Charge relay system; for serine protease NS3 activity
Complete loss of nuclear localization; when associated with A-2906.
Complete loss of nuclear localization; when associated with A-2909.
Disrupts dimer formation, subcellular localization as well as enzymatic activity.
ER anchor for capsid protein C, removed in mature form by serine protease NS3
Essential for 2'-O-methyltransferase activity
Essential for 2'-O-methyltransferase and N-7 methyltransferase activity
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Hydrophobic; homodimerization of capsid protein C
Interacts with and activates NS3 protease
Involved in NS3 ATPase and RTPase activities
N-linked (GlcNAc...) asparagine; by host
Strong reduction of host innate immune responses and viral-induced apoptosis.