3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Putative regulatory protein FmdB Zinc ribbon
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Phosphatidylglycerol lysyltransferase C-terminal
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
TonB-dependent receptor-like beta-barrel
RNA polymerase sigma factor 70 region 4 type 2
Tripartite tricarboxylate transporter substrate binding protein
Activator of Hsp90 ATPase homologue 1-like C-terminal
C4-dicarboxylate ABC transporter substrate-binding protein
Type IV pilus biogenesis and competence protein PilQ
Tryptophan synthase beta chain-like PALP
Major facilitator superfamily (MFS) profile
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Peptide methionine sulphoxide reductase MsrA
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Ionotropic glutamate receptor C-terminal
Solute-binding protein family 3/N-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Alpha-D-phosphohexomutase alpha/beta/alpha
IPTL-CTERM protein sorting domain-containing protein
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
TRAP C4-dicarboxylate transport system permease DctM subunit
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Outer membrane protein assembly factor BamA
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Na+/H+ antiporter MnhB subunit-related protein
Superoxide dismutase copper/zinc binding
ABC transporter substrate-binding protein
Bacteriophage N4 adsorption protein A C-terminal
Gp5/Type VI secretion system Vgr protein OB-fold
Heat-inducible transcription repressor HrcA C-terminal
Winged helix-turn-helix transcription repressor HrcA DNA-binding
Outer membrane protein assembly factor BamD
Glycosyltransferase subfamily 4-like N-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Haem-binding uptake Tiki superfamily ChaN
Haem-binding uptake Tiki superfamily ChaN domain-containing protein
NADH:ubiquinone oxidoreductase 30kDa subunit
Transposase IS116/IS110/IS902 C-terminal
Glycine cleavage T-protein C-terminal barrel
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Proton acceptor; for glutaminase activity
Isocitrate dehydrogenase kinase/phosphatase (AceK) kinase
Isocitrate dehydrogenase kinase/phosphatase (AceK) regulatory
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Alpha-glycerophosphate oxidase C-terminal
Plays an important role in substrate specificity
NADH-rubredoxin oxidoreductase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Transcription elongation factor GreA/GreB C-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Virulence factor membrane-bound polymerase C-terminal
Large ribosomal subunit protein uL15/eL18
Mandelate racemase/muconate lactonizing enzyme C-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Styrene monooxygenase StyA putative substrate binding
RND efflux pump membrane fusion protein barrel-sandwich
Aminoacyl-transfer RNA synthetases class-II family profile
Molybdopterin cofactor biosynthesis C (MoaC)
Formamidopyrimidine-DNA glycosylase catalytic
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Putative type VI secretion system Rhs element associated Vgr
Phosphoadenosine phosphosulphate reductase
Schiff-base intermediate with acetoacetate
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
Twin-arginine translocation pathway signal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
AlgX/AlgJ SGNH hydrolase-like domain-containing protein
Cytochrome b561 bacterial/Ni-hydrogenase
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Leucine-binding protein domain-containing protein
Thymidylate synthase/dCMP hydroxymethylase
Moves into active site upon enzyme activation, plays a role in electron transfer
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
ABC transporter substrate-binding protein PnrA-like
Penicillin-binding protein transpeptidase
Flagellar motor switch protein FliN-like C-terminal
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
DNA-directed DNA polymerase family A palm
Aminoacyl-tRNA synthetase class I anticodon-binding
Disulphide bond isomerase DsbC/G N-terminal
Type VI secretion system IcmF C-terminal
Type II secretion system protein GspG C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Glycerol-3-phosphate dehydrogenase [NAD(P)+]
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Membrane insertase YidC/Oxa/ALB C-terminal
Large ribosomal subunit protein uL2 C-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
Inosine/uridine-preferring nucleoside hydrolase
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Membrane fusion protein biotin-lipoyl like
Glucose-methanol-choline oxidoreductase N-terminal
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Translation elongation factor P/YeiP central
Release factor glutamine methyltransferase N-terminal
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
Shikimate dehydrogenase substrate binding N-terminal
ATP-dependent DNA helicase RecG C-terminal
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
O-(3'-phospho-DNA)-tyrosine intermediate
Carbamoyl-phosphate synthase small subunit N-terminal
Gly-cisPro motif, important for rejection of L-amino acids
Phosphoethanolamine transferase N-terminal
Bacterial type II secretion system protein E
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
UDP N-acetylglucosamine O-acyltransferase C-terminal
Transcription factor NikR nickel binding C-terminal
Calcium/calmodulin-dependent protein kinase II association-domain
General stress protein FMN-binding split barrel
Pyruvate phosphate dikinase AMP/ATP-binding
O-(5'-phospho-DNA)-tyrosine intermediate
Nitrile hydratase alpha /Thiocyanate hydrolase gamma
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Glucan biosynthesis periplasmic MdoG C-terminal
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Bacterial bifunctional deaminase-reductase C-terminal
Chemotaxis methyl-accepting receptor HlyB-like 4HB MCP
ABC-type transport auxiliary lipoprotein component
ABC-type transport auxiliary lipoprotein component domain-containing protein
Lysozyme inhibitor LprI N-terminal domain-containing protein
DNA mismatch repair proteins mutS family
Lipopolysaccharide assembly protein A domain-containing protein
Polymerase/histidinol phosphatase N-terminal
Important for beta-aspartyl-AMP intermediate formation
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Reversibly protonated during proton transport
Type 4 fimbrial biogenesis protein PilX N-terminal
Flagellar assembly protein FliH/Type III secretion system HrpE
Alanyl-transfer RNA synthetases family profile
Signal transduction histidine kinase internal region
Large ribosomal subunit protein uL6 alpha-beta
Aspartate/homoserine dehydrogenase NAD-binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
Cysteine sulfenic acid (-SOH) intermediate
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Could be important to modulate the pK values of the two catalytic cysteine residues
Interacts with tRNA; defines subfamily-specific binding signature
Biopterin-dependent aromatic amino acid hydroxylase family profile
Histidine-specific methyltransferase SAM-dependent
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Interaction with polymerase core subunit RpoC
Proline utilization A proline dehydrogenase N-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
D-(-)-3-hydroxybutyrate oligomer hydrolase
Polysaccharide biosynthesis protein C-terminal
Prokaryotic-type class I peptide chain release factors
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Urease accessory protein UreH-like transmembrane
RNA 2-O ribose methyltransferase substrate binding
Chromosomal replication initiator protein DnaA
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Lipopolysaccharide export system protein LptA
Organic solvent tolerance-like N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
N-end rule aminoacyl transferase C-terminal
Essential for prephenate dehydratase activity
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Ribosome maturation factor RimP N-terminal
Ribosomal RNA adenine methylase transferase N-terminal
Tetrahydrodipicolinate-N-succinyltransferase chain A
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Anthranilate synthase component I N-terminal
Important for interaction with partner proteins
Flagellar hook-length control protein-like C-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
DNA replication/recombination mediator RecO N-terminal
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Alpha/beta hydrolase domain-containing protein
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
FAD-dependent cmnm(5)s(2)U34 oxidoreductase
Required for zinc-mediated homotetramerization and catalytic activity
S-adenosylmethionine-dependent methyltransferase
Prepilin type IV endopeptidase peptidase
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Glycosyl transferase family 3 N-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Quercetin 2,3-dioxygenase C-terminal cupin
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
AB hydrolase-1 domain-containing protein
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Pseudouridine synthase I TruA alpha/beta
Peptidase S9 prolyl oligopeptidase catalytic
Transcription elongation factor GreA/GreB N-terminal
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Heme-copper oxidase subunit III family profile
CobB/CobQ-like glutamine amidotransferase
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Bacterial transcription activator effector binding
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
Adaptive response protein AidB N-terminal
Phosphotransferase system enzyme I N-terminal
Integral membrane protein YccS N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
N6 adenine-specific DNA methyltransferase N-terminal
YbaK/aminoacyl-tRNA synthetase-associated
NIF system FeS cluster assembly NifU N-terminal
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Could play a key role in the communication between the regulatory and the substrate sites
Photosynthesis system II assembly factor Ycf48/Hcf136-like
Photosynthesis system II assembly factor Ycf48/Hcf136-like domain-containing protein
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Mannose-6-phosphate isomerase type II C-terminal
Survival protein SurE-like phosphatase/nucleotidase
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
5-glutamyl coenzyme A thioester intermediate
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
Exonuclease VII large subunit C-terminal
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-93)
PhoD-like phosphatase metallophosphatase
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Ribose-phosphate pyrophosphokinase N-terminal
DNA topoisomerase I catalytic core eukaryotic-type
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Gamma-butyrobetaine hydroxylase-like N-terminal
Endoribonuclease L-PSP/chorismate mutase-like
Gamma-glutamylcyclotransferase AIG2-like
CopL family metal-binding regulatory protein
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Tripartite tricarboxylate transporter substrate binding protein BugD
Type II secretion system protein GspI C-terminal
Poly-beta-hydroxybutyrate polymerase N-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
Transposase IS204/IS1001/IS1096/IS1165 DDE
Small ribosomal subunit protein uS4 N-terminal
Carboxypeptidase regulatory-like domain-containing protein
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Helix-hairpin-helix DNA-binding motif class 1
Pyruvate dehydrogenase E1 component middle
Glucose-methanol-choline oxidoreductase C-terminal