Major facilitator superfamily (MFS) profile
NADH:flavin oxidoreductase/NADH oxidase N-terminal
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
NIF system FeS cluster assembly NifU N-terminal
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
RNA polymerase sigma factor 70 region 4 type 2
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Mandelate racemase/muconate lactonizing enzyme C-terminal
Solute-binding protein family 3/N-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Transposase IS116/IS110/IS902 C-terminal
Small ribosomal subunit protein uS4 N-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
Resolvase/invertase-type recombinase catalytic
Glucose-methanol-choline oxidoreductase N-terminal
Bacterial type II secretion system protein E
Endolytic peptidoglycan transglycosylase RlpA
RlpA-like protein double-psi beta-barrel
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Outer membrane protein assembly factor BamC
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Ionotropic glutamate receptor C-terminal
Heme-copper oxidase subunit III family profile
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Lipopolysaccharide export system protein LptA
Organic solvent tolerance-like N-terminal
Pyridoxamine 5'-phosphate oxidase putative
Acyl-CoA dehydrogenase C-terminal bacterial-type
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Ribosomal RNA adenine methylase transferase N-terminal
Bacterial bifunctional deaminase-reductase C-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Gamma-butyrobetaine hydroxylase-like N-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Flagellar motor switch protein FliN-like C-terminal
Tryptophan synthase beta chain-like PALP
Reversibly protonated during proton transport
Prepilin type IV endopeptidase peptidase
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
NADH:ubiquinone oxidoreductase chain 4 N-terminal
N-end rule aminoacyl transferase C-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Flavocytochrome c sulphide dehydrogenase flavin-binding
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Cysteine sulfenic acid (-SOH) intermediate
Aspartate/homoserine dehydrogenase NAD-binding
Moybdenum cofactor oxidoreductase dimerisation
Membrane fusion protein biotin-lipoyl like
Important for interaction with partner proteins
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Translation elongation factor P/YeiP central
DNA mismatch repair proteins mutS family
Cytochrome b561 bacterial/Ni-hydrogenase
Chromosomal replication initiator DnaA C-terminal
ABC transporter substrate-binding protein PnrA-like
ABC transporter substrate-binding protein PnrA-like domain-containing protein
Contractile injection system tube protein N-terminal
Type IV secretion system coupling protein TraD DNA-binding
Glycine cleavage T-protein C-terminal barrel
S-adenosyl-L-homocysteine hydrolase NAD binding
Regulator of nucleoside diphosphate kinase N-terminal
Transcription elongation factor GreA/GreB C-terminal
Glucose-methanol-choline oxidoreductase C-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Adaptive response protein AidB N-terminal
Plays an important role in substrate specificity
YbaK/aminoacyl-tRNA synthetase-associated
Penicillin-binding protein transpeptidase
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Alanyl-transfer RNA synthetases family profile
Secretin/TonB short N-terminal domain-containing protein
Large ribosomal subunit protein uL15/eL18
Lytic transglycosylase superhelical linker
Proline utilization A proline dehydrogenase N-terminal
High-affinity branched-chain amino acid transport system permease LivHM N-terminal
Heat-inducible transcription repressor HrcA C-terminal
Winged helix-turn-helix transcription repressor HrcA DNA-binding
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:ubiquinone/plastoquinone oxidoreductase chloroplast chain 5 C-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Plays an important role in discriminating NADH against NADPH
Cation-transporting P-type ATPase N-terminal
RND efflux pump membrane fusion protein barrel-sandwich
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Large ribosomal subunit protein uL2 C-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Carbamoyl-phosphate synthase small subunit N-terminal
Tc toxin complex TcA C-terminal TcB-binding
Anthranilate synthase component I N-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Chromosomal replication initiator protein DnaA
Flagellar hook-length control protein-like C-terminal
Thymidylate synthase/dCMP hydroxymethylase
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Required for dimer formation and molybdate binding
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Glycosyl transferase family 3 N-terminal
Type III secretion system flagellar brake protein YcgR PilZN
Glycosyltransferase subfamily 4-like N-terminal
Exonuclease VII large subunit C-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
CNP1-like uncharacterized domain-containing protein
Interaction with polymerase core subunit RpoC
Bacterial virulence domain-containing protein
Biopterin-dependent aromatic amino acid hydroxylase family profile
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Spore coat protein U domain-containing protein
Pilus formation protein N-terminal domain-containing protein
TRAP C4-dicarboxylate transport system permease DctM subunit
ABC-type transport auxiliary lipoprotein component
Positions MEP for the nucleophilic attack
Quercetin 2,3-dioxygenase C-terminal cupin
TonB-dependent receptor-like beta-barrel
Penicillin-binding protein transpeptidase domain-containing protein
Electron transfer via tryptophanyl radical
Hypersensitivity response secretion-like HrpJ
CagE TrbE VirB component of type IV transporter system central
Prokaryotic-type class I peptide chain release factors
Saccharopine dehydrogenase-like C-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Polymerase/histidinol phosphatase N-terminal
5-glutamyl coenzyme A thioester intermediate
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
DNA polymerase III beta sliding clamp central
Large ribosomal subunit protein uL6 alpha-beta
Pyruvate dehydrogenase E1 component middle
Phage terminase large subunit GpA ATPase
Terminase large subunit GpA endonuclease
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
NAD(P) transhydrogenase alpha subunit C-terminal
Mannose-6-phosphate isomerase type II C-terminal
Histidine-specific methyltransferase SAM-dependent
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Gamma-glutamylcyclotransferase AIG2-like
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Phosphatidic acid phosphatase type 2/haloperoxidase
Gp5/Type VI secretion system Vgr protein OB-fold
Cobaltochelatase subunit CobS N-terminal
Tetrahydrodipicolinate-N-succinyltransferase chain A
Glycine zipper 2TM domain-containing protein
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
UDP N-acetylglucosamine O-acyltransferase C-terminal
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Pyruvate phosphate dikinase AMP/ATP-binding
DNA-directed DNA polymerase family A palm
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Required for zinc-mediated homotetramerization and catalytic activity
FAD-dependent cmnm(5)s(2)U34 oxidoreductase
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Interacts with tRNA; defines subfamily-specific binding signature
Membrane insertase YidC/Oxa/ALB C-terminal
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase
BAAT/Acyl-CoA thioester hydrolase C-terminal
Transposase IS204/IS1001/IS1096/IS1165 DDE
Lysidine-tRNA(Ile) synthetase C-terminal
Extradiol ring-cleavage dioxygenase LigAB LigA subunit
Helix-hairpin-helix DNA-binding motif class 1
L-seryl-tRNA selenium transferase N-terminal
Gly-cisPro motif, important for rejection of L-amino acids
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
RNA 2-O ribose methyltransferase substrate binding
Ribose-phosphate pyrophosphokinase N-terminal
PHA accumulation regulator DNA-binding N-terminal
Autotransporter domain-containing protein
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Insecticide toxin TcdB middle/C-terminal
Insecticide toxin TcdB middle/N-terminal
Glucan biosynthesis periplasmic MdoG C-terminal
Proteinase inhibitor I42 chagasin domain-containing protein
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Bacterial collagen-like protein middle domain-containing protein
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Alpha-glycerophosphate oxidase C-terminal
Putative oxidoreductase/dehydrogenase Rossmann-like
Aminoacyl-tRNA synthetase class I anticodon-binding
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
40-residue YVTN family beta-propeller repeat protein
Type 4 fimbrial biogenesis protein PilX N-terminal domain-containing protein
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Glycine zipper domain-containing protein
Haemolysin activator HlyB C-terminal domain-containing protein
Prolyl 3,4-dihydroxylase TPA1/OFD1 N-terminal
Nitrite/Sulfite reductase ferredoxin-like
RNA binding; important for wobble base 34 recognition
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
O-(5'-phospho-DNA)-tyrosine intermediate
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Metallo-beta-lactamase domain-containing protein
Molybdopterin cofactor biosynthesis C (MoaC)
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Peptide methionine sulphoxide reductase MsrA
Inosine/uridine-preferring nucleoside hydrolase
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Polysaccharide biosynthesis protein CapD-like
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Ribulose bisphosphate carboxylase large subunit C-terminal
Putative Flp pilus-assembly TadG-like N-terminal
DNA polymerase III subunit delta C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Catalytic role in ketonization of the dienol substrate (substrate destabilization)
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Bacterial OB-fold domain-containing protein
Soluble ligand binding domain-containing protein
Essential for prephenate dehydratase activity
Endoribonuclease L-PSP/chorismate mutase-like
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Integral membrane protein YccS N-terminal
Transcription elongation factor GreA/GreB N-terminal
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Sodium/calcium exchanger membrane region
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Isocitrate dehydrogenase kinase/phosphatase (AceK) kinase
Isocitrate dehydrogenase kinase/phosphatase (AceK) regulatory
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Proton acceptor; for glutaminase activity
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Glucosamine/galactosamine-6-phosphate isomerase
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Flagellar assembly protein FliH/Type III secretion system HrpE
NADH:ubiquinone oxidoreductase 30kDa subunit
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Ysc84 actin-binding domain-containing protein
NADH-rubredoxin oxidoreductase C-terminal
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Type III secretion system effector delivery regulator TyeA
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Pseudouridine synthase I TruA alpha/beta
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Survival protein SurE-like phosphatase/nucleotidase
Phosphotransferase system enzyme I N-terminal
Outer membrane protein assembly factor BamD
Sulfite:cytochrome C oxidoreductase subunit B
Microcystin LR degradation protein MlrC C-terminal
Microcystin LR degradation protein MlrC N-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization