specificity
Glycoside hydrolase family 31 N-terminal
For 3-hydroxyacyl-CoA dehydrogenase activity
RNA 2-O ribose methyltransferase substrate binding
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Shikimate dehydrogenase substrate binding N-terminal
Pyruvate dehydrogenase E1 component middle
Acyl-ester intermediate; for transpeptidase activity
Proton donor; for transglycosylase activity
Type II secretion system pilot lipoprotein GspS-beta
Lytic transglycosylase superhelical linker
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
DNA mismatch repair proteins mutS family
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Transcriptional regulator SgrR N-terminal HTH
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Phosphotransferase system enzyme I N-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Cobalamin-independent methionine synthase MetE N-terminal
Negative modulator of initiation of replication SeqA N-terminal
Replication modulator SeqA C-terminal DNA-binding
Nucleophile; cysteine thiosulfonate intermediate
High-affinity zinc uptake system protein ZnuA
Methylguanine DNA methyltransferase ribonuclease-like
SsuA/THI5-like domain-containing protein
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Glycoside hydrolase family 42 N-terminal
Resolvase/invertase-type recombinase catalytic
Gly-cisPro motif, important for rejection of L-amino acids
S-adenosylmethionine-dependent methyltransferase
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Autoinducer 2-binding periplasmic protein LuxP
Lysidine-tRNA(Ile) synthetase C-terminal
Major facilitator superfamily associated
NIF system FeS cluster assembly NifU N-terminal
N-end rule aminoacyl transferase C-terminal
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-98)
Heme-copper oxidase subunit III family profile
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
5-glutamyl coenzyme A thioester intermediate
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Cysteine sulfenic acid (-SOH) intermediate
Important for interaction with partner proteins
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Signal transduction histidine kinase 5TM receptor LytS transmembrane region
Aspartate carbamoyltransferase regulatory subunit C-terminal
Aspartate carbamoyltransferase regulatory subunit N-terminal
Large ribosomal subunit protein uL15/eL18
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
ABC transporter substrate-binding protein PnrA-like
Bacterial transcription activator effector binding
RNA binding; important for wobble base 34 recognition
Transglycosylase SLT domain-containing protein
Ionotropic glutamate receptor C-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Exopolysaccharide production protein YjbE
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Small-conductance mechanosensitive channel
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Could be important to modulate the pK values of the two catalytic cysteine residues
DNA polymerase III delta subunit C-terminal
Essential for prephenate dehydratase activity
Pyrimidine nucleoside phosphorylase C-terminal
Large ribosomal subunit protein bL25 L25
Important for autoinhibition of adenylyltransferase activity
Type II secretion system protein GspG C-terminal
Penicillin-binding protein activator LpoA
Chromosome partition protein MukF C-terminal
Chromosome partition protein MukF middle
Chromosome partition protein MukF winged-helix
Carbamoyl-phosphate synthase small subunit N-terminal
Regulator of nucleoside diphosphate kinase N-terminal
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Non-canonical purine NTP phosphatase/PRRC1
Outer membrane protein assembly factor BamC
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Aspartate/homoserine dehydrogenase NAD-binding
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase C-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase N-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
DNA-directed DNA polymerase family B exonuclease
DNA-directed DNA polymerase family B multifunctional
Cytochrome C biogenesis protein transmembrane
Thiol:disulfide interchange protein DsbD N-terminal
Membrane-bound lytic murein transglycosylase F
Influences the redox potential of the prosthetic heme and FAD groups
Involved in heme-bound ligand stabilization and O-O bond activation
Helix-hairpin-helix DNA-binding motif class 1
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Electron transfer via tryptophanyl radical
Prepilin type IV endopeptidase peptidase