Plays an important role in substrate specificity
Pyruvate phosphate dikinase AMP/ATP-binding
Sodium/calcium exchanger membrane region
AMP-activated protein kinase glycogen-binding
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Siroheme decarboxylase AsnC-like ligand binding
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Schiff-base intermediate with dihydroxyacetone-P
ABC transporter substrate-binding protein PnrA-like
Phosphotransferase system enzyme I N-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Guanylate kinase/L-type calcium channel beta subunit
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
RND efflux pump membrane fusion protein barrel-sandwich
Solute-binding protein family 3/N-terminal
Nitrite/Sulfite reductase ferredoxin-like
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
L-seryl-tRNA selenium transferase N-terminal
Involved in ionization of N3 of dUMP, leading to its activation
DNA replication/recombination mediator RecO N-terminal
Putative regulatory protein FmdB Zinc ribbon
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Dinitrogenase iron-molybdenum cofactor biosynthesis
Interaction with polymerase core subunit RpoC
NIF system FeS cluster assembly NifU C-terminal
NIF system FeS cluster assembly NifU N-terminal
Survival protein SurE-like phosphatase/nucleotidase
Outer membrane lipoprotein-sorting protein
Transcription factor NikR nickel binding C-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Positions MEP for the nucleophilic attack
O-(3'-phospho-DNA)-tyrosine intermediate
Contractile injection system tube protein N-terminal
Cytochrome c-type biogenesis protein CcmF C-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Trehalose-6-phosphate phosphatase helical bundle
Alanyl-transfer RNA synthetases family profile
Tryptophan synthase beta chain-like PALP
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Important for beta-aspartyl-AMP intermediate formation
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Glycosyltransferase subfamily 4-like N-terminal
Release factor glutamine methyltransferase N-terminal
Type I restriction enzyme R protein N-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Flagellar basal-body/hook protein C-terminal
Membrane iron-sulfur containing protein FtrD-like
Membrane iron-sulfur containing protein FtrD-like domain-containing protein
Pyruvate ferredoxin oxidoreductase beta subunit C-terminal
Thiamine pyrophosphate enzyme TPP-binding
D-galactarate/Altronate dehydratase C-terminal
Ribosomal RNA adenine methylase transferase N-terminal
6-hydroxymethylpterin diphosphokinase MptE-like
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Exonuclease VII large subunit C-terminal
Polysaccharide biosynthesis protein CapD-like
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Pyrimidine nucleoside phosphorylase C-terminal
Right handed beta helix domain-containing protein
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Transposase IS116/IS110/IS902 C-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
HicB-like antitoxin of toxin-antitoxin system
TonB-dependent receptor-like beta-barrel
NADH-rubredoxin oxidoreductase C-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
RNA polymerase sigma factor 70 region 4 type 2
Flagellar Assembly Protein A N-terminal region
Type II restriction enzyme and methyltransferase RM.Eco57I-like
Carboxypeptidase regulatory-like domain-containing protein
Gp5/Type VI secretion system Vgr protein OB-fold
Pseudouridine synthase I TruA alpha/beta
UDP N-acetylglucosamine O-acyltransferase C-terminal
Polymerase/histidinol phosphatase N-terminal
Terminase large subunit gp17-like C-terminal
Glycoside hydrolase family 57 N-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
ATP synthase F1 complex delta/epsilon subunit N-terminal
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS
Alpha-D-phosphohexomutase alpha/beta/alpha
Reversibly protonated during proton transport
Pyruvate/ketoisovalerate oxidoreductase catalytic
Ionotropic glutamate receptor C-terminal
Flagellar basal body rod protein N-terminal
Penicillin-binding protein transpeptidase
tRNA (guanine-N(1)-)-methyltransferase C-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
NfeD-like C-terminal domain-containing protein
SsuA/THI5-like domain-containing protein
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Peptidase S9 prolyl oligopeptidase catalytic
Glycosyl transferase family 3 N-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Translation elongation factor P/YeiP central
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
Na+/H+ antiporter MnhB subunit-related protein
TRAP C4-dicarboxylate transport system permease DctM subunit
Bacterial type II secretion system protein E
Gamma-glutamylcyclotransferase AIG2-like
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Aconitase A/isopropylmalate dehydratase small subunit swivel
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Aldehyde ferredoxin oxidoreductase N-terminal
Flagella basal body P-ring formation protein FlgA C-terminal
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Arginine decarboxylase C-terminal helical
Formylmethanofuran dehydrogenase subunit E
Small ribosomal subunit protein uS4 N-terminal
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Outer membrane protein beta-barrel domain-containing protein
Membrane insertase YidC/Oxa/ALB C-terminal
Transposase IS204/IS1001/IS1096/IS1165 DDE
Transposase IS204/IS1001/IS1096/IS1165 helix-turn-helix
Transposase IS204/IS1001/IS1096/IS1165 zinc-finger
Flagellar motor switch protein FliN-like C-terminal
Gly-cisPro motif, important for rejection of L-amino acids
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Essential for prephenate dehydratase activity
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Ribulose bisphosphate carboxylase large subunit C-terminal
Ribulose bisphosphate carboxylase large subunit ferrodoxin-like N-terminal
Transcription regulator AsnC/Lrp ligand binding
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Formamidopyrimidine-DNA glycosylase catalytic
Shikimate dehydrogenase substrate binding N-terminal
Lipoprotein YgdI/YgdR-like SH3-like domain-containing protein
Glycogen debranching enzyme bacterial and archaeal type N-terminal
Thioredoxin-like fold domain-containing protein
Prepilin type IV endopeptidase peptidase
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Resolvase/invertase-type recombinase catalytic
Major facilitator superfamily (MFS) profile
ATP-dependent DNA helicase RecG C-terminal
DNA-directed DNA polymerase family A palm
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Cytochrome b561 bacterial/Ni-hydrogenase
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Homocysteine biosynthesis enzyme sulfur-incorporation
O-(5'-phospho-DNA)-tyrosine intermediate
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Glutamate synthase alpha subunit C-terminal
Inner membrane protein YgaP-like transmembrane
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Prokaryotic-type class I peptide chain release factors
NADH:ubiquinone oxidoreductase 30kDa subunit
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Gfo/Idh/MocA-like oxidoreductase N-terminal
ABC-type transport auxiliary lipoprotein component
ABC-type transport auxiliary lipoprotein component domain-containing protein
UDP-glucose/GDP-mannose dehydrogenase C-terminal
ABC transporter substrate binding protein
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
F420-non-reducing hydrogenase iron-sulfur subunit D
Important for substrate specificity; cannot use PPi as phosphoryl donor
Proton acceptor; for glutaminase activity
Glycosyl transferase family 28 C-terminal
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
Large ribosomal subunit protein uL2 C-terminal
Acetylserotonin O-methyltransferase dimerisation
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Glycine cleavage T-protein C-terminal barrel
Gfo/Idh/MocA-like oxidoreductase C-terminal
Chromosomal replication initiator DnaA C-terminal
Phosphoadenosine phosphosulphate reductase
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Flagellar hook-length control protein-like C-terminal
Damage-control phosphatase ARMT1-like metal-binding
AB hydrolase-1 domain-containing protein
Large ribosomal subunit protein uL15/eL18
Carbamoyl-phosphate synthase small subunit N-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Pyridoxamine 5'-phosphate oxidase putative
Probable endolytic peptidoglycan transglycosylase RlpA
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Ribose-phosphate pyrophosphokinase N-terminal
RsbT co-antagonist protein RsbRD N-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
S-adenosyl-L-homocysteine hydrolase NAD binding
Anthranilate synthase component I N-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Important for autoinhibition of adenylyltransferase activity
Cation-transporting P-type ATPase N-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Saccharopine dehydrogenase-like C-terminal
Large ribosomal subunit protein uL6 alpha-beta
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
ADP-ribosylarginine; by dinitrogenase reductase ADP-ribosyltransferase
Magnesium transporter MgtE intracellular
Cysteine sulfenic acid (-SOH) intermediate
Helix-hairpin-helix DNA-binding motif class 1
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Cytochrome C biogenesis protein transmembrane
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Schiff-base intermediate with acetaldehyde
Mannose-6-phosphate isomerase type II C-terminal
Glucosamine/galactosamine-6-phosphate isomerase
ABC-type glycine betaine transport system substrate-binding
Glycosyltransferase family 28 N-terminal
Ribonucleotide reductase large subunit C-terminal
Ribonucleotide reductase large subunit N-terminal
Phosphatidylglycerol lysyltransferase C-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
nitrite reductase (cytochrome; ammonia-forming)