Could be important to modulate the pK values of the two catalytic cysteine residues
Major facilitator superfamily (MFS) profile
Glycine cleavage T-protein C-terminal barrel
Membrane fusion protein biotin-lipoyl like
Signal transduction histidine kinase internal region
O-(5'-phospho-DNA)-tyrosine intermediate
RNA binding; important for wobble base 34 recognition
Peptidase S9 prolyl oligopeptidase catalytic
Pyruvate phosphate dikinase AMP/ATP-binding
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Alpha-N-acetylglucosaminidase C-terminal
Alpha-N-acetylglucosaminidase N-terminal
Alpha-N-acetylglucosaminidase tim-barrel
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Plays an important role in maintaining the position of the catalytic nucleophile
TonB-dependent receptor-like beta-barrel
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Glutathionylspermidine synthase pre-ATP-grasp-like
Outer membrane protein beta-barrel domain-containing protein
Chromosomal replication initiator DnaA C-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Pyrroline-5-carboxylate reductase catalytic N-terminal
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Pyruvate/ketoisovalerate oxidoreductase catalytic
Glycosyltransferase subfamily 4-like N-terminal
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Bacterial bifunctional deaminase-reductase C-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Penicillin-binding protein transpeptidase
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Arginine decarboxylase C-terminal helical
Ribosomal RNA adenine methylase transferase N-terminal
Lipocalin-like domain-containing protein
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
N-acetylneuraminic acid synthase N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Prokaryotic-type class I peptide chain release factors
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Phosphatidic acid phosphatase type 2/haloperoxidase
RNA polymerase sigma factor 70 region 4 type 2
Reversibly protonated during proton transport
UDP N-acetylglucosamine O-acyltransferase C-terminal
Glycoside hydrolase family 57 N-terminal
ParB-related ThiF-related cassette protein E
Large ribosomal subunit protein uL30-like ferredoxin-like fold
CobB/CobQ-like glutamine amidotransferase
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
RND efflux pump membrane fusion protein barrel-sandwich
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Major fimbrial subunit protein N-terminal
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Lysidine-tRNA(Ile) synthetase C-terminal
Plays an important role in substrate specificity
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Shikimate dehydrogenase substrate binding N-terminal
Glucosamine/galactosamine-6-phosphate isomerase
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Trigger factor ribosome-binding bacterial
4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase
Phosphoadenosine phosphosulphate reductase
Saccharopine dehydrogenase-like C-terminal
Small ribosomal subunit protein uS4 N-terminal
ATP-dependent DNA helicase RecG C-terminal
Important for beta-aspartyl-AMP intermediate formation
Gfo/Idh/MocA-like oxidoreductase N-terminal
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Meso-diaminopimelate D-dehydrogenase C-terminal
Putative acyltransferase ACT14924-like acyltransferase
NigD-like C-terminal beta sandwich domain-containing protein
N6 adenine-specific DNA methyltransferase N-terminal
Resolvase/invertase-type recombinase catalytic
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Myo-inositol-1-phosphate synthase GAPDH-like
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Serine aminopeptidase S33 domain-containing protein
Fimbrillin-A associated anchor proteins Mfa1 and Mfa2
Putative beta-lactamase-inhibitor-like PepSY-like
Electron transfer flavoprotein alpha/beta-subunit N-terminal
DNA-directed DNA polymerase family A palm
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Tryptophan synthase beta chain-like PALP
SUF system FeS cluster assembly SufBD N-terminal
Surface glycan-binding protein B xyloglucan binding
Surface glycan-binding protein B xyloglucan binding domain-containing protein
Release factor glutamine methyltransferase N-terminal
RNA 2-O ribose methyltransferase substrate binding
Type I restriction modification DNA specificity
Glycosyl-hydrolase 97 C-terminal oligomerisation
Glycogen debranching enzyme bacterial and archaeal type N-terminal
Fibronectin type-III domain-containing protein
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Thymidylate synthase/dCMP hydroxymethylase
Polysaccharide chain length determinant N-terminal
Transcriptional regulator AbiEi antitoxin N-terminal
Essential for prephenate dehydratase activity
Aspartate carbamoyltransferase regulatory subunit C-terminal
Aspartate carbamoyltransferase regulatory subunit N-terminal
Gp5/Type VI secretion system Vgr protein OB-fold
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
5-glutamyl coenzyme A thioester intermediate
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
Schiff-base intermediate with D-ribose 5-phosphate
Polysaccharide biosynthesis protein C-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Glycosyl hydrolase-like 10 domain-containing protein
Na(+)-translocating NADH-quinone reductase subunit A C-terminal
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Conserved virulence factor B-like winged helix
Mandelate racemase/muconate lactonizing enzyme C-terminal
Solute-binding protein family 3/N-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Cation-transporting P-type ATPase N-terminal
Outer membrane lipoprotein carrier protein LolA
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Putative beta-lactamase-inhibitor-like PepSY-like domain-containing protein
Transposase IS116/IS110/IS902 C-terminal
Ribose-phosphate pyrophosphokinase N-terminal
SusD/RagB family nutrient-binding outer membrane lipoprotein
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Major fimbrial subunit protein N-terminal domain-containing protein
Putative auto-transporter adhesin head GIN
Putative auto-transporter adhesin head GIN domain-containing protein
Calcineurin-like phosphoesterase C-terminal
Calcineurin-like phosphoesterase N-terminal
Exonuclease VII large subunit C-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Beta-xylosidase C-terminal Concanavalin A-like
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Helix-hairpin-helix DNA-binding motif class 1
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Fimbrial subunit protein C-terminal domain-containing protein
Aconitase A/isopropylmalate dehydratase small subunit swivel
Important for substrate specificity; cannot use PPi as phosphoryl donor
4'-phosphopantetheinyl transferase N-terminal
Gliding motility-associated lipoprotein GldB
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
DNA mismatch repair protein MutS-like N-terminal
Glycoside hydrolase GH146 substrate-binding
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Cysteine sulfenic acid (-SOH) intermediate
Peptidoglycan recognition protein family
Anthranilate synthase component I N-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Carboxypeptidase regulatory-like domain-containing protein
Cellulose-binding Sde182 nucleoside hydrolase-like
YbaK/aminoacyl-tRNA synthetase-associated
Type II restriction enzyme and methyltransferase RM.Eco57I-like
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
Cell surface receptor IPT/TIG domain protein
Putative carbohydrate metabolism domain-containing protein
Important for autoinhibition of adenylyltransferase activity
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
tRNA pseudouridylate synthase B C-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Sporulation stage II protein D amidase enhancer LytB N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Alpha galactosidase C-terminal beta sandwich
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
ATP synthase F1 complex delta/epsilon subunit N-terminal
Threonine/serine exporter-like N-terminal
Pseudouridine synthase I TruA alpha/beta
Choloylglycine hydrolase/NAAA C-terminal
Gylcosyl hydrolase 115 C-terminal domain-containing protein
Phosphomannose isomerase type I catalytic
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Polymerase/histidinol phosphatase N-terminal
Alanyl-transfer RNA synthetases family profile
Gly-cisPro motif, important for rejection of L-amino acids
Right handed beta helix domain-containing protein
O-(3'-phospho-DNA)-tyrosine intermediate
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Large ribosomal subunit protein uL15/eL18
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Large ribosomal subunit protein uL6 alpha-beta
Gfo/Idh/MocA-like oxidoreductase C-terminal
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Proton acceptor; for glutaminase activity
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Translation elongation factor P/YeiP central
Glycoside hydrolase family 65 central catalytic
Glycosyl transferase family 3 N-terminal
Glycoside hydrolase family 31 N-terminal
DNA replication/recombination mediator RecO N-terminal
Dienelactone hydrolase domain-containing protein
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Large ribosomal subunit protein uL2 C-terminal