Lytic transglycosylase superhelical linker
Thymidylate synthase/dCMP hydroxymethylase
Isocitrate dehydrogenase kinase/phosphatase (AceK) kinase
Isocitrate dehydrogenase kinase/phosphatase (AceK) regulatory
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Glucose-methanol-choline oxidoreductase C-terminal
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Tryptophan synthase beta chain-like PALP
Moybdenum cofactor oxidoreductase dimerisation
Ribosomal RNA adenine methylase transferase N-terminal
Major facilitator superfamily (MFS) profile
Glucosamine/galactosamine-6-phosphate isomerase
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
ABC-type transport auxiliary lipoprotein component
Aminoacyl-transfer RNA synthetases class-II family profile
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Transposase IS204/IS1001/IS1096/IS1165 DDE
Transposase IS204/IS1001/IS1096/IS1165 helix-turn-helix
Transposase IS204/IS1001/IS1096/IS1165 zinc-finger
Tc toxin complex TcA C-terminal TcB-binding
Glycine zipper 2TM domain-containing protein
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
DNA replication/recombination mediator RecO N-terminal
Solute-binding protein family 3/N-terminal
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Membrane insertase YidC/Oxa/ALB C-terminal
Schiff-base intermediate with substrate; via pyruvic acid
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Type IV secretion system coupling protein TraD DNA-binding
Carboxypeptidase regulatory-like domain-containing protein
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
NIF system FeS cluster assembly NifU N-terminal
Pyridoxamine 5'-phosphate oxidase putative
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Hypersensitivity response secretion-like HrpJ
Type III secretion system effector delivery regulator TyeA
Glycosyltransferase subfamily 4-like N-terminal
Electron transfer via tryptophanyl radical
Acyl-CoA dehydrogenase/oxidase N-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Cytochrome b561 bacterial/Ni-hydrogenase
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Prepilin type IV endopeptidase peptidase
Polymerase/histidinol phosphatase N-terminal
PHA accumulation regulator DNA-binding N-terminal
Glycine cleavage T-protein C-terminal barrel
Outer membrane protein assembly factor BamC
Required for zinc-mediated homotetramerization and catalytic activity
Proline utilization A proline dehydrogenase N-terminal
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
DNA mismatch repair proteins mutS family
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Glycosyl transferase family 3 N-terminal
RNA polymerase sigma factor 70 region 4 type 2
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Positions MEP for the nucleophilic attack
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Gamma-glutamylcyclotransferase AIG2-like
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Quercetin 2,3-dioxygenase C-terminal cupin
UDP N-acetylglucosamine O-acyltransferase C-terminal
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS
Transposase IS116/IS110/IS902 C-terminal
Anthranilate synthase component I N-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Adaptive response protein AidB N-terminal
Interaction with polymerase core subunit RpoC
Penicillin-binding protein transpeptidase
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Activator of Hsp90 ATPase homologue 1-like C-terminal
Important for interaction with partner proteins
RND efflux pump membrane fusion protein barrel-sandwich
Spore coat protein U domain-containing protein
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
ATP synthase F1 complex delta/epsilon subunit N-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Histidine-specific methyltransferase SAM-dependent
Flagellar motor switch protein FliN-like C-terminal
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Endolytic peptidoglycan transglycosylase RlpA
RlpA-like protein double-psi beta-barrel
Bacterial type II secretion system protein E
Bacterial bifunctional deaminase-reductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Release factor glutamine methyltransferase N-terminal
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
TRAP C4-dicarboxylate transport system permease DctM subunit
Chromosomal replication initiator protein DnaA
Aspartate/homoserine dehydrogenase NAD-binding
Chromosomal replication initiator DnaA C-terminal
Integral membrane protein YccS N-terminal
Lysozyme inhibitor LprI N-terminal domain-containing protein
Ribose-phosphate pyrophosphokinase N-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Pseudouridine synthase I TruA alpha/beta
Outer-membrane lipoprotein carrier protein
Translation elongation factor P/YeiP central
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
ABC-type glycine betaine transport system substrate-binding
S-adenosyl-L-homocysteine hydrolase NAD binding
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Survival protein SurE-like phosphatase/nucleotidase
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Glucan biosynthesis periplasmic MdoG C-terminal
Outer membrane lipoprotein-sorting protein
40-residue YVTN family beta-propeller repeat protein
Involved in tetramerization or stability of the tetramer
Sodium symporter small subunit predicted
Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase
BAAT/Acyl-CoA thioester hydrolase C-terminal
DNA polymerase III subunit delta C-terminal
FAD-dependent oxidoreductase 2 FAD binding
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
Poly-beta-hydroxybutyrate polymerase N-terminal
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Polysaccharide biosynthesis protein CapD-like
Phosphatidic acid phosphatase type 2/haloperoxidase
N-end rule aminoacyl transferase C-terminal
Cellulose synthase operon C C-terminal domain-containing protein
Large ribosomal subunit protein uL15/eL18
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Glycine zipper domain-containing protein
NADH-rubredoxin oxidoreductase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
NAD(P) transhydrogenase alpha subunit C-terminal
Gly-cisPro motif, important for rejection of L-amino acids
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Required for dimer formation and molybdate binding
TonB-dependent receptor-like beta-barrel
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Autotransporter domain-containing protein
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Type II restriction enzyme and methyltransferase RM.Eco57I-like
Ysc84 actin-binding domain-containing protein
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Flagellar hook-length control protein-like C-terminal
Mannose-6-phosphate isomerase type II C-terminal
Prokaryotic-type class I peptide chain release factors
Cation-transporting P-type ATPase N-terminal
Lipopolysaccharide export system protein LptA
Organic solvent tolerance-like N-terminal
Flavocytochrome c sulphide dehydrogenase flavin-binding
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Soluble ligand binding domain-containing protein
NADH:ubiquinone oxidoreductase-like 20kDa subunit
RNA binding; important for wobble base 34 recognition
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Essential for prephenate dehydratase activity
L-seryl-tRNA selenium transferase N-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Bacterial collagen-like protein middle domain-containing protein
DNA-binding and helicase activity, interacts with RecC
Nuclease activity, interacts with RecD and RecA
Large ribosomal subunit protein uL2 C-terminal
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Heme-copper oxidase subunit III family profile
CagE TrbE VirB component of type IV transporter system central
N6 adenine-specific DNA methyltransferase N-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
O-(5'-phospho-DNA)-tyrosine intermediate
5-glutamyl coenzyme A thioester intermediate
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
Putative regulatory protein FmdB Zinc ribbon
YbaK/aminoacyl-tRNA synthetase-associated
Large ribosomal subunit protein uL6 alpha-beta
Mandelate racemase/muconate lactonizing enzyme C-terminal
FAD-dependent cmnm(5)s(2)U34 oxidoreductase
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
Bacterial OB-fold domain-containing protein
Gamma-butyrobetaine hydroxylase-like N-terminal
C-type lysozyme inhibitor domain-containing protein
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Reversibly protonated during proton transport
Molybdopterin cofactor biosynthesis C (MoaC)
Peptide methionine sulphoxide reductase MsrA
Plays an important role in substrate specificity
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Choloylglycine hydrolase/NAAA C-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Plays an important role in discriminating NADH against NADPH
RNA 2-O ribose methyltransferase substrate binding
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Polysaccharide biosynthesis protein C-terminal
Phosphotransferase system enzyme I N-terminal
Cysteine sulfenic acid (-SOH) intermediate
Insecticide toxin TcdB middle/C-terminal
Insecticide toxin TcdB middle/N-terminal
Photosynthesis system II assembly factor Ycf48/Hcf136-like
Photosynthesis system II assembly factor Ycf48/Hcf136-like domain-containing protein
CNP1-like uncharacterized domain-containing protein
Polypeptide-transport-associated ShlB-type
Saccharopine dehydrogenase-like C-terminal
Pili assembly chaperone N-terminal domain-containing protein
Microcystin LR degradation protein MlrC C-terminal
Microcystin LR degradation protein MlrC N-terminal
Outer membrane protein assembly factor BamD
Exonuclease VII large subunit C-terminal
Regulator of nucleoside diphosphate kinase N-terminal
High-affinity branched-chain amino acid transport system permease LivHM N-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Pyruvate phosphate dikinase AMP/ATP-binding
Helix-hairpin-helix DNA-binding motif class 1
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
Surface antigen domain-containing protein
Guanylate kinase/L-type calcium channel beta subunit
Membrane fusion protein biotin-lipoyl like
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
AB hydrolase-1 domain-containing protein
Type I restriction modification DNA specificity
Endoribonuclease L-PSP/chorismate mutase-like
Tetrahydrodipicolinate-N-succinyltransferase chain A
Type III secretion system flagellar brake protein YcgR PilZN
Putative Flp pilus-assembly TadG-like N-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Important for autoinhibition of adenylyltransferase activity
Alanyl-transfer RNA synthetases family profile
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
NADH:ubiquinone oxidoreductase chain 4 N-terminal
Pyruvate dehydrogenase E1 component middle
Flagellar assembly protein FliH/Type III secretion system HrpE
NADH:ubiquinone oxidoreductase 30kDa subunit
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
Small ribosomal subunit protein uS4 N-terminal
Alpha-glycerophosphate oxidase C-terminal
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Cobaltochelatase subunit CobS N-terminal
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Heat-inducible transcription repressor HrcA C-terminal
Winged helix-turn-helix transcription repressor HrcA DNA-binding
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Extradiol ring-cleavage dioxygenase LigAB LigA subunit
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Vanillate O-demethylase oxygenase-like C-terminal catalytic
ABC-type transport auxiliary lipoprotein component domain-containing protein
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:ubiquinone/plastoquinone oxidoreductase chloroplast chain 5 C-terminal
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Important for beta-aspartyl-AMP intermediate formation
Ionotropic glutamate receptor C-terminal
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Proton acceptor; for glutaminase activity
DNA-directed DNA polymerase family A palm
Catalytic role in ketonization of the dienol substrate (substrate destabilization)
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation