Major facilitator superfamily (MFS) profile
Solute-binding protein family 3/N-terminal
Exonuclease VII large subunit C-terminal
Bacterial type II secretion system protein E
SAM-dependent methyltransferase TRM5/TYW2-type
Transposase IS116/IS110/IS902 C-terminal
Alanyl-transfer RNA synthetases family profile
DNA replication/recombination mediator RecO N-terminal
Tryptophan synthase beta chain-like PALP
Cell envelope-related transcriptional attenuator
Pyruvate phosphate dikinase AMP/ATP-binding
Aminoacyl-transfer RNA synthetases class-II family profile
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
RNA polymerase sigma factor 70 region 4 type 2
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Pyridoxamine 5'-phosphate oxidase putative
Phosphatidic acid phosphatase type 2/haloperoxidase
Membrane insertase YidC/Oxa/ALB C-terminal
Cytochrome b561 bacterial/Ni-hydrogenase
Pyruvate/ketoisovalerate oxidoreductase catalytic
DNA mismatch repair proteins mutS family
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Resolvase/invertase-type recombinase catalytic
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Homocysteine biosynthesis enzyme sulfur-incorporation
Acetyl-CoA hydrolase/transferase C-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Methylene-tetrahydrofolate reductase C-terminal
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
F420-non-reducing hydrogenase iron-sulfur subunit D
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Helix-hairpin-helix DNA-binding motif class 1
Membrane fusion protein biotin-lipoyl like
RND efflux pump membrane fusion protein barrel-sandwich
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Ionotropic glutamate receptor C-terminal
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Important for beta-aspartyl-AMP intermediate formation
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
tRNA (guanine-N(1)-)-methyltransferase C-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Polymerase/histidinol phosphatase N-terminal
Flagellar hook-length control protein-like C-terminal
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Pyrimidine nucleoside phosphorylase C-terminal
Gly-cisPro motif, important for rejection of L-amino acids
Chromosomal replication initiator DnaA C-terminal
Dinitrogenase iron-molybdenum cofactor biosynthesis
Cytochrome C biogenesis protein transmembrane
6-hydroxymethylpterin diphosphokinase MptE-like
Sporulation transcription regulator WhiA N-terminal
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
RNA binding; important for wobble base 34 recognition
ADP-ribosylarginine; by dinitrogenase reductase ADP-ribosyltransferase
Flagellar assembly protein FliH/Type III secretion system HrpE
Anthranilate synthase component I N-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
NADH:ubiquinone oxidoreductase 30kDa subunit
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Diacylglycerol glucosyltransferase N-terminal
Glycosyl transferase family 28 C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Reversibly protonated during proton transport
Translation elongation factor P/YeiP central
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Acetyl-CoA dehydrogenase-like C-terminal
Large ribosomal subunit protein uL15/eL18
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
YbaK/aminoacyl-tRNA synthetase-associated
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Glutathionylspermidine synthase pre-ATP-grasp-like
Glycosyltransferase subfamily 4-like N-terminal
O-(phosphoribosyl dephospho-coenzyme A)serine
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Glycosyl transferase family 3 N-terminal
Polysaccharide biosynthesis protein CapD-like
O-(5'-phospho-DNA)-tyrosine intermediate
Putative component of 'biosynthetic module'
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Polysaccharide biosynthesis protein C-terminal
Plays an important role in substrate specificity
Prepilin type IV endopeptidase peptidase
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Pyruvate ferredoxin oxidoreductase beta subunit C-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Signal transduction histidine kinase internal region
ABC transporter substrate-binding protein PnrA-like
Nicotinate phosphoribosyltransferase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Penicillin-binding protein transpeptidase
RsbT co-antagonist protein RsbRD N-terminal
DnaJ homologue subfamily C member 28 conserved
DNA-directed RNA polymerase RpoA/D/Rpb3-type
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Sporulation stage IV protein A C-terminal
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Polysaccharide chain length determinant N-terminal
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Putative regulatory protein FmdB Zinc ribbon
Acetyl-CoA hydrolase/transferase N-terminal
Saccharopine dehydrogenase-like C-terminal
Cation-transporting P-type ATPase N-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Large ribosomal subunit protein uL2 C-terminal
Schiff-base intermediate with D-ribose 5-phosphate
Damage-control phosphatase ARMT1-like metal-binding
Large ribosomal subunit protein uL6 alpha-beta
Type III secretion system flagellar brake protein YcgR PilZN
D-galactarate/Altronate dehydratase C-terminal
Siroheme decarboxylase AsnC-like ligand binding
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Alpha-D-phosphohexomutase alpha/beta/alpha
TRAP C4-dicarboxylate transport system permease DctM subunit
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
DNA-directed DNA polymerase family A palm
NIF system FeS cluster assembly NifU N-terminal
HicB-like antitoxin of toxin-antitoxin system
Molybdopterin cofactor biosynthesis C (MoaC)
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Lysidine-tRNA(Ile) synthetase C-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Phosphatidylglycerol lysyltransferase C-terminal
Essential for prephenate dehydratase activity
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Aconitase A/isopropylmalate dehydratase small subunit swivel
Phosphotransferase system enzyme I N-terminal
Ribosomal RNA adenine methylase transferase N-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Could play a key role in the communication between the regulatory and the substrate sites
Formiminotransferase C-terminal subdomain
Formiminotransferase N-terminal subdomain
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
CobB/CobQ-like glutamine amidotransferase
5-glutamyl coenzyme A thioester intermediate
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
CO dehydrogenase/acetyl-CoA synthase complex beta subunit C-terminal
Carbon monoxide dehydrogenase subunit alpha ,N-terminal
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Sporulation stage II protein D amidase enhancer LytB N-terminal
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
CO dehydrogenase/acetyl-CoA synthase delta subunit TIM barrel
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
EfeO-type cupredoxin-like domain-containing protein
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Manganese/iron superoxide dismutase C-terminal
Phosphoribosylformylglycinamidine synthase linker
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
2,4-diaminopentanoate dehydrogenase C-terminal
Dihydrodipicolinate reductase N-terminal
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Increases nucleophilicity of active site Cys
Pseudouridine synthase I TruA alpha/beta
S-adenosyl-L-homocysteine hydrolase NAD binding
PLD phosphodiesterase domain-containing protein
Carbamoyl-phosphate synthase small subunit N-terminal
Survival protein SurE-like phosphatase/nucleotidase
N6 adenine-specific DNA methyltransferase N-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
NADH:ubiquinone oxidoreductase-like 20kDa subunit
RNA 2-O ribose methyltransferase substrate binding
Glycosyltransferase family 28 N-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
RDXXRA motif of the pArg binding pocket involved in allosteric regulation
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
Mannose-6-phosphate isomerase type II C-terminal
Important for interaction with partner proteins
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Flagellar Assembly Protein A N-terminal region
Methylaspartate ammonia-lyase C-terminal
Methylaspartate ammonia-lyase N-terminal
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Septum formation inhibitor MinC C-terminal
Type IV secretion system coupling protein TraD DNA-binding
Transcriptional regulator TetR C-terminal Firmicutes type
Formylmethanofuran dehydrogenase subunit E
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
NADH-ubiquinone oxidoreductase 51kDa subunit FMN-binding
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Flagellar motor switch protein FliN-like C-terminal
Putative oxidoreductase/dehydrogenase Rossmann-like
ATP synthase F1 complex delta/epsilon subunit N-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Important for substrate specificity; cannot use PPi as phosphoryl donor
Heat-inducible transcription repressor HrcA C-terminal
Winged helix-turn-helix transcription repressor HrcA DNA-binding
Involved in ionization of N3 of dUMP, leading to its activation
Moybdenum cofactor oxidoreductase dimerisation
Signal recognition particle SRP54 helical bundle
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Global transcriptional regulator CodY C-terminal
Global transcriptional regulator CodY N-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Dipicolinate synthase subunit A N-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Sugar fermentation stimulation protein C-terminal
Type II secretion system protein GspG C-terminal
Involved in allosteric activation by GTP
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Peptidoglycan recognition protein family
Ribose-phosphate pyrophosphokinase N-terminal
Small ribosomal subunit protein uS4 N-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Glycine cleavage T-protein C-terminal barrel
Ribonucleotide reductase large subunit C-terminal
Ribonucleotide reductase large subunit N-terminal
Interaction with polymerase core subunit RpoC
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity