Anthranilate synthase component I N-terminal
Polymerase/histidinol phosphatase N-terminal
Major facilitator superfamily (MFS) profile
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Gram-positive cocci surface proteins LPxTG
Involved in allosteric activation by GTP
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Thiamine pyrophosphate enzyme TPP-binding
Alpha-D-phosphohexomutase alpha/beta/alpha
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Aminoacyl-transfer RNA synthetases class-II family profile
UDP-glucose/GDP-mannose dehydrogenase C-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Helix-hairpin-helix DNA-binding motif class 1
Inosine/uridine-preferring nucleoside hydrolase
Peptide methionine sulphoxide reductase MsrA
Putative Flp pilus-assembly TadG-like N-terminal
Translation elongation factor P/YeiP central
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Glycosyltransferase subfamily 4-like N-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Restriction endonuclease AspBHI N-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Cell envelope-related transcriptional attenuator
SsuA/THI5-like domain-containing protein
Glycoside hydrolase family 42 N-terminal
tRNA pseudouridine synthase II TruB subfamily 2 C-terminal
tRNA pseudouridylate synthase B C-terminal
Resuscitation-promoting factor core lysozyme-like
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
Pyridoxamine 5'-phosphate oxidase putative
Sodium/calcium exchanger membrane region
Ribosomal RNA adenine methylase transferase N-terminal
Important for substrate specificity; cannot use PPi as phosphoryl donor
Tryptophan synthase beta chain-like PALP
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Mycothiol-dependent maleylpyruvate isomerase metal-binding
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Septum formation-related domain-containing protein
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Probable transposase IS891/IS1136/IS1341
Tetracyclin repressor-like C-terminal group 31
Solute-binding protein family 3/N-terminal
RNA polymerase sigma factor 70 region 4 type 2
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Tat pathway signal sequence domain protein
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Reversibly protonated during proton transport
Phosphoadenosine phosphosulphate reductase
Exonuclease VII large subunit C-terminal
YbaK/aminoacyl-tRNA synthetase-associated
Prokaryotic-type class I peptide chain release factors
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Na+/H+ antiporter MnhB subunit-related protein
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Arabinogalactan endo-beta-1,4-galactanase
SUF system FeS cluster assembly SufBD N-terminal
ABC-type glycine betaine transport system substrate-binding
Transcription regulator AsnC/Lrp ligand binding
Ribose-phosphate pyrophosphokinase N-terminal
Penicillin-binding protein transpeptidase
Damage-control phosphatase ARMT1-like metal-binding
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Positions MEP for the nucleophilic attack
Thiopeptide-type bacteriocin biosynthesis
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Beta-hexosaminidase bacterial type N-terminal
DNA primase/polymerase bifunctional N-terminal
Large ribosomal subunit protein uL2 C-terminal
NADH-rubredoxin oxidoreductase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Glucose-methanol-choline oxidoreductase N-terminal
Gp5/Type VI secretion system Vgr protein OB-fold
O-(5'-phospho-DNA)-tyrosine intermediate
Mandelate racemase/muconate lactonizing enzyme C-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Interaction with polymerase core subunit RpoC
Heat-inducible transcription repressor HrcA C-terminal
Alpha-L-arabinofuranosidase B arabinose-binding
Sporulation transcription regulator WhiA N-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Large ribosomal subunit protein uL15/eL18
LPXTG cell wall anchor domain-containing protein
Plays an important role in substrate specificity
Heme-copper oxidase subunit III family profile
ATP synthase F1 complex delta/epsilon subunit N-terminal
Bifunctional glucose-6-phosphate/mannose-6-phosphate isomerase C-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
non-reducing end alpha-L-arabinofuranosidase
Peptidase S9 prolyl oligopeptidase catalytic
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Acetylserotonin O-methyltransferase dimerisation
Membrane insertase YidC/Oxa/ALB C-terminal
Alpha-glycerophosphate oxidase C-terminal
Proton acceptor; for glutaminase activity
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Glycoside hydrolase family 31 N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
S-adenosyl-L-homocysteine hydrolase NAD binding
Removed in mature form; by autocatalysis
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Cytochrome b/b6 N-terminal region profile
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
NIF system FeS cluster assembly NifU N-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Bacterial type II secretion system protein E
Carbamoyl-phosphate synthase small subunit N-terminal
Prepilin type IV endopeptidase peptidase
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
N6 adenine-specific DNA methyltransferase N-terminal
Shikimate dehydrogenase substrate binding N-terminal
Peptidase M1 membrane alanine aminopeptidase
Protein O-mannosyl-transferase C-terminal four TM
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
PhoD-like phosphatase metallophosphatase
Phosphomannose isomerase type I catalytic
Transition state stabilizer; via amide nitrogen
Schiff-base intermediate with D-ribose 5-phosphate
Type ISP restriction-modification enzyme LLaBIII C-terminal specificity
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Glucosamine/galactosamine-6-phosphate isomerase
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
N-acetylneuraminic acid synthase N-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Glutathionylspermidine synthase pre-ATP-grasp-like
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
6-phosphogluconate dehydrogenase C-terminal
Pyruvate dehydrogenase E1 component middle
Cysteine sulfenic acid (-SOH) intermediate
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Cytochrome bc1 complex Rieske iron-sulfur subunit
Essential for prephenate dehydratase activity
Bacterial bifunctional deaminase-reductase C-terminal
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Important for beta-aspartyl-AMP intermediate formation
Acyltransferase MbtK/IucB-like conserved
Schiff-base intermediate with substrate; via pyruvic acid
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Glycosyl hydrolase-like 10 domain-containing protein
Glycosyl transferase family 3 N-terminal
Squalene cyclase C-terminal domain-containing protein
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Gly-cisPro motif, important for rejection of L-amino acids
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)
Moybdenum cofactor oxidoreductase dimerisation
Glycerophosphoryl diester phosphodiesterase family protein
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Resolvase/invertase-type recombinase catalytic
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Pseudouridine synthase I TruA alpha/beta
ABC transporter substrate-binding protein PnrA-like
Histidine-specific methyltransferase SAM-dependent
Myo-inositol-1-phosphate synthase GAPDH-like
Adaptive response protein AidB N-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Involved in ionization of N3 of dUMP, leading to its activation
Cell wall-active antibiotics response LiaF-like C-terminal
Styrene monooxygenase StyA putative substrate binding
Alanyl-transfer RNA synthetases family profile
Cytochrome C biogenesis protein transmembrane
Streptomyces killer toxin-like beta/gamma crystallin domain-containing protein
Alpha-L-rhamnosidase six-hairpin glycosidase
Bacterial alpha-L-rhamnosidase N-terminal
Elongation factor G-binding protein C-terminal treble-clef zinc-finger
4'-phosphopantetheinyl transferase N-terminal
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
Probable subtilase-type protease inhibitor
Small ribosomal subunit protein uS4 N-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
DNA replication/recombination mediator RecO N-terminal
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Nucleophile; cysteine thiosulfonate intermediate
Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
Phosphocysteine intermediate; for EIIB activity
Aspartate/homoserine dehydrogenase NAD-binding
RNA 2-O ribose methyltransferase substrate binding
DNA-directed DNA polymerase family A palm
Could be important to modulate the pK values of the two catalytic cysteine residues
Methionyl-tRNA synthetase anticodon-binding
Nicotinate phosphoribosyltransferase N-terminal
Release factor glutamine methyltransferase N-terminal
Lon proteolytic domain-containing protein
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Could play a key role in the communication between the regulatory and the substrate sites
Phosphatidylglycerol lysyltransferase C-terminal
Methylguanine DNA methyltransferase ribonuclease-like
DnaJ homologue subfamily C member 28 conserved
6-phosphogluconate dehydrogenase NADP-binding
Phosphoribosylformylglycinamidine synthase linker
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Cytochrome oxidase subunit II copper A binding
Endoribonuclease L-PSP/chorismate mutase-like
Phosphotransferase system enzyme I N-terminal
Glycine cleavage T-protein C-terminal barrel
Large ribosomal subunit protein uL6 alpha-beta
Glycoside-hydrolase family GH114 TIM-barrel