Heat-inducible transcription repressor HrcA C-terminal
Sporulation stage II protein D amidase enhancer LytB N-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Bacterial type II secretion system protein E
Schiff-base intermediate with acetaldehyde
DNA polymerase III beta sliding clamp central
Proton acceptor; for glutaminase activity
Reversibly protonated during proton transport
Mannose-6-phosphate isomerase type II C-terminal
Glycosyltransferase subfamily 4-like N-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Copper amine oxidase-like domain-containing protein
PsbP C-terminal domain-containing protein
Ionotropic glutamate receptor C-terminal
Solute-binding protein family 3/N-terminal
Small ribosomal subunit protein uS4 N-terminal
RNA polymerase sigma factor 70 region 4 type 2
Dinitrogenase iron-molybdenum cofactor biosynthesis
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Beta-xylosidase C-terminal Concanavalin A-like
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Nicotinamide phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Flagellar motor switch protein FliN-like C-terminal
Transposase IS204/IS1001/IS1096/IS1165 DDE
Transposase IS204/IS1001/IS1096/IS1165 helix-turn-helix
Transposase IS204/IS1001/IS1096/IS1165 zinc-finger
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
FAD-dependent oxidoreductase 2 FAD binding
Tryptophan synthase beta chain-like PALP
Important for interaction with partner proteins
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Thiamin pyrophosphokinase thiamin-binding
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Exonuclease VII large subunit C-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Signal transduction histidine kinase dimerisation/phosphoacceptor
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
NIF system FeS cluster assembly NifU N-terminal
General stress protein FMN-binding split barrel
Putative component of 'biosynthetic module'
Helix-hairpin-helix DNA-binding motif class 1
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Resolvase/invertase-type recombinase catalytic
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Flagellar hook-length control protein-like C-terminal
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Cation-transporting P-type ATPase N-terminal
ABC transporter substrate-binding protein PnrA-like
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Polysaccharide biosynthesis protein C-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
DNA mismatch repair proteins mutS family
Phosphatidic acid phosphatase type 2/haloperoxidase
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Penicillin-binding protein transpeptidase
Putative amidase domain-containing protein
Polymerase/histidinol phosphatase N-terminal
Flagellar basal body rod protein N-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Large ribosomal subunit protein uL2 C-terminal
Important for beta-aspartyl-AMP intermediate formation
Gly-cisPro motif, important for rejection of L-amino acids
Membrane fusion protein biotin-lipoyl like
Membrane fusion protein biotin-lipoyl like domain-containing protein
Flagellar basal-body/hook protein C-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Cysteine sulfenic acid (-SOH) intermediate
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Phosphocysteine intermediate; for EIIB activity
S-adenosylmethionine-dependent methyltransferase
Dipicolinate synthase subunit A N-terminal
Major facilitator superfamily (MFS) profile
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Phage conserved hypothetical protein C-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
Na+-translocating membrane potential-generating system MpsC
CobB/CobQ-like glutamine amidotransferase
Involved in ionization of N3 of dUMP, leading to its activation
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Phage terminase large subunit C-terminal
Phage terminase large subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Cytochrome oxidase subunit II transmembrane region profile
Transposase IS116/IS110/IS902 C-terminal
DNA replication/recombination mediator RecO N-terminal
6-hydroxymethylpterin diphosphokinase MptE-like
Bacterial bifunctional deaminase-reductase C-terminal
Pyruvate/ketoisovalerate oxidoreductase catalytic
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Alpha-D-phosphohexomutase alpha/beta/alpha
Signal transduction histidine kinase internal region
Pyrimidine nucleoside phosphorylase C-terminal
Involved in allosteric activation by GTP
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Flagellar Assembly Protein A N-terminal region
Pseudouridine synthase I TruA alpha/beta
Sporulation stage IV protein A C-terminal
Restriction system protein Mrr-like N-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Ribosomal RNA adenine methylase transferase N-terminal
Bacterial transcription activator effector binding
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Cell wall binding repeat-containing protein
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
O-(3'-phospho-DNA)-tyrosine intermediate
Large ribosomal subunit protein uL15/eL18
Large ribosomal subunit protein bL9 C-terminal
ADP-ribosylarginine; by dinitrogenase reductase ADP-ribosyltransferase
Shikimate dehydrogenase substrate binding N-terminal
Fatty acid kinase subunit A-like C-terminal
Translation elongation factor P/YeiP central
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Glycosyl transferase family 3 N-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
Prokaryotic-type class I peptide chain release factors
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Integron-associated effector binding protein
Cell envelope-related transcriptional attenuator
Meso-diaminopimelate D-dehydrogenase C-terminal
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Nitrite/Sulfite reductase ferredoxin-like
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Alanyl-transfer RNA synthetases family profile
Aspartate/homoserine dehydrogenase NAD-binding
YbaK/aminoacyl-tRNA synthetase-associated
Large ribosomal subunit protein uL6 alpha-beta
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
SUF system FeS cluster assembly SufBD N-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Chromosomal replication initiator DnaA C-terminal
Glycoside hydrolase family 31 N-terminal
Ribose-phosphate pyrophosphokinase N-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Lysidine-tRNA(Ile) synthetase C-terminal
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Glycogen debranching enzyme bacterial and archaeal type N-terminal
Glycoside hydrolase family 42 N-terminal
Terminase large subunit-like endonuclease
Sodium/calcium exchanger membrane region
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
Carbamoyl-phosphate synthetase large subunit-like ATP-binding
Formamidopyrimidine-DNA glycosylase catalytic
Pyruvate phosphate dikinase AMP/ATP-binding
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Phosphoribosylformylglycinamidine synthase linker
tRNA pseudouridylate synthase B C-terminal
Phosphotransferase system enzyme I N-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Threonine/serine exporter-like N-terminal
Regulator of chromosome condensation RCC1
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
ATPsynthase alpha/beta subunit N-terminal extension
Phosphodiester glycosidase domain-containing protein
Saccharopine dehydrogenase-like C-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
SsuA/THI5-like domain-containing protein
Bacterial Ig-like domain-containing protein
Phosphomannose isomerase type I catalytic
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
ABC-type uncharacterised transport system
Aconitase A/isopropylmalate dehydratase small subunit swivel
Schiff-base intermediate with D-ribose 5-phosphate
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Nicotinate phosphoribosyltransferase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Could play a key role in the communication between the regulatory and the substrate sites
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Positions MEP for the nucleophilic attack
Type VII secretion system protein EssD-like
Choice-of-anchor A domain-containing protein
Sporulation transcription regulator WhiA N-terminal
AraC-type arabinose-binding/dimerisation
Plays an important role in substrate specificity
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Increases nucleophilicity of active site Cys
Choloylglycine hydrolase/NAAA C-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
X-X-X-Leu-X-X-Gly heptad repeat-containing protein
Release factor glutamine methyltransferase N-terminal
Global transcriptional regulator CodY C-terminal
Global transcriptional regulator CodY N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Putative aromatic acid exporter C-terminal
Terminase large subunit gp17-like C-terminal
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Transcription regulator AsnC/Lrp ligand binding
Essential for prephenate dehydratase activity
Prepilin type IV endopeptidase peptidase
Pyridoxamine 5'-phosphate oxidase putative
Phosphoadenosine phosphosulphate reductase
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Damage-control phosphatase ARMT1-like metal-binding
RNA binding; important for wobble base 34 recognition
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
DNA-directed DNA polymerase family A palm
Sigma 54 modulation/S30EA ribosomal protein C-terminal