Trimeric autotransporter adhesin YadA-like C-terminal membrane anchor
Trimeric autotransporter adhesin YadA-like stalk
Glycosyltransferase subfamily 4-like N-terminal
Periplasmic nitrate reductase, electron transfer subunit
DNA mismatch repair MutH/Type II restriction enzyme Sau3AI
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
Ribose-phosphate pyrophosphokinase N-terminal
Flagellar motor switch protein FliN N-terminal
Flagellar motor switch protein FliN-like C-terminal
Gp5/Type VI secretion system Vgr protein OB-fold
Putative type VI secretion system Rhs element associated Vgr
Aminoacyl-transfer RNA synthetases class-II family profile
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
FAD-dependent oxidoreductase 2 FAD binding
Cysteine sulfenic acid (-SOH) intermediate
Major facilitator superfamily associated
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Proton acceptor; for decarboxylase activity
Proton donor; for decarboxylase activity
Proton donor; for formyltransferase activity
Cytochrome c-type biogenesis protein CcmF C-terminal
Aspartate/homoserine dehydrogenase NAD-binding
Phosphocysteine intermediate; for EIIB activity
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Major facilitator superfamily (MFS) profile
Organic solvent tolerance-like N-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
CobB/CobQ-like glutamine amidotransferase
Disulphide bond isomerase DsbC/G N-terminal
6-phosphogluconate dehydrogenase C-terminal
Flagellar basal body rod protein N-terminal
Could play a key role in the communication between the regulatory and the substrate sites
Tryptophan synthase beta chain-like PALP
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Polymerase/histidinol phosphatase N-terminal
Terminase large subunit-like endonuclease
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
DNA replication/recombination mediator RecO N-terminal
Menaquinone biosynthesis protein MenD middle
Large ribosomal subunit protein uL6 alpha-beta
RNA polymerase sigma factor 70 region 4 type 2
Polysaccharide lyase family 8 C-terminal
Thymidylate synthase/dCMP hydroxymethylase
Cytochrome C biogenesis protein transmembrane
Cytochrome b561 bacterial/Ni-hydrogenase
RND efflux pump membrane fusion protein barrel-sandwich
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Negative modulator of initiation of replication SeqA N-terminal
Replication modulator SeqA C-terminal DNA-binding
Survival protein SurE-like phosphatase/nucleotidase
O-(3'-phospho-DNA)-tyrosine intermediate
Phosphoadenosine phosphosulphate reductase
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Flagellar basal-body/hook protein C-terminal
Transposase IS116/IS110/IS902 C-terminal
Outer-membrane lipoprotein carrier protein
Important for beta-aspartyl-AMP intermediate formation
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Large ribosomal subunit protein uL2 C-terminal
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Sugar fermentation stimulation protein C-terminal
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Glucosamine/galactosamine-6-phosphate isomerase
High-affinity zinc uptake system protein ZnuA
Shikimate dehydrogenase substrate binding N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Outer membrane protein assembly factor BamE
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Non-canonical purine NTP phosphatase/PRRC1
O-(5'-phospho-DNA)-tyrosine intermediate
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
O-(phosphoribosyl dephospho-coenzyme A)serine
Solute-binding protein family 3/N-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Alanyl-transfer RNA synthetases family profile
Important for interaction with partner proteins
Hypersensitivity response secretion-like HrpJ
Aconitase A/isopropylmalate dehydratase small subunit swivel
Bacterial type II secretion system protein E
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
Appears to be important in orienting the phosphate for catalysis
YdgH/BhsA/McbA-like domain-containing protein
Resolvase/invertase-type recombinase catalytic
Peptidase S9 prolyl oligopeptidase catalytic
DNA-directed DNA polymerase family B multifunctional
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Mandelate racemase/muconate lactonizing enzyme C-terminal
Bacteriophage T7 Gp4 DNA primase/helicase N-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
DNA mismatch repair proteins mutS family
Membrane fusion protein biotin-lipoyl like
UDP N-acetylglucosamine O-acyltransferase C-terminal
Release factor glutamine methyltransferase N-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
TtsA-like Glycoside hydrolase family 108
NADH:ubiquinone oxidoreductase-like 20kDa subunit
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Ionotropic glutamate receptor C-terminal
YbaK/aminoacyl-tRNA synthetase-associated
Inosine/uridine-preferring nucleoside hydrolase
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Polysaccharide chain length determinant N-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Calcium/calmodulin-dependent protein kinase II association-domain
Calcium/calmodulin-dependent protein kinase II association-domain domain-containing protein
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Exonuclease VII large subunit C-terminal
Integral membrane protein YccS N-terminal
Transcriptional regulator SgrR N-terminal HTH
Molybdopterin cofactor biosynthesis C (MoaC)
Glycosyl transferase family 3 N-terminal
Beta/gamma crystallin 'Greek key' domain-containing protein
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Mechanosensitive ion channel inner membrane
Alpha-D-phosphohexomutase alpha/beta/alpha
ABC-type transport auxiliary lipoprotein component
Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS
Interaction with polymerase core subunit RpoC
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Threonine/serine exporter-like N-terminal
Small ribosomal subunit protein uS4 N-terminal
TonB-dependent receptor-like beta-barrel
Important for substrate binding and specificity
Reversibly protonated during proton transport
Periplasmic binding protein/LacI sugar binding
Outer membrane protein assembly factor BamA
Acyl-ester intermediate; for transpeptidase activity
Penicillin-binding protein transpeptidase
Proton donor; for transglycosylase activity
Transglycosylase PBP1b N-terminal transmembrane
Protein-methionine-sulfoxide reductase catalytic subunit MsrP
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Polysaccharide biosynthesis protein C-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Membrane insertase YidC/Oxa/ALB C-terminal
TRAP C4-dicarboxylate transport system permease DctM subunit
Dinitrogenase iron-molybdenum cofactor biosynthesis
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-98)
Tetrahydrodipicolinate-N-succinyltransferase chain A
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Fimbrial-type adhesion domain-containing protein
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Lipopolysaccharide export system protein LptA
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Large ribosomal subunit protein bL25 L25
Aspartate carbamoyltransferase regulatory subunit C-terminal
Aspartate carbamoyltransferase regulatory subunit N-terminal
YbhB/YbcL family Raf kinase inhibitor-like protein
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Proline utilization A proline dehydrogenase N-terminal
Phosphomannose isomerase type I catalytic
Phosphomannose isomerase type I helical insertion
Essential for prephenate dehydratase activity
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
RNA 2-O ribose methyltransferase substrate binding
Translocation and assembly module subunit TamA
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
NADH:ubiquinone oxidoreductase 30kDa subunit
Thiol:disulfide interchange protein DsbD N-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
NIF system FeS cluster assembly NifU C-terminal
Outer membrane protein assembly factor BamB
Thiol:disulfide interchange protein DsbD
Plays an important role in discriminating NADH against NADPH
Penicillin-binding protein activator LpoA
Pyrimidine nucleoside phosphorylase C-terminal
Prokaryotic-type class I peptide chain release factors
Outer membrane protein assembly factor BamC
Gly-cisPro motif, important for rejection of L-amino acids
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Required for zinc-mediated homotetramerization and catalytic activity
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Anthranilate synthase component I N-terminal
NIF system FeS cluster assembly NifU N-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Required for dimer formation and molybdate binding
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Proton acceptor; for glutaminase activity
Sodium/calcium exchanger membrane region
FAD-dependent cmnm(5)s(2)U34 oxidoreductase
N6 adenine-specific DNA methyltransferase N-terminal
Bacteriophage tail tape measure C-terminal
Bacteriophage tail tape measure N-terminal
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
HupH hydrogenase expression protein C-terminal
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
L-seryl-tRNA selenium transferase N-terminal
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Phosphotransferase system enzyme I N-terminal
Cation-transporting P-type ATPase N-terminal
Phosphoethanolamine transferase N-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Regulator of nucleoside diphosphate kinase N-terminal
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Erythronate-4-phosphate dehydrogenase dimerisation
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Flagellar hook-length control protein-like C-terminal
Plays a key role in the stabilization of the transition state and positioning the aldehyde component
Nucleoside-specific channel-forming protein Tsx
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Pyruvate phosphate dikinase AMP/ATP-binding
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Thiol:disulfide interchange protein DsbL
DnaJ homologue subfamily C member 28 conserved
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Type I restriction modification DNA specificity
DNA polymerase III delta subunit C-terminal
Pyruvate dehydrogenase E1 component middle
Involved in allosteric activation by GTP
DNA polymerase III subunit delta C-terminal
Chromosome partition protein MukF C-terminal
Chromosome partition protein MukF middle
Chromosome partition protein MukF winged-helix
Prepilin type IV endopeptidase peptidase
Formate-dependent nitrite reductase complex subunit
Small-conductance mechanosensitive channel
DNA-directed DNA polymerase family A palm
Glutathionylspermidine synthase pre-ATP-grasp-like
Helix-hairpin-helix DNA-binding motif class 1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
Bacterial toxin RNase RnlA/LsoA N-terminal
Bacterial toxin RNase RnlA/LsoA N-terminal repeated
Interacts with tRNA; defines subfamily-specific binding signature
Bacterial OB-fold domain-containing protein
Virulence factor membrane-bound polymerase C-terminal
Positions MEP for the nucleophilic attack
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Yop protein translocation protein D periplasmic
Increases nucleophilicity of active site Cys
Plays an important role in substrate specificity
Outer membrane protein assembly factor BamD
Glycine cleavage T-protein C-terminal barrel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Alpha-glycerophosphate oxidase C-terminal
Precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase
Uroporphyrinogen-III C-methyltransferase
Toxin VasX N-terminal region domain-containing protein
Polypeptide-transport-associated ShlB-type
Lysidine-tRNA(Ile) synthetase C-terminal
Autotransporter domain-containing protein
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Flagellar assembly protein FliH/Type III secretion system HrpE
Translation elongation factor P/YeiP central
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
RNA binding; important for wobble base 34 recognition
May be important for providing the necessary conformational flexibility for enzymatic catalysis