Molybdopterin cofactor biosynthesis C (MoaC)
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Major facilitator superfamily (MFS) profile
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Phosphoethanolamine transferase N-terminal
Glycosyl transferase family 3 N-terminal
Ion-translocating oxidoreductase complex subunit G
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
FAD-dependent oxidoreductase 2 FAD binding
Phosphatidic acid phosphatase type 2/haloperoxidase
Appears to be important in orienting the phosphate for catalysis
Tryptophan synthase beta chain-like PALP
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Interaction with polymerase core subunit RpoC
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
RND efflux pump membrane fusion protein barrel-sandwich
O-(5'-phospho-DNA)-tyrosine intermediate
Glycosyltransferase subfamily 4-like N-terminal
YdgH/BhsA/McbA-like domain-containing protein
Membrane fusion protein biotin-lipoyl like
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Ionotropic glutamate receptor C-terminal
Solute-binding protein family 3/N-terminal
Peptidase S9 prolyl oligopeptidase catalytic
Menaquinone biosynthesis protein MenD middle
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Transposase IS116/IS110/IS902 C-terminal
Chromosome partition protein MukF C-terminal
Chromosome partition protein MukF middle
Chromosome partition protein MukF winged-helix
Aminoacyl-transfer RNA synthetases class-II family profile
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
Gamma-glutamylcyclotransferase AIG2-like
Small-conductance mechanosensitive channel
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
DnaJ homologue subfamily C member 28 conserved
Anthranilate synthase component I N-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Helix-hairpin-helix DNA-binding motif class 1
Chitobiase/beta-hexosaminidases N-terminal
Aspartate/homoserine dehydrogenase NAD-binding
Integral membrane protein YccS N-terminal
Important for beta-aspartyl-AMP intermediate formation
TtsA-like Glycoside hydrolase family 108
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
O-(phosphoribosyl dephospho-coenzyme A)serine
Interacts with tRNA; defines subfamily-specific binding signature
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
L-seryl-tRNA selenium transferase N-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
DNA polymerase III delta subunit C-terminal
Greasy slide, important in sugar transport
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Schiff-base intermediate with substrate; via pyruvic acid
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Outer membrane protein assembly factor BamD
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
UDP N-acetylglucosamine O-acyltransferase C-terminal
Translation elongation factor P/YeiP central
RNA 2-O ribose methyltransferase substrate binding
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Acyl-CoA dehydrogenase/oxidase N-terminal
Involved in allosteric activation by GTP
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
DNA-directed DNA polymerase family A palm
Glucan biosynthesis periplasmic MdoG C-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Lipopolysaccharide export system protein LptA
Organic solvent tolerance-like N-terminal
Transcriptional regulator SgrR N-terminal HTH
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Glycoside hydrolase family 31 N-terminal
Schiff-base intermediate with substrate; via topaquinone
Nucleophile; methyl group acceptor from either O6-methylguanine or O4-methylthymine
Nucleophile; methyl group acceptor from methylphosphotriester
Erythronate-4-phosphate dehydrogenase dimerisation
Phosphomannose isomerase type I C-terminal
Phosphomannose isomerase type I catalytic
Phosphomannose isomerase type I helical insertion
TonB-dependent receptor-like beta-barrel
Cytochrome b561 bacterial/Ni-hydrogenase
RNA polymerase sigma factor 70 region 4 type 2
SUF system FeS cluster assembly SufBD N-terminal
Outer membrane protein assembly factor BamB
Cell wall hydrolase SleB domain-containing protein
Tellurite resistance methyltransferase TehB-like
NADH-rubredoxin oxidoreductase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Important for interaction with partner proteins
Periplasmic binding protein/LacI sugar binding
The binding site for the sugar molecule has not yet been established, but C-87 may be involved
Bacterial surface antigen (D15) domain-containing protein
Influences the redox potential of the prosthetic heme and FAD groups
Involved in heme-bound ligand stabilization and O-O bond activation
Alpha-glycerophosphate oxidase C-terminal
Small ribosomal subunit protein uS4 N-terminal
DNA polymerase III subunit delta C-terminal
Glycine cleavage T-protein C-terminal barrel
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
SsuA/THI5-like domain-containing protein
Required for dimer formation and molybdate binding
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Pyruvate/ketoisovalerate oxidoreductase catalytic
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Large ribosomal subunit protein uL6 alpha-beta
RNA binding; important for wobble base 34 recognition
Ribosomal RNA adenine methylase transferase N-terminal
Proton acceptor; for decarboxylase activity
Proton donor; for decarboxylase activity
Proton donor; for formyltransferase activity
UDP-glucose/GDP-mannose dehydrogenase C-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Quercetin 2,3-dioxygenase C-terminal cupin
Non-canonical purine NTP phosphatase/PRRC1
Important for substrate binding and specificity
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Mandelate racemase/muconate lactonizing enzyme C-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Prepilin type IV endopeptidase peptidase
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
ABC-type glycine betaine transport system substrate-binding
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
High-affinity zinc uptake system protein ZnuA
Penicillin-binding protein activator LpoA
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
Essential for degradation by Lon protease
NIF system FeS cluster assembly NifU C-terminal
Outer membrane protein assembly factor BamE
Acyl-ester intermediate; for transpeptidase activity
Penicillin-binding protein transpeptidase
Proton donor; for transglycosylase activity
Transglycosylase PBP1b N-terminal transmembrane
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Isocitrate dehydrogenase kinase/phosphatase (AceK) kinase
Isocitrate dehydrogenase kinase/phosphatase (AceK) regulatory
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Schiff-base intermediate with acetaldehyde
Aspartate carbamoyltransferase regulatory subunit C-terminal
Aspartate carbamoyltransferase regulatory subunit N-terminal
Pyruvate dehydrogenase E1 component middle
YbaK/aminoacyl-tRNA synthetase-associated
Could play a key role in the communication between the regulatory and the substrate sites
4'-phosphopantetheinyl transferase N-terminal
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Membrane-bound lytic murein transglycosylase A
Penicillin-insensitive murein endopeptidase
Mechanosensitive ion channel inner membrane
Reversibly protonated during proton transport
Glucose-methanol-choline oxidoreductase C-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase C-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase N-terminal
Essential for prephenate dehydratase activity
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
High-affinity branched-chain amino acid transport system permease LivHM N-terminal
5-glutamyl coenzyme A thioester intermediate
Negative modulator of initiation of replication SeqA N-terminal
Replication modulator SeqA C-terminal DNA-binding
Sodium/calcium exchanger membrane region
Gp5/Type VI secretion system Vgr protein OB-fold
Putative type VI secretion system Rhs element associated Vgr
Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Type VI secretion system IcmF C-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Positions MEP for the nucleophilic attack
Proline utilization A proline dehydrogenase N-terminal
DNA-binding and helicase activity, interacts with RecC
Nuclease activity, interacts with RecD and RecA
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Phosphotransferase system enzyme I N-terminal
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Release factor glutamine methyltransferase N-terminal
Type I restriction modification DNA specificity
Aminoacyl-tRNA synthetase class I anticodon-binding
Bacterial type II secretion system protein E
Precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase
Uroporphyrinogen-III C-methyltransferase
Pyrimidine nucleoside phosphorylase C-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
DNA replication/recombination mediator RecO N-terminal
Cob(I)alamin adenosyltransferase N-terminal
TRAP C4-dicarboxylate transport system permease DctM subunit
Heme-copper oxidase subunit III family profile
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
HicB-like antitoxin of toxin-antitoxin system
Curli production assembly/transport component CsgE
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Lysozyme inhibitor LprI N-terminal domain-containing protein
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Chromosomal replication initiator DnaA C-terminal
Polymerase/histidinol phosphatase N-terminal
Exonuclease VII large subunit C-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Major facilitator superfamily associated
Acyl-CoA dehydrogenase C-terminal bacterial-type
Acyl-CoA dehydrogenase/oxidase C-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Carbamoyl-phosphate synthase small subunit N-terminal
Interaction with tRNA; Important for base-flipping
Pseudouridine synthase I TruA alpha/beta
Divergent polysaccharide deacetylase family protein
ATP synthase F1 complex delta/epsilon subunit N-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
ABC-type transport auxiliary lipoprotein component
Glycosyl transferase family 8 C-terminal
Cysteine sulfenic acid (-SOH) intermediate
Glutathionylspermidine synthase pre-ATP-grasp-like
Membrane insertase YidC/Oxa/ALB C-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
Bacterial transcription activator effector binding
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
L,D-transpeptidase catalytic domain-containing protein
Polysaccharide chain length determinant N-terminal
DNA-3-methyladenine glycosylase AlkA N-terminal
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Phosphocysteine intermediate; for EIIB activity
6-phosphogluconate dehydrogenase C-terminal
Lysidine-tRNA(Ile) synthetase C-terminal
Mannose-6-phosphate isomerase type II C-terminal
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Peptide methionine sulphoxide reductase MsrA
Lytic transglycosylase superhelical linker
Glyceraldehyde-3-phosphate dehydrogenase
Gly-cisPro motif, important for rejection of L-amino acids
For 3-hydroxyacyl-CoA dehydrogenase activity
Transcription factor NikR nickel binding C-terminal
Survival protein SurE-like phosphatase/nucleotidase
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Arginine decarboxylase C-terminal helical
Periplasmic nitrate reductase, electron transfer subunit
Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with Met-249)
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-102)
Membrane-bound lytic murein transglycosylase C
Could be important to modulate the pK values of the two catalytic cysteine residues
Tetrahydrodipicolinate-N-succinyltransferase chain A
Prokaryotic-type class I peptide chain release factors
Involved in tetramerization or stability of the tetramer
DNA mismatch repair MutH/Type II restriction enzyme Sau3AI
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Outer-membrane lipoprotein carrier protein
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
NIF system FeS cluster assembly NifU N-terminal
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Methylguanine DNA methyltransferase ribonuclease-like
Catalytic role in ketonization of the dienol substrate (substrate destabilization)
Adaptive response protein AidB N-terminal
Large ribosomal subunit protein uL2 C-terminal
Type VI secretion system lipoprotein TssJ
Large ribosomal subunit protein bL25 L25
RNA methyltransferase SpoU/TrmH type C-terminal
Inosine/uridine-preferring nucleoside hydrolase
Sugar fermentation stimulation protein C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Thiol:disulfide interchange protein DsbD
Cytochrome c-type biogenesis protein CcmF C-terminal
Required for zinc-mediated homotetramerization and catalytic activity
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
DNA-directed DNA polymerase family B multifunctional
Threonine/serine exporter-like N-terminal
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Outer-membrane lipoprotein Wza C-terminal
Thymidylate synthase/dCMP hydroxymethylase
Important for autoinhibition of adenylyltransferase activity
Plays an important role in substrate specificity
Ribose-phosphate pyrophosphokinase N-terminal
Superoxide dismutase copper/zinc binding
S-adenosyl-L-homocysteine hydrolase NAD binding
Alanyl-transfer RNA synthetases family profile
Pyruvate phosphate dikinase AMP/ATP-binding
Glucose-methanol-choline oxidoreductase N-terminal
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
Outer membrane protein assembly factor BamA
Regulator of nucleoside diphosphate kinase N-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Large ribosomal subunit protein uL15/eL18
Probable transposase IS891/IS1136/IS1341