COP9/Signalosome and eIF3 complex-shared subunit 1
G-protein coupled receptors family 1 profile
Specificity protein transcription factor 1
Ribonucleoside-diphosphate reductase small chain
Probable glucosamine-6-phosphate isomerase
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
In deg-1(u38) and deg-1(u529); degeneration.
In bp555; viable, but growth retarded during embryogenesis and have a shorter lifespan. 20-30% of animals exhibit embryonic lethality and 50% of hatched embryos die during larval development. Lysosomal defects characterized by an accumulation of ribosomal RNA and ribosomal proteins in lysosomes throughout development, which results in enlarged lysosomes.
In qx245; viable, but growth retarded during embryogenesis and have a shorter lifespan. 20-30% of animals exhibit embryonic lethality and 50% of hatched embryos die during larval development. Lysosomal defects characterized by an accumulation of ribosomal RNA and ribosomal proteins in lysosomes throughout development, which results in enlarged lysosomes. This defect is suppressed in either an atg-2 bp576, epg-6 bp242 or lgg-1 bp500 mutant background. Lysosomal defects are not rescued; when associated with A-118.
Lysosomal defects; when associated with E-119.
Zinc finger transcription factor family protein 30
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Histone H3-like centromeric protein cpar-1
Loss of cleavage during meiosis I metaphase-anaphase transition. No effect on chromosome localization.
Homodimerizes but do not form higher ordre structures.
SXP/RAL-2 family protein Ani s 5-like cation-binding
Major facilitator superfamily (MFS) profile
GPI ethanolamine phosphate transferase 1 C-terminal
Intron-binding protein aquarius N-terminal
Eukaryotic translation initiation factor 6
Does not affect localization to the ciliary transition zone.
Does not localize to the ciliary transition zone.
Does not localize to the ciliary transition zonee.
Increases cilium length. Affects localization to the ciliary transition zone.
Lipid-binding serum glycoprotein C-terminal
Lipid-binding serum glycoprotein N-terminal
In ot354; decreased expression of srh-234 in the cell body of ADL sensory neurons.
In n771; temperature-sensitive multivulva phenotype in a lin-8 n111, n2741, n2376, n2378, n2403, n2738, n2731 or n2739 mutant background.
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
In oj29; induces centrosome defects leading to defects in bipolar spindle assembly.
In or183; induces centrosome defects leading to defects in bipolar spindle assembly.
In or188; results in centrosome duplication defects resulting in failure to assemble the bipolar spindle. In some animals, the embryonic lethaliy phenotype is rescued in a szy-20 (bs52) loss of function mutant background with 65% of embryos displaying centrosome duplication.
Ankyrin repeat and LEM domain-containing protein 1 homolog
Failure to localize to midbodies and hypersensitivity to ionizing radiation; when associated with Ala-556. In a RNAi-mediated capg-1 knockdown, excessive and persistent chromatin-bridge formation; when associated with Ala-556.
Failure to localize to midbodies and hypersensitivity to ionizing radiation; when associated with Ala-558. In a RNAi-mediated capg-1 knockdown, excessive and persistent chromatin-bridge formation; when associated with Ala-558.
In mn155; increase of rad-51 foci in meiotic prophase and increase in rmh-1 foci in mid pachytene. In a RNAi-mediated mcm-7 or capg-1 knockdown, unresolved chromatin bridges at the end of cell division and reduced embryonic viability.
In op444; severe reduction in endonucleolytic activity. Severe embryonic lethality of progeny of adults treated with X-ray, UV-C light or cisplatin characterized by chromosome mis-segregation and formation of anaphase bridges. Irradiated L1 larvae are uncoordinated and have a protruding vulva. In germline cells, cell cycle arrest and apoptosis following DNA damage are not affected. In addition, progeny of non-irradiated adults die at the embryonic stage in a baf-1 and unc-32 mutant background.
Increased sensitivity to ionizing radiation, decreased localization to the midbody and lack of phosphorylation; when associated with Ala-192. In a RNAi-mediated capg-1 knockdown, delayed midbody localization and persistent chromatin bridge formation; when associated with Ala-192.
Increased sensitivity to ionizing radiation, decreased localization to the midbody and lack of phosphorylation; when associated with Ala-194. In a RNAi-mediated capg-1 knockdown, delayed midbody localization and persistent chromatin bridge formation; when associated with Ala-194.
7TM GPCR serpentine receptor class x (Srx)
CCR4-NOT transcription complex subunit 7
G-protein coupled receptors family 3 profile
Huntington interacting protein related 1
In sa300; complete loss of posterior body wall contraction (pBoc).
Increased Na(+)/H(+) exchange activity and strong extended pBoc. Complete rescue of pBoc defect in the null mutant.
Limited Na(+)/H(+) exchange activity, low amplitude pH oscillations and reduced strength in pBoc.
Reduced Na(+)/H(+) exchange activity but complete rescue of pBoc defect in the null mutant.
Reduced pBoc strength, low amplitude pH oscillations, and suppressed ability to rescue pBoc defect in the null mutant. Accumulates in intracellular space.
Glycosyltransferase family 92 protein C33H5.2
Probable ATP-dependent RNA helicase DDX55 homolog
Probable DNA-directed RNA polymerases I, II, and III subunit RPABC2
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
In qm189; normal complex III assembly, but a decrease in complex activity.
Mitochondrial import inner membrane translocase subunit TIM14
Abolished phosphatase activity towards phosphatidylinositol 3-phosphate (PI3P) phosphatidylinositol 3,5-bisphosphate (PI35P).
In tm4475; viable but display 36% embryonic lethality and 45% larval arrest. Reduces survival of L1 larvae in nutrient-deprived conditions. Defective autophagosome maturation and degradation of autophagic protein aggregates.
Probable replication factor A 73 kDa subunit
In gk438569; disrupts axonal connections between the male-specific sensory neuron HOA and the interneuron AVG, and between the two PHC sensory neurons and the AVG interneuron. No disruption to the connection between HOA and the PHC neurons.
DNA-directed DNA polymerase family A palm
Enoyl-[acyl-carrier-protein] reductase, mitochondrial
Domain of unknown function DB domain-containing protein
In cc615; approximately 30% larval and adult lethality. Abnormal cell cleavage orientation, under-proliferation and cell fate transformation in the mesodermal (M) lineage. Abolishes M-lineage specific expression of hlh-1. At late L1 stage, animals contain a reduced number of M lineage descendants. Defects in expression of ceh-36 and odr-1 in AWC neurons. Abnormal excretory duct and pore development in early L1 larvae.
In cs71; abnormal excretory duct and pore development in early L1 larvae, leading to abnormal duct and pore shape.
In oy88; multiple morphological defects of AWC sensory neurons, including truncated dendrites, abnormal axonal branching and axonal trajectories and altered cell body positions. Altered expression of ceh-36 homeobox gene and odr-1 receptor-type guanylate cyclase in AWC neurons and altered expression of differention markers in ASH, ASK and AIM neurons.
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in NEDD8)
In ox196; induces defects in protease involved in ecdysis.
Serine/threonine specific protein phosphatases
Putative uncharacterized protein T27A8.3
Guanine nucleotide-binding protein alpha-2 subunit
In gk430078; increases the number of lgg-1-containing protein aggregates in neuronal cell bodies, but not neurites, of AIY interneurons.
In gk628327; increases the number of lgg-1-containing protein aggregates in neuronal cell bodies, but not neurites, of AIY interneurons. Increases the number of lgg-1-containing protein aggregates in neurites of AIY interneurons in a unc-16 ju146 mutant background.
In ola316; defective maturation of autophagosomes with increased numbers of immature autophagic vacuoles. Increases the number of lgg-1-containing protein aggregates in neuronal cell bodies, but not neurites, of AIY interneurons. Increases the number of lgg-1-containing protein aggregates in neurites of AIY interneurons in a unc-16 ju146 mutant background.
Mediator of RNA polymerase II transcription subunit 14
Vacuolar protein sorting-associated protein 33A
Ubiquitin-activating enzyme E1 C-terminal
MAP kinase-interacting serine/threonine-protein kinase mnk-1
In e1034; induces defects in chemotaxis to NaCl.
In ot63; leads to a loss of expression of lim-6 and cgy-7 in left ASE chemosensory neurons.
In ot70; leads to a loss of expression of lim-6 and cgy-7 in left ASE chemosensory neurons.
In p692 and p696; induces defects in chemotaxis to NaCl.
Probable S-adenosylmethionine synthase 4
Coiled-coil domain-containing protein 149
In ku167; suppresses an activated ras mutation and dramatically enhances phenotypes of mpk-1 MAP kinase and ksr-1 mutations. Moderate increase in resistance to nicotine-induced paralysis.
In ku242; suppresses an activated ras mutation and dramatically enhances phenotypes of mpk-1 MAP kinase and ksr-1 mutations. Abolishes interaction with let-60.
Probable insulin-like peptide alpha-type 1
Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1)
CAP-Gly domain-containing linker protein 1 homolog
In sy433; Reduces induction of expression of heat shock protein hsp-16.2 in response to heat-shock.
Nuclear hormone receptor family member nhr-80
Acetyl-CoA acetyltransferase homolog, mitochondrial
In mg368; increased uptake of the lipophilic dye Nile Red and the synthetic fatty acid analog C1-BODIPY-C12.
Hydroxyacid-oxoacid transhydrogenase, mitochondrial
Probable rRNA-processing protein EBP2 homolog
Abolishes phosphorylation. Severe reduction in binding to plk-1 and plk-2.
Phosphomimetic mutant which severely abolishes interaction with plk-1 and plk-2.
In n2259; induces very short defecation cycle periods.
In sa201; induces very short defecation cycle periods.
In u7; weak antimorph that induces very short defecation cycle periods.
In cas452; suppresses the anterior migration of mutant mig-13 expressing PQR cells, which are descendents of Q neuroblasts. Abolishes interaction with abl-1 in yeast two-hybrid assay.
9 X 4 AA repeats of M-[D/E]-[I/L/M]-[S/T]
In n1993; disrupts F-actin polarization in VD neuron growth cone. In VD neurons, increases growth cone filopodial protrusion, characterized by an accumulation of plus-end microtubule, and formation of ectopic axons in a mig-2 mu28 mutant background. Defects in connections between BDU and PLM neurons. Reduced membrane protrusion.
In n3246; in HSN neurons, severe reduction in mig-10 ventral enrichment and mild defect in axonal guidance but normal final migration to the ventral nerve cord. Dopaminergic neurodegeneration in 20% of animals in response to oxidative stress-induced by the neurotoxin 6-hydroxydopamine (6-OHDA). Dopaminergic neurodegeneration is partially suppressed in a ttr-33 (gt1983) mutant background in response to 6-OHDA. Defects in connections between BDU and PLM neurons. Reduced membrane protrusion.
In xd33; defects in connections between BDU and PLM neurons. Reduce membrane protrusion.
May be constitutively active. Enhances interaction with chdp-1 protein compared to N-17 mutant. Formation of ectopic processes often branched in PDE neurons.
May be mimicking the GDP-bound inactive state. Reduces interaction with chdp-1 compared to the V-12 mutant.
May lock enzyme in its GTP-bound active state. Defect in distal tip cell (DTC) migration.
Inactive angiotensin-converting enzyme-related protein
Prokaryotic-type class I peptide chain release factors
Probable methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial
Abolishes binding to cdc-42 and rescues the endosomal cargo sorting defect in the double toca-1 and toca-2 mutant.
Abolishes binding to wve-1 and rescues the endosomal cargo sorting defect in the double toca-1 and toca-2 mutant.
Transducer of Cdc42-dependent actin assembly protein 2 homolog
Potassium channel tetramerisation-type BTB
In cb101; highly resistant to monepantel.
In cb103; highly resistant to monepantel.
In ox429; mild swimming defects and lethargic movement when crawling on a food-free environment.
Increases sensitivity to betaine. Leads to death during larval development in most cases, with escapees reaching to adulthood but being hypercontracted and uncoordinated.
Neurotransmitter-gated ion-channel ligand-binding
Neurotransmitter-gated ion-channel transmembrane
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D 2
In oy63; Suppresses several phenotypes in a Ser/Thr kinase kin-29 mutant background; dauer pheromone hypersensitivity, reduced chemoreceptor gene expression and also decreased body length.
In oy65; Suppresses several phenotypes in a Ser/Thr kinase kin-29 mutant background; dauer pheromone hypersensitivity, reduced chemoreceptor gene expression and also decreased body length.
G-patch domain and KOW motifs-containing protein homolog 1
In ot108; defects in left/right asymmetry in the gustatory ASE neurons. Significantly reduced expression of LIM homeobox protein lim-6.
Disrupts nuclear localization. Localizes to the cytoplasm; when associated with 372-A--A-381.
Impairs nuclear export signal. Disrupts cytoplasmic localization, conferring nuclear localization during interphase. Localizes to the cytoplasm; when associated with 366-A--A-371.
In he118; no effect on viability, embryogenesis or fertility. Disrupts cell cycle arrest of vulval precursor, intestinal, and hypodermal cells, and of precursor cells that give rise to male specific structures during postembryonic development. Vulval precursor cells undergo an extra round of cell division during the L2 larval stage of development, but the additional precursor cells do not disrupt formation of the vulval structure and animals undergo normal vulval morphogenesis during the L4 larval stage. Does not result in defects in cytokinesis. Overexpression of the cyclin dependent kinase inhibitor cki-1, or knockout with the G1/S-specific cyclin-E cye-1 (eh10), rescues the cell division phenotype.
Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term
Does not suppress the locomotion defect of the kin-20 ox423 mutant.
In ju924; increases ama-1 'Ser-5' phosphorylation, alters usage of internal polyadenylation sites (PAS) in unc-44 and dlk-1 pre-mRNAs. Restores ama-1 binding to neuron-specific PASs, expression of unc-44 in neurons and vulva, and suppresses abnormal synapse and axon formation in a sydn-1 (ju541) mutant background.
No obvious phenotype. Fails to suppress abnormal synapse and axon formation in a sydn-1 and syd-2 mutant background.
RNA polymerase II subunit A C-terminal domain phosphatase ssup-72
Suppresses the locomotion defect of the kin-20 ox423 mutant.
Nose resistant-to-fluoxetine protein N-terminal
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2
Nuclear hormone receptor family member nhr-174
In gv560; significantly increased levels of ida-1 in a subset of neurons including VC4, VC5, and ALA. Significantly increased levels of synaptotagmin snt-1 and serotonin, whereas rab-3 and unc-31 levels remain unchanged. Significant increase in egg-laying in response to exogenous serotonin. Increased sensitivity to aldicarb. Increased numbers of presynaptic dense-core vesicles (DCVs) in ventral cord neurons. Extra presumptive neurons along the posterior ventral midline and an uncoordinated phenotype. Reduction in dauer formation at 25 degrees Celsius in a daf-28 mutant background.
In ls20; misexpression of touch neuron genes in the BDU neurons. Homeotic transformation of BDU to ALM neurons, based on altered cell body and axonal morphology and ectopically expressed ALM markers in BDU, including abnormal expression of mec-3, mec-4, mec-7, mec-17 and eat-4. Motility defects, lethargic and uncoordinated. Significantly increased levels of ida-1 in a subset of neurons including VC4, VC5, and ALA. Increased number of cell corpses in the anterior ventral nerve cords in a ced-1 mutant background.
In ls64; misexpression of touch neuron genes in the BDU neurons. Motility defects, lethargic and uncoordinated. Increased numbers of VC and VC-like neurons in the ventral nerve cords of adult hermaphrodites.
In ls65; misexpression of touch neuron genes in the BDU neurons. Motility defects, lethargic and uncoordinated.
In n3098; misexpression of touch neuron genes in the BDU neurons. Increased number of cell corpses in the anterior ventral nerve cords in a ced-1 mutant background. Motility defects, lethargic and uncoordinated. Absence of VB motoneurons and the abnormality in VA motoneurons. Significantly increased levels of ida-1 in a subset of neurons including VC4, VC5, and ALA. Increased numbers of VC and VC-like neurons in the ventral nerve cords of adult hermaphrodites in a ced-3 mutant background.
Transcription factor CBF/NF-Y/archaeal histone
Serine/threonine-protein phosphatase 6 regulatory subunit
UV-stimulated scaffold protein A homolog
In m77; constitutive dauer formation at 25 degrees Celsius, an egg laying defect (Egl), abnormal social aggregation - also known as clumping behavior (Cpy), and a dark intestine (Din).
In sa340; constitutive dauer formation at 25 degrees Celsius, an egg laying defect (Egl), abnormal social aggregation - also known as clumping behavior (Cpy), and a dark intestine (Din).
In sa535; constitutive dauer formation at 25 degrees Celsius, an egg laying defect (Egl), abnormal social aggregation - also known as clumping behavior (Cpy), and a dark intestine (Din).
Probable elongation factor 1-beta/1-delta 1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit dad-1
N-acylethanolamine-hydrolyzing acid amidase
N-acylethanolamine-hydrolyzing acid amidase subunit alpha
N-acylethanolamine-hydrolyzing acid amidase subunit beta
Golgi SNAP receptor complex member 2 homolog memb-1
Helical; Anchor for type IV membrane protein
Glycosyl transferase family 28 C-terminal
NAD-dependent protein deacetylase sir-2.1
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Pre-mRNA processing factor 4 (PRP4)-like
Guanine nucleotide-binding protein alpha-11 subunit
Little or no effect, suggesting that it acts as an alpha-like subunit.
Loss of function, suggesting that it acts as an alpha-like subunit.
Endoplasmic reticulum vesicle transporter C-terminal
Endoplasmic reticulum vesicle transporter N-terminal
Nuclear hormone receptor family member nhr-8
3-beta hydroxysteroid dehydrogenase/isomerase
Glucosamine 6-phosphate N-acetyltransferase
Probable peptidylglycine alpha-hydroxylating monooxygenase 1
Translation factor GUF1 homolog, mitochondrial
In wy622; mislocalization of synaptic vesicles to the dendrites is rescued in cdk-5 mutants.
Nuclear hormone receptor family member nhr-71
In cc561; low frequency of embryonic lethality, with embryos arresting paralyzed at the two-fold stage (Pat); increases in frequency significantly on an hnd-1 or unc-120 mutant background. Many embryos that survive to hatch become uncoordinated, dumpy larvae.
Myoblast determination protein 1 homolog
Expected to give rise to a constitutively active GTP-bound state. Cilia-related sensory abnormalities, but undergoes intraflagellar transport, but at a reduced frequency compared to wild-type.
Expected to give rise to an inactive GDP-bound state. Cilia-related sensory abnormalities and failure to undergo intraflagellar transport.
DNA-directed RNA polymerases I, II, and III subunit RPABC5
Intraflagellar transport associated protein 2
In e1063; about 80% animals reach adulthood.
In e2; about 80% animals reach adulthood. No effect on interaction with daf-18. Increased daf-18 protein levels in embryos. May lack kinase activity. Animals lay an increased number of unfertilized oocytes compared to wild-type. Reduced brood size. No effect on major sperm protein (MSP) binding. In a RNAi-mediated nhr-6 knockdown background, enhanced reduction in brood size.
In e699; most die as larvae. Animals lay an increased number of unfertilized oocytes compared to wild-type. Reduced brood size. No effect on major sperm protein (MSP) binding. In a RNAi-mediated nhr-6 knockdown background, enhanced reduction in brood size.
In ju22; about 80% animals reach adulthood.
In ju8; most die as larvae. Animals lay an increased number of unfertilized oocytes compared to wild-type. No effect on major sperm protein (MSP) binding.
Helical; Signal-anchor for type II membrane protein
Putative alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Eukaryotic translation initiation factor 3 subunit H
Elimination of the nitric oxide-evoked calcium flux to the cytoplasm in ASJ sensory neurons. Defect in avoidance of P.aeruginosa.
In nu517; abolishes the calcium flux to the cytoplasm in the ASJ sensory neurons in response to the removal of a nitric oxide stimulus. No defect in P.aeruginosa avoidance.
No change in suppression of the constitutive dauer formation phenotype in a daf-28(sa191) mutant background. No impact on skn-1 nuclear localization.
Probable insulin-like peptide beta-type 2
AMP-activated protein kinase glycogen-binding
Probable peptidyl-alpha-hydroxyglycine alpha-amidating lyase pgal-1
Probable GMP synthase [glutamine-hydrolyzing]
In dz203 and gk606935; defective formation of the somatosensory dendritic arbor of PVD sensory neurons.
In gk609178; defective formation of the somatosensory dendritic arbor of PVD sensory neurons.
In gk660807; does not cause defects in the formation of the somatosensory dendritic arbor of PVD sensory neurons.
In gk751884; does not cause defects in the formation of the somatosensory dendritic arbor of PVD sensory neurons.
In gk762721; does not cause defects in the formation of the somatosensory dendritic arbor of PVD sensory neurons.
In gk808537; does not cause defects in the formation of the somatosensory dendritic arbor of PVD sensory neurons.
In gk864764; defective formation of the somatosensory dendritic arbor of PVD sensory neurons.
In wy935; defective formation of the somatosensory dendritic arbor of PVD sensory neurons. Secondary dendrites that extend from the PVD neuronal cell body are disorganized and fail to form 'T' shaped tertiary dendrites, and furthermore no quaternary dendritic branches are formed.
In wy953; defective formation of the somatosensory dendritic arbor of PVD sensory neurons. Secondary dendrites that extend from the PVD neuronal cell body are disorganized and fail to form 'T' shaped tertiary dendrites, and furthermore no quaternary dendritic branches are formed.
Leukocyte cell-derived chemotaxin-2 homolog
Phosphate carrier protein, mitochondrial
Single-stranded DNA-binding protein, mitochondrial
In cs24; viable with no visible phenotype. Suppresses multivulva formation in a let-60 n1046 mutant background.
In ku123; viable with no visible phenotype. Suppresses multivulva formation in a let-60 n1046 mutant background.
Serine/threonine-protein phosphatase 2A regulatory subunit sur-6
Inosine/uridine-preferring nucleoside hydrolase
G patch domain-containing protein 1 homolog
Nuclear hormone receptor family member nhr-31
GRIP and coiled-coil domain-containing protein 2
CCAAT/enhancer-binding protein homolog 2
In gk509377; low-fat phenotype. Increases expression of ech-1.1 mRNA and decreases fat-5 mRNA.
In h254; lethal at late embryonic stage.
In h384; probably catalytically inactive. Lethal at late embryonic stage.
In h427; lethal at late embryonic stage.
In h520; lethal at late embryonic stage.
In fr2; almost completely abolishes induction of nlp-29 expression upon infection with Drechmeria coniospora or upon injury. Induction of nlp-29 unaffected by osmotic stress.
Probable G-protein coupled receptor B0563.6
Putative ATP-dependent RNA helicase T26G10.1
Receptor-type tyrosine-protein phosphatase-like ida-1
Histone-lysine N-methyltransferase, H3 lysine-79 specific
Abrogates cholesterol dehydrogenase activity.
RNA polymerase III subunit RPC82-related helix-turn-helix
Peptidyl-prolyl cis-trans isomerase sig-7
Dimethyladenosine transferase 1, mitochondrial
Does not impair binding to gsp-1 and gsp-2.
Plasma membrane calcium-transporting ATPase mca-1
In ks67; constitutive dauer formation at 25 degrees Celsius.
In m84; constitutive dauer formation with mild defect in dauer recovery. Mild inhibition of chemotaxis responses to some volatile attractants.
In m87; temperature sensitive constitutive dauer formation with severe defect in dauer recovery. Loss of chemotaxis responses to non-volatile and some volatile attractants.
In nu629; abolishes the calcium flux to the cytoplasm in the ASJ sensory neurons in response to the addition and removal of a nitric oxide stimulus.
In p169; temperature sensitive constitutive dauer formation with severe defect in dauer recovery.
In gk1246; results in defective clearance of paternal mitochondria in 1-cell stage embryos, and impaired accumulation of the autophagosome marker lgg-1 in 1-cell stage embryos and oocytes.
In tm4102; results in defective clearance of paternal mitochondria and impaired accumulation of the autophagosome marker lgg-1 in 1-cell stage embryos.
Inhibitor of nuclear factor kappa-B kinase epsilon subunit homolog 1
Localizes to paternal organelles and interacts with allo-1 in embryos, but does not rescue the paternal mitochondrial clearance defect in the ikke-1 gk1264 mutant.
In reb2; severe reduction in catalytic activity toward fatty-acid CoA and ascaroside-CoA. Increases ATP and FAD binding. No defect in the production of various ascarosides apart from a slight accumulation of asc-C11. Accumulation of indol-3-carbonyl (IC)-asc-C7. Enhances accumulation of IC-asc-C7 and IC-asc-C9 in a acox-1.4 (reb6) and acox-3 (tm4033) mutant background.
Loss of ATP and FAD binding. Severe loss of catalytic activity toward ascaroside-CoA and fatty acyl-CoA substrates. Defects in the processing of ascarosides with 13-, 11-, 9-, and 7-carbon side chains. No defect in subcellular location.
Loss of ATP binding and severe reduction in FAD binding.
Reduced catalytic activity toward ascaroside asc-C9-CoA, but not toward fatty acyl-CoA substrates. Has a slight activity toward asc-omega-C5-CoA. Shows catalytic activity toward asc-omega-C5-CoA without affecting activity toward asc-C9-CoA, asc-omega-C7-CoA or fatty acyl-CoA; when associated with A-118 and F-245.
Shows catalytic activity toward asc-omega-C5-CoA without affecting activity toward asc-C9-CoA, asc-omega-C7-CoA or fatty acyl-CoA; when associated with A-118 and E-301.
Shows catalytic activity toward asc-omega-C5-CoA without affecting activity toward asc-C9-CoA, asc-omega-C7-CoA or fatty acyl-CoA; when associated with F-245 and E-301.
26S proteasome non-ATPase regulatory subunit 4
Polypeptide N-acetylgalactosaminyltransferase 4
Probable RNA methyltransferase Y17G7B.18
Alpha galactosidase C-terminal beta sandwich
High basal kinase activity, loss of phorbol ester-stimulated kinase activity and ability to phosphorylate pmk-1; when associated with D-925.
High basal kinase activity, loss of phorbol ester-stimulated kinase activity and ability to phosphorylate pmk-1; when associated with D-929.
Loss of sensitivity to phorbol ester or DAG stimulation of kinase activity. Loss of sensitivity to phorbol ester or DAG stimulation of kinase activity; when associated with G-332.
Loss of sensitivity to phorbol ester or DAG stimulation of kinase activity; when associated with G-484. No effect on sensitivity to phorbol ester, loss of DAG stimulation of kinase activity.
Loss of sensitivity to phorbol ester stimulation of kinase activity.
Moderate loss of sensitivity to phorbol ester stimulation of kinase activity.
Small increase in basal kinase activity, no effect on sensitivity to phorbol ester stimulation of kinase activity.
Tryptophan synthase beta chain-like PALP
Aminoacyl-transfer RNA synthetases class-II family profile
Protein-lysine N-methyltransferase M142.8
Probable galactose-1-phosphate uridylyltransferase
Acetylcholine receptor subunit alpha-type acr-7
Cysteine sulfenic acid (-SOH) intermediate
In qt23; induces defects in RNA silencing.
In qt34; induces defects in RNA silencing.
Systemic RNA interference defective protein 5
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
RecQ-mediated genome instability protein 1 homolog
Nuclear hormone receptor family member nhr-3
In or131; loss of pop-1 asymmetry and protruding vulva phenotype and defects in gonadal migration and development.
In t1512; intestine cells absent but have an excess of pharyngeal cells, symmetrical localization of pop-1 and symmetrical T-cell division.
Defective in germ line development protein 3
In e1339; abnormal repetitive turning behavior during male mating.
Receptor-like tyrosine-protein kinase kin-16
Kelch repeat and BTB domain-containing protein F47D12.7
BTB and MATH domain-containing protein 41
In e1062; lethality at embryonic or larval stages, or adult head epidermal morphological defects. Male tail spicule defects. Anatomy of the anterior ganglion is severely disturbed and expression of unc-86 is abolished in several neurons in the head.
In e1796; adult male tail ray morphology defects. Some mutants show defects in gonadal distal tip cell (DTC) migration. Cell fate transformations of head lateral epidermis in some animals. About 50% of individuals have reduced expression of the integrin alpha pat-2. Abolishes expression of hlh-17 in both dorsal and ventral CEPsh glia.
In e648; lethality at embryonic or larval stages. The few surviving adults have defects in head morphogenesis, resulting from defects in the embryonic migration or determination of head hypodermal cells. Male tail spicule defects. Defective dopaminergic neuron specification. Expression of ceh-32 is abolished in some head hypodermal cells. Anatomy of the anterior ganglion is severely disturbed and expression of unc-86 is abolished in several neurons in the head. Defects in gonadal distal tip cell migration in larval development. Abnormal BAG sensory neuron fate. Defects in male specific postembryonic blast cell (B cell) fate specification. Expression of hlh-17 abolished in both dorsal and ventral CEPsh glia.
In ju468; lethality at embryonic or larval stages, or adult head epidermal morphological defects. Severely defective function of chemosensory BAG neurons. Normal BAG sensory neuron fate, but reduced expression of neuropeptide flp-17 in the BAG neurons. Reduced expression of receptor-type guanylyl cyclase gcy-9. Expression of hlh-17 abolished in both dorsal and ventral CEPsh glia.
In k109; embryonic or larval lethality in a few mutants. Male tail spicule defects. Almost abolishes expression of hlh-17 and ptr-10 in dorsal CEPsh glia, whereas nearly half of animals express both these genes in ventral CEPsh glia. No defect in head morphogenesis.
In k143; embryonic lethality in a few mutants. Anterior and posterior defects in gonadal distal tip cell (DTC) migration. No defect in head morphogenesis.
In mw105; defects in gonadal distal tip cell migration in larval development. About 50% of individuals have reduced expression of the integrin alpha pat-2. Hermaphrodites express integrin alpha ina-1 abnormally, beyond the egg-laying stage.
In ns157; defects in AWC, AFD and ADF axon guidance. Shorter CEP dendrites. Almost abolishes expression of hlh-17 and ptr-10 in dorsal CEPsh glia, whereas nearly half of animals express both these genes in ventral CEPsh glia.
In ot266; defective dopaminergic neuron specification. Normal BAG sensory neuron fate, but reduced expression of neuropeptide flp-17 in the BAG neurons.
In ot292; defective dopaminergic neuron specification.
In sy281; defects in head morphogenesis, resulting from defects in the embryonic migration or determination of head hypodermal cells. Male tail spicule defects. Reduces expression of hlh-17 and ptr-10 in both dorsal and ventral CEPsh glia.
In sy66; lethality at embryonic or larval stages. The few surviving adults have defects in head morphogenesis, resulting from defects in the embryonic migration or determination of head hypodermal cells. Male tail spicule defects. Defects in male specific postembryonic blast cell (B cell) fate specification.
In we4; lethality at embryonic or larval stages, or adult head epidermal morphological defects.
In wz25; abnormal BAG sensory neuron fate and inappropriate expression of the transcription factor ets-5 in non-BAG cells.
In my22; abnormal accumulation of pkd-2 and klp-6 in cilia and dendrites of male CEM, HOB and RnB neurons. Age-dependent defects in cilia structure associated with impaired osmolarity responses. Microtubule polyglutamylation levels are increased in CEM neuron cilia but reduced in the middle segment of amphid neuron cilia. Impaired male mating behavior.
In y1; leads to XX-specific lethality. Surviving hermaphrodites exhibit increased X-linked gene transcripts and a shorter and stouter body morphology. XO animals are wild-type males. Defects in mitotic chromosome segregation.
Electron transfer flavoprotein beta subunit lysine methyltransferase homolog
In e995; suppresses the uncoordinated phenotype of the unc-17 G347R mutation.
In ust56; results in increase of antisense ribosomal siRNAs production and depletion of crn-3 and exos-1 proteins from the nucleoli. Reduces the brood size when animals are grown at 20 degrees Celsius. Causes sterility when animals are grown at 25 degrees Celsius.
Probable exosome complex exonuclease RRP44
In ik1; temperature-sensitive mutant with low incidence of embryonic lethality.
Mediator of RNA polymerase II transcription subunit 8
In R866; loss of activity and increased phosphorylation.
In R895; loss of activity and increased phosphorylation.
Putative UDP-glucuronosyltransferase ugt-47
Dihydrolipoyl dehydrogenase, mitochondrial
Guanine nucleotide-binding protein alpha-3 subunit
In syls25; constitutively active. In adults, premature death resulting from internal egg hatching. Increased lifespan and resistance to oxidative stress when progeny overgrowth is prevented. Reduction in pde-1, pde-5, daf-7, ins-7 and daf-28 mRNA levels.
Reduced daf-7 expression in ASJ neurons.
Defective in their response to diacetyl but wild type response to other odorants.
Nuclear hormone receptor family member nhr-40
Glycine cleavage T-protein C-terminal barrel
Putative tyrosine-protein phosphatase C15H7.3
Mutation mimics constitutively active 'GTP-locked' form of protein; does not affect interaction with rsf-1 in vitro.
Mutation mimics dominant negative 'GDP-locked' form of protein; abolishes interaction with rsf-1 in vitro.
Probable ornithine aminotransferase, mitochondrial
Platelet-derived growth factor (PDGF) family profile
Spliceosome-associated protein CWC15 homolog
Fails to rescue the defects in germ cell corpse clearance in the vps-18 (tm1125) deletion mutant; when associated with A-923.
Fails to rescue the defects in germ cell corpse clearance in the vps-18 (tm1125) deletion mutant; when associated with A-925.
Vacuolar protein sorting-associated protein 18 homolog
Transmembrane protein 131-like N-terminal
Transmembrane protein 131-like conserved
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
Anaphase-promoting complex subunit emb-1
In hc57 and hc62; temperature sensitive mutants with no visible phenotype at 16 degrees Celsius, but mutants arrest at metaphase of meiosis I at 24 degrees Celsius.
Disrupts binding to H3K9-methylated peptides.
Gamma tubulin complex component protein N-terminal
Nascent polypeptide-associated complex subunit alpha-like UBA
In m130; loss of dauer larvae formation and dauer pheromone production.
Non-specific lipid-transfer protein-like 2
In gm16; causes arrest at the L1 larval stage, defects in hermaphrodite-specific neuron migration, and impairs pharynx attachment to the nose.
In gm48; in some mutants, causes arrest at the L1 larval stage and defects in hermaphrodite-specific neuron migration.
In qm162; maternal-effect mutation. Partial loss-of-function. Prolongs embryonic and postembryonic development, increases lifespan, reduces brood size, reduces the rate of pharyngeal pumping and increases the defecation cycle rate. Animals appear slimmer and more transparent. In response to a thiamine-depleted diet, the pharyngeal pumping rate further reduces and animals subsquently die. In the absence of food, animals die within a few days as arrested L1 larvae and fail to resume development when placed in the presence of food. No effect on oxygen consumption rate. Reduces lifespan in aha-1, ceh-18, hif-1, jun-1, nhr-105 or taf-4 RNAi mutant background.
In gt1681; in larvae, enhances neurodegeneration of dopaminergic neurons induced by the oxidative stress agent 6-hydroxydopamine (6-OHDA). Hypersensitivity to 6-OHDA is abolished in a dat-1 (ok157) mutant background and partially reduced in a dop-2 or dop-3 mutant background. Reduces dopamine reuptake by transporter dat-1. Loss of cell membrane localization.
In vc2026; enhances neurodegeneration of dopaminergic neurons induced by the oxidative stress agent 6-hydroxydopamine (6-OHDA).
Probable NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
Glutathione gamma-glutamylcysteinyltransferase
Potassium channel voltage dependent KCNQ C-terminal
Putative H/ACA ribonucleoprotein complex subunit 2-like protein
In mg415; adults have a shorter body length. Suppresses the eversion of the vulva (the Evl phenotype) and precocious alae formation in an miR-84 overexpressing background.
In mg431; suppresses the eversion of the vulva (the Evl phenotype) in an miR-84 overexpressing background.
Ribosome biogenesis protein BMS1/TSR1 C-terminal
Important for asc-omega-C5-CoA binding and thus substrate specificity
In gk386052; increases production of asc-omega-C5 and reduces the production of asc-omega-C3.
Probable G-protein coupled receptor frpr-1
Calcium uniporter protein, mitochondrial
Strongly reduced sensitivity to ruthenium red inhibition.
Mitochondrial apoptosis-inducing factor C-terminal
Reduces DNase activity. Abolishes DNase activity; when associated with A-15 and A-17.
Reduces DNase activity; when associated with A-15. Abolishes DNase activity; when associated with A-15 and A-115.
Reduces DNase activity; when associated with A-17. Abolishes DNase activity; when associated with A-17 and A-115.
HEAT repeat-containing protein 1 homolog
Uncharacterized GTP-binding protein C02F5.3
Greatly reduces E3 ligase activity and decreases smo-1 chain formation.
In isoform 2, isoform 4, isoform 5 and isoform 6.
Mitochondrial cytochrome c oxidase subunit VIc/VIIs
In yp14; temperature-sensitive. Embryonic lethality in 6% of animals at 20 degrees Celsius and in 41.6% of animals at 25 degrees Celsius. Fertile at 20 degrees Celsius, but sterile at 25 Degrees Celsius. In sterile mutants at 25 degrees Celsius, 40% of oocytes contain unpaired chromosomes. Defective germ cell immortality at 20 degrees Celsius, which is more prominent at 25 degrees Celsius. The germ cell immortality defect is due to an X chromosome segregation defect, which results in a high proportion of male progeny (Him phenotype). Disrupted inheritance of small RNA-mediated genome silencing over multiple generations. Decreased levels of total 22GRNAs and miRNAs. Increased phosphorylation of histone H3 at 'Ser-10' and 'Thr-3' in oocytes at 25 degrees Celsius. Reduced di- and trimethylation of 'Lys-9' of histone H3 in the diakinesis phase of prophase I in meiotic oocytes at 25 degrees Celsius. Double knockout with the lab-1 tm1791, hrde-1 tm1200 or rsd-6 yp11 mutant increases the incidence of sterility at 25 degrees Celsius as compared to the single mutants.
Serine/threonine-protein phosphatase PP1-beta
Constitutively active and results in reduced lin-28 protein levels. Rescues the seam cell number and vulval developmental defects of the lin-28 n719 loss of function mutant.
Loss of ced-3-mediated cleavage in vitro. Partially prevents reduction of lin-28 protein levels in vivo. About 20 percent of mutants fail to reach adulthood. Defects in alae morphology.
Loss of ced-3-mediated cleavage in vitro. Prevents reduction of lin-28 protein levels in vitro.
Reduced ced-3-mediated cleavage in vitro.
Nuclear hormone receptor family member nhr-154
Proton myo-inositol cotransporter hmit-1.2
Tetratricopeptide repeat-containing protein trd-1
B lymphocyte-induced maturation protein 1 homolog
1.2-fold decrease in RNA binding affinity. 11-fold decrease in RNA binding affinity; when associated with R-313. 1.3-fold decrease in RNA binding affinity; when associated with R-315.
1.3-fold decrease in RNA binding affinity; when associated with K-314.
11-fold decrease in RNA binding affinity; when associated with K-314.
19-fold decrease in RNA binding affinity.
26-fold decrease in RNA binding affinity.
64-fold decrease in RNA binding affinity.
Female germline-specific tumor suppressor gld-1
Important for the interaction between KH and Qua2 domains
In rrr1; 89-fold decrease in RNA binding affinity. Small abnormal stacked oocytes and feminization of germline. Overexpression of oma-2 and to a lesser extent of egg-1 in germline.
May abolish phosphorylation by cdk-2. Increased expression in the gonad mitotic zone and reduction in the size of the mitotic region; when associated with A-22 and A-348.
May abolish phosphorylation by cdk-2. Increased expression in the gonad mitotic zone and reduction in the size of the mitotic region; when associated with A-22 and A-39.
May abolish phosphorylation by cdk-2. Increased expression in the gonad mitotic zone and reduction in the size of the mitotic region; when associated with A-39 and A-348.
Moderate decrease in homodimer stability.
Qua1 domain; involved in homodimerization
In cu8; probable loss of dihydroorotase activity. Severe late stage embryonic lethality in 50% of animals. The few surviving mutants have a shorter and thicker pharyngeal isthmus, an abnormal knobbed tail, mild egg-laying defects, moderate fluid accumulation in the coelom and a slower growth. Actin and intermediate filaments are disorganized in the pharynx. Moderate reduction in heparan sulfate levels and increased levels of chondroitin sulfate. In an umps-1 zu456 mutant background, prevents the formation of abnormally enlarged gut granules in embryos. Complete embryonic lethality in a rnst-2 qx245 mutant background.
Cation diffusion facilitator family protein 1
In n2527; loss of zinc transport from intestinal cells to pseudocoelom.
In fd2; viable. Gonad morphological defects in a lin-35 RNAi background.
Abolishes ATP-binding and enzymatic activity. Abolishes microtubule severing. Forms homohexamers.
Abolishes ATP-binding and reduces enzymatic activity. Abolishes microtubule severing. Forms homohexamers.
Abolishes enzymatic activity. Abrogates microtubule severing, promotes homohexamerization and promotes association with microtubules.
Abolishes microtubule severing. Abolishes microtubule localization; in association with A-318.
Abolishes microtubule severing. Disperse cytoplasmic localization. Abolishes microtubule localization; in association with A-318.
Abolishes microtubule severing. Disperse cytoplasmic localization. Does not abolish microtubule localization; in association with A-318.
Abolishes microtubule severing; in association with P-498.
Abolishes microtubule severing; in association with P-502.
Does not abolish microtubule severing. Disperse cytoplasmic localization.
Increases enzymatic activity. Forms homohexamers. Localizes to microtubules, but microtubule severing is abolished. Abolishes microtubule localization; in association with A-312, A-321 or A-357. Does not abolish microtubule localization; in association with A-347 or A-356.
Important for beta-aspartyl-AMP intermediate formation
Structural maintenance of chromosomes-like protein 1
Nuclear hormone receptor family member nhr-7
Steroidogenic acute regulatory-like protein 1
Probable DNA replication complex GINS protein PSF1
Probable glycerol-3-phosphate dehydrogenase, mitochondrial
X-linked retinitis pigmentosa GTPase regulator homolog
Abolishes ligase activity; when associated with A-222.
Abolishes ligase activity; when associated with A-225.
In e2518; defects in patterning of the dopaminergic neurons of the male-specific genital sensilla (simple sense organs) known as rays. Males abnormally express dopamine transporter cat-2 and synthesize dopamine in the A-type neurons of the rays. Males are unable to sire progeny due to abnormal tail and gonad morphology, whereas hermaphrodites have no obvious phenotypic defects.
Dual specificity tyrosine-phosphorylation-regulated kinase mbk-1
Drought induced 19 protein type zinc-binding
Domain of unknown function DX domain-containing protein
In n745; on a ubc-18 mutant background, 4% of larvae display a Pun (pharyngeal unattached) phenotype, whereby the pharynx fails to elongate and form an attachment to the anterior alimentary opening or buccal cavity.
Retinoblastoma-like protein homolog lin-35
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase hpo-8
Nitrilase and fragile histidine triad fusion protein NitFhit
Failure in quaternary dendritic arbor formation of the PVD sensory neurons.
In e1745; temperature sensitive. At the restrictive temperature of 25 degrees Celsius, causes reduction of the numbers and extensions of the quaternary dendritic branches, reduced numbers of menorah and ectopic branches from the primary and secondary dendrites of the PVD sensory neurons. Reduced synapse formation between the PHB and AVA neurons and defects in the behavioral avoidance response towards sodium dodecyl sulfate. Defects in PVD primary branch extensions when associated with sax-7(nj48), dma-1(wy686) or mnr-1(wy758).
In gm30; fluid accumulation in the pseudocoelom, reduced size and loss of both motility and fertility.
In n1635; fluid accumulation in the pseudocoelom.
In n1641; fluid accumulation in the pseudocoelom, reduced size and loss of both motility and fertility.
In n1649; slight fluid accumulation in the pseudocoelom.
In n1660; fluid accumulation in the pseudocoelom, reduced size and loss of both motility and fertility.
Loss of activity. Reduced synapse formation between the PHB and AVA neurons and defects in the behavioral avoidance response towards sodium dodecyl sulfate.
Receptor-type tyrosine-protein phosphatase
Superoxide dismutase [Mn] 1, mitochondrial
Nuclear hormone receptor family member nhr-57
Histone H3-like centromeric protein hcp-3
BTB/POZ domain-containing protein Y57A10B.3
In ay38; loss of dopamine transporter dat-1 expression in midbody neurons (PDE).
In ay42; loss of dopamine transporter dat-1 expression in midbody neurons (PDE).
In mu290; egg laying defects, abnormal migration of QR neuroblast lineage cells and BDU interneurons, and vulval protrusions. Loss of expression of dopamine pathway genes, including dopamine transporter dat-1, in midbody neurons (PDE).
In mn415; enhances accumulation of an alternatively spliced isoform of unc-52 that skips exon 17. Selective suppressor of unc-52 missense mutations in exon 17.
Required and sufficient for interaction with smu-2
Smu-1 suppressor of mec-8 and unc-52 protein
Peptidase M1 membrane alanine aminopeptidase
Receptor-like tyrosine-protein kinase kin-15
Putative cystathionine beta-synthase cbs-2
Extracellular serine/threonine protein kinase CeFam20
In nu518; diminishes the calcium flux to the cytoplasm in the ASJ sensory neurons upon removal of a nitric oxide stimulus.
Protein N-terminal glutamine amidohydrolase
Causes constitutive phosphatidylserine cell surface exposure.
Loss of ced-3-mediated cleavage. Reduced phosphatidylserine cell surface exposure in apoptotic cells. Reduced number of cell corpses at the comma stage followed by an increase at the 4-fold stage.
No defect in apoptosis during embryogenesis.
NEDD8-activating enzyme E1 regulatory subunit
Probable DNA-directed RNA polymerase II subunit RPB11
In e2770; temperature sensitive mutant. At the permissive temperature of 15 degrees Celsius, few animals survive and are short and stouter, with impaired col-19 assembly in the alae. At the restrictive temperature of 25 degrees Celsius, embryonic lethal at the 3-fold stage with few surviving animals arresting at the L1 larval stage.
In e2920; temperature sensitive mutant. At the permissive temperature of 15 degrees Celsius, few animals survive and are short and stouter.
In ju345; temperature sensitive mutant. At the permissive temperature of 15 degrees Celsius, 80 percent of animals are viable. Severe lethality in a sqt-3 (sc8) mutant background.
Transcription initiation factor TFIID subunit 5
Enhanced basal guanylate cyclase activity.
In ns335; enhanced basal guanylate cyclase activity. Exhibits fewer and shorter microvilli of the AFD thermosensory neurons. Defects in thermotaxis.
Reduced basal guanylate cyclase activity and reduced chloride sensitivity.
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Gamma-glutamylcyclotransferase AIG2-like
Calcium load-activated calcium channel homolog
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
Proteasome activator complex subunit 4 C-terminal
Causes abnormal proximal proliferation in the germline and / or tumorous germline phenotypes.
In wy755; egg-laying defect due to, at least in part, the absence of muscle plasma membrane extensions, known as muscle arms, on type 2 vulval muscles (vm2).
On lag-2 mutant background, typical mutant phenotype absent; however, on the same mutant background, activates lin-12 in the vulval precursor cells (VPCs) causing formation of ectopic vulvae, and / or activates glp-1, causing tumorous germline phenotype. On a glp-1 mutant background, hermaphrodites may have tumorous germlines at the permissive temperature (15 degrees Celsius) but, after shifting to the restrictive temperature (25 degrees Celsius), the germ cells enter meiosis.
Impaired gonadal localization and DTC posterior migration; when associated with Q-52; Q-65; Q-123 and Q-350. Normal localization and slight impairment in DTC posterior migration; when associated with Q-350. Elongated pharynx; when associated with Q-52; Q-65; Q-123; Q-172; Q-183; Q-189 and Q-350.
Impaired gonadal localization and DTC posterior migration; when associated with Q-52; Q-65; Q-123; Q-172 and Q-189. Elongated pharynx; when associated with Q-52; Q-65; Q-123; Q-172; Q-189; Q-218; Q-219 and Q-350.
Impaired gonadal localization and DTC posterior migration; when associated with Q-52; Q-65; Q-172; Q-183 and Q-189. Elongated pharynx; when associated with Q-52; Q-65; Q-172; Q-183; Q-189; Q-218; Q-219 and Q-350.
Impaired gonadal localization and slight impairment in DTC migration. Impaired gonadal localization and DTC posterior migration; when associated with Q-52; Q-65; Q-123; Q-183 and Q-189. Elongated pharynx; when associated with Q-52; Q-65; Q-123; Q-183; Q-189; Q-218; Q-219 and Q-350.
Impaired gonadal localization and slight impairment in DTC posterior migration. Impaired gonadal localization and DTC posterior migration; when associated with Q-52; Q-123; Q-172; Q-183 and Q-189. Elongated pharynx; when associated with Q-52; Q-123; Q-172; Q-183; Q-189; Q-218; Q-219 and Q-350.
Impaired gonadal localization and slight impairment in DTC posterior migration. Impaired gonadal localization and DTC posterior migration; when associated with Q-52; Q-65; Q-123; Q-172 and Q-183. Elongated pharynx; when associated with Q-52; Q-65; Q-123; Q-172; Q-189; Q-218; Q-219 and Q-350.
Impaired gonadal localization and slight impairment in DTC posterior migration. Impaired gonadal localization and DTC posterior migration; when associated with Q-65; Q-123; Q-172; Q-183 and Q-189. Elongated pharynx; when associated with Q-65; Q-123; Q-172; Q-183; Q-189; Q-218; Q-219 and Q-350.
In k135; DTCs migrate along the ventral surface but then return toward the dorsal surface. Loss of gonadal basement membrane localization. Pharyngeal corpus and isthmus are elongated in larvae and adults.
In k176 and k169; Impaired DTC migration and loss of gonadal basement membrane localization in 20 percent of mutants. Pharynx is elongated.
Increased propeptide cleavage and impaired DTC migration. Normal gonadal localization.
Loss of function; induces defects in DTCs migration.
Normal propeptide cleavage, gonadal localization and DTC migration.
Probable loss of catalytic activity. No cleavage of the propeptide. Loss of gonadal basement membrane localization in 60 percent of mutants and abnormal DTC migration. Pharynx is elongated.
Slight impairment in DTC posterior migration.
Slight impairment in DTC posterior migration. Impaired gonadal localization and DTC posterior migration; when associated with Q-52; Q-65; Q-123; Q-218 and Q-219. Normal localization and slight impairment in DTC posterior migration; when associated with Q-218 and Q-219. Elongated pharynx; when associated with Q-52; Q-65; Q-123; Q-172; Q-183; Q-189; Q-218 and Q-219.
Probable signal recognition particle 19 kDa protein
Adenosine 3'-phospho 5'-phosphosulfate transporter 2
In ns789; impairs nerve ring assembly due to non-commissural interneurons AIY failing to extend dorsally and enter the nerve ring. This phenotype is enhanced in a chin-1 ns399 mutant background.
Chaperonin homolog Hsp-60, mitochondrial
The measured mass is that of either AADGAPLIRF-amide 1 or AADGAPLIRF-amide 2.
In tm794; irregular structure of the dense bodies, aberrant muscle-muscle cell contacts and irregular deb-1/vinculin localization to muscle cell contacts. Increase of unc-95 localization to the muscle dense bodies. Continuous distal tip cell migration in the posterior gonad past the midline during adulthood. When associated with RNAi-mediated knockdown of cdcc-55, increased severity of the distal tip cell migration defects.
Abolishes interaction with rad-51, but binding to ssDNA is retained. Loss of D-loop formation in the presence of rad-51. Loss of inhibition of ATP hydrolysis by rad-51.
Cleavage stimulation factor subunit 1 dimerisation
In yb1423; defective alternative splicing of the let-2 gene whereby intron 10 within the let-2 pre-mRNA is not removed.
Probable translation initiation factor eIF-2B subunit gamma
Abolishes localization to the nuclear envelope of hyp7 precursor cells.
In e1174; defects in nuclear migration in distal tip cells and hyp7 hypodermal precursor cells.
In e1410; defects in nuclear migration and anchoring in hyp7 hypodermal precursor cells. Defective male pronuclear migration in one-cell embryos following fertilization. Reduced number of viable progeny following incubation with the DNA cross-linking agent cisplatin.
In e1411; defective nuclear migration in hyp7 hypodermal precursor cells. Does not affect unc-83 localization to the nuclear membrane in embryos. May reduce interaction with lmn-1. Reduces number of viable progeny following incubation with the DNA cross-linking agent cisplatin.
In n321 and n399; defects in nuclear migration and anchoring in hyp7 hypodermal precursor cells. No defects in localization to the nuclear envelope, however unc-83 localization to the nuclear envelope is abolished. Reduced number of viable progeny following incubation with the DNA cross-linking agent cisplatin.
In n322; defects in nuclear migration in hyp7 hypodermal precursor cells. No nuclear envelope localization defects in hyp7 precursor cells. Does not affect the localization of unc-83 to the nuclear membrane in embryos.
In n323; defective nuclear migration and anchoring in hyp7 hypodermal precursor cells. No defects in localization to the nuclear envelope, however unc-83 localization to the nuclear envelope is abolished.
In n371; defects in nuclear migration and anchoring in hyp7 hypodermal precursor cells. No defects in localization to the nuclear envelope, however unc-83 localization to the nuclear envelope is abolished.
In sa61; defects in nuclear migration and anchoring in hyp7 hypodermal precursor cells. No defects in localization to the nuclear envelope, however unc-83 localization to the nuclear envelope is abolished.
May be involved in the interaction with lmn-1
Nuclear migration and anchoring protein unc-84
Required for nuclear envelope localization
In ax110; embryos are arrested at the one-cell stage. No extrusion of polar bodies. Multiple rounds of DNA replication occur without cytokinesis. Slower chromosome segregation during the first embryonic mitosis but no chromosome separation defects during meiosis. Reduced cortical granules exocytosis during anaphase I resulting in eggshell defects. Loss of meiotic spindle and cortical granule localization. In a php-5 (av101) mutant background, cortical granule exocytosis and chromosome segregation are normal.
In ax521; embryos are arrested at the one-cell stage. No extrusion of polar bodies. Multiple rounds of DNA replication occur without cytokinesis. Slower chromosome segregation during the first embryonic mitosis but no chromosome separation defects during meiosis. Reduced cortical granules exocytosis during anaphase I resulting in eggshell defects. Loss of cortical granule localization.
In e2406; temperature sensitive mutant which at the restrictive temperature of 25 degrees Celsius displays slow chromosome segregation and lacks cytokinesis in the one-cell stage embryo and during meiosis I. Reduced cortical granules exocytosis during anaphase I. Loss of cortical granule localization. Loss of cytokinesis resulting from furrow regression. At the end of second meiotic division, causes a premature dissociation of the two centrioles in spermatocytes. Permanent localization to centrosome throughout meiosis. Abnormal localization to sperm DNA in to a foci near the sperm chromatin in fertilized embryos.
Probable loss of catalytic activity. Stronger accumulation at chromosomes, centrosomes, spindle, cleavage furrow and midbody during the first embryonic mitosis.
Loss of ATP binding and impaired rotation between the two ATP-binding regions in the hexamer. Complete loss of catalytic activity. Complete loss of catalytic activity without affecting oligomerization; when associated with A-257.
Loss of ATP binding. Complete loss of catalytic activity.
Loss of ATP binding. Complete loss of catalytic activity. Complete loss of catalytic activity without affecting oligomerization; when associated with A-365 and A-530.
Loss of interaction with ufd-2 but not with atx-3.
Restores normal catalytic activity; when associated with Q-311.
Severe loss of ATP hydrolysis without affecting ATP binding and loss of cooperativity between the 2 ATP-binding regions. Slight reduction in catalytic activity; when associated with A-354, A-365, A-467, S-467 or P-467. Complete loss of catalytic activity; when associated with Q-584. Restores normal catalytic activity; when associated with H-471.
Severe loss of ATP hydrolysis without affecting ATP binding and moderate reduction in cooperativity between the 2 ATP-binding regions.
Severe loss of ATP hydrolysis without affecting ATP binding.
Severe loss of ATP hydrolysis without affecting ATP binding. Does not affect rotation between the 2 ATP-binding regions in the hexamer in presence of ATP or ADP. Complete loss of catalytic activity; when associated with Q-311.
Severe reduction in catalytic activity. Complete loss of catalytic activity; when associated with A-354.
Severe reduction in catalytic activity. Complete loss of catalytic activity; when associated with A-365.
Slight reduction in catalytic activity. Slight reduction in catalytic activity; when associated with Q-311. Complete loss of catalytic activity; when associated with A-257 or A-642. Does not affect oligomerization; when associated with A-257.
Slight reduction in catalytic activity. Slight reduction in catalytic activity; when associated with Q-311. Complete loss of catalytic activity; when associated with A-631.
Slight reduction in catalytic activity; when associated with Q-311.
Transitional endoplasmic reticulum ATPase homolog 1
Iron/zinc purple acid phosphatase-like C-terminal
In HC78; induces an aberrant localization of tubulin in spermatids.
In hc196; failed spermatocyte division in a zipt-7.1 mutant (ok971) background.
Disintegrin and metalloproteinase domain-containing protein adm-2
In fd130; viable and no visible phenotype in wild type background. Suppression of molting defects in nekl-2(fd81);nekl-3(gk894345) double mutant background.
Results in strong suppression of molting defects in nekl-2(fd81);nekl-3(gk894345) mutants.
In y356; 92% of hermaphrodites are viable. Increases the hermaphrodite viability of the sex-1 y424 mutant from 20% to 51%. Double knockout with the sea-2 y407 mutant increases the hermaphrodite viability of the sex-1 y424 mutant from 20% to 77%. Double knockout with sea-2 y407 increases the hermaphrodite viability of the double fox-1(y303) and sex-1(y263) mutant from 0% to 70%. All males are viable in a sea-2(y426) mutant background. Only 17% of hermaphrodites are viable in a knockout with sea-2(y426), fox-1(y303) and sex-1(y424). The viability of hermaphrodites is reduced to 11% in a triple xol-1(y9), sex-1(y263) and sdc-2 RNAi mutant background. The viability of hermaphrodites is reduced to 51% in a quadruple sea-2(y407), xol-1(y9), sex-1(y263) and sdc-2 RNAi mutant background.
In qa6909; strong suppressor of the developmental delay phenotype of hif-1 mutants when grown under iron limiting conditions.
In qa6910; strong suppressor of the developmental delay phenotype of hif-1 mutants when grown under iron limiting conditions.
Nuclear hormone receptor family member nhr-14
Loss of activity. Decrease in glr-1 synaptic localization.
Loss of activity. Decrease in glr-1 synaptic localization. Loss of polarized trafficking of dense-core vesicles in DB motor neurons.
Domain of unknown function WSN domain-containing protein
Histone acetyl transferase HAT1 N-terminal
Platelet-activating factor acetylhydrolase homolog 2
Cell division control protein 42 homolog
In a cwn-1 mutant background results in ALM polarity defects.
May lock enzyme in its GTP-bound active state. Defect in distal tip cell (DTC) migration. Partially rescues the axon guidance defects of AIY interneurons in kpc-1 (gk8) and chin-1 (ns399) double mutants.
Probable NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial
Converts the channel ion selectivity from anionic to cationic.
Converts the channel ion selectivity from anionic to cationic; most selective for potassium ions.
In n3034; locomotory rate of food-deprived animals is significantly faster than that of the wild type; resistant to exogenous serotonin treatment, unlike wild-type animals.
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central
Putative G-protein coupled receptor B0244.4
Failure to restore avoidance to the aversive compounds octanol and quinine in animals lacking endogenous grk-2. Failure to rescue defective egg laying in grk-2 mutants.
Failure to restore locomotion in animals lacking endogenous grk-2. Reduced ability to restore avoidance to the aversive compounds octanol and quinine in animals lacking endogenous grk-2. Failure to restore avoidance to octanol and quinine in animals lacking endogenous grk-2; when associated with E-567.
Failure to restore locomotion in animals lacking endogenous grk-2. Significantly restored avoidance of aversive compounds octanol and quinine in animals lacking endogenous grk-2. Failure to restore avoidance to octanol and quinine in animals lacking endogenous grk-2; when associated with Q-587.
Failure to restore locomotion or avoidance to the aversive compounds octanol and quinine in animals lacking endogenous grk-2.
In rt97; dramatic decrease in grk-2 protein levels, defective egg laying, reduced serotonin levels, increased levels of the serotonin metabolite 5-hydroxyindoleacetic acid, increased levels of amine oxidase amx-2 in early adult stages, reduced levels of phosphorylated amx-2, severe defect in octanol avoidance and severely impaired chemotaxis to attractive compounds including 0.1-100 mMNaCl although mutants show avoidance to 25 mMNaCl after pre-exposure to 100 mMNaCl.
In yak18; decreased body length, slow locomotion and defective egg laying.
No effect on ability to restore locomotion or avoidance to the aversive compounds octanol and quinine in animals lacking endogenous grk-2.
In eb62; viable but induces male sterility due to abnormal sperm.
In eb88; induces inviable embryos and larvae.
In eb90; induces inviable embryos and larvae.
In eb94; viable but induces male sterility due to abnormal sperm.
In eb95; induces defects in spermatogenesis.
In hc144; induces defects in spermatogenesis.
In hc145; induces defects in spermatogenesis.
In q89; dominant allele that induces an arrest of spermatogenesis at early stages.
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase wee-1.3
Cation-transporting P-type ATPase N-terminal
Doublesex- and mab-3-related transcription factor dmd-5
In gk408945; alterations in AVG interneuron synaptic wiring. Suppresses the ectopic synapses formed between PHB and AVG neurons when AVG is masculinized by cell-specific expression of fem-3 in hermaphrodites. Defects in male mating behavior; reduced efficiency in locating vulva of partner.
In or593; decrease in abundance at centromeres.
In or628; decrease in abundance at centromeres.
In or643; decrease in abundance at centromeres and in the cytoplasm and reduction in tac-1 binding.
Single-stranded DNA-binding protein homolog sam-10
Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial
Actin binding, actin severing, Ca-sensitive
Inhibitory for phosphatidylinositol 4,5-bisphosphate binding activity
Loss of processing. Impaired elimination of synapses in adults.
Necessary for barbed end capping activity
Required for phosphatidylinositol 4,5-bisphosphate binding and regulation
Required for synapse elimination during development
Very-long-chain 3-oxooacyl-coA reductase let-767
May prevent interaction with Rho GTPases. Defect in commissural axon guidance in ventral motoneurons in an RNAi-mediated max-2 knockdown background. Rescues anterior gonad morphology defects in pax-1 ok488 mutants.
May prevent interaction with pix-1. Fails to rescue distal tip cell migration defect in an RNAi-mediated max-2 knockdown background.
Probable loss of activity. Fails to rescue distal tip cell migration defect in an RNAi-mediated max-2 knockdown background.
In e1338; homeotic transformation of ALM to BDU neurons, based on altered cell body and axonal morphology and ectopically expressed BDU markers in ALM, including abnormal expression of ceh-14, flp-10, nlp-1, ser-2 and zig-3. Abnormal ectopic expression of ALN markers lad-2 and cho-1 in tail neurons. PVD neurons have severe dendritic branching defects, and significantly longer axonal projection in the ventral nerve cord. On either egl-44 or egl-46 mutant backgrounds, abolishes expression of tyramine receptor ser-2. Abolishes expression of alr-1 in a specific set of touch receptor neurons.
ATP-dependent Clp protease proteolytic subunit 1, mitochondrial
In cc604; lacks postembryonic mesodermal lineage (M lineage) derived coelomocytes (CCs). Exhibits loss of dorsal, and duplication of ventral, postembryonic mesodermal lineage (M lineage) descendants. On lin-12 or lag-1 mutant backgrounds, dorsoventral polarity of the M lineage is reversed. Transcription factor unc-130 ectopically expressed in all M lineage cells from the 1-M stage through to the 18-M stage, whereas in wild-type only expressed in ventral M lineage starting from the 8-M stage.
In cc606; lacks postembryonic mesodermal lineage (M lineage) derived coelomocytes (CCs).
In wk55; in larval L1 through L3 stages, shows a reduced growth rate, and after L3, growth rate increases to a wild-type rate and finally gives the adult animals an intermediate body length. Male-specific genital sensilla (simple sense organs), known as rays, fuse abnormally.
NF-kappa-B inhibitor-interacting Ras-like protein
Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate
Schiff-base intermediate with dihydroxyacetone-P
Cilia- and flagella-associated protein 20
tRNA-splicing endonuclease subunit Sen54 N-terminal
In db719; defective aggregation behavior.
Interleukin cytokine receptor-related protein 1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase
Probable dolichol-phosphate mannosyltransferase subunit 3
In ku217; disrupts tail tip morphogenesis resulting in retention of the pointed larval tail tip in adult males (also known as the Lep phenotype). Causes embryonic and larval lethality, sterility, egg-laying defects, and abnormal vulval precursor cell differentiation. Abolishes expression of the transcription factor dmd-3 in hyp8-11 tail tip cells.
Nuclear hormone receptor family member nhr-25
Serine/threonine-protein kinase receptor
receptor protein serine/threonine kinase
In st567; severe paralysis at embryonic 1-fold stage followed by an arrest in elongation at 2-fold stage. Loss of myosin and actin organization in embryonic muscles.
Acetylcholine receptor subunit beta-type acr-3
Non-centrosomal microtubule array protein 1
Putative G-protein coupled receptor B0244.5
In mnm-2(et2); Defective formation of the distal end of the two M2 motor neurons with M2 growth cones forming at the correct position but stalling or erring ipsilaterally to produce abnormal trajectories and thick growth cone remnants. mnm-2 expression is gradually lost in both the M2 and M3 motor neurons in contrast to the wild-type where expression is maintained in the M3 neurons. Functional impairment of the M3 neuron with dramatically reduced pharyngeal pumping.
In gg662; disrupts inheritance of small RNA-induced gene silencing.
In gg663; disrupts inheritance of small RNA-induced gene silencing.
In xf23 and gg661; displays a gradual decline of fertility over successive generations, also called a mortal germline phenotype (Mrt). Defective formation of liquid-like condensates in the cytoplasm called Z granules, whereby Z granules are larger in size and there are fewer compared to wild-type. There are fewer pid-4-expressing germ cell foci. Does not affect the number of pid-5-expressing germ cell foci. Defective gene silencing mediated by a class of 21 nucleotide PIWI-interacting RNAs (piRNAs) that possess a uracil residue at the 5'-end (also called 21U-RNAs). Does not reduce the levels of 21U-RNAs. Reduces the levels of secondary and tertiary 22G-siRNAs, which are a class of 22 nucleotide small interfering RNAs (siRNAs) that possess a triphosphorylated guanine residue at the 5'-end. Reduces the levels of 26G-siRNAs, which are a class of 26 nucleotide siRNAs that possess a guanine residue at the 5'-end. Does not reduce the levels of microRNAs (miRNAs). Disrupts inheritance of small RNA-induced gene silencing. Impairs silencing of the DNA transposable element Tc1. Enhances the impaired silencing of the DNA transposable element Tc1 in a hrde-1 tm1200 mutant background. Results in sterility, a high incidence of females phenotype and defective activity of the PIWI-interacting RNA (piRNA) silencing pathway in a pid-1 xf35 mutant background.
In n1435, n3942, n4253 and n4254; loss of function.
In n1550, n3310, e2655 and 2661; gain of function, uncoordinated rubber band response in heterozygous mutants, inviable in homozygous mutants.
In n190, n598, n2353 and n2356; loss of function.
In n191, n2283 and n2286; loss of function.
In n2360 and n2361; partial loss of function.
In n264 and n3977; loss of function. Not required for sup-18 mediated regulation.
In n3976; loss of function. Not required for sup-18 mediated regulation.
In n4265 and n3975; loss of function. Not required for sup-18 mediated regulation.
May be important for regulation by and/or interaction with sup-10
Two pore potassium channel protein sup-9
Nuclear hormone receptor family member nhr-18
Thioredoxin reductase-like selenoprotein T homolog selt-1.2
In mg561; defective expression of the proteasomal subunit rpt-3 in a pbs-5 (proteasomal subunit) mutant background.
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase
Ubiquitin carboxyl-terminal hydrolase 14
In vv137; 3% embryonic lethality and 3% of surviving progeny are male. Does not abolish zhp-4 recruitment to the synaptonemal complex between homologous chromosome pairs during pachytene. 95% embryonic lethality, 43% of surviving progeny are male and abolishes recruitment to chromosomes at any meiotic stage in a zhp-4 vv138 mutant background.
BTB and MATH domain-containing protein 40
Probable tRNA (uracil-O(2)-)-methyltransferase
Abolishes binding to the tri-methylated 'Lys-9' residues on histone H3; when associated with A-111.
Abolishes binding to the tri-methylated 'Lys-9' residues on histone H3; when associated with A-87.
von Hippel-Lindau tumor suppressor homolog
Biopterin-dependent aromatic amino acid hydroxylase family profile
Guanine nucleotide exchange protein smcr-8
Putative ribosomal protein S6 kinase alpha-2
Probable actin-related protein 2/3 complex subunit 4
C-terminal domain (CTD); 28 X 7 AA approximate tandem repeats of Y-[ST]-P-[ST]-S-P-[AGKNQRST]
DNA-directed RNA polymerase II subunit RPB1
In dz185; increased secondary dendritic branches in PVD neurons.
In gk(333538); normal secondary dendritic branches in PVD neurons.
In gk(779937); increased secondary dendritic branches in PVD neurons.
In my24; highly disorganized and truncated dauer-specific branching of the IL2Q neuron and disorganized and truncated branching of the PVD and FLP neurons in adults.
In ns623; uncoordinated movements in a chin-1 ns399 mutant background. Impaired nerve ring assembly due to follower axons of neurons including the amphid-commissure neuron (AFD), and the non-commissural interneurons AIY and PVQ, failing to extend dorsally and enter the nerve ring. SubL pioneer axons enter the nerve ring, but exhibit fasciculation defects.
In wy1060; loss of propeptide cleavage, trapped secondary dendrite branches and loss of tertiary and quaternary dendrite branches; when associated with A-136.
In wy1060; loss of propeptide cleavage, trapped secondary dendrite branches and loss of tertiary and quaternary dendrite branches; when associated with A-143.
In xr58; partial trapping of secondary dendrite branches next to primary dendrite branches. Forms tertiary and quaternary branches but with substantial overlap between tertiary dendrite branches. Increased dma-1 protein levels in PVD neuron dendrites.
In s2575; larvae arrest during the L2 larval stage.
In s2630; larvae arrest during the L1 to L2 transition.
No defect in SDQL axon migration. Restores SDQL axon migration in a sup-17 (n316) mutant background.
V-type proton ATPase 116 kDa subunit a 3
In e1265; mislocalized presynaptic proteins to dendrites in PVD neurons. increased survival in response to hypoxia induced by sodium azide. Abnormal accumulation of egl-21, egl-3, FMRFamide-like peptides (FaRPs) and snb-1 in neuronal cell bodies. Reduced number of neuron cell corpses in a hyperactive mec-4 or deg-3 mutant background.
Probable metabotropic glutamate receptor mgl-1
In q689; some adult mutants show gonadal defects, which become more prevalent on an hnd-1 mutant background. Absent or misplaced somatic gonadal precursor cells (SGPs) in the gonadal primordium during embryogenesis.
In or207; temperature sensitive. At 15 degrees Celsius, there are no observed changed in meiosis or mitosis. At 20 or 25 degrees Celsius, meiosis appears normal, embryos are not viable and eggs do not complete the first embryonic division due to defects in chromosome segregation and cytokinesis. In these embryos, phosphorylation of histone H3 is abrogated, but this is not abrogated in germ line nuclei. Embryonic viability is increased in a lab-1 tm1791 mutant background and 17% of embryos complete embryogenesis and reach adulthood as fertile animals. Moreover, the phosphorylation of histone H3 defect is rescued in 30% of these embryos.
In mu294; abnormal Q neuroblast lineage migration.
Loss of chemotaxis to alkaline pH. No effect on chemotaxis toward Na+. Normal cilium localization.
No effect on chemotaxis to alkaline pH. No effect on chemotaxis toward Na+. Normal cilium localization.
In sa692; constitutive dauer formation at high temperature and impaired migration of ALM, BDU, CAN and HSN neurons, and QR neuroblast descendants during development. Moderate defect in ALM polarity.
In xd13; mild defect in ALM polarity and in QR neuroblast descendant migration.
Probable loss of kinase activity. Abnormal locomotion. No increase in dauer formation.
Probable loss of kinase activity. Increased number of interconnected AIM neurons when expressed in a wild type background.
Probable translation initiation factor eIF-2B subunit alpha
Probable tRNA pseudouridine synthase tag-124
Cullin-associated NEDD8-dissociated protein 1
In gt1981; in larvae, enhances neurodegeneration of CEP and DEP dopaminergic neurons induced by the oxidative stress agent 6-hydroxydopamine (6-OHDA). Increases expression of oxidative stress genes in response to paraquat and hydrogen peroxide. Increases paralysis induced by high dopamine levels. No defect in dopamine signaling and intestinal permeability. Reduced lifespan and slower development in response to oxidative agent paraquat.
Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
In Isoform c; abolishes interaction with gpa-14.
Required for the interaction with gpa-14
Locomotion is almost completely impaired. Severe reduction in synaptic vesicle endocytosis and in the rate of excitatory postsynaptic currents (EPSCs) at neuromuscular junctions.
May increase membrane-binding activity in vitro. Does not affect its localization to synaptic vesicles.
In M3; results in loss of enzymatic activity; when associated with F-166 and F-437.
In M3; results in loss of enzymatic activity; when associated with F-92 and F-166.
In M3; results in loss of enzymatic activity; when associated with F-92 and F-437.
Uncharacterized calcium-binding protein C07A9.5
In bx108; enhances the loss of male-specific genital sensilla (simple sense organs) known as rays, on a lin-32 mutant background. Slightly reduces binding to DNA as a heterodimer with lin-32.
In bx115; enhances the loss of male-specific genital sensilla (simple sense organs) known as rays, on a lin-32 mutant background. Causes defects in all three ray cell types. Slightly reduces binding to DNA as a heterodimer with lin-32.
Fails to rescue pkd-2 defects. Prevents phosphorylation at this site.
Phospho-mimetic. Acts as if constitutively phosphorylated.
In HC140ts; causes sterility at 25 degrees Celsius.
In IT112ts; causes sterility at 25 degrees Celsius.
Protein-serine O-palmitoleoyltransferase porcupine
Does not bind rae-1; and when associated with A-2084 and A-2087.
Does not bind rae-1; when associated with A-2084 and A-2088.
Does not bind rae-1; when associated with A-2087 and A-2088.
In ju44; total number of the synaptic vesicle GFP puncta is reduced.
In ky346; total number of the synaptic vesicle GFP puncta is reduced. Overextension of ALM neuron axon which terminates with a hook. PLM neuron axon terminates with a hook. Severe loss of synaptic branch formation in PLM neuron.
In ur299; PLM touch neuron anterior process axon often extends beyond the normal termination point at the AVM cell body. Suppresses motor neuron dorsal guidance defects in an unc-6 mutant background.
O-linked (Xyl...) (glycosaminoglycan) serine
Reduced heperan sulfate binding; when associated with A-71 and A-214.
Reduced heperan sulfate binding; when associated with A-71 and A-86.
Reduced heperan sulfate binding; when associated with A-86 and A-214.
Does not prevent inhibition of air-2 kinase activity or interaction with air-2.
No effect on catalytic activity. Prevents inhibition of air-2 kinase activity or interaction with air-2.
Severe loss of catalytic activity. Prevents inhibition of air-2 kinase activity without affecting the interaction with air-2.
Ragulator complex protein LAMTOR2 homolog
Defective mRNA binding, A-to-I editing and interaction with adr-2; when associated with 223-E--A-227.
Defective mRNA binding, A-to-I editing and interaction with adr-2; when associated with 584-E--A-588.
Disintegrin and metalloproteinase domain-containing protein unc-71
In ay17; sex myoblast migration defects.
In ay44; sex myoblast migration defects.
In ay46; sex myoblast migration defects.
In ay47; sex myoblast migration defects.
In ay48; sex myoblast migration defects.
In ay64; sex myoblast migration defects.
Guanine nucleotide-binding protein alpha-8 subunit
Probable insulin-like peptide beta-type 3
Mitochondrial import inner membrane translocase subunit Tim8
Abolishes binding to dlc-1. Reduces nuclear accumulation of mett-10; when associated with A-421; A-423 and A-424. Blocks nuclear entry, and results in cytoplasmic localization of the mutant mett-10 protein; when associated with 361-A--A-367 DEL; A-421; A-423 and A-424.
Does not block nuclear entry. Blocks nuclear entry, and results in cytoplasmic localization of the mutant mett-10 protein; when associated with A-420; A-421; A-423 and A-424.
In g38; at 25 degrees Celsius animals are either sterile or maternal-effect lethal and display a protruding vulva phenotype. Enhanced nuclear proliferation defects in germ cells in a weak loss of function dhc-1 (js319) mutant background.
In oj32; at 25 degrees Celsius animals are either sterile or maternal-effect lethal and display a protruding vulva phenotype. Enhanced nuclear proliferation defects in germ cells in a weak loss of function dhc-1 (js319) mutant background.
In ok2204; at 25 degrees Celsius animals are either sterile or maternal-effect lethal, display a protruding vulva phenotype, and germ cells have abnormalities in meiotic development and mitotic progression; when associated with 1-M--T-260 DEL. Enhanced nuclear proliferation defects in germ cells in a weak loss of function dhc-1 (js319) mutant background; when associated with 1-M--T-260 DEL.
In ok2204; at 25 degrees Celsius animals are either sterile or maternal-effect lethal, display a protruding vulva phenotype, and germ cells have abnormalities in meiotic development and mitotic progression; when associated with E-292. Enhanced nuclear proliferation defects in germ cells in a weak loss of function dhc-1 (js319) mutant background; when associated with E-292.
In oz36; at 25 degrees Celsius animals are either sterile or maternal-effect lethal, display a protruding vulva phenotype, a distended intestinal lumen, tumor formation, and germ cells have abnormalities in meiotic development. Enhanced tumor formation in weak loss of function dhc-1 (or195) or dhc-1 (js319) mutant backgrounds. Enhanced nuclear proliferation defects in germ cells in a weak loss of function dhc-1 (js319) mutant background.
In tm2697; at 25 degrees Celsius animals are either sterile or maternal-effect lethal and display a protruding vulva phenotype. Enhanced nuclear proliferation defects in germ cells in a weak loss of function dhc-1 (js319) mutant background.
Reduces binding to dlc-1. Abolishes binding to dlc-1, and reduces nuclear accumulation of mett-10; when associated with A-420; A-421 and A-423. Blocks nuclear entry, and results in cytoplasmic localization of the mutant mett-10 protein; when associated with 361-A--A-367 DEL; A-420; A-421 and A-423.
Reduces binding to dlc-1. Abolishes binding to dlc-1, and reduces nuclear accumulation of mett-10; when associated with A-420; A-421 and A-424. Blocks nuclear entry, and results in cytoplasmic localization of the mutant mett-10 protein; when associated with 361-A--A-367 DEL; A-420; A-421 and A-424.
Reduces binding to dlc-1. Abolishes binding to dlc-1, and reduces nuclear accumulation of mett-10; when associated with A-420; A-423 and A-424. Blocks nuclear entry, and results in cytoplasmic localization of the mutant mett-10 protein; when associated with 361-A--A-367 DEL; A-420; A-423 and A-424.
U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase
Splicing factor 3B subunit 6-like protein
In ju1121; defective dorsal D (DD) GABAergic motor neurons rewiring. Impairs the function of myrf-2 by obstructing its function in the complex formed between myrf-1 and myrf-2.
Lethality at the L2 larval stage. Localizes to the cytoplasm during the viable stages. Localizes to nuclei of seam cells, epidermal cells, and intestinal cells. Precocious synaptic rewiring of DDGABAergic motor neurons whereby dorsal synapses are not uniformly distributed along the dorsal cord, meaning some synaptic rewiring of DDGABAergic motor neurons occurs, but not always. Advances M-cell lineage division. Delays M-cell lineage division in a myrf-2 ybq42 mutant background.
Lethality at the L2 larval stage. Localizes to the nucleus. Defective synaptic rewiring of DDGABAergic motor neurons.
Lethality at the L2 larval stage. Only localizes to the cytoplasm during the viable stages. Abolishes synaptic rewiring of DDGABAergic motor neurons in a myrf-2 ybq42 mutant background.
Lethality at the larval developmental stage; when associated with A-483. Only localizes to the cell membrane during viable stages; when associated with A-483. Defective synaptic rewiring of DDGABAergic motor neurons; when associated with A-483.
Myelin regulatory factor homolog 1, C-terminal
Myelin regulatory factor homolog 1, N-terminal
Prevents cleavage and generation of Myelin regulatory factor homolog 1, N-terminal part. Lethality at the larval developmental stage; when associated with A-488. Only localizes to the cell membrane during viable stages; when associated with A-488. Defective synaptic rewiring of DDGABAergic motor neurons; when associated with A-488.
O-linked (Xyl...) (chondroitin sulfate) serine
Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial
Nuclear hormone receptor family member nhr-121
Probable histone-lysine N-methyltransferase set-23
Kinase dead. Defective extension of muscle arms towards motor neuron targets.
Probable dual specificity protein kinase madd-3
Abhydrolase domain-containing protein abhd-5.2
Interaction with galactose moiety of substrate glycoprotein
N-linked (GlcNAc...) asparagine; atypical
26S proteasome non-ATPase regulatory subunit 14
Phosphatidic acid phosphatase type 2/haloperoxidase
In mg144; causes a delay in apoptosis during embryonic development. Suppresses the dauer arrest phenotype of the age-1(mg44) null mutant.
Probable loss of kinase activity. Increased apoptosis during embryonic development in an akt-2 tm1075 mutant background.
Glutamine/asparagine-rich protein mdt-30
Nucleolar pre-ribosomal-associated protein 1 C-terminal
In ju328; about 2.5% embryonic and 2.5% larval lethality in offspring. Variably abnormal epidermal morphology (vab phenotype) in 24% of offspring.
In ju358; 31% embryonic and 47% larval lethality. Variably abnormal epidermal morphology (vab phenotype) in 21% of remaining offspring. Progressive detachment of body wall muscles from the epidermis during larval development and defective vulval muscle attachment, which results in egg-laying defects. Progressive distortion of the anterior pharyngeal bulb in adults. Defective axon guidance and promotes axon regrowth following injury. Basement membrane defects. The nicotinic acetylcholine receptor (nAChR) agonist levamisole suppresses the epidermal morphology defects, but only slightly suppresses the muscle detachment defects. Lethal phenotypes are suppressed, but the vab phenotype is more prevalent; when association with A-755. The lethality, epidermal morphological and egg-laying defects are suppressed in a pxn-1 mutant (ok785) background. Basement membrane defects are suppressed by the let-805 ju1123 mutant.
In ju379; embryonic elongation defects resulting in lethality at the three-fold stage in the majority of animals. About 25-30% embryonic and 30% larval lethality in offspring. Variably abnormal epidermal morphology (vab phenotype) in 25% of offspring.
In ju436; viable with variably abnormal epidermal morphology (vab phenotype) in 20% of offspring. Enhances the lethality in the emb-9 b189 mutant.
Suppresses the lethal phenotypes and enhances the variably abnormal epidermal morphology (vab phenotype) of the pxn-2 ju358 mutant.
Putative choline-phosphate cytidylyltransferase
In k146; reduced migration of the gonad arms in both the anterior and posterior direction.
In k166; reduced migration of the gonad arms in both the anterior and posterior direction.
Abolishes binding to goa-1 and ability of gbas-1 to activate goa-1.
G-protein alpha subunit activating protein gbas-1
In gk136226; no major changes in egg-laying behavior with mutants shutting off egg laying during starvation and resuming egg laying when re-fed as in wild-type animals. Mutants show a decrease in the number of laid eggs under fed and re-fed conditions.
In gk578844; no major changes in egg-laying behavior with mutants shutting off egg laying during starvation and resuming egg laying when re-fed as in wild-type animals. Mutants show a decrease in the number of laid eggs under fed and re-fed conditions.
Serine/threonine-protein kinase tousled-like 1
Mannose-1-phosphate guanyltransferase beta
MAP kinase-activating death domain protein
Nuclear hormone receptor family member nhr-65
Regulator of microtubule dynamics protein 1
Probable loss of putative coiled-coil structure. Survival of linker cell in 14 percent of animals; when associated with P-1734; P-1737; P-1874; P-1877 and P-1998; in isoform d.
Probable loss of putative coiled-coil structure. Survival of linker cell in 14 percent of animals; when associated with P-1734; P-1737; P-1874; P-1877 and P-2001; in isoform d.
Probable loss of putative coiled-coil structure. Survival of linker cell in 14 percent of animals; when associated with P-1734; P-1737; P-1874; P-1998 and P-2001; in isoform d.
Probable loss of putative coiled-coil structure. Survival of linker cell in 14 percent of animals; when associated with P-1734; P-1737; P-1877; P-1998 and P-2001; in isoform d.
Probable loss of putative coiled-coil structure. Survival of linker cell in 14 percent of animals; when associated with P-1734; P-1874; P-1877; P-1998 and P-2001; in isoform d.
Probable loss of putative coiled-coil structure. Survival of linker cell in 14 percent of animals; when associated with P-1737; P-1874; P-1877; P-1998 and P-2001; in isoform d.
Inward rectifier potassium channel irk-1
PAN2-PAN3 deadenylation complex subunit PAN3
In ay73; partial rod-like larval lethality. Surviving mutant have a thin body and no vulva. Rescues fluid accumulation in clr-1 e1745ts mutant.
In n1619; lethal at the larval stage, mild defect in vulva development and partially impaired sex myoblast migration. Rescues fluid accumulation in crl-1 e1745ts mutant.
In n1779; mild defect in vulva development and partially impaired sex myoblast migration. Causes ectopic muscle membrane extension. Reduced lev-1 synaptic levels. Moderate increase in resistance to nicotine-induced paralysis. Rescues fluid accumulation in crl-1 e1745ts mutant.
In n1781; no obvious defects. Partially rescues fluid accumulation in crl-1 e1745ts mutant.
In n2195; loss of interaction with soc-1. Partially restores normal vulva induction in let-60 n1046gf mutant. Partially rescues fluid accumulation in crl-1 e1745ts mutant. Partially prevents constitutive dauer formation in daf-2 m577 mutant.
N-end rule aminoacyl transferase C-terminal
Multidrug resistance-associated protein 5
Voltage-dependent calcium channel unc-36
26S proteasome non-ATPase regulatory subunit 6
Elongation of long chain fatty acids protein 6
Cation-transporting P-type ATPase C-terminal
Plasma membrane calcium transporting P-type ATPase C-terminal
Probable cardiolipin synthase (CMP-forming)
In ku263; sterile. Vulval cell division defects, resulting in asymmetric vulval invaginations at the L4 larval stage. Gonad development defects, where the gonad arms are shorter than in wild-type. Reduces the number of oocytes in the proximal gonad arm. The hermaphrodite gonad lacks a transition zone and pachytene nuclei and oocytes have an abnormal morphology. Fewer uterine cells, abnormal and small uteri and an endomitotic oocyte phenotype (also called an Emo phenotype), in which chromosomes have gone through endoreduplication without cytokinesis and karyokinesis. Impairs assembly of the synaptonemal complex between homologous chromosomes and disrupts homologous chromosome pairing, sister chromatid cohesion and localization of cohesin complex subunit rec-8 to chromosomes in the pachytene zone of the gonad. Defective DNA double-strand break repair during meiosis resulting in an accumulation of rad-51-positive recombination intermediates in the mid and late pachytene region of the germline. No increase in apoptosis in response to the accumulation of recombination intermediates, indicative of a defective DNA damage response. Furthermore, hus-1, a component of the 9-1-1 cell-cycle checkpoint response complex which is required for inducing apoptosis in response to DNA damage, does not accumulate on the recombination intermediates.
Sodium/potassium-transporting ATPase subunit beta-1
In ga111; at the restrictive temperature of 25 degrees Celsius, causes an increase in gld-1 expression and a loss of cep-1 expression in late pachytene germ cells. Loss of egl-1 mRNA expression in response to gamma irradiation. 70 percent of mutants have germ cells arrested at the pachytene stage; phenotype is reversible and meiosis can resume. At the somewhat permissive temperature of 20 degrees Celsius has reduced live brood size; brood size further decreased in pzf-1 mutant background. At the restrictive temperature of 26 degrees Celsius, are completely sterile. Partial phosphorylation at Thr-256 and Tyr-258.
In ku1; loss of function and ATP-binding. Lack of tail swelling, severe constipation and loss of ilys-3 expression up-regulation following M.nematophilium infection.
In gm133; at early larval stage L1, the majority of animals appear to lack both ALA and RID neurons, while others show a single neuron.
In gm58; larval lethality. Abolishes expression of ttx-3 in AIY neurons late in embryogenesis at the 3-fold stage and in larvae, but not in earlier embryo.
Causes weak somatic masculinization; prevents binding with tra-1.
MX regulatory domain; required for tra-1 binding
In su1006; body is twisted into a right-handed helix (roller phenotype). Roller phenotype is sensitive to changes in diet leading to metabolic disruption, such as reduction in vitamin B12 intake.
In ok395; accelerated prophase I progression, aberrant oocyte development and ectopic apoptosis in the germline. Shorter gonads, reduction in nuclei, increase in mitotic index, decrease in early meiotic nuclei and sterility. Increase in and premature chromosomal loading of rad-51 and cosa-1 during meiosis. Increased and ectopic phosphorylation levels of mapk-1 (isoform a).
In ez16; defects in gonad morphology; failure to elongate normally and feminization of male (X0) gonad, such as developing a vulva, are the most drastic and most frequent abnormalities. Hermaphrodites are infertile. Abolishes expression of homeobox egl-5 in somatic gonadal precursor cells, Z1 and Z4, during larval L1 stage.
Polyadenylation and cleavage factor homolog 11
NPC intracellular cholesterol transporter 1 homolog 2
Abolishes myristoylation and transport to nucleus.
In mr17; chromosome segregation and orientation defects with increased anaphase bridges and chromosome lagging which have sister chromatids with a single kinetochore connected to microtubules emanating from both spindle poles. Furthermore, centromere organization is disrupted. Chromosomes display morphological impairments such as chromosome twisting, and have condensation and sister centromere attachment defects. Inhibition of spindle microtubules with the drug nocodazole, impairs sister centromere attachment defects further. Does not localize to mitotic chromosomes. Specifically, does not localize to the centromeres of metaphase chromosomes.
Probable trafficking protein particle complex subunit 13 homolog
BTB and MATH domain-containing protein 34
Thymidylate synthase/dCMP hydroxymethylase
In ok3503; Impaired zinc excretion in response to increased levels of dietary zinc.
Phosphoethanolamine N-methyltransferase 2
Promotes infection by the microsporidian pathogen N.parisii as in wild-type.
Uncharacterized RING finger protein C32D5.10
In ju598; impaired movement of intraflagellar transport proteins along the ciliary axoneme and accumulation of intraflagellar protein-B at the ciliary tip. Accumulation of all BBSome proteins around the ciliary base.
Probable ubiquitin-conjugating enzyme protein 17
In op481; defects in axon guidance in D-type motor neurons in a sdn-1 (zh20) mutant background.
Preferentially binds to the unmethylated 'Lys 4' residue of histone H3.
Required for binding to histone H3 methylated at 'Lys-4' in vitro
Probable small nuclear ribonucleoprotein Sm D2
In u168; defective mechanosensation, lack of interaction with mec-3 and lack of maintained mec-3 gene expression. No egg-laying or Q neuroblast lineage defects.
In u5; defective mechanosensation, lack of interaction with mec-3 and lack of maintained mec-3 gene expression. No egg-laying or Q neuroblast lineage defects. Abolishes expression of ALM neuron-specific genes mec-17 and mec-4. Abnormal, ectopic expression of BDU-specific genes ceh-14, flp-10 and zig-3 in ALM.
Peroxisomal coenzyme A diphosphatase ndx-8
Loss of dimerization; when associated with P-208.
Loss of dimerization; when associated with P-215.
In ak66; induces delayed reaction times; when exposed to a drop of hyperosmotic solution.
Immunoglobulin domain-containing protein oig-4
In kr39; the mutant protein is intracellularly retained in body wall muscle cells and not localized to neuromuscular junctions.
Does not interact with unc-18. Locomotion defects and resistant to acetylcholine esterase inhibitor Aldicarb.
In e246; causes constitutive dauer formation, defects in locomotion and increases life span. Restores pharyngeal pumping in animals overexpressing lin-3.
54% loss of activity. Does not rescue engulfment defects seen in ced-1(e1735) mutants. Reduced phosphorylation by src-1. Reduced interaction with nck-1. Does not affect binding to ced-6 or trim-21.
85% loss of activity. Does not attenuate engulfment defects seen in ced-1(e1735) mutants. Severely impaired interaction with ced-6. Increased protein levels, reduced polyubiquitination and reduced degradation rate.
Does not attenuate engulfment defects seen in ced-1(e1735) mutants. Does not affect binding to ced-6. Reduced polyubiquitination and reduced degradation rate.
In e1735; defective clearance of apoptotic cell corpses in embryos.
In e1797, n2000, and n2092; increase in corpses in L1 head.
In e1801; increase in corpses in L1 head.
In n1951; increase in corpses in L1 head.
In n1995; increase in corpses in L1 head.
In n2089; increase in corpses in L1 head.
In n2091; increase in corpses in L1 head.
Nuclear protein localization protein 4 homolog 1
Loss of terminal uridylyltransferase activity.
U6 snRNA-specific terminal uridylyltransferase
Probable ATP synthase subunit g 1, mitochondrial
DNA polymerase alpha catalytic subunit N-terminal
DNA-directed DNA polymerase family B exonuclease
DNA-directed DNA polymerase family B multifunctional
Zinc finger DNA-directed DNA polymerase family B alpha
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members
Mediator of RNA polymerase II transcription subunit 4
DEAD-box ATP-dependent RNA helicase rde-12
Transcription initiation factor IIA subunit 2
Methyl-CpG binding protein 2/3 C-terminal
Nuclear transcription factor Y subunit nfyc-1
FMP27/BLTP2/Hobbit GFWDK motif-containing RBG unit
Leucine-rich repeat-containing protein let-4
LDL receptor repeat-containing protein egg-2
Histone-binding protein RBBP4 N-terminal
Mediator of RNA polymerase II transcription subunit 1.2
Clathrin/coatomer adaptor adaptin-like N-terminal
Coatomer gamma subunit appendage Ig-like subdomain
Constitutively active (GTP-locked form). Reduces spontaneous reversal rate and mechanosensitivity. Punctate localization in the dendrites and cell body cytosol of neurons as in wild-type. Promotes the punctate localization of lin-10. Few glr-1-positive ventral cord puncta accumulate, but several large glr-1-positive puncta accumulate in neuron cell bodies. This is suppressed in a unc-11 e47 mutant background.
Constitutively inactive (GDP-locked form). May abolishes interaction with eat-17. Diffusely distributed in the dendrites and cell body cytosol of neurons. Disrupts the punctate localization of lin-10.
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial
Tetratricopeptide repeat protein 7 N-terminal
Cytochrome c oxidase subunit 6A, mitochondrial
Centromere/kinetochore protein zw10 homolog
Probable Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase
Translocon-associated protein subunit beta
Nuclear hormone receptor family member nhr-44
Mitochondrial import inner membrane translocase subunit TIM50
Prion-like-(Q/N-rich) domain-bearing protein 25
Transient receptor potential cation channel subfamily A member 1 homolog
Putative sodium-dependent excitatory amino acid transporter glt-6
Mitogen-activated protein kinase kinase kinase mom-4
C-type lectin domain-containing protein 38
Putative galactoside 2-alpha-L-fucosyltransferase svh-11
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Probable phosphorylase b kinase regulatory subunit alpha
In rh103; excretory canal tubulogenesis defects including shortened canals with multiple lumens and increased canal width.
Probable G-protein coupled receptor F27E5.5
Probable actin-related protein 2/3 complex subunit 5
Probable methylenetetrahydrofolate reductase (NADPH)
Disrupts homodimer formation. Reduced adenylyltransferase activity when associated with G-274.
Enhanced adenylyltransferase activity. Promiscuous use of ATP, GTP, CTP or UTP. In vitro adenylyltransferase activity towards histones H2A, H2B, H3.1, H3.2 and H3.3, but not H1 or H4. Increases resistance to P.aeruginosa-mediated killing. Reduced adenylyltransferase activity when associated with D-298.
Important for autoinhibition of adenylyltransferase activity
In yn32: Results in lethality and destabilized protein structure.
Reduced heparin binding; when associated with A-374.
Reduced heparin binding; when associated with A-378.
Results in destabilized protein structure; when associated with C-348 and K-377.
Results in destabilized protein structure; when associated with C-368 and K-377.
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
Eukaryotic translation initiation factor 3 subunit L
Defective in cullin neddylation protein 1
In am117; extended lifespan, decrease in early progeny production, resulting in smaller self-fertile brood size, and an increase in late progeny production, which results in an extended self-fertile reproductive lifespan. Increased movement characterized by an increased number of body bends per minute. Animals are thinner and smaller with a reduced body volume (also known as a scrawny phenotype), and this is most likely due to heightened bacteria avoidance behavior and impaired food digestion. Older animals exhibit increased pharyngeal pumping. Abnormal pharyngeal grinder morphology and defective function results in the accumulation of pathogenic bacteria, such as E.coli, in the intestine. Accumulation of the transcription factor hlh-30 in the nucleus following exposure to E.coli, which likely leads to increased expression of pathogen response genes including clec-7, clec-60 and clec-82. Reduced survival following exposure to Gram-negative bacteria P.aeruginosa.
In OR213ts; induces defective centrosomes at restrictive temperature when homozygous.
Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.1
Abolishes interaction with ima-3 in vitro.
CCAAT/enhancer-binding protein homolog 1
In ag33; Resistant to effects of toxin ToxA from Gram-positive bacterium P.aeruginosa. Suppresses lifespan reduction caused by P.aeruginosa in a nipi-3 mutant background.
In ju1518; Suppresses developmental arrest in a nipi-3 mutant background.
In ju1519; Suppresses developmental arrest in a nipi-3 mutant background.
In ju1521; Blocks injury-induced axon regrowth. Suppresses developmental arrest in a nipi-3 mutant background.
In ju1590; Blocks injury-induced axon regrowth.
In ju634; Blocks injury-induced axon regrowth. Suppresses developmental arrest in a nipi-3 mutant background.
In ju640; Suppresses neuronal defects in a E3 ubiquitin-protein ligase rpm-1 mutant background.
In ju659; Suppresses neuronal defects in a E3 ubiquitin-protein ligase rpm-1 mutant background.
In u819; Suppresses microtubule disruption in touch receptor neurons caused by colchicine.
N' domain; required for axon regeneration
Does not affect expression pattern. Does not rescue the seam cell developmental timing defects of the sea-2 bp283 mutant.
Does not affect expression pattern. Does not rescue the seam developmental timing defects of the sea-2 b283 mutant.
In bp283; extended lifespan, and a slow accumulation of dcap-1-positive P-bodies compared to wild-type, indicative of a slower ageing rate. Delays the L2 to L3 larval stage switch. Defective seam cell development due to delayed divisions and failed fusions during the L2 and L3 larval stages. This increases the number of seam cells at later larval stages and delays their terminal differentiation, resulting in discontinuous alae formation. Ectopic expression of the heterochronic protein lin-28 whereby, in contrast to wild-type, lin-28 is expressed in the head, tail and in seam cells of L3 and L4 larvae. Prominent nuclear localization of the transcription factor daf-16 in the intestine resulting in the transcription of daf-16 targets. The seam cell development defects are enhanced in a daf-2 e1370 mutant background. The seam cell development defects are suppressed in a lin-28 n719 mutant background. Partially suppresses the premature alae formation defect in a hbl-1 RNAi mutant background. Suppresses the embryonic lethality of hermaphrodites in the double fox-1 and sex-1 RNAi mutant background.
In isoform a, isoform b, isoform c and isoform j.
In isoform b, isoform h, isoform i, isoform j, isoform l, isoform m, isoform o and isoform q.
In isoform c, isoform d, isoform e, isoform f, isoform h, isoform j, isoform k, isoform l and isoform m.
In isoform d, isoform m, isoform q and isoform r.
In isoform k, isoform l, isoform n and isoform o.
Loss of catalytic activity; when associated with A-339.
Severe loss of catalytic activity. Loss of catalytic activity; when associated with 186-A-A-187.
Putative 1-acyl-sn-glycerol-3-phosphate acyltransferase acl-1
Nuclear hormone receptor family member nhr-52
Abolishes interaction with bbs-5. Unable to target to cilia.
Uncharacterized tRNA-dihydrouridine synthase-like protein C45G9.2
Probable G-protein coupled receptor F27E5.8
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
Protein-lysine methyltransferase C42C1.13
In ot327; larval lethality. Abolishes expression of homeobox genes ttx-3 and ceh-10 in the AIY/SMDD lineage in the embryo, and also in the AIY interneuron at larval stages.
Changes relative Ca2+ and Cl-permeabilities.
Probably disrupts GTPase-activating activity. Unable to rescue par-6 localization in pac-1 mutant embryos.
Required for localization to adherens junctions
Glycoside hydrolase family 31 N-terminal
Ig-like and fibronectin type-III domain-containing protein 2
Receptor-type tyrosine-protein phosphatase dep-1
Substrate trapping with much higher affinity for substrates let-23 and pat-3.
Sodium/calcium exchanger membrane region
In qm27; embryonic lethality and morphological defects in larva. Embryos show failure in dorsal epidermal cell intercalation, failure of ventral epidermal cell enclosure, and arrest during elongation. Causes aberrant nuclear localization in neuroblasts. Nuclear expression of zinc-finger protein die-1 is significantly reduced. Embryonic lethality exacerbated by simultaneous RNAi-mediated knockdown of transcription factor aptf-4.
In ot64; Abolishes expression of gcy-6, gcy-7, lim-6 and flp-4 in the ASEL gustatory neuron, and causes ectopic expression of gcy-5 and cog-1 in ASEL. Abolishes expression of microRNA gene lsy-6. Ectopic expression of pgl-1 and glh-1, forming perinuclear granules in various somatic cells. Protruding vulva, abnormally migrating gonad arms and sterility.
In ot77; Causes ectopic expression of gcy-5 in ASEL gustatory neurons.
Mitochondrial prohibitin complex protein 2
Probable protein phosphatase methylesterase 1
Probable 3-hydroxyacyl-CoA dehydrogenase F54C8.1
In n5655; suppresses the defects in egg-laying and response to reoxygenation of paqr-2 mutants.
In n5657; suppresses the defects in egg-laying and response to reoxygenation of paqr-2 mutants.
In n5661; suppresses the defects in egg-laying and response to reoxygenation of paqr-2 mutants.
In n5876; suppresses the defects in egg-laying and response to reoxygenation of paqr-2 mutants.
In n5877; suppresses the defects in egg-laying and response to reoxygenation of paqr-2 mutants.
In n5879; suppresses the defects in egg-laying and response to reoxygenation of paqr-2 mutants.
Has no effect on efficiently routing num-1 to the cell periphery; when associated with A-17.
Has no effect on efficiently routing num-1 to the cell periphery; when associated with A-65.
Promotes accumulation of num-1 in the cytoplasm; when associated with Q-17.
Promotes accumulation of num-1 in the cytoplasm; when associated with Q-65.
snRNA-activating protein complex subunit 4 homolog
ATP synthase subunit delta, mitochondrial
In jn13; in males, suppresses premature sperm activation in a swm-1 (me66) mutant background.
In jn21; in males, suppresses premature sperm activation in a swm-1 (me66) mutant background.
In jn2; male and hermaphrodite fertility is normal. Suppresses premature sperm activation in a swm-1 (me66) mutant background.
In ky395; Abnormal expression of olfactory receptor str-2 in AWB olfactory neurons, defects in foraging behavior, and aberrant movements. Repulsive olfactory neuron AWB is transformed into the attractive olfactory neuron AWC.
In ky403; Abnormal expression of olfactory receptor str-2 in AWB olfactory neurons, defects in foraging behavior, and aberrant movements. Repulsive olfactory neuron AWB is transformed into the attractive olfactory neuron AWC. Reduced expression of tph-1 and reduced serotonin immunoreactivity in serotonergic ADF neurons. Expression of neuropeptide flp-12 is abolished in the SMB sensory/inter/motor neurons. Expression of terminally differentiated SMB markers including cholinergic genes is abolished, but pan-neuronal genes such as chaperone unc-119 are unchanged. Exhibits aberrant expression of some but not all genes which are markers of RID motorneuron differentiation.
Ionotropic glutamate receptor C-terminal
Ionotropic glutamate receptor L-glutamate and glycine-binding
In n112; weak synthetic multivulva phenotype. Temperature-sensitive multivulva phenotype in a lin-8 n111 mutant background.
Loss of kinase activity. Reduction in src-1 and src-2-mediated tyrosine phosphorylation. Mutants arrest at L1 larval stage.
Serine-threonine/tyrosine-protein kinase catalytic
Nuclear hormone receptor family member nhr-4
Rho guanine nucleotide exchange factor osg-1
Probable mitochondrial pyruvate carrier 1
Reduces hydrolysis of inosine, adenosine and guanosine by a factor of about 120-fold. May be involved in leaving group activation, acting as a general acid required to protonate the N7 of the purine leaving group.
Reduces hydrolysis of inosine, adenosine, and guanosine by a factor of about 14-, 22-, and 10-fold, respectively.
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase
ABC transporter ATP-binding protein/permease wht-3
Putative G-protein coupled receptor F59B2.13
Heme-copper oxidase subunit III family profile
Fatty-acid and retinol-binding protein 1
Abolishes the increased glr-1 expression associated with coexpression of usp-46 with wdr-20 and wdr-48. Does not rescue the decreased glr-1 levels seen in usp-46 mutants. No effect on interaction with glr-1.
Ubiquitin carboxyl-terminal hydrolase 46
Protein arginine methyltransferase NDUFAF7 homolog, mitochondrial
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
In isoform b, isoform c, isoform d and isoform e.
In rj1; 21% embryonic lethality, reduced egg laying and a 0.6% increase in the number of male progeny. Delayed progression of meiosis, which most likely results from defective disassembly of synaptonemal complex proteins, and defective chromosome alignment, segregation and condensation.
Necessary and sufficient for interaction with oma-1
Transcription initiation factor TFIID subunit 4
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Fumarylacetoacetate hydrolase domain-containing protein 1
Constitutively active. Normal P cell migration. No effect on viability or fertility.
Dominant negative. Defective ventral migration of P cells leading to defective gonad development. Severely uncoordinated.
Abolishes self-association and enhances interaction with isoform c.
Important for interaction between isoform a and isoform c
In ju476; does not affect c mRNA levels. Restores normal motor neuron presynapse morphology and number in a rpm-1 mutant background. Suppresses microtubule disruption in touch receptor neurons caused by colchicine.
In ju586; restores motor neuron normal presynapse morphology and number in a rpm-1 mutant background.
In ju588; restores motor neuron normal presynapse morphology and number in a rpm-1 mutant background.
In ju591; restores normal motor neuron presynapse morphology and number in a rpm-1 mutant background.
In ju598; restores normal motor neuron presynaspe morphology and number in a rpm-1 mutant background.
In ju620; restores normal motor neuron presynapse morphology and number in a rpm-1 mutant background.
In ju636; restores normal motor neuron presynapse morphology and number in a rpm-1 mutant background.
In u815; Suppresses microtubule disruption in touch receptor neurons caused by colchicine.
In u816; Suppresses microtubule disruption in touch receptor neurons caused by colchicine.
In u817; Suppresses microtubule disruption in touch receptor neurons caused by colchicine.
In u818; Suppresses microtubule disruption in touch receptor neurons caused by colchicine.
In u820; Suppresses microtubule disruption in touch receptor neurons caused by colchicine.
Mitogen-activated protein kinase kinase kinase dlk-1
Phosphomimetic mutant. Enhances self-association and increases binding of the hexapeptide motif to the kinase domain; when associated with E-874.
Phosphomimetic mutant. Enhances self-association and increases binding of the hexapeptide motif to the kinase domain; when associated with E-878.
Prevents phosphorylation. Enhances binding to isoform c; when associated with A-874.
Prevents phosphorylation. Enhances binding to isoform c; when associated with A-878.
Prevents self-association or interaction with isoform c.
5-glutamyl glycerylphosphorylethanolamine
May act as a substrate filter by repelling compounds with a negatively charged alpha-carboxylate
O-phosphoseryl-tRNA(Sec) selenium transferase
In e2680; resistant to infection by M.nematophilum and prevents biofilm formation by Y.pseudotuberculosis.
In e2689; no obvious morphological defects, but in combination with RNAi-mediated knockdown of nstp-4, has misshapen gonad arms and accumulation of oocytes.
In e2797; no obvious morphological defects, but in combination with RNAi-mediated knockdown of nstp-4, has misshapen gonad arms and accumulation of oocytes.
In yj10; no obvious morphological defects, but in combination with RNAi-mediated knockdown of nstp-4, has misshapen gonad arms and accumulation of oocytes.
UDP-galactose/UDP-N-acetylglucosamine transporter srf-3
Loss of activity. No effect on embryo viability and mdf-1 recruitment to unattached kinetochores.
Loss of interaction with mdf-1 but not with bub-3. No effect on embryo viability and severe loss of mdf-1 recruitment to unattached kinetochores; when associated with K-777.
Loss of interaction with mdf-1 but not with bub-3. No effect on embryo viability and severe loss of mdf-1 recruitment to unattached kinetochores; when associated with K-781.
Mitotic checkpoint serine/threonine-protein kinase bub-1
No effect on embryo viability, severe loss of mdf-1 recruitment to unattached kinetochores and probably loss of kinase activity; when associated with N-718.
No effect on embryo viability, severe loss of mdf-1 recruitment to unattached kinetochores and probably loss of kinase activity; when associated with N-847.
In e767; growth arrest, severe blistering of the cuticle, incomplete molting and mild shorter and stouter body shape. Resistant to iodide toxicity. Reduced catalase activity. In a pah-1(tm520) mutant background, growth arrest in early larval development, severe cuticle abnormalities with large blisters and increased superoxide dismutase activity.
In im10; blistered cuticle phenotype with accumulation of cellular material in blisters.
In mac40; blistered cuticle phenotype in some animals with blisters containing cellular material. Resistant to iodide toxicity.
Peroxidase-like; mediates peroxidase activity
Inward rectifier potassium channel C-terminal
Potassium channel inwardly rectifying transmembrane
In lev-11-rg1; disrupts most steps of male mating behavior except spicule insertion.
In lev-11-sy558; induces spicule protraction (Prc phenotype). Prc phenotype is suppressible by food deprivation.
In lev-11-x12; confers levamisole resistance.
In ok360; 25 percent of F1 progeny die at the embryonic stage. Embryos are arrested at the 100-150 cell stage and fail to undergo morphogenesis. Accumulation of abnormally processed yolk proteins in large cytoplasmic vesicles and delay in the degradation/recycling of the yolk protein receptor rme-2. In the gonad, fails to eliminate germ cell corpses in an age-dependent manner.
In qx304; temperature sensitive. At the restrictive temperature of 25 degrees Celsius, causes an accumulation of germ cell corpses in the gonad in an age-dependent manner. In embryos, accumulation of abnormally processed yolk proteins, and of endocytic and autophagic cargos. Does not affect lysosomal localization.
In t3423; temperature sensitive. Embryonic lethal at the restrictive temperature of 25 degrees Celsius. In oocytes and embryos, causes an intracellular accumulation of enlarged neutral lipid-containing droplets.
In t3438; temperature sensitive. Embryonic lethal at the restrictive temperature of 25 degrees Celsius. In oocytes and embryos, causes an intracellular accumulation of enlarged neutral lipid-containing droplets.
In yq89; temperature sensitive. At the restrictive temperature of 25 degrees Celsius, causes an accumulation of germ cell corpses in the gonad in an age-dependent manner. Accumulation of abnormally processed yolk proteins. Does not affect lysosomal localization.
Probably causes cpl-1 misfolding resulting in its accumulation within the ER and loss of endolysosome localization; when associated with A-32.
Probably causes cpl-1 misfolding resulting in its accumulation within the ER and loss of endolysosome localization; when associated with A-35.
MinK-related peptide, potassium channel accessory subunit protein 4
Arf-GAP with ANK repeat and PH domain-containing protein cnt-2
Probable loss of GTPase-activating protein (GAP) activity. Production of extra A/PVM neurons.
Probable loss of cognate arf binding and production of extra A/PVM neurons, when associated with S-837.
Probable loss of cognate arf binding and production of extra A/PVM neurons, when associated with S-840.
Anaphase-promoting complex subunit CDC26
In N2409; loss of GABA transport into synaptic vesicles.
Probable arginine--tRNA ligase, cytoplasmic
Nuclear hormone receptor family member nhr-100
In sa23; loss of production of several nlp and flp neuropeptides. Reduced enrichment of unc-13 at presynaptic active sites of neuromuscular junctions. Mutants are constipated due to a defect in body wall muscle and intestinal contractions and have a slightly longer defecation cycle. Reduced uptake and accumulation of triglycerides in the intestine. Mild body thrashing.
In sv75; intestinal lipid droplets are smaller and their number is reduced. Reduced uptake and accumulation of triglycerides in the intestine.
In sv76; intestinal lipid droplets are smaller and their number is reduced. Reduced uptake and accumulation of triglycerides in the intestine.
Glyceraldehyde-3-phosphate dehydrogenase 1
In LBV003; confers resistance to N,N-diethyl-meta-toluamide (DEET).
Histone-lysine N-methyltransferase Suv4-20
Acts as a suppressor of lem-4l(ax475) mutant.
In n4564 n5214; temperature sensitive phenotype with embryonic lethality at 25 degrees Celsius and wild type phenotype at 15 degrees Celsius. Splicing of tos-1 mRNA is defective with increased intron 1 retention and exon 3 skipping, although there is no obvious recognition of the cryptic 3' splice site in tos-1 intron 1.
In n5214; no effect on tos-1 mRNA splicing.
Mitochondrial import inner membrane translocase subunit tim-22
BPTI/Kunitz inhibitor domain-containing protein C02F12.5
Cytoplasmic polyadenylation element-binding protein 2
Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal
Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1
Guanine nucleotide-binding protein alpha-17 subunit
In ky879; defects in GPCR expression in the AWC neurons.
Loss of chemotactic and osmotic avoidance responses.
Does not cause significant conformational changes the last cytoplasmic domain.
In isoform a, isoform b, isoform c and isoform d.
In isoform a, isoform b, isoform e and isoform f.
In isoform b, isoform d, isoform f and isoform h.
Piezo-type mechanosensitive ion channel component 1
Reduces brood size and ovulation rates, and there is an accumulation of ooplasmic uterine masses.
Nuclear hormone receptor family member nhr-106
CREB-H transcription factor homolog let-607
CaiB/baiF CoA-transferase family protein ZK892.4
Uncharacterized monothiol glutaredoxin F10D7.3
Pre-rRNA-processing protein TSR1 homolog
DNA-directed DNA polymerase family B mitochondria/virus
Mediator of RNA polymerase II transcription subunit 13
Skn-1 dependent zygotic transcript 1 protein
Confers similar gating properties to isoform b; in isoform a.
Confers similar gating properties to isoform b; in isoform a. Reduced sensitivity to MTSET-mediated inhibition; when associated with C-167; in isoform a.
Constitutive activation and loss of pH sensitivity; in isoform a.
Constitutive activation, loss of pH sensitivity, loss of sensitivity to chloride levels and conditioning depolarizing voltages; in isoform b.
Constitutively active, loss of inhibition by gck-3-mediated phosphorylation.
Essential for gck-3-mediated inhibition of channel activity
In n995; increase channel activity and accumulation of eggs in the uterus resulting from a defect in egg-laying. Reduced HSN activity. Reduced sensitivity to gck-3-mediated inhibition; in isoform a.
Increased sensitivity to MTSET-mediated inhibition; in isoform a and isoform b. Inhibition is slower; in isoform a. Reduced sensitivity to MTSET-mediated inhibition; when associated with D-559; in isoform a.
Phosphomimetic mutant whose activity is sensitive to gck-3-mediated inhibition and to cell swelling-induced activation. Severe reduction in channel activity, loss of cell swelling-induced activation; when associated with E-747.
Phosphomimetic mutant whose activity is sensitive to gck-3-mediated inhibition but insensitive to cell swelling-induced activation. Severe reduction in channel activity, loss of cell swelling-induced activation; when associated with E-742.
Adenomatous polyposis coli protein-related protein 1
In bp298; at the L4 larval stage, seam cells divide asymmetrically as opposed to symmetrically leading to an increased number of seam cells at the young adult stage. Defective asymmetric division of the V5.p seam cell and 45.5% of animals develop two postdeirids due to symmetric division of the V5.p seam cell.
Required for interaction with bar-1 and hmp-2
Beta-adaptin appendage C-terminal subdomain
Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain
Putative forkhead-related transcription factor fkh-5
Nuclear hormone receptor family member nhr-34
Polycomb group RING finger protein 3 homolog mig-32
Specificity protein transcription factor 2
Proton donor; shared with dimeric partner
Stacks against the aromatic ring of pyridoxal phosphate and stabilizes reaction intermediates
Defects in chromosome segregation in meiosis and mitosis.
Required for association with mitotic chromosomes
Required for chromosome segregation, nuclear growth, nucleoplasmic accumulation and cell cycle timing, but not required for nuclear envelope and kinetochore localization
Required for nuclear envelope and kinetochore localization
In 5500; impaired hypoxia-induced behavioral plasticity.
In ia38; loss of inhibition of hif-1 activity.
Probable S-adenosylmethionine synthase 3
In op309; severe reduction in PI3P and PI(3,5)P2 dephosphorylation. Increased levels of PI3P in intracellular vesicles. Restores the engulfment of cell corpses in a ced-6 n1813 mutant background.
Mitochondrial import receptor subunit tomm-70
Transmembrane BAX inhibitor motif-containing protein 4
Coatomer beta subunit appendage platform
Structural maintenance of chromosomes protein 1
Essential for specifying initiation versus elongation step of the polyglutamylase activity
Impairs increase in tubulin glutamylation levels in sensory cilia in response to starvation. Has no effect on basal tubulin glutamylation levels in sensory cilia.
Increases basal tubulin glutamylation levels in sensory cilia.
Significantly reduces transport of UDP-GalNAc and UDP-GlcNAc into vesicles.
Transport of UDP-GalNAc severely impaired, but transport of UDP-GlcNAc virtually unaffected.
UDP-N-acetylglucosamine/UDP-N-acetylgalactosamine transporter nstp-4
In h1983; reduction in the number of eggs laid.
Probable 3',5'-cyclic phosphodiesterase pde-5
Interchain (between alpha and beta subunits)
ER membrane protein complex subunit 1 C-terminal
Mitochondrial import receptor subunit TOM7 homolog
CREB-regulated transcription coactivator 1 homolog
Calcineurin binding site mutation. Loss of nuclear translocation in response to increased calcium influx.
Loss of phosphorylation. Leads to nuclear sequestration; when associated with A-179.
Loss of phosphorylation. Leads to nuclear sequestration; when associated with A-76.
In n1792; mild defects in neurite positioning along the anterior posterior axis with ventral D-type GABAergic neurons displaying posterior neurites, instead of anterior neurites, which results in ventrodorsal commissures positioned on the posterior side of their cell body. Defective localization of grdn-1 to the distal dendrites of PQR sensory neurons. Instead grdn-1 either localizes to ectopic cellular compartments such as the soma and dendritic base, in posteriorly projecting or misrouted dendrites, or is undetectable.
Transmembrane protein 127 transmembrane region
In gon-10; specific defects in gonadogenesis and vulval development.
In as42; defects in egg-laying associated with embryonic hatching within the mother (also called the bag of worms phenotype).
In p675; impaired thermotaxis and chemotaxis towards NaCl, hypersensitivity to low osmotic conditions, enhanced olfactory adaptation to isoamyl alcohol. Slow growth rate and body is smaller and slender with a transparent appearance resulting from a thinner cuticle. Reduced brood size associated with egg retention. Partially resistant to serotonin-induced egg laying. Increased susceptibility to nicotine-mediated paralysis. Impaired mating behavior and reduced localization of pkd-2 to neuronal cilium. Impaired CO2 avoidance. Impaired coelomocyte endocytosis, apical endocytosis in intestine and recycling of synaptic vesicles at synapses.
Interaction with PxIxIF motif in substrate
Interaction with PxVP motif in substrate
Serine/threonine-protein phosphatase 2B catalytic subunit
Nuclear hormone receptor family member nhr-213
In fq1; cytological defects in the pachytene and diakinesis phases of meiotic prophase in the germline. Abolishes loading of cohesin complex components smc-1, smc-3 and rec-8 onto the to the axial element of meiotic chromosomes in the germline, however these subunits do accumulate in the mitotic nuclei and the meiotic S phase nuclei that precede the start of meiotic prophase. Abrogates assembly of the synaptonemal complex between homologous chromosomes. Does not affect the loading of condensin and the smc-5/6 complex onto meiotic chromosomes. Defective DNA double-strand break repair during meiosis resulting in an accumulation of rad-51-positive recombination intermediates and elongated rad-51-positive recombination structures in the mid and late pachytene region of the germline. No increase in apoptosis in response to the accumulation of recombination intermediates, indicative of a defective DNA damage response. Furthermore, hus-1, a component of the 9-1-1 cell-cycle checkpoint response complex which is required for inducing apoptosis in response to DNA damage, does not accumulate on the recombination intermediates.
In qt13; complete resistance to RNAi following soaking in dsRNA solution or ingestion of bacteria expressing dsRNA.
In qt20; complete resistance to RNAi following soaking in dsRNA solution or ingestion of bacteria expressing dsRNA.
In qt42; defective avoidance behavior in response to P.aeruginosa.
No detectable dsRNA uptake and only partial rescue of gene silencing defect in sid-2 deletion mutant.
Reduced dsRNA uptake but complete rescue of gene silencing defect in sid-2 deletion mutant.
Systemic RNA interference defective protein 2
Large ribosomal subunit protein uL10-like insertion
Phosphomimetic mutant which shows no defect in embryo elongation.
U2A'/phosphoprotein 32 family A C-terminal
Probable dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase
In mg125; suppresses the constitutive dauer arrest phenotype on a daf-7 mutant background.
In mg132; suppresses the constitutive dauer arrest phenotype on a daf-7 mutant background.
Serine/threonine-protein kinase pink-1, mitochondrial
Adenosine 3'-phospho 5'-phosphosulfate transporter 1
Probable 3',5'-cyclic phosphodiesterase pde-4
Organic solute transporter alpha-like protein 3
Fails to rescue the nep-2 olfactory plasticity defect, suggesting that peptidase activity is required for olfactory plasticity; when associated with F-571.
Fails to rescue the nep-2 olfactory plasticity defect, suggesting that peptidase activity is required for olfactory plasticity; when associated with F-575.
Likely abolishes phosphorylation. Almost complete rescue of fluid accumulation in clr-1 e1745ts mutant; when associated with F-20; F-112; F-171; F-181; F-220; F-232; F-293; F-306; F-354; F-365 and F-378. No rescue of fluid accumulation in clr-1 e1745ts mutant; when associated with F-20; F-112; F-171; F-181; F-220; F-232; F-293; F-306; F-354; F-365; F-378 and F-408.
Likely abolishes phosphorylation. Almost complete rescue of fluid accumulation in clr-1 e1745ts mutant; when associated with F-20; F-31; F-112; F-171; F-181; F-220; F-232; F-293; F-306; F-354 and F-365. No rescue of fluid accumulation in clr-1 e1745ts mutant; when associated with F-20; F-31; F-112; F-171; F-181; F-220; F-232; F-293; F-306; F-354; F-365 and F-408.
Likely abolishes phosphorylation. Almost complete rescue of fluid accumulation in clr-1 e1745ts mutant; when associated with F-20; F-31; F-112; F-171; F-181; F-220; F-232; F-293; F-306; F-354 and F-378. No rescue of fluid accumulation in clr-1 e1745ts mutant; when associated with F-20; F-31; F-112; F-171; F-181; F-220; F-232; F-293; F-306; F-354; F-378 and F-408.
Likely abolishes phosphorylation. Almost complete rescue of fluid accumulation in clr-1 e1745ts mutant; when associated with F-20; F-31; F-112; F-171; F-181; F-220; F-232; F-293; F-306; F-365 and F-378. No rescue of fluid accumulation in clr-1 e1745ts mutant; when associated with F-20; F-31; F-112; F-171; F-181; F-220; F-232; F-293; F-306; F-365; F-378 and F-408.
Likely abolishes phosphorylation. Almost complete rescue of fluid accumulation in clr-1 e1745ts mutant; when associated with F-20; F-31; F-112; F-171; F-181; F-220; F-232; F-293; F-354; F-365 and F-378. No rescue of fluid accumulation in clr-1 e1745ts mutant; when associated with F-20; F-31; F-112; F-171; F-181; F-220; F-232; F-293; F-354; F-365; F-378 and F-408.
Likely abolishes phosphorylation. Almost complete rescue of fluid accumulation in clr-1 e1745ts mutant; when associated with F-20; F-31; F-112; F-171; F-181; F-220; F-232; F-306; F-354; F-365 and F-378. No rescue of fluid accumulation in clr-1 e1745ts mutant; when associated with F-20; F-31; F-112; F-171; F-181; F-220; F-232; F-306; F-354; F-365; F-378 and F-408.
Likely abolishes phosphorylation. Almost complete rescue of fluid accumulation in clr-1 e1745ts mutant; when associated with F-20; F-31; F-112; F-171; F-181; F-220; F-293; F-306; F-354; F-365 and F-378. No rescue of fluid accumulation in clr-1 e1745ts mutant; when associated with F-20; F-31; F-112; F-171; F-181; F-220; F-293; F-306; F-354; F-365; F-378 and F-408.
Likely abolishes phosphorylation. Almost complete rescue of fluid accumulation in clr-1 e1745ts mutant; when associated with F-20; F-31; F-112; F-171; F-181; F-232; F-293; F-306; F-354; F-365 and F-378. No rescue of fluid accumulation in clr-1 e1745ts mutant; when associated with F-20; F-31; F-112; F-171; F-181; F-232; F-293; F-306; F-354; F-365; F-378 and F-408.
Likely abolishes phosphorylation. Almost complete rescue of fluid accumulation in clr-1 e1745ts mutant; when associated with F-20; F-31; F-112; F-171; F-220; F-232; F-293; F-306; F-354; F-365 and F-378. No rescue of fluid accumulation in clr-1 e1745ts mutant; when associated with F-20; F-31; F-112; F-171; F-220; F-232; F-293; F-306; F-354; F-365; F-378 and F-408.
Likely abolishes phosphorylation. Almost complete rescue of fluid accumulation in clr-1 e1745ts mutant; when associated with F-20; F-31; F-112; F-181; F-220; F-232; F-293; F-306; F-354; F-365 and F-378. No rescue of fluid accumulation in clr-1 e1745ts mutant; when associated with F-20; F-31; F-112; F-181; F-220; F-232; F-293; F-306; F-354; F-365; F-378 and F-408.
Likely abolishes phosphorylation. Almost complete rescue of fluid accumulation in clr-1 e1745ts mutant; when associated with F-20; F-31; F-171; F-181; F-220; F-232; F-293; F-306; F-354; F-365 and F-378. No rescue of fluid accumulation in clr-1 e1745ts mutant; when associated with F-20; F-31; F-171; F-181; F-220; F-232; F-293; F-306; F-354; F-365; F-378 and F-408.
Likely abolishes phosphorylation. Almost complete rescue of fluid accumulation in clr-1 e1745ts mutant; when associated with F-31; F-112; F-171; F-181; F-220; F-232; F-293; F-306; F-354; F-365 and F-378. No rescue of fluid accumulation in clr-1 e1745ts mutant; when associated with F-31; F-112; F-171; F-181; F-220; F-232; F-293; F-306; F-354; F-365; F-378 and F-408.
Likely abolishes phosphorylation. Rescues fluid accumulation in clr-1 e1745ts mutant; when associated with F-202.
Likely abolishes phosphorylation. Rescues fluid accumulation in clr-1 e1745ts mutant; when associated with F-340.
Likely abolishes phosphorylation. Weak rescue of fluid accumulation in clr-1 e1745ts mutant. No rescue of fluid accumulation in clr-1 e1745ts mutant; when associated with F-20; F-31; F-112; F-171; F-181; F-220; F-232; F-293; F-306; F-354; F-365 and F-378.
No rescue of fluid accumulation in clr-1 e1745ts mutant.
Rescues fluid accumulation in clr-1 e1745ts mutant; when associated with A-200.
Rescues fluid accumulation in clr-1 e1745ts mutant; when associated with A-239 and A-240.
DNA-directed RNA polymerase I subunit RPA2 homolog
Reduced survival as a result of infection with Gram-positive bacterium B.thuringiensis.
GPI ethanolamine phosphate transferase 2 C-terminal
Calcium-activated potassium channel BK alpha subunit
Calcium-activated potassium channel slo-1
Helical; Voltage-sensor; Name=Segment S4
In ky399gf; gain of function. Insensitive to the acetylcholinesterase inhibitor aldicarb, and locomotory speed defects. In an erg-28 mutant background, these defects are suppressed.
In md1715; induces prolonged synaptic release.
Nuclear hormone receptor family member nhr-42
Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66
In e580; no effect on unc-9 localization to gap junction in PLM neurons.
In var1; defective ADL, ADF, AWB and AWC sensory neuron cilia.
Nuclear hormone receptor family member nhr-108
COA8 family protein Y39B6A.34, mitochondrial
Causes abnormal proximal proliferation in the germline and formation of ectopic vulvae.
Causes abnormal proximal proliferation in the germline and formation of ectopic vulvae. Also, expression pattern of glp-1 is abnormal, being found in both distal and proximal regions of the germline. On a lag-2(q411) mutant background, causes death soon after hatching.
Causes formation of ectopic vulvae. On a lag-2(q411) mutant background, suppresses abnormal phenotype.
In q411; causes death of first stage L1 larvae with various cell fate transformations.
Nuclear hormone receptor family member nhr-2
Membrane insertase YidC/Oxa/ALB C-terminal
Probable 3',5'-cyclic phosphodiesterase pde-1
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Lipid droplet-regulating VLDL assembly factor AUP1 homolog
Vacuolar protein sorting-associated protein 54 N-terminal
3beta-hydroxysteroid dehydrogenase dhs-16
Glycosyltransferase family 92 protein F49C12.5
Prevents interaction with cdc-48 without affecting the interaction with cdt-1 and ubiquitinated protein substrates.
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
In or198; at 25 degrees Celsius, embryonic lethal due to incomplete cytokinesis with ectopic furrow formation and mis-orientation of mitotic spindle. Reduced cul-3 neddylation.
NEDD8-activating enzyme E1 catalytic subunit
In e491; low-penetrant disruption (57%) of tail tip morphogenesis resulting in retention of the pointed larval tail tip in adult males (also known as the Lep phenotype). This phenotype is enhanced by RNAi against sma-2.
Glycyl lysine isopeptide (Gly-Lys) (interchain with K-129 in atg-5)
In ut163; moderate increase in constitutive dauer larva formation at 25 degrees Celsius. Constitutive larva dauer formation is further increased in absence of cholesterol. Lack of radial constriction in the pharynx of constitutive dauer-like larvae.
In ut187 and ut157; moderate increase in constitutive dauer formation at 25 degrees Celsius. Constitutive dauer formation is further increased in absence of cholesterol. Normal lifespan.
Probable mitochondrial import inner membrane translocase subunit tim-17B.1
NADH:ubiquinone oxidoreductase 30kDa subunit
Eukaryotic translation initiation factor 2-alpha kinase pek-1
In tu439; strong resistance to B. thuringiensis-mediated killing. Resistant to infection by S.aureus. Reduced life span. RNAi-mediated knockdown of pmk-1 (by injection) abolishes resistance to B.thuringiensis. Deficient for RNAi-mediated knockdown by feeding; in association with S-53.
In tu439; strong resistance to B.thuringiensis-mediated killing. Resistant to infection by S.aureus. Reduced life span. RNAi-mediated knockdown of pmk-1 (by injection) abolishes resistance to B.thuringiensis. Deficient for RNAi-mediated knockdown by feeding; in association with N-307.
In bp4; ectopic expression of the homeobox protein egl-5 in the head and mid-body regions.
In bp5; ectopic expression of the homeobox protein egl-5 in the head and mid-body regions.
Nuclear transcription factor Y subunit nfya-1
Probable cleavage and polyadenylation specificity factor subunit 1
Nucleoporin Nup133/Nup155-like C-terminal
Zinc finger transcription factor family protein 17
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
BRICHOS domain-containing protein C09F5.1
Guanine nucleotide-binding protein alpha-6 subunit
Nuclear hormone receptor family member nhr-62
EGF-like domain-containing protein C02B10.3
Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]
Increases substrate binding and reduces catalytic activity.
Increases substrate binding and slightly reduces catalytic activity. Reduces catalytic activity; when associated with A-121.
Increases substrate binding and slightly reduces catalytic activity. Reduces catalytic activity; when associated with A-76.
No Effect on substrate binding or catalytic activity.
No effect on substrate binding and reduces catalytic activity.
No effect on substrate binding and strongly reduces catalytic activity.
Slight decrease in substrate binding and slight increase in catalytic activity.
Slight increase in substrate binding and enzyme activity.
Slight increase in substrate binding and no effect on catalytic activity.
Slight increase in substrate binding and reduces catalytic activity.
In ct226; temperature-sensitive. In embryos from homozygous mutants, hermaphrodites reared at 25 degrees Celsius, the E cells divide early with abnormal spindle orientations and fail to migrate into the embryo, and no subsequent gastrulation movements occur.
Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-1
Heterogeneous nuclear ribonucleoprotein A1
Phosphatidylinositol 3-kinase catalytic subunit type 3
Probable V-type proton ATPase subunit H 1
Serine/threonine-protein phosphatase PP1-gamma
Abolishes phosphorylation. Prolonged dynamic state of syp-3 at the synaptonemal complex during pachytene, increased DNA double-strand break formation, increased germ cell apoptosis and reduced brood size.
Phosphomimetic mutant. Less dynamic state of syp-3 at the synaptonemal complex during pachytene, decreased DNA double-strand break formation, increased germ cell apoptosis and reduced brood size.
C-type lectin domain-containing protein 87
Acylamino-acid-releasing enzyme N-terminal
Peptidase S9 prolyl oligopeptidase catalytic
Mitochondrial-processing peptidase subunit alpha
Biogenesis of lysosome-related organelles complex 1 subunit 6
In jg34; Shorter and stouter body. Abnormal localization of the collagen proteins rol-6 and col-19. In mutants lacking rol-6, suppresses body rolling and restores normal orientation of alea.
In jg43; Abnormal localization of the collagen proteins rol-6 and col-19.
U3 small nucleolar RNA-associated protein 18 homolog
In bp242; defective degradation of protein aggregates. Suppresses the lysosomal accumulation of ribosomal RNA and ribosomal proteins in a rnst-2 qx245 mutant background.
Reduces, but does not abolish, phosphatidylinositol binding.
C-type lectin domain-containing protein 88
Mediator of RNA polymerase II transcription subunit 18
Spermatogenesis-defective protein spe-17
Exocyst complex subunit Exo70 C-terminal
Putative endoplasmic reticulum metallopeptidase 1-A
In n150; temperature-sensitive mutant. Loss of nlp and flp neuropeptide production. Egg-laying defects characterized by egg retention and resistance to serotonin and imipramine-induced egg-laying. Restores sensitivity to nose touch in a glr-1 n2461 mutant background.
In n588; loss of nlp and flp neuropeptide production. Egg-laying defects characterized by egg retention and resistance to serotonin and imipramine-induced egg-laying. Coiling behavior.
In n589; temperature-sensitive mutant. Egg-laying defects characterized by egg retention and resistance to serotonin and imipramine-induced egg-laying. Coiling behavior. Increases spontaneous convulsions in an acr-2 n2420 mutant background.
In n729; loss of nlp and flp neuropeptide production. Egg-laying defects characterized by egg retention and resistance to serotonin and imipramine-induced egg-laying. Coiling behavior.
In nu349; egg-laying defects characterized by egg retention and resistance to serotonin and imipramine-induced egg-laying. Loss of localization to secretory vesicles in axons. Loss of FMRFamide-like peptide (FaRP) production in neurons. Resistance to acetylcholine esterase inhibitor aldicarb-induced paralysis. Insensitive to body touch but not to nose touch. Restores sensitivity to nose touch, high osmolarity and volatile repellents in a glr-1 n2461 or lin-10 n1508 mutant background.
Required for ubiquitination-mediated degradation
Uncharacterized mitochondrial carrier C16C10.1
Putative metalloproteinase inhibitor tag-225
Probable histone chaperone asf-1-like protein
Sodium-dependent high-affinity dicarboxylate transporter 2
Abolishes editing of clec-41 RNA, leads to a threefold reduction in expression of clec-41 mRNA in neural cells and impairs chemotaxis.
Double-stranded RNA-specific adenosine deaminase adr-2
Partial reduction in ced-3-mediated cleavage; when associated with E-182 and E-225.
Partial reduction in ced-3-mediated cleavage; when associated with E-182 and E-253.
Partial reduction in ced-3-mediated cleavage; when associated with E-225 and E-253.
Ral GTPase-activating protein subunit alpha/beta N-terminal
Vacuolar protein sorting-associated protein 54
Vacuolar protein sorting-associated protein 54 C-terminal
Sex determination and dosage compensation protein sdc-2
Dominant negative effect on function in transcription regulation and mesodermal cells fate specification. Delayed development. Impaired vulval and non-striated enteric muscles development.
Dominant negative effect on function in transcription regulation and mesodermal cells fate specification. Impaired vulval and non-striated enteric muscles development.
Dominant negative effect on function in transcription regulation and mesodermal cells fate specification. Impaired vulval muscles development.
No effect on vulval muscles development. Decreased brood size.
Uncharacterized peptidase C1-like protein F26E4.3
Putative carbonic anhydrase-like protein 2
Putative 6-pyruvoyl tetrahydrobiopterin synthase
Eukaryotic translation initiation factor 4E-4
Putative transcription elongation factor S-II
Putative pseudouridine synthase B0024.11
Probable loss of catalytic activity. Severe loss of bivalent chromosome formation in diakinetic oocytes.
Serine/threonine-protein phosphatase 4 catalytic subunit 1
Putative polypeptide N-acetylgalactosaminyltransferase 11
Phosphatidylcholine:ceramide cholinephosphotransferase 1
Lowers pKa of C-terminal Cys of first active site
Lowers pKa of C-terminal Cys of second active site
Pleckstrin homology domain-containing family D member 1
Abolishes phosphorylation by activated cmk-1.
Defects in associative long-term memory (LTM) formation.
In isoform a, isoform c, isoform d, isoform e and isoform g.
TM2 domain-containing protein Y66D12A.21
In cas36; production of an extra neuron from the Q lineage.
In n1126; defective hermaphrodite specific neurons (HSN).
In rp15; egg-laying defective and partial loss of expression of guanylyl cyclase gcy-33.
In sy628; decreased mating efficiency in males, as a result of deficiency in vulval location. Abolishes expression of ceh-26, lov-1, and dramatically reduces expression of pkd-2 and nlp-8, in the HOB neuron of homozygous males. Has a mild egg-laying defect.
In yad83; significantly enlarged AMsh glial cells.
Transcription initiation factor TFIID subunit 9
Helical; Signal-anchor for type III membrane protein
Putative serine/threonine-protein kinase ZK507.1
In hp731; decreases glutamate levels. Rescues the defective backwards locomotion or 'reversals' movements phenotype and decreases the increased glutamate levels in ubr-1 mutants.
Probable 5-hydroxyisourate hydrolase ZK697.8
Acidic leucine-rich nuclear phosphoprotein 32-related protein 2
CRAL-TRIO domain-containing protein F28H7.8
DNA-directed RNA polymerase II subunit rpb-9
In mj261; defective gene silencing mediated by a class of 21 nucleotide PIWI-interacting RNAs (piRNAs) that possess a uracil residue at the 5'-end (also called 21U-RNAs). Reduces the levels of mature piRNAs. Disrupts the inheritance of endogenous small RNA-induced gene silencing. Does not disrupt the inheritance of exogenous small RNA-induced gene silencing. Reduces binding of RNA polymerase II to DNA transposable elements from the DNA transposon families, Chapaev-2 and CEMUDR1. Disrupts the accumulation of inst-6 at piRNA genes and as a results decreases the number of 20 nucleotide long 3' nascent RNA cleavage fragments, which is an indicator of reduced Integrator complex activity.
ATP synthase F(0) complex subunit B2, mitochondrial
Ribosome biogenesis regulatory protein homolog
Probable sodium/potassium-transporting ATPase subunit beta-3
In allele hyl-2(gnv1); abrogates ceramide synthase activity and increases sensitivity to anoxia.
DNA-directed RNA polymerase subunit 2 hybrid-binding
Mediator of RNA polymerase II transcription subunit 7
Probable 2,4-dienoyl-CoA reductase decr-1.2 [(3E)-enoyl-CoA-producing]
Ubiquitin carboxyl-terminal hydrolase family 1 cysteine active-site
In ev554; uncoordinated movement defects whereby animals exhibit a kink in the normal wavelike motion during backwards movements. Axon guidance defects. The axons of DD and VD motorneurons do not reach the dorsal cord and instead extend along longitudinal paths at aberant axial levels. The axons of DA and DB motorneurons do not grow to their targets in the dorsal cord and instead extend along subdorsal longitudinal paths. Some motorneurons display excessive branching and disorganized trajectories. Does not have distal tip cell (DTC) migration defects and partially suppresses DTC migration defects when on an unc-130 mutant background. Similar frequency of DA and DB motor axon guidance defects on the unc-130 or unc-40 mutant backgrounds. Exhibit similar locomotion defects on a daf-4 mutant background. Enhances ray fusion defects on an efn-4 mutant background. Suppresses the anterior touch neuron axon guidance defects in an unc-5 over-expression mutant background.
In ev566; axon guidance defects, but at a lower frequency than in ev557 or ev554 mutants.
Probable histone deacetylase complex subunit SAP18
Abolishes phosphorylation. Loss of kinase activity; when associated with A-276.
Abolishes phosphorylation. Loss of kinase activity; when associated with F-278.
RNA polymerase II assembly factor Rtp1 C-terminal
Probable insulin-like peptide beta-type 1
No poly(ADP-ribose) glycohydrolase activity in vitro.
Poly (ADP-ribose) glycohydrolase (PARG) catalytic
Reduced poly(ADP-ribose) glycohydrolase activity in vitro.
In BN21; temperature-sensitive allele, which produces fertile progeny at permissive temperature (16 degrees Celsius) and sterile progeny at restrictive temperature (25 degrees Celsius), probably due to a mislocation into the cytoplasm.
In n486; egg-laying defects. Hermaphrodite-specific neurons (HSN) are absent or misplaced. Males do not produce progeny and often display gross abnormalities of tail morphology. Abnormal development of the male-specific genital sensilla (simple sense organs), known as rays. Defects in rectal epithelium, including, in males, absent or grossly abnormal spicules, gubernaculum, and proctodeal chamber and, in both males and hermaphrodites, defects in defecation. Insensitive to both light and heavy touch in the tail. Alters the fates of PLM touch neurons; substantially reduces expression of mec-3 and causes abnormal morphology. Defects in the posterior ventral neuroectoderm. Male somatic gonad is grossly abnormal and exhibits gene expression typical of adult hermaphrodite gonad, but there are no obvious gonadal defects in the hermaphrodite.
Nuclear hormone receptor family member nhr-136
Completely abolishes catalytic activity.
Glutathione-independent glyoxalase DJR-1.1
Nuclear hormone receptor family member nhr-13
Chromodomain-helicase-DNA-binding protein 3 homolog
Nuclear hormone receptor family member nhr-43
Tubulin polymerization-promoting protein homolog
Nuclear hormone receptor family member nhr-28
Fails to interact with siRNAs and localizes predominantly to the cytoplasm.
Nuclear transcription factor Y subunit nfya-2
Endoplasmic reticulum junction formation protein lunapark-1
Probable DNA polymerase epsilon subunit 2
Signal recognition particle 9 kDa protein
Disrupts location in axons. Loss of neurotransmission.
Impairs responsiveness to aldicarb, probably due to loss of kinase function.
Impairs translocation to the presynaptic membrane.
Impairs localization to the sensory compartment and the protein accumulates in vesicular structures in both amphid and phasmid ciliated sensory neurons.
In jhu431; ciliogenesis defects resulting in shorter cilia which lack distal segments with decreased levels of intraflagellar transports proteins osm-6, osm-5, che-11 and bbs-7 in cilia. Dendrite extension defects resulting in short phasmid dendrites and truncated amphid dendrites. Impairs localization to the sensory compartment in amphids and phasmids and the protein accumulates in glial cells.
Ubiquitin fusion degradation protein 1 homolog
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Gly-Pro-Asn (GPN)-loop; involved in dimer interface
Stabilizes the phosphate intermediate; shared with dimeric partner
Protection of telomeres protein 1 ssDNA-binding
In k172; reduced chondroitin levels. Impaired directed migration of gonadal distal tip cells and mild defect in vulva morphogenesis. Normal fertility.
In k175; reduced chondroitin levels. Impaired directed migration of gonadal distal tip cells and hermaphrodite specific neurons; mild defect in vulva morphogenesis. Normal fertility.
Glycylpeptide N-tetradecanoyltransferase C-terminal
Glycylpeptide N-tetradecanoyltransferase N-terminal
Probable glycylpeptide N-tetradecanoyltransferase
Probable isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
In ar523; suppresses the hermaphrodite gonadal development defect in a lin-12 mutant background.
In n1253; suppresses the hermaphrodite gonadal development and egg-laying defects in a lin-12 mutant background. Defects in larval stage-specific division of seam cells, leading to reiteration of the typical L2 divisions at the L3 stage; phenotype exacerbated in various mutant backgrounds, e.g. in combination with lin-46, or dcr-1 or let-7. Defect in the development and division of distal tip cells (DTCs), located at the tip of each gonad arm. Abnormal timing of expression of hunchback-like protein hbl-1 at the larval L3 stage.
Interaction with 5' end of substrate DNA
In h292; induces defects in entry into meiosis and abolishes interaction with gld-3.
In allele m122; forms many dauer larvae; when associated with A-105.
In allele m122; forms many dauer larvae; when associated with E-110.
In allele m138; forms many dauer larvae.
In allele p168; forms many dauer larvae.
In ky803; reduces expression of the G protein-coupled receptor (GPCR) srsx-3 in the AWC neuron.
Non-structural maintenance of chromosome element 4 C-terminal
Homeodomain-interacting protein kinase 1
Abolishes association with the phosphatase dep-1.
In ok804163; Impairs axon regeneration after injury.
In zh105; abolishes phosphorylation and enhances recruitment of tln-1 to the plasma membrane. Reduces the vulval lumen diameter and partially suppresses the Apf phenotype caused by hyperactive let-23 signaling in the double dep-1/lip-1 loss of function mutant. Increases vulval induction in the dep-1/lin-7 loss of function mutant.
Probable N-acetylgalactosaminyltransferase 6
AT-rich interactive domain-containing protein arid-1
In isoform a, isoform d, isoform f and isoform h.
Putative polypeptide N-acetylgalactosaminyltransferase 10
2 X 9 AA tandem repeats of [DE]-P-P-I-V-D-L-D-[ED]
3' overhang DNA-binding; via amide nitrogen
Pseudouridine synthase I TruA alpha/beta
RNA polymerase-associated protein RTF1 homolog
Important for DNA bending; intercalates between base pairs of target DNA
O-(5'-phospho-DNA)-tyrosine intermediate
Putative DNA topoisomerase 2, mitochondrial
Putative carbonic anhydrase-like protein 1
Abolished interaction with tax-6 in a yeast two-hybrid assay.
May be required for inhibiting calcineurin activity
Reduced body size as compared to wild-type.
Resistant to serotonin-induced egg laying, a behavior positively regulated by calcineurin activity, resulting in a reduced number of eggs laid in a tax-6 (jh107) gain-of-function mutant background.
High-energy light unresponsive protein 1
In xu10; loss of phototaxis behavior due to impaired photoreceptor activity.
In xu7; loss of phototaxis behavior. Loss of phototransduction in ASJ neurons. Slightly reduces lifespan under constant white light exposure as compared to wild-type.
In xu8; loss of phototaxis behavior due to impaired photoreceptor activity.
Nearly abolished photoreceptor activity.
Little poly(ADP-ribose) glycohydrolase activity in vitro.
Probable ATP synthase subunit g 2, mitochondrial
In vv103; 95% embryonic lethality and 35% of surviving progeny are male. Abolishes localization of zhp-3 to chromosomes throughout meiotic prophase and defective chiasmata formation during meiotic recombination. Impairs localization of rmh-1, msh-5 and cosa-1 at crossover sites resulting in defective crossovers and chromosome remodeling and segregation. Increased rad-51 positive nuclei at late pachytene indicative of increased double strand break formation. This is futher increased in a rad-54 RNAi-mediated knockdown background.
In vv138; 75% embryonic lethality and 35% of surviving progeny are male. Chromosome segregation defects due to impaired recruitment to the synaptonemal complex between homologous chromosome pairs during pachytene. Defective localization of the scaffolding protein rmh-1 and cosa-1 at crossover sites. Reduced number of crossovers that form are competent to initiate chromosome remodeling. 95% embryonic lethality, 43% of surviving progeny are male and abolished recruitment to chromosomes at any meiotic stage in a zhp-3 vv137 mutant background.
In vv96; 95% embryonic lethality and 35% of surviving progeny are male. Defective chiasmata formation during meiotic recombination. Reduces localization of zhp-3 to chromosomes during late pachytene. Impairs localization of rmh-1, msh-5 and cosa-1 at crossover sites resulting in defective crossovers and chromosome remodeling and segregation. No bivalent chromosomes are formed at diakinesis in a rmh-1 jf92 mutant background.
In ns169; reduces expression of ver-1 in amphid sheath glia.
In ns178 and ns171; defective amphid glia remodeling. Reduces expression of ver-1 in amphid sheath glia.
Diffuse cytosolic localization in 500-cell embryos with no punctate pattern of distribution which is in contrast to wild-type.
Does not rescue the degradation defect in the lgg-2 bp556 mutant.
Impairs tethering between adjacent membranes.
In bp556; defective degradation of protein aggregates during embryogenesis and early larval stages with an accumulation of sqst-1-containing aggregates in embryos and up until the L1 stage of larval development.
Phosphatidylethanolamine amidated glycine
Phosphatidylserine amidated glycine; alternate
In os26; impairs asymmetric division of T-cells.
Mediator of RNA polymerase II transcription subunit 12
Vacuolar protein sorting-associated protein 52 homolog
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Probable inactive acireductone dioxygenase 1
May disrupt ATP binding. Severe defect in apoptotic cell corpse clearance in gonads.
Uncharacterized protein F13E9.13, mitochondrial
Transmembrane protein adipocyte-associated 1 homolog
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase sqv-8
In n2825; embryos are arrested at the bean/comma or 2/3-fold embryonic stages. Pharyngeal isthmus is shorter and thicker.
In n2843; embryos are predominantly arrested at the bean/comma embryonic stage.
In n2847; embryos are predominantly arrested at the bean/comma embryonic stage.
In n2851; embryos are predominantly arrested at the bean/comma embryonic stage.
GDP-fucose protein O-fucosyltransferase 1
In me42; results in elevated levels of embryonic lethality, increased frequency of male progeny, chromosome segregation defects, lack of chiasmata and impaired homologous chromosome pairing.
In dh1127; reduces brood size, there is a developmental delay in reaching adulthood and results in a shorter body size. Does not affect pharyngeal pumping rate. Resistant to heat and oxidative stress. Increased sensitivity to pathogenic bacteria such as S.aureus, E.faecalis and P.aeruginosa at both 20 and 25 degrees Celsius. Splicing defects of genes such as prg-2, gyg-1 and tos-1 upon infection by S.aureus. Reduces expression of nlp-34, M01G12.9 and cyp-37B1 following S.aureus infection. Increases expression of lys-3, irg-2, irg-1 and fmo-2 under non-infected conditions.
Spo11/DNA topoisomerase VI subunit A N-terminal
Interferon regulatory factor 2-binding protein 1 & 2 zinc finger
Does not affect the number of eggs laid and male progeny developed; increases embryonic and larval lethality. Causes elevated chromosome movement in early prophase I.
Does not affect the number of eggs laid and male progeny developed; increases embryonic and larval lethality. Does not affect chromosome movement speed in early prophase I.
General receptor for phosphoinositides 1-associated scaffold protein 1 homolog
Proton myo-inositol cotransporter hmit-1.1
Restriction endonuclease homology domain
Uncharacterized membrane protein F35D11.3
Polypeptide N-acetylgalactosaminyltransferase 5
Abolishes localization to the periciliary membrane compartment in AWB sensory neurons; when associated with A-250.
Abolishes localization to the periciliary membrane compartment in AWB sensory neurons; when associated with A-252.
Required for localization to cilia in AWB sensory neurons
ATP-dependent (S)-NAD(P)H-hydrate dehydratase
In os13; temperature-sensitive hypomorphic mutation with weak embryonic lethality which disrupts asymmetric division of T blast cells resulting in a phasmid socket absent phenotype in addition to egg-laying defectiveness, protrusive vulva and other vulval developmental defects and which exacerbates the reduced vulval induction phenotype of let-23(sy1) mutants; when associated with I-673.
In os13; temperature-sensitive hypomorphic mutation with weak embryonic lethality which disrupts asymmetric division of T blast cells resulting in a phasmid socket absent phenotype in addition to egg-laying defectivness, protrusive vulva and other vulval developmental defects and which exacerbates the reduced vulval induction phenotype of let-23(sy1) mutants; when associated with F-697.
In sy598; enhances the multivulval phenotype of let-23(sa62) mutants.
Modest effect on worm viability. Significantly enhances lethality of pbrm-1 RNAi knock-down.
No obvious defects in viability, growth, development or brood size in vivo. Significantly enhances lethality of pbrm-1 RNAi knock-down. Enhances brood size reduction phenotype in a pbrm-1 mutant background.
SWI/SNF chromatin remodeling complex core catalytic subunit swsn-4
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit stt-3
Interacts with target acceptor peptide in protein substrate
N-linked (GlcNAc...) (high mannose) asparagine
Lacks DEP domain, but unexpectedly, still localizes to centrosomes, to the cell cortex, to the cleavage furrow, and to the nuclei of Q, Q.a and Q.p.
Lacks putative MAPK docking sites and intervening sequence; localizes to nuclei and centrosomes of Q, Q.p and Q.a neuroblasts but fails to localize to the cortex, or furrow, of these cells when they divide.
Required for localization to cell cortex and cleavage furrow
Nuclear hormone receptor family member nhr-134
Probable G-protein coupled receptor npr-29
In dg047; reduced survival in response to infection by E.faecalis, C.albicans, S.aureus and C.diphtheriae. Slightly reduced survival in response to infection by E.coli. Loss of cuticle integrity.
In gk252521; reduced survival in response to infection by E.faecalis, C.albicans, S.aureus and C.diphtheriae. Slightly reduced survival in response to infection by E.coli. Loss of cuticle integrity.
In syb482; reduced survival in response to infection by E.faecalis.
In ns235 and ns252; abolishes expression of VEGF-related protein ver-1 in AMsh glia when cultured at 25 degrees Celsius.
In ns259; homozygous sterile. Significantly reduced expression of VEGF-related protein ver-1 in AMsh glia when cultured at 25 degrees Celsius.
In ns260; homozygous lethal. Significantly reduced expression of VEGF-related protein ver-1 in AMsh glia when cultured at 25 degrees Celsius.
In oy26; defects in morphology of the AFD neuron sensory endings. Cryophilic thermotaxis behavior when placed on a thermal gradient - preference for <20 degrees Celsius. Significantly reduced expression of VEGF-related protein ver-1 in AMsh glia in the dauer larval stage.
Differentially expressed in FDCP 8 homolog
Acetylcholine receptor subunit alpha-type acr-15
Eukaryotic glycogen debranching enzyme N-terminal
Glycogen debranching enzyme glucanotransferase
Putative UDP-glucuronosyltransferase ugt-50
Uncharacterized lin-8 family protein lido-16
Probable electron transfer flavoprotein subunit alpha, mitochondrial
Trafficking protein particle complex subunit 11
No effect on the interaction with kgb-1; when associated with N-581.
Partially abolishes the interaction with kgb-1; when associated with N-581.
Partially abolishes the interaction with kgb-1; when associated with W-588. No effect on the interaction with kgb-1; when associated with W-589.
Guanine nucleotide-binding protein G(o) subunit alpha
In sa734; abnormal distribution of male-derived sperm in the hermaphrodite uterus following mating, with sperm accumulating at the spermathecal-uterine valve 1 hour following mating. Defective dopamine signaling, with defective locomotion and irregular activation of the crh-1/CREB1 transcription factor in cholinergic SIA neurons in the presence of food.
Probably constitutively active. Inhibition of axon regeneration.
Glutamate receptor ionotropic, kainate glr-3
In xu261; abolishes cold receptor function. Decreases signal transduction during cold thermoreception signaling in intestine and ASER neuron.
ATP-grasp fold succinyl-CoA synthetase-type
In e151 and n3412; drastically reduces expression of acetylcholine receptor genes acr-5 and acr-16. In a bnc-1 mutant background, abolishes expression of the BMP-like protein unc-129 in DA and DB motor neurons (MNs); furthermore, ectopic expression of unc-129 in VA and VBMNs is also lost. In a mab-9 mutant background, ectopic expression of Degenerin del-1 gene in DA and DBMNs is abolished. Increased number of VC and VC-like neurons in the ventral nerve cords of adult hermaphrodites.
Eukaryotic translation initiation factor 5A-1
Translation elongation factor IF5A C-terminal
In h769; sex myoblasts (SM) are transformed into body-wall muscles (BWM), and coelomocytes transformed into their ventral counterparts, the SM progenitors, which subsequently give rise to two BWMs. Expression of sem-2 is abolished in the M mesoblast-derived lineage.
In ku200; disrupts function in the vulva and mesoderm. Vulval precursor cells (VPC), P5.p and P7.p, adopt abnormal cell fates. Expression of lin-39 in vulval cells reduced drastically.
In n1378; severe pleiotropic abnormalities, including defects in the development of the sex myoblasts, a mesodermal cell type, and of two classes of neurons, the DVB and AVLGABAergic motor neurons. Absence of sex myoblasts in 98% of L3 larvae, defects in differentiation of hermaphrodite-specific neurons (HSN), and M mesoblast-derived coelomocytes (CC) absent in 30% of L3 larvae. Sex myoblasts (SM) are transformed into body-wall muscles (BWM), and coelomocytes transformed into their ventral counterparts, the SM progenitors, which subsequently give rise to two BWMs. Distended intestine in only 2% of adults. Vulval precursor cells (VPC), P5.p and P7.p, adopt abnormal cell fates. Reduced touch-response. Reduced gst-4 expression.
In n2654; severe pleiotropic abnormalities, including defects in the development of the sex myoblasts, a mesodermal cell type, and of two classes of neurons, the DVB and AVLGABAergic motor neurons. Absence of sex myoblasts in 7% of L3 larvae, defects in differentiation of hermaphrodite-specific neurons (HSN), and M mesoblast-derived coelomocytes (CC) absent in 2% of L3 larvae. Distended intestine in 84% of adults. Vulval precursor cells (VPC), P5.p and P7.p, appear to adopt normal cell fates. Reduced touch-response.
Vacuolar protein sorting-associated protein 16 homolog
Putative succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
In nj40; induces defects in thermotaxis.
Loss of tra-2 (isoform a) cleavage. Prevents female sexual development.
Reduces susceptibility to B.thuringiensis endotoxin Cry6Aa.
Ubiquitin-fold modifier-conjugating enzyme 1
2 X 10 AA repeats of N-[ED]-E-L-P-E-T-E-P-E
Dihydropyrimidine dehydrogenase [NADP(+)]
Damage-control phosphatase ARMT1-like metal-binding
In hmn51; causes URX dendrite overgrowth.
In hmn5; overgrowth of URX dendrite, extending up to 150% of its normal length, making a U-turn at the nose and looping back in the direction of the cell body rather than ceasing growth at the tip of the nose, with increasing dendrite outgrowth from larval stages to adult animals. Rarely, starved animals exhibit ectopic branching of the URX dendrites.
In vt32; loss of function allele that displays reserpine-sensitive swimming-induced paralysis phenotype.
Probable insulin-like peptide beta-type 5
Probable loss of processing by protease bli-4. Severe reduction in Ca(2+) signal in AWC neuron and in chemotaxis in response to high salt concentrations.
Sodium- and chloride-dependent betaine transporter
FYVE, RhoGEF and PH domain-containing protein tag-77
Probable insulin-like peptide gamma-type 1
Thioredoxin-related transmembrane protein 2 homolog
Probable [pyruvate dehydrogenase (acetyl-transferring)] kinase, mitochondrial
Acetylcholine receptor-like protein cup-4
In ar494; coelomocyte endocytosis defect.
Pelle-like serine/threonine-protein kinase pik-1
In allele qa5001; increased sensitivity to oxygen.
Probable cytosolic Fe-S cluster assembly factor oxy-4
May be required for autoinhibition within the klp-11/klp-20 heterodimer
In ta208; embryonic lethality in some animals and reduces brood size. Some animals have abnormal germ-line development and gonad morphology. In severely affected animals, either gonads fail to develop or small traces of gonads are located around the vulva. Mild defecation defects. Disrupts the localization of rab-5, rab-7 and rab-27. Reduces the number of body bends in response to exogenous melatonin. Mild resistance to the acetylcholinesterase inhibitor aldicarb. However, induces paralysis in response to aldicarb in some animals.
Rab proteins geranylgeranyltransferase component A 1
Mediator of RNA polymerase II transcription subunit 17
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase
BTB and MATH domain-containing protein 47
Putative thiosulfate sulfurtransferase mpst-1
Nuclear envelope integral membrane protein
2-oxoglutarate dehydrogenase, mitochondrial
In ot16; midline crossover defects of PVQL and PVQR axons.
Nuclear hormone receptor family member nhr-115
Vacuolar protein sorting-associated protein 51 homolog
Zinc finger CCCH domain-containing protein 15 homolog
Guanine nucleotide-binding protein alpha-4 subunit
In eb29; reduces self-fertility at 25 degrees Celsius which is almost abolished at 18 degrees Celsius.
In eb30; reduces self-fertility at 25 degrees Celsius which is almost abolished at 18 degrees Celsius.
In hc110; reduces self-fertility at 25 degrees Celsius which is almost abolished at 18 degrees Celsius. Spermatogenesis arrest at the spermatocyte stage. Spermatocytes have defective fibrous body-membranous organelle complexes (FBMOs) causing vacuolation of the cytoplasm. The few produced spermatids exhibit an incomplete penetrance for tubulin mis-segregation during the second meiotic division.
In hc93; reduces self-fertility at 25 degrees Celsius which is almost abolished at 18 degrees Celsius. Suppresses neurodegeneration of touch-receptor neurons in a mec-4 (u231) mutant background.
Cadherin EGF LAG seven-pass G-type receptor fmi-1
In gm188; synaptic defects. HSN axon guidance defects. Does not display PVP axon guidance defects.
In ju43; synaptic defects caused by disrupted neuromuscular junction formation whereby aberrantly shaped and enlarged snb-1-positive synaptic vesicles abnormally cluster at GABAergic and cholinergic neuromuscular junctions. Defective snb-1-positive vesicle clustering is more severe at GABAergic neuromuscular junctions. PVP and HSN axon guidance defects. Does not display PVQ axon guidance defects.
In ju58; synaptic defects caused by disrupted neuromuscular junction formation whereby aberrantly shaped and enlarged snb-1-positive synaptic vesicles abnormally cluster at dorsal D-type and ventral D-type GABAergic and cholinergic neuromuscular junctions. Defective snb-1-positive vesicle clustering is more severe at GABAergic neuromuscular junctions. Incomplete axon extension of dorsal D-type GABAergic motorneurons. GABAergic motorneurons exit the ventral cord on the incorrect side and have defects in axon extension.
In rh308; synaptic defects. Axon guidance defects. In 81% of animals, the PVPR axon irregularly crosses the ventral midline and joins the right axon track. PVQ axons irregularly cross the ventral midline multiple times and often stop prematurely before reaching the nerve ring. In the majority of animals, HSN axon guidance is disrupted along the ventral nerve cord (VNC) axon tracks where HSN axons circle the vulva and HSN axons often project to the posterior instead of the anterior side after leaving the vulva region. HSN axons also often cross the ventral midline outside the vulva region and the HSN axons that extended along the VNC often stop before reaching the nerve ring. Dorsal D-type and ventral D-type GABAergic motorneurons erroneously guided axons into the left VNC axon track. Guidance of the commissures of the dorsal D-type and ventral D-type GABAergic and the cholinergic DA/DB motoneurons were partially disrupted. Irregular midline crossing of command interneuron axons. Defects in neurite positioning along the anterior posterior axis with ventral D-type GABAergic neurons displaying posterior neurites, instead of anterior neurites, which results in ventrodorsal commissures positioned on the posterior side of their cell body. Defective guidance of the AIY axon into the nerve ring, which impairs nerve ring assembly.
In sa310; suppression of constitutive dauer formation phenotype on a daf-8; daf-14 double mutant background.
In mg285; causes precocious hypodermal seam cell fusion and adult alae production in larval stages L3 and L4.
In sa62; multivulva phenotype. RNAi-mediated knockdown of let-765 suppresses the multivulva phenotype. Multivulva phenotype enhanced in a swsn-4 (sy598) mutant background.
In sy10; severe larval lethality, lack of vulva induction, infertile and lack of male spicule formation. Impaired ovulation characterized by a delay in the initiation of ovulatory sheath cell contractions and prolonged ovulatory contractions.
In sy16; larval lethality and lack of vulva induction. Viability, vulva induction but not fertility are restored in a let-60 (n1046gf) mutant background. Viability is not restored in a lfe-1 (sy290) or lfe-2 (sy326) mutant background. Fertility is restored in a let-60 (n1046gf) and lfe-1 (sy290) mutant background.
In sy1; reduces vulval induction. The vulval induction incidence is further reduced in a chp-1 tm2277 mutant background and in swsn-4 (os13) and swsn-1 (os22) mutant backgrounds.
Echinoderm microtubule-associated protein-like elp-1
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Glutaminyl-tRNA synthetase class Ib non-specific RNA-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
MOG interacting and ectopic P-granules protein 1
In bx37; disrupts tail tip morphogenesis resulting in retention of the pointed larval tail tip in 33% of adult males (also known as the Lep phenotype).
In bx42; disrupts tail tip morphogenesis resulting in retention of the pointed larval tail tip in 33% of adult males (also known as the Lep phenotype). Defective sexual maturation of AIM, CEM and AWA neurons in males.
C-type lectin domain-containing protein 91
Symmetric dimethylarginine; by PRMT5; in vitro
In tm2656; no resistance to levamisole or nicotine-induced paralysis. No defect in levamisole or nicotine-induced postsynaptic currents in muscles.
Nuclear hormone receptor family member nhr-76
Mitochondrial-processing peptidase subunit beta
Required for the specific determination of the substrate cleavage site
Probable DNA-directed RNA polymerases I and III subunit RPAC2
Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
Phosphoethanolamine N-methyltransferase 1
In qd182; reduces tyrosine aminotransferase activity by 90% and results in increased tyrosine levels. Delays development, increases embryonic lethality and results in germline defects in response to increased levels of meta-tyrosine, but not in response to increased levels of tyrosine (para-tyrosine). Delays the development to reproductive adults in response to oxidative stress induced by the superoxide paraquat, with only 4.9% developing into fertile adults. Increases dauer formation in an eak-4 mg348 mutant background. Reduces dauer formation in an eak-4 mg348 and aak-2 gt33 mutant background.
Increases dauer formation in an eak-4 mg348 mutant background. Suppresses fah-1 RNAi-mediated toxicity.
Vacuolar protein sorting-associated protein 11 homolog
Anaphase-promoting complex subunit 4-like WD40
Vacuolar protein sorting-associated protein 8 central
Loss of palmitoylation and myristoylation resulting in loss of association with the cell membrane. Severe loss of axonal, dendritic and cilia localization in AWC, AWB and BAG neurons.
Loss of palmitoylation resulting in loss of association with the cell membrane. Moderate loss of axonal, dendritic and cilia localization in AWC, AWB and BAG neurons.
Serine/threonine-protein phosphatase with EF-hands pef-1
GDP-fucose protein O-fucosyltransferase 2
Abolishes phosphorylation and causes a decrease in the number of germline progenitors.
Phosphomimetic mutant which inhibits axon regrowth following axotomy of PLM neurons.
Probable loss of kinase activity. Enhanced axonal regrowth following axotomy of PLM neurons.
Glucose-methanol-choline oxidoreductase N-terminal
BTB and MATH domain-containing protein 38
DNA mismatch repair proteins mutS family
Putative peroxisomal biogenesis factor 19
Probable ATP-dependent RNA helicase DHX35 homolog
Minichromosome loss protein Mcl1 middle region
F-box/WD repeat-containing protein mec-15
In hd1; interneuron axon guidance defects in the ventral nerve cord (VNC). Reduced expression of tyrosine monooxygenase cat-2 in dopaminergic neurons.
In ot417; defects in dopaminergic neuron fate. Reduced expression of tyrosine monooxygenase cat-2 in dopaminergic neurons.
In rh300; interneuron axon guidance defects in the ventral nerve cord (VNC). Partial differentiation defects of the VNC pioneer neuron, AVG. Abolishes expression of tyrosine monooxygenase cat-2 in the male-specific ray neurons and other dopaminergic neurons.
Sterility along with defects in ovulation, slow growth and stunted gonad development; pBoc arrhythmia and fluid accumulation in the pseudocoel; when associated with A-55.
Sterility along with defects in ovulation, slow growth and stunted gonad development; pBoc arrhythmia and fluid accumulation in the pseudocoel; when associated with A-57.
Alpha/beta hydrolase domain-containing protein aho-3
Impaired starvation-induced thermotaxis plasticity.
No defect in starvation-induced thermotaxis plasticity. Impaired starvation-induced thermotaxis plasticity and loss of localization to neuronal sensory endings, when associated with S-35; S-38 and S-39.
No defect in starvation-induced thermotaxis plasticity. Impaired starvation-induced thermotaxis plasticity, when associated with S-34; S-35 and S-38 or S-35; S-36 and S-38. Loss of localization to neuronal sensory endings, when associated with S-34; S-35 and S-38.
No defect in starvation-induced thermotaxis plasticity. Impaired starvation-induced thermotaxis plasticity, when associated with S-34; S-35 and S-39 or S-35; S-36 and S-39. Loss of localization to neuronal sensory endings, when associated with S-34; S-35 and S-39.
No defect in starvation-induced thermotaxis plasticity. Impaired starvation-induced thermotaxis plasticity, when associated with S-34; S-38 and S-39 or S-36; S-38 and S-39. Loss of localization to neuronal sensory endings, when associated with S-34; S-38 and S-39.
No defect in starvation-induced thermotaxis plasticity. Impaired starvation-induced thermotaxis plasticity, when associated with S-35; S-38 and S-39.
In sy702; causes decrease in lin-39 expression in L3 larvae.
Zinc finger BED domain-containing protein 3
V-type proton ATPase 21 kDa proteolipid subunit c""" /id="PRO_0000454080
Decreased inhibition of forskolin-stimulated cAMP formation in response to dopamine but not in response to 5-HT.
In zu364; embryonic lethal with embryos failing to elongate and displaying a humpback phenotype in which embryos contain a dorsal hump. Localizes exclusively to the cytoplasm rather than adherens junctions.
Phospho-null mutation. No obvious phenotype.
Phosphomimetic mutation. Initially localizes to adherens junctions, but the distribution at the junctions becomes punctate during late embryonic elongation with excursions forming orthogonal to the junctions between lateral seam cells and the dorsal and ventral neighboring cells. Defects in F-actin filament organization that include wavy and irregularly spaced filaments and the occasional aggregation of multiple bundles at single points along the adherens junction.
In gk769190; defects in sarcomere and mitochondrial organization. No motility defects.
Sorbin and SH3 domain-containing protein 1 homolog
In sa54; suppresses the phenotype of a lin-12 mutation that induces constitutive activity upon lin-12.
Acetylcholine receptor subunit alpha-type unc-63
BTB and MATH domain-containing protein 15
Putative zinc finger matrin-type protein snu-23
Abhydrolase domain-containing protein abhd-5.1
Gamma-aminobutyric acid receptor subunit beta
In gu85; fails to bind DNA. Defects in the morphology of vulval structures, resulting in protruding vulva and occasional bivulva phenotypes in adults. Reduced brood size. Embryonic and L1 larval arrest and morphological defects.
Specificity protein transcription factor 3
Nucleolus and neural progenitor protein-like N-terminal
Nuclear hormone receptor family member nhr-125
ER membrane protein complex subunit 7 homolog
Impairs its biological function; when associated with Q-203.
Impairs its biological function; when associated with Q-571.
Transmembrane cell adhesion receptor mua-3
Rab3 GTPase-activating protein catalytic subunit
Elongation of long chain fatty acids protein 2
26S proteasome non-ATPase regulatory subunit 1
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Doublesex- and mab-3-related transcription factor dmd-4
In ot990; results in defective pruning on the PHB to AVG synaptic connection in hermaphrodites. May affect binding to ubiquitin.
Transcription initiation factor TFIID subunit 1
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Probable mitochondrial tRNA-specific 2-thiouridylase 1
In R367; temperature sensitive. Adults are paralyzed. Induces disorganized body wall muscle. Disrupted integrin attachment complexes in muscle, which results in degradation of muscle proteins in the cytosol, myofibrillar defects and disruption of sarcomere organization. Mitochondrial fragmentation.
Cytoplasmic FMR1-interacting protein homolog
In allele nrg-6(SA526); fluoxetine induced nose contraction, pale eggs, yolk accumulation and embryonic lethality.
Cytochrome b-c1 complex subunit 1, mitochondrial
In gk-773708; development defects in stereotyped left/right axon guidance choices within the GABAergic motor neuron circuit.
Mitochondrial sodium/calcium exchanger protein
Major facilitator superfamily associated
In sm151; weak loss of function mutation, does not bind to sel-10 protein.
U3 small nucleolar RNA-associated protein 13 C-terminal
In mg543; defective expression of the proteasomal subunit rpt-3 in a pbs-5 (proteasomal subunit) mutant background.
In mg544; defective expression of the proteasomal subunit rpt-3 in a pbs-5 (proteasomal subunit) mutant background.
In mg555; defective expression of the proteasomal subunit rpt-3 in a pbs-5 (proteasomal subunit) mutant background.
In mg557; defective expression of the proteasomal subunit rpt-3 in a pbs-5 (proteasomal subunit) mutant background.
In mg563; defective expression of the proteasomal subunit rpt-3 in a pbs-5 (proteasomal subunit) mutant background.
In mg572; fails to cleave isoform a of the transcription factor skn-1 (skn-1a). Defective expression of the proteasomal subunit rpt-3 in a pbs-5 (proteasomal subunit) mutant background.
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1
Nuclear hormone receptor family member nhr-86
Abolishes ubiquitin ligation activity; prevents ubiquitination of Kruppel-like factor klf-1.
Polypeptide N-acetylgalactosaminyltransferase 3
Biogenesis of lysosome-related organelles complex 1 subunit 2
Probable aconitate hydratase, mitochondrial
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Ribosomal RNA-processing protein 12-like conserved
Probable RING finger protein 207 homolog
PAC-1 interacting and coiled-coil domain-containing protein 1
Does not rescue the defects in paternal mitochondrial clearance in the ikke-1 gk1264 mutant.
Impairs binding to lgg-1. Does not affect accumulation on paternal organelles in embryos, but lgg-1 is not recruited and paternal mitochondria are retained and are not cleared.
Reduces phosphorylation. Localizes to paternal organelles in 1-cell stage embryos, but does not completely rescue the defects and clearance of paternal organelles in the allo-1 tm4756 mutant.
Nuclear hormone receptor family member nhr-47
In gm321; abnormal distal tip cell migration after the first turn during gonad morphogenesis.
In k140; abnormal posterior, and to a lesser extent anterior, distal tip cell (DTC) migration after the first turn during gonad morphogenesis. Reduced localization of fibulin fbl-1 to the gonad basement membrane. Anterior DTC migration is more severely affected in a mig-17 (k174) or nid-1 (cg119) mutant background. Normal DTC migration is restored in a fib-1 (k201 or k206) or let-2 (k196) mutant background.
In tk35; abnormal distal tip cell migration after the first turn during gonad morphogenesis.
In ot720; abolishes unc-129 expression in DA and DB motor neurons. Causes ectopic expression of transcription factor bnc-1 in DA and DB motor neurons.
In e1393; constitutive dauer formation at 25 degrees Celsius.
In m121; constitutive dauer formation at 25 degrees Celsius.
In m85; constitutive dauer formation at 25 degrees Celsius. In the ovaries, the germ line mitotic zone at the distal end is significantly extended, with an increased number of metaphase and telophase cells. Reduces interaction between daf-3 and daf-14. On an nhr-69 mutant background, has defects in dauer entry and exit, and impaired Insulin/IGF-1-like signaling (IIS). Reduces binding of nhr-69 to the promoter, and up-regulates expression, of the potassium channel gene exp-2.
In sa234; constitutive dauer formation at 25 degrees Celsius.
In sa343; constitutive dauer formation at 25 degrees Celsius.
Mediator of RNA polymerase II transcription subunit 31
Transient-receptor-potential-like protein
Facilitated glucose transporter protein 1
Neuronal acetylcholine receptor subunit eat-2
Protein phosphatase 1 regulatory subunit 21 N-terminal
G-protein coupled receptors family 2 profile 2
Nonsense-mediated mRNA decay factor SMG8
In vv44; Loss of proper chromosome pairing and early initiation of synapsis resulting in a loss of chiasma formation and chromosome segregation during oocyte meiosis I. Severe embryonic lethality and the few surviving adults are mostly male. Loss of sun-1 and zyg-12 patch formation along the nuclear envelope and of sun-1 phosphorylation at 'Thr-12' during early prophase.
In 2141; reduces number of germline progenitors at the semi-permissive temperature (20 degrees Celsius). All germ cells differentiate at the restrictive temperature (25 degrees Celsius). Defects in maintenance of the developmentally arrested larval state known as dauer, in response to pheromone; similar phenotype in absence of pheromone, when on a daf-7 mutant background. Increases longevity and reduces nucleoli size (20 degrees Celsius). Increased longevity and reduced nucleoli size phenotypes are suppressed in an ncl-1 mutant background (20 degrees Celsius). Autophagy levels are increased due the up-regulation of transcription factor pha-4 and its autophagy-related target genes. Increases lipase activity. The increase in autophagy and lipase activity is partially suppressed in a lipl-4 RNAi-mediated background.
In 2144; moderate increase in aak-2 phosphorylation.
In ar202; formation of proximal germ cell-derived tumors.
In q224; at the restrictive temperature of 25 degrees Celsius, loss of interaction of lag-3 with lip-1 promoter. Loss of mpk-1 isoform b expression probably due to a lack of germline.
Peptide (Met-Gly) (interchain with G-Cter in ubiquitin)
Structure-specific endonuclease subunit SLX1 homolog
Suppresses fah-1 RNAi-mediated toxicity.
Acetylcholine-gated chloride channel subunit acc-2
Decreased dimethylation of 'Lys-36' of histone H3.
Histone-lysine N-methyltransferase set-18
Eukaryotic translation initiation factor 3 subunit B
Rad21/Rec8-like protein C-terminal eukaryotic
Disruption of Y-to-PDA transdifferentiation.
Disruption of Y-to-PDA transdifferentiation; when associated with S-1001; S-1025 and S-1028.
Disruption of Y-to-PDA transdifferentiation; when associated with S-998; S-1001 and S-1025.
Disruption of Y-to-PDA transdifferentiation; when associated with S-998; S-1001 and S-1028.
Disruption of Y-to-PDA transdifferentiation; when associated with S-998; S-1025 and S-1028.
In fp11; loss of demethylase activity and disruption of Y-to-PDA transdifferentiation.
In fp25; loss of demethylase activity and disruption of Y-to-PDA transdifferentiation.
Required for binding of unc-3 and for function in Y-to-PDA transdifferentiation
Adenylyltransferase and sulfurtransferase MOCS3
Cysteine persulfide intermediate; for sulfurtransferase activity
Glycyl thioester intermediate; for adenylyltransferase activity
Mediator of RNA polymerase II transcription subunit 22
Chromatin target of PRMT1 protein C-terminal
Putative UDP-glucuronosyltransferase ugt-58
Probable cation-transporting ATPase W08D2.5
Cytoplasmic polyadenylation element-binding protein 1
Methylmalonic aciduria type A homolog, mitochondrial
Probable glutathione transferase omega-2
Leucine-rich repeat-containing protein egg-6
Probable vesicular glutamate transporter eat-4
C-type lectin domain-containing protein 141
NADH-rubredoxin oxidoreductase C-terminal
Nuclear hormone receptor family member nhr-130
Molybdenum cofactor biosynthesis protein-like
Phosphoadenosine phosphosulphate reductase
Abnormal endosomal localization upon hypoxia treatment; when associated with A-16; A-27; A-29; A-156; A-202; A-359; A-425; A-445 and A-449.
Abnormal endosomal localization upon hypoxia treatment; when associated with A-16; A-27; A-29; A-88; A-156; A-202; A-359; A-425 and A-445.
Abnormal endosomal localization upon hypoxia treatment; when associated with A-16; A-27; A-29; A-88; A-156; A-202; A-359; A-425 and A-449.
Abnormal endosomal localization upon hypoxia treatment; when associated with A-16; A-27; A-29; A-88; A-156; A-202; A-359; A-445 and A-449.
Abnormal endosomal localization upon hypoxia treatment; when associated with A-16; A-27; A-29; A-88; A-156; A-202; A-425; A-445 and A-449.
Abnormal endosomal localization upon hypoxia treatment; when associated with A-16; A-27; A-29; A-88; A-156; A-359; A-425; A-445 and A-449.
Abnormal endosomal localization upon hypoxia treatment; when associated with A-16; A-27; A-29; A-88; A-202; A-359; A-425; A-445 and A-449.
Abnormal endosomal localization upon hypoxia treatment; when associated with A-16; A-27; A-88; A-156; A-202; A-359; A-425; A-445 and A-449.
Abnormal endosomal localization upon hypoxia treatment; when associated with A-16; A-29; A-88; A-156; A-202; A-359; A-425; A-445 and A-449.
Abnormal endosomal localization upon hypoxia treatment; when associated with A-27; A-29; A-88; A-156; A-202; A-359; A-425; A-445 and A-449.
Loss of cdk-5-mediated regulation of synaptic expression; when associated with A-15; A-26; A28; A-155; A-201; A-358; A-424; A-444 and A-448.
Loss of cdk-5-mediated regulation of synaptic localization; when associated with A-15; A-26; A28; A-87; A-155; A-201; A-358; A-424 and A-444.
Loss of cdk-5-mediated regulation of synaptic localization; when associated with A-15; A-26; A28; A-87; A-155; A-201; A-358; A-424 and A-448.
Loss of cdk-5-mediated regulation of synaptic localization; when associated with A-15; A-26; A28; A-87; A-155; A-201; A-358; A-444 and A-448.
Loss of cdk-5-mediated regulation of synaptic localization; when associated with A-15; A-26; A28; A-87; A-155; A-201; A-424; A-444 and A-448.
Loss of cdk-5-mediated regulation of synaptic localization; when associated with A-15; A-26; A28; A-87; A-155; A-358; A-424; A-444 and A-448.
Loss of cdk-5-mediated regulation of synaptic localization; when associated with A-15; A-26; A28; A-87; A-201; A-358; A-424; A-444 and A-448.
Loss of cdk-5-mediated regulation of synaptic localization; when associated with A-15; A26; A-87; A-155; A-201; A-358; A-424; A-444 and A-448.
Loss of cdk-5-mediated regulation of synaptic localization; when associated with A-15; A28; A-87; A-155; A-201; A-358; A-424; A-444 and A-448.
Loss of cdk-5-mediated regulation of synaptic localization; when associated with A-26; A-28; A-87; A-155; A-201; A-358; A-424; A-444 and A-448.
Critical for interaction with target DNA
Nascent polypeptide-associated complex subunit alpha
Acetylcholine receptor subunit beta-type unc-29
Phytanoyl-CoA hydroxylase-interacting protein-like C-terminal
In ax143 and or224; results in sterility.
In zu464; defective anterior pharynx. Defects in seam cell organization.
In zu466; defective anterior pharynx. Defects in seam cell organization.
Probable delta-1-pyrroline-5-carboxylate synthase
In ky634; absence of chemotaxis to the odorant 2-butanone, which is sensed by AWC(ON), but normal response to the odorant 2,3-pentanedione, which is sensed by AWC(OFF), suggesting the absence of functional AWC(ON) neurons.
Tetratricopeptide repeat protein 21 homolog
Abolishes ligase activity and does not activate the unfolded protein response pathway in response to endoplasmic reticulum stress induced by tunicamycin.
Abolishes ligase activity and is unable to provide a neuroprotective role in degenerating dopamine neurons.
Probable 4-aminobutyrate aminotransferase, mitochondrial
Large ribosomal subunit protein uL15/eL18
Abolishes cleavage of the C-terminal domain. Does not impair localization and localizes to the apical membrane of the vulva and the excretory duct lumen in embryos, as wild-type. Partially rescues the excretory duct defects in the let-653 cs178 mutant.
In cs178; Lethal at the larval stage of development due to discontinuities in the excretory duct tube lumen that prevent fluid excretion.
Not secreted. Does not rescue excretory duct defects in the let-653 cs178 mutant.
Threonylcarbamoyladenosine tRNA methylthiotransferase
Probable 5-hydroxyisourate hydrolase R09H10.3
Chromosome segregation and cytokinesis defective protein 1
In cas11; has extra A/PVM neurons but fewer neurons in the Q.a lineage. In QL.ap neuroblasts, abolishes expression of gcy-32, but ectopically expresses mec-4.
In ku207; egg laying defective phenotype.
In n483; increased uterine cell divisions.
In rp26; egg laying defective phenotype.
U3 small nucleolar ribonucleoprotein protein imp3
Schiff-base intermediate with acetaldehyde
Cytosolic Fe-S cluster assembly factor NUBP1 homolog
In et4; pharynx is twisted without affecting feeding or pumping rate. Causes some twisting in amphid neurons close to the pharynx. NO defect in mig-17 localization.
In sa580; pharynx is twisted without affecting feeding or pumping rate. Causes some twisting in amphid neurons close to the pharynx.
Ubiquinone biosynthesis protein coq-4, mitochondrial
Putative iroquois-class homeodomain protein irx-1
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Growth arrest-specific protein 1 homolog
Abolishes phosphorylation by aak-2 and kin-1. Attenuates interaction with lid-1.
Patanin-like phospholipase domain-containing protein atgl-1
Calcium/calmodulin-dependent protein kinase type 1
Loss of function in cytoplasm and nucleus in FLP thermal nociceptors but no effect on temperature-dependent translocation from cytoplasm to the nucleus. Increased transcription of glutamate receptor glr-1.
Loss of phosphorylation and activation by ckk-1. No effect on function in AFD neurons. Strongly enriched in the cytoplasm regardless of cultivation temperature. Fails to rescue the AFD thermosensory neurons defects of cmk-1 null mutant. Loss of temperature-dependent translocation from cytoplasm to the nucleus during heat acclimation in FLP thermal nociceptors.
Probable fumarate hydratase, mitochondrial
In isoform b, isoform e, isoform f and isoform j.
Loss of E3 ubiquitin protein ligase activity. Decrease in the number of apoptotic corpses in the germline in response to ionizing radiation-mediated DNA damage. Does not affect foci localization in response to ionizing radiation-mediated DNA damage. Does not affect recruitment of cdc-48, atx-3 or proteasome to foci. Does not affect interaction with cdc-48.1.
Loss of interaction with cdc-48.1. Constitutive localization to foci. Decrease in the number of apoptotic corpses in the germline in response to ionizing radiation-mediated DNA damage. No defect in catalytic activity.
Trimeric intracellular cation channel type 1B.2
Mitochondrial import inner membrane translocase subunit Tim9
Ig-like and fibronectin type-III domain-containing protein C27B7.7
Glycosyltransferase family 92 protein F55C10.4
Transcription factor IIIC subunit Tfc1/Sfc1 triple barrel
Maternal effect lethal and loss of phosphatase activity; when associated with I-70.
Maternal effect lethal and loss of phosphatase activity; when associated with N-181.
5-methylcytosine rRNA methyltransferase nsun-4
In mj457; viable and produces viable progeny. Reduces body length. Reduces mitochondrial tRNA and rRNA methylation state. Increases the reduction in body length, and at 25 degrees Celsius reduces the number of progeny in a nsun-1 (mj473), nsun-2 (mj458) and nsun-5 (tm3898) mutant background. Abolishes the methylation of carbon-5 cysteines and its metabolic derivative 2'-O-methyl-5-hydroxymethylcytosine in RNA in a nsun-1 (mj473), nsun-2 (mj458) and nsun-5 (tm3898) mutant background.
Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
Abolishes phosphatidylinositol binding. Abolishes recruitment to phagosome membrane. Does not rescue the apoptotic corpse degradation defect of the atg-18 gk378 mutant.
In s2518; causes recessive maternal effect lethal (Mel) phenotype where homozygotes are viable but offspring display an embryonic lethal phenotype.
In t1456; causes recessive maternal effect lethal (Mel) phenotype where homozygotes are viable but offspring display an embryonic lethal phenotype.
In t1473; causes recessive maternal effect lethal (Mel) phenotype where homozygotes are viable but offspring display an embryonic lethal phenotype; when associated with F-169.
In t1473; causes recessive maternal effect lethal (Mel) phenotype where homozygotes are viable but offspring display an embryonic lethal phenotype; when associated with V-86.
In t1520; causes recessive maternal effect lethal (Mel) phenotype where homozygotes are viable but offspring display an embryonic lethal phenotype.
In t1552; causes recessive maternal effect lethal (Mel) phenotype where homozygotes are viable but offspring display an embryonic lethal phenotype.
In t1555; causes recessive maternal effect lethal (Mel) phenotype where homozygotes are viable but offspring display an embryonic lethal phenotype.
In t1576; causes recessive maternal effect lethal (Mel) phenotype where homozygotes are viable but offspring display an embryonic lethal phenotype.
In t1597; causes recessive maternal effect lethal (Mel) phenotype where homozygotes are viable but offspring display an embryonic lethal phenotype.
In t1607; causes recessive maternal effect lethal (Mel) phenotype where homozygotes are viable but offspring display an embryonic lethal phenotype.
In t1616; causes recessive maternal effect lethal (Mel) phenotype where homozygotes are viable but offspring display an embryonic lethal phenotype.
In t1632; causes recessive maternal effect lethal (Mel) phenotype where homozygotes are viable but offspring display an embryonic lethal phenotype.
In t1665; causes recessive maternal effect lethal (Mel) phenotype where homozygotes are viable but offspring display an embryonic lethal phenotype.
In t1666; causes recessive maternal effect lethal (Mel) phenotype where homozygotes are viable but offspring display an embryonic lethal phenotype.
In t1679; causes recessive maternal effect lethal (Mel) phenotype where homozygotes are viable but offspring display an embryonic lethal phenotype.
Probable DNA-directed RNA polymerases I, II, and III subunit RPABC3
Alpha-glycerophosphate oxidase C-terminal
In t2553; Thermosensitive mutant with reduced stability of the cohesin complex on chromosomes and defective DNA double-stranded break repair.
Structural maintenance of chromosomes protein 3
Probable aromatic-L-amino-acid decarboxylase
Channels open at more negative voltages than wild-type and single mutants; when associated with S-439.
Channels open at more negative voltages than wild-type; when associated with K-142.
In n2332; Channels open at more negative voltages than wild-type and increase in the rate of activation.
In n728; Channels open at more negative voltages than wild-type.
In sa630; Premature egg laying with fewer eggs retained.
Potassium voltage-gated channel protein egl-36
Restores egg-laying activity to n728 mutants.
Ankyrin repeat-containing protein F37A4.4
Biogenesis of lysosome-related organelles complex 1 subunit 5
Cysteine and histidine-rich domain-containing protein 1
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7
Eukaryotic translation initiation factor 3 subunit G
In ju1840; represses the convulsive behavior due to cholinergic hyperexcitation caused by an acr-2 mutant.
In ju807; represses the convulsive behavior due to cholinergic hyperexcitation caused by an acr-2 mutant. No effect on binding to target 5-UTRs.
Nuclear envelope phosphatase-regulatory subunit 1 homolog
Mediator of RNA polymerase II transcription subunit 15
Disrupts the predicted tubulin binding sites and leads to strongly shortened sensory cilia on ASER neurons; when associated with E-281; E-815 and E-1073.
Disrupts the predicted tubulin binding sites and leads to strongly shortened sensory cilia on ASER neurons; when associated with E-34; E-281 and E-1073.
Disrupts the predicted tubulin binding sites and leads to strongly shortened sensory cilia on ASER neurons; when associated with E-34; E-281 and E-815.
Disrupts the predicted tubulin binding sites and leads to strongly shortened sensory cilia on ASER neurons; when associated with E-34; E-815 and E-1073.
In oy106; shortens ASK and ASI cilia length. Defects in pheromone-induced dauer formation in response to the ascarosides ascr#2, ascr#3, ascr#5, ascr#8 and icas#9.
In cas140; production of an extra neuron from the Q lineage and a mild egg-laying defect.
In cas3; production of an extra neuron from the Q lineage and a mild egg-laying defect.
In n1080 and cas58; two-fold reduction in mRNA levels. Production of an extra neuron from the Q lineage and a mild egg-laying defect. Decreased mating efficiency in males, as a result of deficiency in vulval location. Significant decrease in expression of ceh-26 and lov-1 in HOB neuron, and some reduction in expression of pkd-2 and nlp-8.
In n998, n1087 and cas6; two-fold reduction in mRNA levels. Production of an extra neuron from the Q lineage and a mild egg-laying defect.
Transcription enhancer factor-like protein egl-44
Probable NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12
Nonsense-mediated mRNA decay factor SMG9
Greatly reduced nuclease activity in vitro.
In t2079; induces a monopolar spindle assembly during mitosis and failure in cell division. Abolishes interaction with sas-6.
Localizes to the cellular cortex of embryo and promotes robust spindle rocking as in wild-type during the first embryonic mitosis. Inhibits axon regrowth following neuronal injury.
Neuronal immunoglobulin domain-containing protein rig-3
Reduced axonal localization and increased coelomocyte expression, indicating shedding into the body cavity.
NIF system FeS cluster assembly NifU N-terminal
BTB and MATH domain-containing protein 39
In pv18; at the restrictive temperature of 25 degrees Celsius, embryos have cell-cell adhesion defects and die before hatching. The few surviving animals are arrested at the L1 larval stage. At the permissive temperature of 16-20 degrees Celsius, causes a developmental delay. Distal tip cell migration is impaired due to a reduced localization of metalloprotease mig-17 to the gonad basement membrane. Vulva lumen is smaller at the L4 larval stage. Accumulation of UDP-galactose (Gal) and reduction in UDP-N-acetylgalactosamine (GalNAc) levels. Hypersensitivity to a galactose-rich diet characterized by a slow development often resulting in an arrest at the L1 larval stage. Up-regulation of ER stress response protein hsp-4; expression is suppressed in an xbp-1 RNAi-mediated knockdown animals. Reduced survival upon E.faecalis or S.aureus-mediated infection.
Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
In ku113; restores vulva development in a let-60 n1046gf mutant background.
In ku146 and n2522; restores vulva development in a let-60 n1046gf mutant background.
In ku148; restores vulva development in a let-60 n1046gf mutant background.
In ku68; egg-laying defect in 14 percent of mutants. Arrest at the larval stage in 12 percent of mutants and abnormal sex myoblast (SM) migration. Restores vulva development in a let-60 n1046gf mutant background.
In ku83; abnormal sex myoblast (SM) migration. Restores vulva development in a let-60 n1046gf mutant background.
In n1860; arrest at the larval stage in 12 percent of mutants. Restores vulva development in a let-60 n1046gf mutant background.
In n2509; restores vulva development in a let-60 n1046gf mutant background.
In n2519; restores vulva development in a let-60 n1046gf mutant background.
Probable loss of kinase activity. Does not rescue vulva development in a let-60 n1046gf mutant background.
Abhydrolase domain-containing protein lid-1
In isoform b, isoform a, isoform e and isoform f.
Potassium voltage-gated channel protein shk-1
Probable manganese-transporting ATPase catp-8
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 homolog
Ribose-phosphate pyrophosphokinase N-terminal
Vacuolar protein sorting-associated protein 13 DH-like
Vacuolar protein sorting-associated protein 13 VPS13 adaptor binding
Vacuolar protein sorting-associated protein 13 extended chorein
DDB1- and CUL4-associated factor 11 homolog
Probable V-type proton ATPase subunit H 2
Nuclear hormone receptor family member nhr-197
Probable insulin-like peptide alpha-type 3
Vacuolar protein sorting-associated protein 33B
In gm34; absent HSN motoneurons, PHB sensory neurons and PVQ neurons.
In md1712; exhibits partial embryonic lethality that appears to result from defects in the regulation of a subset of centrosome movements during early embryogenesis.
In md303; exhibits partial embryonic lethality that appears to result from defects in the regulation of a subset of centrosome movements during early embryogenesis; impairs interaction with goa-1.
Large ribosomal subunit protein uL2 C-terminal
Calmodulin-binding transcription activator homolog 1
In db1258; defects in aggregation behavior (feeding in groups) and O2-response, in a npr-1 mutant background.
In db1259; defects in aggregation behavior (feeding in groups) and O2-response, in a npr-1 mutant background.
In db1260; defects in aggregation behavior (feeding in groups) and O2-response, in a npr-1 mutant background.
In db973; increased turning frequency both in the presence and absence of a CO2 stimulus. BAGCO2 sensor neurons have higher Ca2+ baselines and Ca2+ responses. In an npr-1 mutant background, has pleiotropic behavioral defects and reduced expression of calmodulin/cmd-1 in several types of neurons.
Nuclear hormone receptor family member nhr-49
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Serine/threonine-protein phosphatase 2A regulatory subunit pptr-1
In av59; no effect on viability observed at 15, 24 and 25 degrees Celsius.
In mr127; temperature sensitive mutant. At the nonpermissive temperature, failure in proper hcp-3 localization on mitotic chromosomes indicating unresolved kinetochores, aberrant localization of the cohesin component scc-1 to mitotic chromosomes and centrosomes, defects in centromere resolution and in proper chromosome segregation during anaphase.
Ack-related non-receptor tyrosine kinase
In zd164; disrupted polarity of the unpaired interneuron AVG.
Probable E3 ubiquitin-protein ligase plr-1
Abolishes phosphorylation which results in constitutive activation. In a wild type background, 76 percent die at the larval stage and 34 percent of surviving animals have abnormalities in the pharynx structure.
Probable loss of kinase activity. In a wild type background, 30 percent die at the larval stage and 4 percent of surviving animals have abnormalities in the pharynx structure.
Ancestral coatomer element 1 Sec16/Sec31
Probable G-protein coupled receptor K01A12.3
Nuclear hormone receptor family member nhr-53
Conserved oligomeric Golgi complex subunit 4
Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase
BAAT/Acyl-CoA thioester hydrolase C-terminal
In gu24; reduced lin-48 expression in hindgut cells.
In gu48; reduced lin-48 expression in hindgut cells.
In bx147; impaired male mating behavior. Some hermaphrodites and males fail to exit the molting cycle and undergo an additional molt. Such males do not fully shed the molted cuticle and die by rupturing through the cloaca. Surviving males have no spicules or fan and the rays appear as finger-like processes. Disrupts tail tip morphogenesis resulting in retention of the pointed larval tail tip in adult males (also known as the Lep phenotype).
In sy68; impaired male mating behavior. Some hermaphrodites and males fail to exit the molting cycle and undergo an additional molt. Such males do not fully shed the molted cuticle and die by rupturing through the cloaca. Surviving males have no spicules or fan and the rays appear as finger-like processes. Disrupts tail tip morphogenesis resulting in retention of the pointed larval tail tip in adult males (also known as the Lep phenotype).
In xd1; loss of neurite growth from RMED and RMEVGABAergic motor neurons.
TWiK family of potassium channels protein 12
Does not develop past the L3 larval stage of development.
Prevents localization to mitochondria. Does not affect nuclear localization. Does not affect the mitochondrial unfolded protein response.
Sterile. Increases nuclear accumulation. Increases the mitochondrial unfolded protein response as indicated by increased expression of hsp-6, clec-47 and cyp-14A4.1. Increases the levels of transcription factors atfs-1 and dve-1 in the nucleus. Compromises mitochondrial membrane potential. Increases 3'-tRNA processing.
Worms develop to adulthood as in wild-type. Defective nuclear localization. Reduces the mitochondrial unfolded protein response and under mitochondrial stress conditions, attenuates the transcription of genes which are up-regulated in the mitochondrial unfolded protein response such as hsp-6 and cyp-14A1.4.
Zinc phosphodiesterase ELAC protein 2 homolog
Probable U3 small nucleolar RNA-associated protein 11
General transcription and DNA repair factor IIH subunit TFB5
In ot86; defects in left/right asymmetry of ASE sensory neurons.
Retinoblastoma-binding protein homolog 5
Actin-depolymerizing factor 2, isoform c
In ot274; expression of the dopamine transporter dat-1 abolished in the PDE mechanosensory neurons forming the posterior deirid ('postdeirid') sensillum. Ectopic formation of CEPV mechanosensory neurons.
In ot280; expression of the dopamine transporter dat-1 abolished in the PDE mechanosensory neurons forming the posterior deirid ('postdeirid') sensillum. Ectopic formation of CEPV mechanosensory neurons.
Ankyrin repeat and KH domain-containing protein mask-1
In isoform b, isoform c, isoform e, isoform g and isoform h.
C-type lectin domain-containing protein 160
Nuclear hormone receptor family member nhr-35
CCR4-NOT transcription complex subunit let-711
Mediator of RNA polymerase II transcription subunit 1.1
Non-structural protein NS3-like DEAD box helicase flavivirus
G-protein coupled receptors family 2 profile 1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8
In n2659; egg laying and defecation defects, and sluggish locomotion. Grows in the presence of aldicarb unlike the wild-type.
Dual specificity mitogen-activated protein kinase kinase mek-2
In n1989; severe constipation following M.nematophilium infection.
In n2678; rescues fluid accumulation in crl-1 e1745ts mutant.
Phosphomimetic mutant which, in a wild type background, induces tail swelling; in association with D-227.
Phosphomimetic mutant which, in a wild type background, induces tail swelling; in association with E-223.
Uncharacterized calcium-binding protein R08D7.5
Folliculin-interacting protein C-terminal
Disintegrin and metalloproteinase domain-containing protein 17 homolog
Vacuolar protein sorting-associated protein 26
Probable splicing factor, arginine/serine-rich 6
Probable G-protein coupled receptor AH9.4
Abolishes dynein recruitment to kinetochores.
In oy10 and ev582; Ectopic expression of odr-7 in an additional pair of cells which adopt an AWA-like sensory neuron fate. Ectopic expression of unc-129 at equal levels in dorsal and ventral body-wall muscle (BWM). Defects in migration of distal tip cells (DTC). Does not bind to unc-129 promoter in vitro.
Helix-hairpin-helix DNA-binding motif class 1
Probable 26S proteasome regulatory subunit rpn-6.2
Nuclear transcription factor Y subunit nfyb-1
Loss of function and reduced binding to unc-40.
Reduced function, and only partially rescues the small body phenotype of the null mutant.
Repulsive guidance molecule B homolog drag-1
Rescues small body size phenotype of null mutants.
BLOC-1-related complex subunit 6 C-terminal helix
Nuclear hormone receptor family member nhr-79
Causes hyperfusion of epidermal cells in embryos.
Probable ubiquitin-conjugating enzyme E2 7
Dauer larva development regulatory growth factor daf-7
In ky771; reduces expression of the G protein-coupled receptor (GPCR) srsx-3 in the AWC neuron.
Defect recruitment by phosphoinositide to phagosomal surface.
Phosphatidylcholine:ceramide cholinephosphotransferase 2
Loss of egl-9-mediated hydroxylation resulting in the loss of interaction with vhl-1. Normal susceptibility to P.aeruginosa killing.
Disrupts formation of specific disulfide bridges resulting in loss of function.
Temperature sensitive for fertility. Wild-type levels of fertility between 16 and 20 degrees Celsius, at 25 degrees Celsius fertility levels drop drastically.
Serine/threonine-protein kinase WARTS homolog
Histone-lysine N-methyltransferase mes-4
In BN87; maternal-effect mutation. Progeny defects in gonad proliferation. Germ cell degeneration. Abolishes histone methyltransferase activity.
In bn67; suppresses the multivulval phenotype of the lin-15A/B n765 mutant.
Abolishes binding to histone H3 trimethylated at 'Lys-9'; in isoform a.
Abolishes binding to histone H3 trimethylated at 'Lys-9'; when associated A-576 and A-580, in isoform a.
In allele lin-61(n3447); reduces binding to histone H3 trimethylated at 'Lys-9'; multivulva phenotype in combination with lin56(n2728).
In allele lin-61(n3624); does not affect binding to histone H3 trimethylated at 'Lys-9'; multivulva phenotype in combination with lin56(n2728).
In allele lin-61(n3736); reduces binding to histone H3 trimethylated at 'Lys-9'; multivulva phenotype in combination with lin56(n2728).
In allele lin-61(n3807); abolishes binding to histone H3 trimethylated at 'Lys-9'; multivulva phenotype in combination with lin56(n2728).
Reduces binding to histone H3 trimethylated at 'Lys-9'; in isoform a.
In ot718; uncoordinated locomotory phenotype. Induces ectopic expression of TGF-b family members unc-129 and dbl-1, and of potassium channel slo-2, in AS motor neurons. Ectopic expression is repressed in an unc-3 mutant background.
Histone-lysine N-methyltransferase set-6
Acetylcholine-gated chloride channel subunit acc-1
Solute carrier family 3 member 2 N-terminal
In allele e1599; hermaphrodites and adult males appear slightly dumpy, with males having swollen bursal rays and much lower mating efficiency than that of wild-type males. When subjected to RNAi knock-down of mab-7 gene, no obvious enhancement of severity in phenotype was observed.
In allele wx74; hermaphrodites and adult males appear slightly dumpy, with males having swollen bursal rays and much lower mating efficiency than that of wild-type males. When subjected to RNAi knock-down of mab-7 gene, no obvious enhancement of severity in phenotype was observed.
NF-kappa-B-activating protein C-terminal
General transcription factor IIH subunit 2
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Phospholipid phosphatase homolog 1.2 homolog
In am130; causes strong resistance to nickel and zinc toxicity.
Abolishes phosphorylation which results in constitutive activation.
Abolishes phosphorylation which results in loss of kinase activity. Loss of interaction with ina-1 and ced-2.
Probable loss of kinase activity. Gonadal defects characterized by the formation of a straight gonad resulting from defects in the first and second turns during development. Abnormal migration of AVM and abnormal guidance of PVM neuron axon.
TATA box-binding protein-associated factor RNA polymerase I subunit B
Probable splicing factor, arginine/serine-rich 4
26S proteasome non-ATPase regulatory subunit 8
V-type proton ATPase 16 kDa proteolipid subunit c 2
V-type proton ATPase 16 kDa proteolipid subunit c 3
C-type lectin domain-containing protein 158
Probable U2 small nuclear ribonucleoprotein A'
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Putative serine/threonine-protein kinase F31E3.2
Eukaryotic translation initiation factor 3 subunit K
In ky630; initiates but fails to maintain AWC asymmetry in L1 larvae. Adults fail to express the G protein-coupled receptor gene str-2 in either AWC neuron. Mild defect in butanone chemotaxis, normal for chemotaxis to 2,3-pentanedione.
In n387; defects in vulval developmental. Multiple vulvae in different genetic backgrounds, either with lin-8, or lin-15, or lin-38 mutants, when grown at 15 degrees Celsius.
In n388; defects in vulval developmental. Increased resistance to ER stress.
Required for interaction with hpl-2 isoform a
Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2
Loss of autophosphorylation activity. Slight loss of binding to egg-4 and egg-5.
Loss of phosphorylation by cdk-1. Loss of kinase activity.
Loss of tyrosine phosphorylation. Reduced binding to egg-4 and egg-5 and translocation to the cytoplasm; when associated with F-619.
Reduced binding to egg-4 and egg-5 and translocation to the cytoplasm; when associated with F-621.
In sbj2; hypersensitive to UVB irradiation.
Structural maintenance of chromosomes protein 5
Putative sphingomyelin phosphodiesterase asm-3
Uncharacterized RING finger protein B0416.4
Nuclear hormone receptor family member nhr-20
In gm83; defect in the coordination of locomotion. Defects in pathfinding by AVKR and AVKL interneuron axons, and PVQL and HSNL axons, and reduced FMRFamide immunoreactivity.
Nuclear hormone receptor family member fax-1
4 X 6 AA repeat of L-[KH]-[KSH]-[VT]-[EP]-[TV]
Moderate reduction in actin polymerization inhibition. Complete loss of actin sequestering activity and moderate reduction in actin polymerization inhibition; when associated with 100-A--A-103 and 134-A--A-137. Complete loss of actin sequestering activity and severe reduction in actin polymerization inhibition; when associated with 62-A--A-65 and 134-A--A-137. Moderate loss of actin sequestering activity and moderate reduction in actin polymerization inhibition; when associated with 62-A--A-65 and 100-A--A-103.
Moderate reduction in actin polymerization inhibition. Complete loss of actin sequestering activity and severe reduction in actin polymerization inhibition; when associated with 24-A--A-27 and 134-A--A-137. Severe loss of actin sequestering activity and moderate reduction in actin polymerization inhibition; when associated with 62-A--A-65 and 134-A--A-137. Moderate loss of actin sequestering activity and slight reduction in actin polymerization inhibition; when associated with 24-A--A-27 and 62-A--A-65.
Severe reduction in actin polymerization inhibition. Complete loss of actin sequestering activity and severe reduction in actin polymerization inhibition; when associated with 24-A--A-27 and 134-A--A-137. Severe loss of actin sequestering activity and moderate reduction in actin polymerization inhibition; when associated with 100-A--A-103 and 134-A--A-137. Moderate loss of actin sequestering activity and slight reduction in actin polymerization inhibition; when associate d with 24-A--A-27 and 100-A--A-103.
Slight reduction in actin polymerization inhibition. Complete loss of actin sequestering activity and severe reduction in actin polymerization inhibition; when associated with 24-A--A-27 and 62-A--A-65. Complete loss of actin sequestering activity and moderate reduction in actin polymerization inhibition; when associated with 24-A--A-27 and 100-A--A-137. Severe loss of actin sequestering activity and moderate reduction in actin polymerization inhibition; when associated with 62-A--A-65 and 100-A--A-103.
In ju4; Causes severe epidermal morphology defects, including progressive accumulation of the cuticle and degeneration of the underlying epidermis, accelerated wound closure, and disorganization and hyper-stabilization of epidermal microtubules. Reduces microtubule growth rates. Increased ptrn-1 filaments in the anterior lateral epidermis. In L4 larvae and in adults, disrupts expression of specific unc-44 mRNAs in L4 seam cells and in head and tail epidermal cells. Reduces nuclear localization of pinn-1 in epidermal cells. Increases expression of antimicrobial peptides. Epidermal defects are suppressed in an unc-44 or ptrn-1 mutant background.
Normal localization and movement along microtubules and no exhibition of epidermal morphology defects.
Failure to shed the cuticle in the middle part of the body at the end of the first molt.
Abolishes the uptake of arginine and lysine.
Cleavage/polyadenylation specificity factor A subunit C-terminal
Cleavage/polyadenylation specificity factor A subunit N-terminal
Glycosyltransferase family 92 protein R07B7.12
Fails to rescue fluid accumulation in clr-1 e1745ts mutant.
Probable loss of phosphatase activity. Fails to rescue fluid accumulation in clr-1 e1745ts mutant.
Tyrosine-protein phosphatase non-receptor type ptp-2
Resistance to inhibitors of cholinesterase protein 19
Probable glycerol-3-phosphate acyltransferase, mitochondrial
TATA box binding protein associated factor (TAF) histone-like fold
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase wee-1.1
Histone-lysine N-methyltransferase set-2
In e1752; dopaminergic neurodegeneration in 60% of animals in response to oxidative stress induced by the neurotoxin 6-hydroxydopamine (6-OHDA).
In ky713; loss of chemotaxis response to butanone. Defect in sensory integration when confronted to two opposing environmental chemicals.
4-hydroxybenzoate polyprenyltransferase, mitochondrial
In n1274; worms appear reduced in size with defective body muscles.
In n490; worms appear reduced in size with defective body muscles.
In n506; worms appear hypercontracted and paralyzed.
Eukaryotic translation initiation factor 2 subunit 2
In tk102; defective cessation of distal tip cell migration during gonadal development.
Zinc finger BED domain-containing protein 39
Rap guanine nucleotide exchange factor 1
Mannose-P-dolichol utilization defect 1 protein homolog
Interacts with unc-108 (GTP-bound form). Disrupts dense vesicle maturation in cholinergic motoneurons.
Nuclear hormone receptor family member nhr-90
Inactive protein-tyrosine phosphatase egg-5
In isoform a, isoform f, isoform g, isoform h, isoform l and isoform m.
Loss of interaction with kin-2 resulting in constitutive activation; when associated with Q-125 (in isoform a).
Loss of interaction with kin-2 resulting in constitutive activation; when associated with R-234 (in isoform a).
cAMP-dependent protein kinase catalytic subunit
Ciliary defects in the AWB sensory neuron.
In hmn1; dendrites of URX and BAG sensory neurons fail to extend. Defective cilium basal body positioning in AQR sensory neurons sometimes resulting in cilia assembling at ectopic cellular locations such as the soma and proximal axons. AQR and PQR dendrite morphology defects including misrouted dendrites which extended posteriorly. Multipolar and unipolar AQR morphology. Dendrites and axons arise from a common process instead of opposites poles of the soma. Truncated dendrites. Dendrite defects are more severe in AQR neurons than PQR neurons. No defects in axon morphology. Disrupts hmr-1 localization to distal AQR dendrites. Instead hmr-1 is diffusely distributed, absent or it aberrantly localizes to the AQR cell body.
In hmn4; dendrites of URX and BAG sensory neurons fail to extend.
In hmn7; dendrites of URX and BAG sensory neurons fail to extend.
In hmn8; dendrites of URX and BAG sensory neurons fail to extend.
In ns303; defective dendrite extension of AWA, AWB, URX and BAG sensory neurons. Disrupts the retrograde extension of URX and BAG dendrites during embryo elongation, whereby URX and BAG dendrite endings become displaced from the nose and fail to extend normally. Defective cilium basal body positioning in AQR sensory neurons. AQR and PQR dendrite morphology defects including misrouted dendrites which extended posteriorly. Multipolar and unipolar AQR morphology. Dendrites and axons arise from a common process instead of opposites poles of the soma. Truncated dendrites. Dendrite defects are more severe in AQR neurons than PQR neurons. No defects in axon morphology. Disrupts hmr-1 localization to distal AQR dendrites. Instead hmr-1 is diffusely distributed, absent or it aberrantly localizes to the AQR cell body.
In ot146; Impairs left/right asymmetric gene expression programs of two gustatory neurons, ASEL and ASER. In particular, markers of ASER cell fate, such as receptor-type guanylate cyclase gcy-5, are gained in ASEL, but ASEL fate markers are unaffected.
Ankyrin repeat and LEM domain-containing protein 2 homolog
In ax475 mutant; temperature-sensitive mutant. No visible phenotype at 16 degrees Celsius. At 25 degrees Celsius embryos die early during development due to defects in nuclear envelope reassembly.
2-oxoacid dehydrogenase acyltransferase catalytic
Probable dynein light chain 2, cytoplasmic
DNA-directed RNA polymerases I, II, and III subunit RPABC1
Acetylcholine receptor subunit beta-type acr-2
In n2420; constitutively active. Spontaneous convulsions and shrinking behavior in response to touch. Convulsions are suppressed in an unc-74, unc-50, unc-38 or unc-63 mutant background. Enhanced neurotransmitter release by cholinergic motoneurons and reduced neurotransmitter release by GABAergic motoneurons. Increases neuropeptide flp-18 expression in cholinergic B-type motor neurons. Increases sensitivity to paralysis induced by acetylcholine esterase inhibitor aldicarb or acetylcholine agonist levamisole in L3-L4 larvae and adults.
Nuclear hormone receptor family member nhr-16
In sa469; defects in hindgut development. Produces ectopic spicule cells. Defects in the development of U, F and K' hindgut cells. Morphological defects in excretory duct cells. Increases sensitivity to salt (NaCl) in the environment, reducing viability.
In sy234; defects in hindgut development. Abnormal F, B and U cell lineages in male tail. Produces ectopic spicule cells. Defects in the development of U, F and K' hindgut cells.
In sy548; defects in hindgut development. Defects in the development of U, F and K' hindgut cells.
Transcription factor ovo-like homolog lin-48
Probable complex I intermediate-associated protein 30, mitochondrial
DDB1- and CUL4-associated factor homolog 1
In m86; abolishes expression of ceh-26 and nlp-8 in the male-specific hook neuron HOB. Substantially reduces non-sex-specific expression of ceh-26 in some head neurons. Reduces male-specific expression of pkd-2 in the four ciliated CEM neurons in the head, and the HOB and B-type ray neurons in the tail. Causes constitutive formation of dauer larvae.
In gb404; reduces ability to avoid the noxious chemical quinine, chloroquine, amodiaquine, primaquine, quinacrine, shikimic acid, denatonium, ethidium bromide, zinc ions, sodium dodecyl sulfate and low pH environments. Due to inability to avoid quinine, results in enhanced pheromone-induced dauer formation in response to the ascaroside ascr#3.
In gb681; reduces ability to avoid the noxious chemical quinine.
In oy105; defects in pheromone-induced dauer formation in response to the ascarosides ascr#3 and icas#9.
For molybdenum cofactor biosynthesis protein C activity
Molybdenum cofactor biosynthesis protein A
Molybdenum cofactor biosynthesis protein C
Molybdenum cofactor biosynthesis protein moc-5
In n179; precocious onset of tail tip retraction resulting in over-retracted and shortened adult male tails (also known as the Ore phenotype). Premature alae formation at the L3 larval stage. Premature alae formation is partially suppressed in a sea-2 bp283 mutant background. Enhances the precocious development, semi-dumpy, vulval protrusions and egg-laying defects in a dcap-1 tm3163 mutant background at 25 degrees Celsius. Partially suppresses the enhanced dauer phenotype of dcap-1 tm3163 mutants at 25 degrees Celsius. Abolishes expression of the immunoglobulin domain gene zig-4 in the interneuron PVT during the L1 larval stage.
In sa485; alteration of vulval-gonadal synchrony.
In syb5772; abolishes binding to nlp-45 promoter DNA sequence in vitro and causes sterility, dumpy appearance, protruding vulva, precocious alae, and derepression of nlp-45 gene expression at an improper time during the larval L1 stage; in association with A-430, A-432 and A-433.
In syb5772; abolishes binding to nlp-45 promoter DNA sequence in vitro and causes sterility, dumpy appearance, protruding vulva, precocious alae, and derepression of nlp-45 gene expression at an improper time during the larval L1 stage; in association with A-430, A-432 and A-435.
In syb5772; abolishes binding to nlp-45 promoter DNA sequence in vitro and causes sterility, dumpy appearance, protruding vulva, precocious alae, and derepression of nlp-45 gene expression at an improper time during the larval L1 stage; in association with A-430, A-433 and A-435.
In syb5772; abolishes binding to nlp-45 promoter DNA sequence in vitro and causes sterility, dumpy appearance, protruding vulva, precocious alae, and derepression of nlp-45 gene expression at an improper time during the larval L1 stage; in association with A-432, A-433 and A-435.
Involved in sequence-specific DNA-binding
Small nuclear ribonucleoprotein Prp3 C-terminal
Translocon-associated protein subunit alpha
Eukaryotic translation initiation factor 4E-binding protein Mextli homolog
Reduced binding to ife-3; when associated with D-497.
Reduced binding to ife-3; when associated with D-504.
In ox34; defective in posterior body wall contraction (pBoc).
In ox38; defective in posterior body wall contraction (pBoc).
In ox7dm; defective in posterior body wall contraction (pBoc).
In ox9; defective in posterior body wall contraction (pBoc).
In sa242; defective in posterior body wall contraction (pBoc).
In sa297; defective in posterior body wall contraction (pBoc).
Probable tubulin polyglutamylase ttll-15
Putative aldehyde dehydrogenase family 7 member A1 homolog
SWI/SNF nucleosome remodeling complex component
Severe loss of interaction with ppfr-1 and mei-1.
Putative sphingolipid delta(4)-desaturase/C4-monooxygenase
Loss of catalytic activity. Loss of autoprocessing.
Removed in mature form by autoprocessing
In wk70; reduced body size in hermaphrodites, probably due to abnormal postembryonic growth, but without embryonic or larval lethality. Fusions of male-specific genital sensilla (simple sense organs) known as rays. Decrease in lipid levels at the L4 larval stage. Disrupted aversive learning. Expression of Runt-related transcription factor rnt-1 is abolished, when combined with RNAi-mediated knockdown of CBF beta homolog bro-1. Hatched larvae show considerably lower expression of rnt-1, but normal levels in embryos.
Serine/threonine-protein phosphatase Pgam5, mitochondrial
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase
Organic solute transporter alpha-like protein 2
Aspartate/homoserine dehydrogenase NAD-binding
In qm34; temperature sensitive mutant resulting in elongation arrest and over 80% embryonic lethality at 25 degrees Celsius due to epithelial defects during elongation with cysts forming inside the embryo and/or cells leaking out from the embryo body.
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
Reduced binding to ced-3. No effect on ced-3 autoactivation. Delays the ced-3 activation by ced-4. Causes ectopic cell death during development.
Nuclear hormone receptor family member nhr-218
Serine/threonine-protein phosphatase PP1-alpha
Dual specificity protein phosphatase lip-1
In zh32; at the restrictive temperature of 25 degrees Celsius, 87 percent of mutants have endomitotic oocytes.
Stress-activated map kinase-interacting protein 1 homolog
CCR4-Not complex component Not N-terminal
Nuclear hormone receptor family member nhr-9
Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase
Zmiz1 N-terminal tetratricopeptide repeat
In xf14; abolishes the interaction with pid-3. May abolish the interaction with erh-2. Reduces stability and reduces levels of a class of 21 nucleotide PIWI-interacting RNAs (piRNAs) that possess a uracil residue at the 5'-end (also called 21U-RNAs).
May be required for interaction with erh-2
In lin-26(mc1); embryonic lethality and the death of many hypodermal cells.
In lin-26(mc2); embryonic lethality due to a failure of hypodermal cells to enclose the embryo.
In lin-26(n156); hypodermal Pn.p cells express a neural fate; animals lack a vulva. Shows a small but significant decrease in lin-39 at the early larval L3 stage.
Segment polarity protein dishevelled homolog mig-5
In gk892586; accumulation of ascarosides asc-C7 and asc-C9.
In reb6; accumulation of ascaroside asc-C9 and reduced production of asc-delta-C7 and asc-delta-C9. No defect in indol-3-carbonyl(IC)-ascaroside production. Enhances accumulation of IC-asc-C7 and IC-asc-C9 in a acox-1.1 (reb2) and acox-3 (tm4033) mutant background.
ATP synthase subunit beta, mitochondrial
Probable DNA-directed RNA polymerase III subunit RPC6
2,3-bisphosphoglycerate-independent phosphoglycerate mutase
Cationic amino acid transporter C-terminal
Probable actin-related protein 2/3 complex subunit 3
Putative H/ACA ribonucleoprotein complex subunit 3
Nuclear hormone receptor family member nhr-10
Constitutively active. Undergoes autophosphorylation in vitro.
Loss of adaptive behavior upon prolonged exposure to attractive odorants.
Loss of body size, reduced locomotion in the presence of food, a pale intestine, increased intestinal fat storage, and a decreased propensity to form dauer larvae.
Loss of nuclear translocation mediated by cGMP. Loss of nuclear translocation upon prolonged exposure to attractive odorants.
Loss of nuclear translocation upon prolonged exposure to attractive odorants.
No obvious phenotype. May cause partial loss of kinase activity.
Abolishes nuclear asymmetry, defective in nuclear export and loss of par-5 interaction; when associated with A-107; A-109; A-118 and A-120.
Abolishes nuclear asymmetry, defective in nuclear export and loss of par-5 interaction; when associated with A-107; A-109; A-118 and A-127.
Abolishes nuclear asymmetry, defective in nuclear export and loss of par-5 interaction; when associated with A-107; A-109; T-120 and A-127.
Abolishes nuclear asymmetry, defective in nuclear export and loss of par-5 interaction; when associated with A-107; A-118; T-120 and A-127.
Abolishes nuclear asymmetry, defective in nuclear export and loss of par-5 interaction; when associated with A-109; A-118; T-120 and A-127.
Ectopically activates ttx-3 expression in the SIAD/SIBV lineage neuroblast.
In q624; low penetrance defects including abnormal gonad development, L1 viability and T-cell defects. Severe loss of M lineage-derived coelomocytes and sex myoblasts.
In q645; abnormal gonad development and hermaphrodites are sterile. Formation of ectopic M lineage-derived coelomocytes on the dorsal side and ectopic sex myoblast on the ventral side. Simultaneous RNAi-mediated knockdown of ceh-34 causes a loss of all M lineage-derived coelomocytes. Abolishes interactions with beta-catenin/sys-1.
Sufficient for interaction with beta-catenin/sys-1
CTD nuclear envelope phosphatase 1 homolog
Queuine tRNA-ribosyltransferase accessory subunit 2
Glycosyltransferase family 92 protein ZK381.2
Tubulin--tyrosine ligase-like protein 12
Protein phosphatase 1 regulatory subunit 37 homolog
Does not suppress the increased number of convulsions in the acr-2 (acetylcholine-gated cation channel) gain of function mutant; when associated with I-314.
In ju825; gain of function mutation. Irregular 'curly' body posture and slow locomotion. Slow locomotion defect suppressed in an acc-4 null background. Reduces the amplitude and suppresses synaptic vesicle release from the presynaptic membrane of cholinergic motor neurons during the late phase of synaptic transmission. Fully suppresses sensitivity to the acetylcholine esterase inhibitor aldicarb in lgc-46 null mutants. Suppresses the increased number of convulsions in the double acr-2 gain of function and acc-4 null mutant background. Does not suppress the increased number of convulsions in the acr-2 gain of function mutant; when associated with E-301.
In e1459; Disruption of myofilament periodicity and thin filament accumulation at the end of muscle cells.
Glycosyl-hydrolase family 116 N-terminal
Glycosyl-hydrolase family 116 catalytic region
DNA endonuclease activator Ctp1 C-terminal
In px34; results in arrest at larval stage L3, but with continued pharyngeal pumping regardless of arrest, perturbed vulval development, blocked gonadogenesis, increased intestinal lipids, abundant epidermal granules and smaller nucleoli.
Probable calcium-binding mitochondrial carrier K02F3.2
Nuclear hormone receptor family member nhr-64
Alpha-D-phosphohexomutase alpha/beta/alpha
Propionyl-CoA carboxylase alpha chain, mitochondrial
In hp684; animals are viable, but display defective locomotion that progressively develops from the late larval stage into adulthood. Animals are capable of backwards locomotion or 'reversals' movements, but exhibit limited body flexing, with decreased body curvature during reversals, increased duration of reversals and a reduced frequency of reversal initiation compared to wild-type. Reduced bending is due to a defective activation pattern of A class motor neurons, whereby the posterior clusters of A class motor neurons DA7, VA10 and VA11, that innervate body wall muscles to execute reversals, are activated at the same time, which is in contrast to wild-type. Animals also display morphological and synaptic activity defects in AVA and AVE interneurons. Increases glutamate levels which is likely through increased got-1.2 activity. Defective reversals movement phenotype and increased glutamate levels are rescued in the got-1.2 hp731 mutant.
In hp820; animals are viable, but display defective locomotion that progressively develops from the late larval stage into adulthood. Animals are capable of backwards locomotion or 'reversals' movements, but exhibit limited body flexing, with decreased body curvature during reversals, increased duration of reversals and a reduced frequency of reversal initiation compared to wild-type. Reduced bending is due to a defective activation pattern of A class motor neurons, whereby the posterior clusters of A class motor neurons DA7, VA10 and VA11, that innervate body wall muscles to execute reversals, are activated at the same time, which is in contrast to wild-type. Animals also display morphological and synaptic activity defects in AVA and AVE interneurons. Increases glutamate levels which is likely through increased got-1.2 activity. Defective reversals movement phenotype and increased glutamate levels are rescued in the got-1.2 hp731 mutant.
In hp821; animals are viable, but display defective locomotion that progressively develops from the late larval stage into adulthood. Animals are capable of backwards locomotion or 'reversals' movements, but exhibit limited body flexing, with decreased body curvature during reversals, increased duration of reversals and a reduced frequency of reversal initiation compared to wild-type. Reduced bending is due to a defective activation pattern of A class motor neurons, whereby the posterior clusters of A class motor neurons DA7, VA10 and VA11, that innervate body wall muscles to execute reversals, are activated at the same time, which is in contrast to wild-type. Animals also display morphological and synaptic activity defects in AVA and AVE interneurons. Increases glutamate levels which is likely through increased got-1.2 activity. Defective reversals movement phenotype and increased glutamate levels are rescued in the got-1.2 hp731 mutant.
In tm5996; increases lin-28 protein levels 30 hours post feeding. Enhances the excessive seam cell proliferation phenotype and enhances the delay in temporal cell fate patterning of seam cells during the progression of larval development of the ain-1 ku322 mutant.
In qm133; shortened defecation cycle length and lack of enteric muscle contractions.
Succinate dehydrogenase assembly factor 2, mitochondrial
RNA polymerase II subunit A C-terminal domain phosphatase
Probable trafficking protein particle complex subunit 2
Sodium-dependent low-affinity dicarboxylate transporter 1
Leucine-rich repeats and immunoglobulin-like domains protein sma-10
In ft15; suppresses the defect in expression of vit-3 caused by lin-29 mutation.
In mg455; impairs intracellular trafficking of cell membrane receptors. Reduces localization of the cell membrane receptor mig-14 to the basolateral cell membrane and instead mig-14 mis-localizes to late endosomal/early lysosomal structures near the apical cell membrane.
FAD-dependent oxidoreductase 2 FAD binding
High basal kinase activity, loss of phorbol ester-stimulated kinase activity.
Increase in sensitivity to phorbol ester or DAG stimulation of kinase activity. Loss of sensitivity to phorbol ester or DAG stimulation of kinase activity; when associated with G-109.
Increase in sensitivity to phorbol ester-stimulation of kinase activity.
Loss of basal kinase activity and phorbol ester-stimulated kinase activity. Resistant to proteasome-mediated degradation.
Loss of sensitivity to phorbol ester or DAG stimulation of kinase activity. Loss of sensitivity to phorbol ester or DAG stimulation of kinase activity; when associated with G-197.
No effect on basal kinase activity, phorbol ester-stimulated kinase activity, or stability.
Important for the stable binding to the membranes
Probable loss of phosphatase activity. No rescue of abnormal axon termination in a fsn-1 mutant background.
In allele mu78; randomize the neuroblast QL and QR asymmetrical pattern of mab-5 expression.
In dpy-19(e1295); randomize the neuroblast QL and QR asymmetrical pattern of mab-5 expression. Abolishes C-mannosyltransferase activity in vitro.
Mediator of RNA polymerase II transcription subunit 29
26S rRNA (cytosine-C(5))-methyltransferase nsun-1
In mj437; viable and produce viable progeny. Reduces body length. Increases the reduction in body length, and at 25 degrees Celsius there is a reduced number of progeny in a nsun-4 (mj457), nsun-2 (mj458) and nsun-5 (tm3898) mutant background. Abolishes methylation of carbon-5 cysteines and its metabolic derivative 2'-O-methyl-5-hydroxymethylcytosine in RNA in a nsun-4 (mj457), nsun-2 (mj458) and nsun-5 (tm3898) mutant background.
Uso1/p115-like vesicle tethering protein C-terminal
Vesicle tethering protein Uso1/P115-like head
Probable phosphoribosylformylglycinamidine synthase
Probable H/ACA ribonucleoprotein complex subunit 1-like protein
RNA polymerase II-associated factor 1 homolog
Programmed cell death protein 10 homolog
26S proteasome non-ATPase regulatory subunit 3
In rr92; germline hyperplasia during dauer development.
No defect in neuronal polarity and synaptic organization.
STE20-related kinase adapter protein strd-1
In allele g23/hc70; temperature-sensitive lethality during late embryogenesis.
In allele g34; temperature-sensitive lethality during late embryogenesis.
In b189; temperature-sensitive mutant. At the subrestrictive temperature of 22 degrees Celsius, causes the formation of ectopic presynaptic boutons on the ventral cord axons. Enhances the lethality of the pxn-2 ju436 mutant at 20 degrees Celsius.
In ju1197; suppresses the lethal phenotypes of the pxn-2 tm3464 mutant.
In xd51; formation of ectopic presynaptic boutons on the ventral cord axons associated with a disruption of synapse basement membrane.
S-Lysyl-methionine sulfilimine (Lys-Met) (interchain with M-1623)
S-Lysyl-methionine sulfilimine (Met-Lys) (interchain with K-1741)
In av40; Causes abnormal male tail morphology when cultured at 25 degrees Celsius at the larval L2 stage.
Putative ATP synthase subunit f, mitochondrial
Probable gamma-butyrobetaine dioxygenase
Does not affect ced-3-mediated cleavage.
Locomotor defects due to neuronal dysfunction. Difficulty performing omega bends but no defects in reversals. Does not affect fertility.
Glutathione-independent glyoxalase DJR-1.2
Increased sensitivity to oxidative stress when exposed to cumene hydroperoxide.
In n2570; Defective enteric muscle contraction.
In n2641; Defective enteric muscle contraction.
In n2676; Defective enteric muscle contraction.
In sa6; Defective enteric muscle contraction and shortening of defecation cycle. Reduced fatty acid uptake by intestinal cells.
In it20; embryonic lethal with embryos arresting between the 64-128 cell stage. Reduces the number of type I and II 21U-RNAs (a class of 21 nucleotide PIWI-interacting RNAs (piRNAs) that possess a uracil residue at the 5'-end).
In ust95; reduces the accumulation of type I and II 21U-RNAs. Unlike wild-type, does not localize to perinuclear foci. Does not cause sterility. Does not exhibit chromosome segregation defects.
In y2; sterile. Maternal effect lethal (Mel) phenotype. Reduces the number of type I and II 21U-RNAs (a class of 21 nucleotide PIWI-interacting RNAs (piRNAs) that possess a uracil residue at the 5'-end).
In n372; alters cell fate specification within the V5 lineage, and also causes anterior V cells to generate V5-like lineages, including ectopic formation of neuronal structures called postdeirids. Ectopic postdeirids are not formed on a lin-32 mutant background.
JNK1/MAPK8-associated membrane protein homolog
In lst466; increased accumulation of intestinal fat in adults. Significant reduction in cuticle permeability.
RNA-polymerase II-associated protein 3-like C-terminal
rRNA N6-adenosine-methyltransferase metl-5
Peptide methionine sulphoxide reductase MsrA
In or369 and or402; temperature sensitive mutant which is embryonic lethal at 26 degrees Celsius, with defective pronuclear migration and reduced zyg-9 binding.
In or455; temperature sensitive mutant which is embryonic lethal at 26 degrees Celsius, with defective pronuclear migration.
Transforming acid coiled-coil-containing protein 1
Uncoordinated. 70% embryos are arrested at the 2- to 3-fold stage. 50% embryos fail to hatch. Fails to clear apoptotic cells during embryogenesis. Embryonic cells exhibit abnormal lysosomes that are filled with dense membranous materials.
Uncoordinated. Resistant to acetylcholinesterase inhibitor aldicarb-induced paralysis. No defect in acetylcholine receptor agonist levamisole-induced paralysis. Synaptic vesicles are less acidic. Prevents intracellular acidification and suppresses neurodegeneration of touch-receptor neurons in a mec-4 (u231) mutant background. Heterozygotes, but not homozygotes, have reduced body length and have defect in shedding the cuticle after the last molt.
Putative serine/threonine-protein kinase K06H7.1
Vacuolar protein sorting-associated protein 28 homolog
Mitochondrial import receptor subunit TOM20 homolog
Abolishes catalytic activity. Animals have an extended lifespan, an extended reproductive lifespan, have fewer hatched progeny and display increased motility.
PLD motif; required for enzymatic activity
Inactive protein-tyrosine phosphatase egg-4
Strongly reduced interaction with mbk-2; when associated with A-599 and A-603.
Strongly reduced interaction with mbk-2; when associated with A-599 and A-606.
Strongly reduced interaction with mbk-2; when associated with A-603 and A-606.
Armadillo repeat-containing protein wrm-1
SAM-dependent methyltransferase TRM5/TYW2-type
Dual specificity mitogen-activated protein kinase kinase sek-1
In ag1; loss of pmk-1 phosphorylation. Upon pathogenic bacterial infection, decrease in survival rate and severe loss of gst-4 and gsc-1 expression. Loss of nlp-29 expression in response to fungal infection. Moderate decrease in survival rate upon C.cinerea galectin Cgl2 exposure. Promotes linker cell survival in 53 percent of animals. Egg-laying defect. Normal development and lifespan.
Phosphomimetic mutant which likely results in constitutive activation. Loss of str-2 expression in either of the AWC neurons; when associated with D-204.
Phosphomimetic mutant which likely results in constitutive activation. Loss of str-2 expression in either of the AWC neurons; when associated with D-208.
In wg1000; catalytically inactive. Binds to 5'-triphosphorylated RNAs, but does not convert them to 5'-monophosphorylated RNAs. Reduces levels of 26G small interfering RNAs (siRNAs), which are a classes of 26 nucleotide siRNAs that possess a guanine residue at the 5'-end. Furthermore, 40% of the 26G-siRNAs present are 5'-triphosphorylated.
RNA/RNP complex-1-interacting phosphatase homolog
Nuclear hormone receptor family member nhr-51
In or452; defective bipolar spindle assembly and loss of centrosomal pcmd-1 in early embryos.
Failure to rescue silencing defect in sid-3 mutants.
In qt32; induces defects in mobile RNA silencing.
In qt38; induces defects in mobile RNA silencing.
Guanine nucleotide-binding protein-like 3 homolog
In bp576; Accumulation of early autophagic structures and defective degradation of P-granules and protein aggregates. Irregular distribution of protein aggregates containing the autophagy protein atg-9. Suppresses the lysosomal accumulation of ribosomal RNA and ribosomal proteins in a rnst-2 qx245 mutant background.
Nuclear hormone receptor family member nhr-97
Biogenesis of lysosome-related organelles complex 1 subunit 1
Nuclear hormone receptor family member nhr-124
In ku491; 50% reduction in fertility as compared to wild-type. Reduces function during postembryonic development. Defective alae formation.
In mac33; blistered cuticle phenotype with blisters containing cellular material. Resistant to iodide toxicity.
In mac499; resistance to iodide toxicity.
Extracellular superoxide dismutase [Cu-Zn]
Superoxide dismutase copper/zinc binding
Acetylcholine receptor subunit alpha-type unc-38
Apoptosis-antagonizing transcription factor C-terminal
Abolishes phosphorylation. Reduced embryo viability and, pie-1 and mex-5 degradation in embryonic somatic cells. Severe reduction in binding to plk-1 and plk-2. Prevent subsequent phosphorylation by plk-1.
Loss of phosphorylation and zygotic asymmetry.
Histone-lysine N-methyltransferase mes-2
In bn48; maternal-effect mutation. Progeny defects in gonad proliferation. Germ cell degeneration. Reduced levels of 'H3-K27Me2' and 'H3-K27Me3'.
In bn72; maternal-effect mutation. Progeny defects in gonad proliferation. Germ cell degeneration. Reduced levels of 'H3-K27Me2' and 'H3-K27Me3'.
Protein-L-isoaspartate O-methyltransferase
Probable methylmalonyl-CoA mutase, mitochondrial
Vacuolar protein 14 C-terminal Fig4-binding
In ar197; results in suppression of Sel-12 mutant phenotypes.
Rapamycin-insensitive companion of mTOR N-terminal
Rapamycin-insensitive companion of mTOR middle
Mutant protein accumulates in the intestinal nuclei and inhibits the mitochondrial unfolded protein response (mtUPR) on an atfs-1 mutant background, or in response to phenazines.
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase pps-1
Bicarbonate transporter-like transmembrane
In hc163; low fertility affecting males more severely. Mild defect in the initial formation of fibrous bodies-membranous organelles structures in spermatocytes. Precocious initiation of spermiogenesis but with few spermatids maturing into spermatozoa. Restores fertility in spe-8, spe-12, spe-27 or spe-29 mutants by rescuing initiation of spermiogenesis.
In hc163; premature spermatid activation in spermathecae. Premature spermatid activation in spermathecae is suppressed in a zipt-7.1 mutant (ok971) background.
In hc164, hc176 and hc187; restores fertility in spe-27 mutants by rescuing initiation of spermiogenesis.
In hc165; restores fertility in spe-27 mutants by rescuing initiation of spermiogenesis.
In hc166; restores fertility in spe-27 mutants by rescuing initiation of spermiogenesis.
In hc167; restores fertility in spe-27 mutants by rescuing initiation of spermiogenesis.
In hc168; restores fertility in spe-27 mutants by rescuing initiation of spermiogenesis.
In hc169; restores fertility in spe-27 mutants by rescuing initiation of spermiogenesis.
In hc172; restores fertility in spe-27 mutants by rescuing initiation of spermiogenesis.
In hc173; restores fertility in spe-27 mutants by rescuing initiation of spermiogenesis.
In hc174; restores fertility in spe-27 mutants by rescuing initiation of spermiogenesis.
In hc175; restores fertility in spe-27 mutants by rescuing initiation of spermiogenesis.
In hc186; restores fertility in spe-27 mutants by rescuing initiation of spermiogenesis.
In hc188; restores fertility in spe-27 mutants by rescuing initiation of spermiogenesis.
In hc189; restores fertility in spe-27 mutants by rescuing initiation of spermiogenesis.
In hc92 and hc143; sterile. Failure to assemble MSP into fibrous bodies and absence of spermatids due to spermatocytes arresting at the diakinesis stage.
Catalytic activity is restored; when associated with 2-G-S-255 DEL or 2-G-E-444 DEL.
Cytokinesis is impaired during the embryonic first mitotic division. Specifically, lacks membrane contraction and pseudocleavage. Fails to extrude polar bodies. Fails to segregate P-granules to the posterior cortex. Redistribution of cortical actin to form an anterior actin cap after pronuclear migration is impaired as well as the actin-myosin-mediated polarization of yolk granules. During late anaphase, the formation of actin contractile ring is partially impaired. Impaired osmoregulation causing embryos to swell.
Lacks catalytic activity in vitro. Catalytic activity is restored; when associated with Y-1135.
Ubiquitin carboxyl-terminal hydrolase cyk-3
Cilia- and flagella-associated protein 36
DBC1/CARP1 catalytically inactive NUDIX hydrolase
Acetylcholine receptor subunit alpha-type acr-16
Putative serine/threonine-protein phosphatase C27B7.6
LDL receptor repeat-containing protein egg-1
Probable adenylate kinase isoenzyme ZK673.2
In n1162; reduces the number of apoptotic corpses and restores the number of male tail rays in an icd-1 RNAi background.
In n1948; no effect on the interaction with mac-1.
Loss of dimerization without affecting interaction with ced-9, loss of ced-3 activation and severe reduction in the number of cell corpses in embryos in a ced-1 mutant background; when associated with E-252 and E-255.
Loss of dimerization without affecting interaction with ced-9, loss of ced-3 activation and severe reduction in the number of cell corpses in embryos in a ced-1 mutant background; when associated with E-255 and E-256.
Severe reduction in the number of cell corpses in embryos in a ced-1 mutant background.
Severe reduction in the number of cell corpses in embryos in a ced-1 mutant background. Loss of dimerization without affecting interaction with ced-9, loss of ced-3 activation and severe reduction in the number of cell corpses in embryos in a ced-1 mutant background; when associated with E-252 and E-256.
Partial sensitivity to Cu(2+). May prevent interaction with mlk-1 when phosphorylated at Tyr-209 which in turn may prevent the interaction between mlk-1 and mek-1. No effect on the association with mek-1. Severe sensitivity to Cu(2+) and no effect on the association with mek-1; when associated with K-234.
Weak sensitivity to Cu(2+). Severe sensitivity to Cu(2+) and no effect on the association with mek-1; when associated with K-136. Abolishes interaction with svh-2.
Histone-lysine N-methyltransferase met-2
Guanine nucleotide-binding protein alpha-16 subunit
In it143ts; temperature sensitive mutant. 70 percent of embryonic lethality. In 31 percent of EMS blastomeres, loss of nuclear rotation resulting in the transversal localization of the mitotic spindle.
Mediator of RNA polymerase II transcription subunit 11
In ct73; uncoordinated locomotion, withered tail morphology, egg-laying defects, protruding vulvae and multiple vulvae. Defective pharyngeal development, which results in animals appearing starved. Mesodermal lineage and neuronal cell migration and specification defects.
In e257; uncoordinated locomotion, withered tail morphology, egg-laying defects, protruding vulvae and multiple vulvae. Defective pharyngeal development, which results in animals appearing starved. Mesodermal lineage and neuronal cell migration and specification defects. Abolishes differentiation of RID peptidergic neurons.
In hp701; abolishes differentiation of RID peptidergic neurons.
In rh72; uncoordinated locomotion, withered tail morphology, egg-laying defects, protruding vulvae and multiple vulvae. Defective pharyngeal development, which results in animals appearing starved. Mesodermal lineage and neuronal cell migration and specification defects.
Steroid hormone receptor family member cnr14
E3 ubiquitin-protein ligase RING2 homolog spat-3
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1
Nuclear hormone receptor family member nhr-11
No obvious phenotype. No sumoylation; when associated with R-2882 and R-2884.
No sumoylation; when associated with R-2874 and R-2882.
No sumoylation; when associated with R-2874 and R-2884.
Results in no phosphorylation at S-2909, T-2912, S-2915 and S-2918. Retains ability to bind to hmp-2.
Results in no phosphorylation at S-2915 and S-2918. Upon phosphorylation by kin-19, there is increased binding to hmp-2.
In e5; defects in male mating behavior with spicule protrusion impairments. Impairs dopamine signaling.
In hs10; defects in male mating behavior with spicule protrusion impairments. Impairs dopamine signaling.
In hs9; defects in male mating behavior with spicule protrusion impairments. Impairs dopamine signaling.
In rg396; increases backwards movements. Defects in male mating behavior with spicule protrusion impairments. Impairs dopamine signaling.
Histone-lysine N-methyltransferase set-25
No effect on localization to nuclear foci.
Probable 26S proteasome regulatory subunit 6B
Messenger RNA-binding inhibitor of apoptosis 1
Probable 26S proteasome regulatory subunit 10B
In av26; weak suppressor of mat-3 mutations.
In ax148; maternal-effect embryonic lethal.
In ax79 and ax136; results in sterility.
In or172, or180 and or187; maternal-effect embryonic lethal.
Putative UDP-glucuronosyltransferase ugt-46
Does not impair function (unlike the corresponding mutation in atg-16.1, which causes defects in autophagy).
In bp636; results in defective degradation of sqst-1.
In ku354; drastically reduces wwp-1-dependent ubiquitin ligase activity. Marked reduction in brood size. On a lin-35 mutant background, 4% of larvae display a Pun (pharyngeal unattached) phenotype, whereby the pharynx fails to elongate and form an attachment to the anterior alimentary opening or buccal cavity. Increases to 40% Pun phenotype animals on a lin-35 mutant background combined with RNAi-mediated knockdown.
Loss of kgb-1 inhibition. No effect on interaction with pmk-3.
In q222; 6 percent of mutant mothers' progeny is sterile at the permissive temperature (16 degrees Celsius) and 77 percent at the restrictive temperature (25 degrees Celsius). Low levels of embryonic lethality.
In q367; 12 percent of mutant mothers' progeny is sterile at the permissive temperature (16 degrees Celsius) and 79 percent at the restrictive temperature (25 degrees Celsius). Low levels of embryonic lethality.
Mediator of RNA polymerase II transcription subunit 10
Uncharacterized MFS-type transporter C09D4.1
Required for tertiary structure stability of the protein
Eukaryotic translation initiation factor 3 subunit I
Represses the convulsive behavior due to cholinergic hyperexcitation caused by an acr-2 mutant.
Abolishes the interaction with lgg-1 and lgg-2.
Impairs interaction with lgg-1 and lgg-2.
In bp400; mutant protein does not form aggregates, but cytoplasmic localization is diffuse throughout embryogenesis.
In bp401; temperature sensitive with the mutant protein forming 'speckles' at 15 degrees Celsius and diffusely localized at 25 degrees Celsius.
Required for interaction with lgg-1 and lgg-2
Required for self-association and interaction with pgl-3
3-phosphoinositide-dependent protein kinase 1
In sa680; developmental arrest at dauer stage, extended life span, increased body size, low fertility, and defects in egg-laying and social behavior. Fails to avoid NaCl after exposure to NaCl under starvation conditions. Restores normal AIY interneuron neurite outgrowth in a daf-18 (mg198) background mutant.
In sa709; increased resistance to oxidative stress induced by paraquat. daf-16 mainly localizes to the nucleus as opposed to the cytoplasm as it does in wild-type.
Prion-like-(Q/N-rich) domain-bearing protein 8
In tm1516; significant anterior displacement of the first sensory ray of the male tail. Anterior displacement of ray 1 is enhanced on a bar-1 mutant background. Reduced lifespan, further reduced on a daf-2 mutant background. Reduced N.parisii spore levels, further reduced on an mdl-1 mutant background.
NPC intracellular cholesterol transporter 1 homolog 1
Organic solute transporter alpha-like protein 1
In me85; late onset mitotic defects where old adults display enlarged nuclei in the mitotic region of the germ line. The number of these enlarged nuclei increases with age. Defective homologous chromosome pairing evident by nuclei with variable degrees of chromosome clustering persisting into the pachytene region. Diakinesis oocytes do form chiasmata as in wild-type, but in contrast to wild-type, the number of chiasmata decreases with age. X-chromosomes are frequently involved in non-homologous synapses. Increases the number of sun-1-positive foci in transition zone nuclei during meiotic prophase, but these foci fail to form large aggregates, have reduced movement and reduced number of fusion events. Lower basal rate of oxygen consumption.
In oj35; reduces growth rate and results in vulval defects. Produces dead eggs at a restrictive temperature. Defective cell division and cytokinesis during embryogenesis. Fails to extrude extra maternal pronuclei and displays abnormally large polar bodies following alignment of the meiotic spindle. Delayed maternal pronuclear migration, and paternal pronuclear envelope decay near the posterior cortex prior to the pronuclei meeting. Defective orientation of the first mitotic spindle where the mitotic spindle aligns transversely to the anterior-posterior axis. This leads to a mispositioned cleavage plane that does not coordinate with the polarity axis, and results in a failure of the asymmetric division. Astral microtubules are excessive in length as compared to wild-type and make contact with the cortex and continue to grow along it. Embryonic localization of dnc-1 to the centrosomes, along spindle microtubules, and to the plus ends of astral microtubules is similar to wild-type, but it is enriched at posterior structures resembling P granules. In addition, dnc-2 is enriched in the pericentriolar region, the mitotic spindle and cytoplasm. 40% increase in ATP concentration compared to wild-type. The egg lethality and spindle rotation defects are suppressed in a smg-1 RNAi mutant background.
Dehydrogenase/reductase SDR family member 4
Nuclear hormone receptor family member nhr-96
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Uncharacterized calcium-binding protein C50C3.5
Post-GPI attachment to proteins factor 3
In ky791; reduces expression of the G protein-coupled receptor (GPCR) srsx-3 in the AWC neuron.
In p678; defects in the avoidance of P.aeruginosa and of nitric oxide. In nu629; abolishes the calcium flux to the cytoplasm in the ASJ sensory neurons in response to the addition and removal of a nitric oxide stimulus.
In g25; temperature-sensitive mutant. At the restrictive temperature of 25 degrees Celsius, causes 96 percent embryonic lethality. At the permissive temperature of 22.5 degrees Celsius, partially restores normal distal tip cell migration in a mig-17 (k174) mutant background.
In g30; temperature-sensitive mutant. At the restrictive temperature, causes 90 percent lethality. At the permissive temperature of 16 degrees Celsius, causes the formation of ectopic presynaptic boutons on the ventral cord axons.
In g37 and b246; 9% lethal. Moderate reduction in basement membrane localization associated with a moderate accumulation in muscle cell cytoplasm. At the restrictive temperature of 25 degrees Celsius, causes a reduction of nid-1 recruitment to the gonad basement membrane. At the permissive temperature of 22.5 degrees Celsius, partially restores normal distal tip cell migration in a mig-17 (k174) mutant background.
In ju1166; suppresses the lethal phenotypes of the pxn-2 tm3464 mutant.
In ju1180; suppresses the lethal phenotypes of the pxn-2 tm3464 mutant.
In k193; temperature-sensitive mutant. At both the restrictive and permissive temperatures, causes 16-20 percent embryonic lethality. Slight reduction in basement membrane localization associated with a slight intracellular accumulation in muscle and distal tip cells (DTC). In a mig-17 (k174) mutant background, restores normal DTC migration and nid-1 basement membrane localization. Enhances the lethality of the pxn-2 mutant (ju432).
In k196; temperature-sensitive mutant. At the restrictive temperature of 25 degrees Celsius, causes 85 percent larval lethality. Slight reduction in basement membrane localization associated with a slight intracellular accumulation in muscle and distal tip cells (DTC). In a mig-17 (k174) mutant background, restores normal DTC migration and nid-1 basement membrane localization.
F-box/WD repeat-containing protein sel-10
In n1074; masculinizing phenotype. Does not self-interact in vitro or bind to skr-1 protein.
Vacuolar protein sorting-associated protein 55 homolog
In k201/tk51; slight defect in posterior DTC migration. In a let-2 (k196) mutant background, partially prevents anterior DTC migration. Restores normal DTC migration and nid-1 basement membrane localization in a mig-17 (k174) mutant background but not in a mig-17 (k174) and nid-1 (cg119) mutant background. Restores nid-1 basement membrane localization in a mig-17 (k174) mutant background.
In k206; No defect in DTC migration. In a let-2 (k196) mutant background, partially prevents anterior DTC migration. Restores normal DTC migration and nid-1 basement membrane localization in a mig-17 (k174) mutant background but not in a mig-17 (k174) and nid-1 (cg119) mutant background.
Hypoxia-inducible factor prolyl hydroxylase
Loss of hydroxylase activity resulting in loss of oxygen-mediated hif-1 degradation. Inhibition of hif-1 transcriptional activity, which is independent of egl-9 hydroxylase activity, is only slightly affected. Loss of glr-1 recycling; in isoform e.
Loss of interaction with cysl-1 associated with a loss of hypoxia-mediated inhibition of behavior adaptation.
Probable muscarinic acetylcholine receptor gar-1
In OR28; defects in localization of aph-2.
Nuclear hormone receptor family member nhr-77
Guanine nucleotide-binding protein subunit beta-2
In fr68; severe loss of nlp-29 expression upon D.coniospora infection.
Lim and transglutaminase domain protein ltd-1
Potential vesicular glutamate transporter vglu-3
Defective pharyngeal development protein 4
In q400; induces embryonic developmental arrest and lack of a pharynx.
26S proteasome non-ATPase regulatory subunit RPN1 C-terminal
Molybdopterin synthase sulfur carrier subunit
In ye107; resistant to Bacillus thuringiensis crystal5B toxin.
RecQ mediated genome instability protein 1-like N-terminal helical
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
Histone-lysine N-methyltransferase set-1
Beta-lactamase domain-containing protein 2
In isoform a, isoform c, isoform e, isoform g, isoform i, isoform k, isoform m and isoform r.
Glycosyltransferase family 92 protein F13G3.3
In ga94; displays vulval defects and are unable to lay eggs, but still executes lateral hypodermal terminal differentiation.
In n546; fails to execute adult-specific terminal differentiation at the larval L4 molt and instead reiterates larval differentiation program. On a him-5 mutant background, males failed to mate with unc-13 hermaphrodites. Males have shortened spicules, male-specific mating structures. Males also exhibit delayed ray formation and gonad migration defects. Up-regulates nhr-23 and nhr-25 about 12-fold relative to the wild type in adult hermaphrodites.
In sy292; egg-laying defective. Fails to specify uterine pi-cell fate, has an abnormal uterine-vulval connection and vulval gene expression patterns are altered.
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
In y607; sex-specific enrichment of H4K20me1 is abolished from X chromosomes in XX adults and embryos. Elevated X-linked gene transcription relative to autosomes. Leads to increased X chromosome volume. Results in less distinct chromosome organization and reduced boundary strength of topologically associating domains (TADs). Loss of H4K20me1 enrichment on autosomes and decompaction in male and hermaphrodite meiotic germ cells. Suppresses the X0-specific lethality in a xol-1 mutant background, where the DCC is inappropriately activated.
In y618; sex-specific enrichment of H4K20me1 is abolished from X chromosomes in XX adults and embryos. Elevated X-linked gene transcription relative to autosomes. Leads to increased X chromosome volume. Suppresses the X0-specific lethality in a xol-1 mutant background, where the DCC is inappropriately activated.
In y622; loss of demethylase activity. Sex-specific enrichment of H4K20me1 is abolished from X chromosomes in XX adults and embryos. Elevated X-linked gene transcription relative to autosomes. Leads to increased X chromosome volume. Suppresses the X0-specific lethality in a xol-1(y9) mutant background, where the DCC is inappropriately activated.
In qn40; defective sleep induction following heat stress in a flp-13 overexpressing mutant background.
In qn44; defective sleep induction following heat stress in a flp-13 overexpressing mutant background.
In qn49; defective sleep induction following heat stress in a flp-13 overexpressing mutant background.
In qn51; defective sleep induction following heat stress in a flp-13 overexpressing mutant background.
In qn52; defective sleep induction following heat stress in a flp-13 overexpressing mutant background.
In qn53; defective sleep induction following heat stress in a flp-13 overexpressing mutant background.
In qm182; lipid contents in the intestine increases by 40%, and by 80% on a klf-3 mutant background. Suppresses the delayed germline development and egg-laying on a clk-1 mutant background, but does not affect the rate of postembryonic development; when associated with F-62.
In qm182; lipid contents in the intestine increases by 40%, and by 80% on a klf-3 mutant background. Suppresses the delayed germline development and egg-laying on a clk-1 mutant background, but does not affect the rate of postembryonic development; when associated with T-146.
Microsomal triglyceride transfer protein homolog
Mitochondrial import receptor subunit TOM22 homolog
In ga96; causes defects in embryonic development, larval body morphology and vulval development. Adult hermaphrodites have gonad migration defects in which one or both arms of the developing gonad fail to turn correctly. Decrease in the number of ventral hypodermal cells (Pn.p cells) and in the number of ventral cord neurons (Pn.a cells). Ectopic expression of scm in P cells in 27% of animals raised at the restrictive temperature, 25 degrees Celsius.
Transcription initiation factor TFIID subunit 12
Structural maintenance of chromosomes protein 4
Intraflagellar transport protein 46 homolog
Does not localize to the nuclear envelope of hyp7 hypodermal precursor cells.
Localizes normally to the nuclear envelope of hyp7 hypodermal precursor cells and interacts with unc-84, however hyp7 hypodermal precursor cells exhibit failed nuclear migration.
Localizes normally to the nuclear envelope of hyp7 hypodermal precursor cells and interacts with unc-84, however hyp7 hypodermal precursor cells exhibit failed nuclear migration. Rescues the nuclear migration defect in hyp7 hypodermal precursor cells in the null mutant.
Localizes normally to the nuclear envelope of hyp7 hypodermal precursor cells, however hyp7 hypodermal precursor cells exhibit failed nuclear migration.
Localizes normally to the nuclear envelope of hyp7 hypodermal precursor cells, however hyp7 hypodermal precursor cells exhibit failed nuclear migration. Rescues the nuclear migration defect in hyp7 hypodermal precursor cells in the null mutant.
Normal synapse localization, locomotion and, endogenous and evoked excitatory postsynaptic currents; when associated with N-380.
Normal synapse localization, locomotion and, endogenous and evoked excitatory postsynaptic currents; when associated with S-378.
Probable loss of catalytic activity. Reduced locomotion and severe reduction in endogenous and evoked excitatory postsynaptic currents.
Probable geranylgeranyl transferase type-2 subunit beta
Ubiquitin fusion degradation protein 3 homolog
Abolishes sumoylation. Does not affect nuclear localization during mitochondrial stress. Enhances transcriptional activity.
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in smo-1)
In et15; probably reduces its mitochondrial import. Constitutively activates the mitochondrial unfolded protein response. Reduced axonal degeneration and death following anoxia-reperfusion.
In et18; reduces its mitochondrial import, constitutively activates the mitochondrial unfolded protein response and up-regulates transcription of several innate immune response genes. Increases resistance to P.aeruginosa-mediated infection. Reduces the levels of deleterious mtDNA.
Loss of nuclear import. Prevents up-regulation of hsp-60 in response to P.aeruginosa-mediated infection. Assembly of complex I and ATP synthase and oxygen consumption are reduced in a spg-7 RNAi-mediated knockdown background.
Stress activated transcription factor atfs-1
In e1511; reduces the fidelity of mitotic chromosome segregation at 25 degrees Celsius.
Putative H/ACA ribonucleoprotein complex subunit 4
Interleukin cytokine receptor-related protein 2
Probable cleavage and polyadenylation specificity factor subunit 2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3
In pk3321; defective avoidance behavior in response to P.aeruginosa.
In qt10; Failure to spread gene silencing signal. Loss of binding to shorter than 100 base-pair long dsRNA and decreased affinity for longer RNA species. Decreased RNA transport.
In qt4; Failure to spread gene silencing signal.
Loss of binding to shorter than 100 base-pair long dsRNA and decreased affinity for longer RNA species. Decreased RNA transport.
Systemic RNA interference defective protein 1
L-2-hydroxyglutarate dehydrogenase, mitochondrial
Loss of X chromosome association and failure in dosage compensation complex assembly; when associated with S-2080; S-2083 and S-2119.
Loss of X chromosome association and failure in dosage compensation complex assembly; when associated with S-2080; S-2083 and S-2122.
Loss of X chromosome association and failure in dosage compensation complex assembly; when associated with S-2080; S-2119 and S-2122.
Loss of X chromosome association and failure in dosage compensation complex assembly; when associated with S-2083; S-2119 and S-2122.
TWiK family of potassium channels protein 7
Nuclear hormone receptor family member nhr-209
In mg326; increases constitutive dauer larva formation at 25 degrees Celsius in akt-1 mg306 mutant background.
In mg348; wild-type lifespan. Moderate increase in constitutive dauer larva formation at 27 degrees Celsius. Significant increase in dauer larva formation in response to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) at 25 degrees Celsius. This phenotype is abrogated in an aak-2 gt33 mutant background. Increases dauer formation in a hpd-1 ok1955 mutant background. Increases dauer formation and increases aak-2 phosphorylation, but does not impair energy production in a tatn-1 RNAi mutant background. Reduces dauer formation in a tatn-1 RNAi or tatn-1 qd182 and aak-2 gt33 mutant background.
Probable loss of myristoylation. Loss of membrane localization.
Probable dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3
5-glutamyl coenzyme A thioester intermediate
Probable succinyl-CoA:3-ketoacid coenzyme A transferase, mitochondrial
No effect on binding with num-1 (isoform a and isoform c).
Prevents binding with num-1 (isoform a and isoform c).
Abolishes enzyme activation but has no effect on disulfide bond formation or dimer formation; when associated with A-167.
Abolishes enzyme activation but has no effect on disulfide bond formation or dimer formation; when associated with A-169.
In transgene rescue experiments with doxa-1 loss-of-function mutant, results in reduced capacity of the transgene to revert increased survival in excess iodide, an oxidative stressor.
In e270; axon outgrowth, pioneering and pathfinding defects; mechanosensory defects.
In e419; axon outgrowth and pathfinding defects; mechanosensory defects; abolishes expression of oligopeptide transporter pept-3 in AVE neurons, and both FMRFamide related neuropeptide precursor gene flp-1 and neuron specific calcium sensor ncs-1 in AVK neurons. Abolishes expression of seven-transmembrane receptor srb in ASH neurons. Chemical synaptic connectivity is reduced in neurons that normally express unc-42 in the pre- and post-synaptic neurons. Reduces expression of vesicular acetylcholine transporter unc-17 and hence cholinergic identity in all but one of the normally unc-42(+) neurons. Reduces the expression of cholinergic receptor systems, and also the expression of the tyramine-gated chloride channel lgc-55. Highly patterned expression of neuropeptides and neuropeptide receptors is severely affected. Expression of innexins inx-18a and inx-19 is selectively down-regulated in those neurons that normally express unc-42. Abolishes expression of putative osmosensor osm-10 in ASH neurons.
In gm23; axon pioneering and pathfinding defects.
Constitutively active (GTP-locked form). Localizes to the cortical granules in oocytes. Recruits sep-1 to cortical granules in embryos following fertilization.
Constitutively inactive (GDP-locked form). Diffusely localized. Fails to localize to the cortical granules in oocytes. Does not recruit sep-1 to cortical granules in embryos following fertilization. In glr-1 expressing neurons reduces the number of glr-1-positive puncta in a rab-6.2 tm2254 mutant background.
Bifunctional L-3-cyanoalanine synthase/cysteine synthase
Probable G-protein coupled receptor C06G4.5
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase daf-18
Probable loss of lipid phosphatase activity without affecting protein phosphatase activity. Fails to prevent both constitutive dauer formation and increased lifespan in a daf-2 (e1370) mutant background. Partially increases the percentage of animals lacking a vulva in a let-23 mutant background and partially reduces the number of animals with multiple vulva in a gain-of-function let-60 mutant background.
Probable loss of phosphatase activity. Stabilizes the interaction with vab-1.
Probable cytosolic iron-sulfur protein assembly protein CIAO1 homolog
Guanine nucleotide exchange factor rei-2
In pe902; severe loss of chemotaxis in response to Cl-.
In pe905; moderate loss of chemotaxis in response to Cl-.
In pe922; moderate loss of chemotaxis in response to Cl-.
Required for endoplasmic reticulum targeting
Required and sufficient for interaction with smu-1
Smu-2 suppressor of mec-8 and unc-52 protein
Probably constitutively active. Does not reduce paralysis induced by aldicarb treatment.
Probably nucleotide-free or GDP-bound. Reduces paralysis induced by aldicarb treatment.
Nuclear hormone receptor family member nhr-217
In hp2; abnormal morphology of GABAergic neuromuscular junctions and reduced synaptic transmission. Severe impaired interaction with egl-3 and loss of egl-3 ubiquitination.
Nuclear hormone receptor family member nhr-167
In isoform h, isoform j, isoform k, isoform l, isoform m and isoform n.
In isoform j, isoform k, isoform m and isoform o.
In ju146; increases the number of lgg-1-containing protein aggregates in the neurites of AIY interneurons. This is further increased in either an atg-4.2 ola316 or atg-4.2 gk628327 mutant background. Reduces the retrograde trafficking of autophagosomes in AIY neurites, but increases anterograde autophagosome trafficking and increases the number of autophagosomes which are not trafficked. This results in an abnormal accumulation of autophagic vacuoles in neurites.
In n730; increases the number of lgg-1-containing protein aggregates in the neurites of AIY interneurons.
In sa3; Defecation defect. Reduced fatty acid uptake into the cytoplasm of intestinal cells and reduced triglycerides in the intestine.
3beta-hydroxysteroid dehydrogenase/Delta(5)-Delta(4) isomerase 1
Serine/threonine-protein kinase receptor sma-6
Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-5
Ribosome biogenesis protein WDR12 homolog
In n2839; 50 percent reduction in brood size. Partial collapse of vulva invagination. Reduced levels of chondroitin and heparan sulfate proteoglycans associated with a reduction in the chondroitin chain length.
In n2844; F1 adults accumulate eggs in the uterus. Embryos are predominantly arrested at the bean/comma embryonic stage.
A disintegrin and metalloproteinase with thrombospondin motifs adt-1
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
Histone-lysine N-methyltransferase set-17
In n5017; Reduces the number of eggs laid. In males, there is a 50% reduction in the number of spermatids per spermatheca which reduces male fertility. Reduces the transcription of major sperm proteins and the number of fibrous-body membranous organelles in the cytoplasm of spermatocytes. Reduces the methylation of 'Lys-4' of histone H3.
Signal recognition particle subunit SRP72
Putative ATP synthase subunit epsilon, mitochondrial
Nuclear hormone receptor family member nhr-69
Eukaryotic translation initiation factor 2A
In isoform 1, isoform 2, isoform 5 and isoform 7.
Phorbol ester/diacylglycerol-binding protein unc-13
Calcium uptake protein 1 homolog, mitochondrial
In jh139; reduces brood size and body length.
Ubiquitin-conjugating enzyme E2 variant 1
Probable histone-lysine N-methyltransferase lin-59
In ok257; Disrupts seam cell division and alae formation. Reduces the total number of microRNAs and reduces microRNA-mediated gene silencing. Disrupts the localization of alg-1 to endomembranes. Increases the expression of lin-41 protein, which is a target for the let-7 microRNA. Increases the number of animals with a burst vulva phenotype in a let-7 n2853 mutant background. The seam cell division and alae formation defects are suppressed in a rab-6.1 or rab-6.2 RNAi mutant background.
In qbc24; males are sterile. Disrupts seam cell division and alae formation. Disrupts the localization of alg-1 to endomembranes, and instead alg-1 accumulates in the perinuclear region. Reduces the total number of microRNAs and reduces microRNA-mediated gene silencing. Specifically reduces the association of alg-1 with microRNAs. Increases the expression of lin-41 protein, which is a target for the let-7 microRNA. The seam cell division and alae formation defects are suppressed in a rab-6.1 or rab-6.2 RNAi mutant background. The localization of alg-1 is restored in a rab-6.1 RNAi mutant background.
Abscisic acid G-protein coupled receptor-like
In n1653; no effect on the interaction with ced-4. Normal elimination of presynaptic components in RME neurons in adults. No effect on mitochondrial dynamics and morphology during early embryonic development.
In n1950; gain of function mutant. No effect on the interaction with ced-4. Impaired elimination of presynaptic components in RME neurons in adults. Abnormal accumulation of F-actin at the non-eliminated transient synapses in DD neuron dorsal cord in L4 larvae. No effect on mitochondrial dynamics and morphology during early embryonic development.
In n2812; significantly reduces localization of drp-1 to mitochondria. No effect on mitochondrial dynamics and morphology during early embryonic development.
Significantly reduced interaction with drp-1 in vitro.
Putative pyridoxal-phosphate dependent protein F13B12.4
Mediator of RNA polymerase II transcription subunit 21
Patatin-like phospholipase domain-containing protein ZK370.4
BLOC-1-related complex subunit 8 homolog
In ju1056; Loss of gsnl-1 cleavage. Impaired elimination of presynaptic components in RME neurons in adults. Abnormal accumulation of F-actin at the non-eliminated transient synapses in DD neuron dorsal cord in L4 larvae.
In n1040; increased autoprocessing in absence of ced-4. Autoprocessing is blocked in presence of npp-14 and reduced in presence of both ced-4 and npp-14. Loss of embryonic and postembryonic apoptosis resulting in survival of cells in the head, ventral cord, postdeirid sensilla and Q descendants in a ced-1 mutant background defective in cell-corpse clearance. Apoptosis is partially restored in a ced-1 (e1735) and npp-14 (sm160) double mutant background.
In n1229/n1164; severe reduction in catalytic activity. Partially processed. Reduction in the number of apoptotic cells in the anterior pharynx. In a ced-1 mutant background, loss of embryonic and postembryonic apoptosis resulting in survival of cells in the head, ventral cord, postdeirid sensilla, Q descendants and cells of the anterior pharynx.
In n2427/n2438; slight reduction in catalytic activity. Almost complete processing. Slight reduction in the number of apoptotic cells in the anterior pharynx. Reduction is higher in a drp-1 or fis-2 mutant background. Reduction in number of eggs laid. In a ced-9 (n1653) mutant background, causes 60 percent embryonic lethality.
In n2433; loss of catalytic activity. Loss of processing. Severe reduction in the number of apoptotic cells in the anterior pharynx. Loss of embryonic apoptosis in a ced-1 mutant background defective in cell-corpse clearance. Impaired axonal regeneration following injury. Resistance to S.typhimurium-mediated killing.
In n2439; increased autoprocessing in absence of ced-4. Autoprocessing is blocked in presence of npp-14 and reduced in presence of both ced-4 and npp-14. Loss of embryonic and postembryonic apoptosis resulting in survival of cells in the anterior pharynx in a ced-1 mutant background defective in cell-corpse clearance. Apoptosis is partially restored in a ced-1 (e1735) and npp-14 (sm160) double mutant background.
In n2449; normal autoprocessing. No effect on embryonic and postembryonic apoptosis in a ced-1 mutant background defective in cell-corpse clearance.
In n718; increased autoprocessing in absence of ced-4. Autoprocessing is blocked in presence of npp-14 and reduced in presence of both ced-4 and npp-14. Loss of embryonic and postembryonic apoptosis resulting in survival of cells in the head, ventral cord, postdeirid sensilla and Q descendants in a ced-1 mutant background defective in cell-corpse clearance. Apoptosis is partially restored in a ced-1 (e1735) and npp-14 (sm160) double mutant background.
Loss of catalytic activity. Prevents cell death. Loss of processing. No effect on the interaction with ced-4. Loss of interaction with octameric ced-4; when associated with 391-D--D-393.
Loss of interaction with octameric ced-4; when associated with S-358.
Superoxide dismutase [Mn] 2, mitochondrial
Probable DNA replication complex GINS protein PSF2
Putative patatin-like phospholipase domain-containing protein M110.7
DOMON domain-containing protein Y73F4A.2
Nuclear hormone receptor family member nhr-111
Putative serine/threonine-protein kinase R03D7.5
In h1959ts; temperature sensitive mutant that can be maintained at 20 degrees Celsius, but that results in embryonic lethality at 25 degrees Celsius.
In h1962ts; temperature sensitive mutant that can be maintained at 20 degrees Celsius, but that results in the production of unfertilized eggs and therefore sterility at 25 degrees Celsius.
In ye31; resistant to Bacillus thuringiensis crystal5B toxin. Susceptible to C.cinerea galectin Cgl2.
Probable acyl-coenzyme A oxidase acox-1.5
In e1926; aberrant development of all three cell types forming the male-specific genital sensilla (simple sense organs) known as rays. 81% ray loss. Ray loss phenotype exacerbated on hlh-2 mutant background. Drastically reduces binding to DNA as a heterodimer with hlh-2.
In u282; 99% loss of the male-specific genital sensilla (simple sense organs) known as rays, and tail touch insensitivity.
Sodium-dependent high-affinity dicarboxylate transporter 3
Probable small nuclear ribonucleoprotein F
In ok3161; partially lethal. Gonads are smaller than wild type. The few surviving adults have egg-laying defects and a protruding vulva. F1 progeny die at the embryonic stage and the few surviving larvae do not reach adulthood. Embryos exhibit severe defects in early cell divisions that result in nuclei of different sizes.
SWI/SNF chromatin-remodeling accessory subunit 2
In eb105; defect in spermatogenesis. Temperature sensitive fertility defect.
In eb106; defect in spermatogenesis. Temperature sensitive fertility defect.
In eb118; defect in spermatogenesis. Temperature sensitive fertility defect.
In eb64; defect in spermatogenesis. Slightly temperature sensitive fertility defect. Does not affect spe-10 localization.
Probable DNA polymerase delta small subunit
Mitochondrial import receptor subunit TOM40 homolog
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
Reduced sumoylation; when associated with R-291, R-314 and R-408.
Reduced sumoylation; when associated with R-291, R-408 and R-420.
Reduced sumoylation; when associated with R-314, R-408 and R-420.
Phytanoyl-CoA dioxygenase domain-containing protein 1 homolog
In allele gon-2(dx22); gonadless phenotype.
In allele gon-2(dx58); gonadless phenotype.
In allele gon-2(dx87); gonadless phenotype.
In allele gon-2(q362); gonadless phenotype.
In allele gon-2(q388); gonadless phenotype.
In E1120; paralyzed, egg laying defective and dumpy.
Required for interaction with unc-14 and vab-8
Serine/threonine-protein phosphatase 4 catalytic subunit 2
Putative 1-acyl-sn-glycerol-3-phosphate acyltransferase acl-2
Nuclear hormone receptor family member nhr-23
Probable glycerol-3-phosphate dehydrogenase 2
Interferon-related developmental regulator C-terminal
Interferon-related developmental regulator N-terminal
Nuclear hormone receptor family member nhr-59
Putative RNA polymerase II subunit B1 CTD phosphatase rpap-2
In hc108; self-sterility in hermaphrodites but normal male fertility.
In hc134ts; temperature-sensitive self-sterility in hermaphrodites but normal male fertility.
In hc40; self-sterility in hermaphrodites but normal male fertility.
In hc53; self-sterility in hermaphrodites but normal male fertility.
In hc79; self-sterility in hermaphrodites but normal male fertility.
5'-AMP-activated protein kinase catalytic subunit alpha-1
Probable voltage-gated potassium channel subunit kvs-4
Probable U6 snRNA-associated Sm-like protein LSm4
Probable E3 ubiquitin-protein ligase rnf113
Inositol polyphosphate-related phosphatase
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 homolog
In bx91; induces derepression of homeotic genes and affects sumoylation at 25 degrees Celsius.
Loss of cAMP binding which may prevent dissociation from kin-1. Contraction of enteric muscles is partially impaired.
cAMP-dependent protein kinase regulatory subunit
Probable splicing factor, arginine/serine-rich 1
In ar515; in 25 percent of mutants, abnormal anterior migration of QL neuroblast descendants.
Inhibits fluid uptake endocytosis in coelomocytes. Localizes in aggregates at the plasma membrane and/or to vesicles close to the plasma membrane. Abnormal anterior migration of QL neuroblast descendants. Reduction in the number of synapses formed in DA9 neurons.
Nuclear hormone receptor family member nhr-89
Abolishes interaction with unc-83 isoform c.
Required for interaction with unc-83 isoform c
Probable serine/threonine-protein phosphatase PP2A regulatory subunit
ALK tyrosine kinase receptor homolog scd-2
In qj141; defective olfactory adaptation resulting in impaired forgetting sensory responses to the odorant diacetyl.
In sa249; moderate decrease in dauer formation. Partially suppresses constitutive dauer formation in mutants of the TGF-beta pathway. Defect in sensory integration when confronted to two opposing environmental chemicals. Defective olfactory adaptation resulting in impaired forgetting sensory responses to the odorant diacetyl.
Probable 3',5'-cyclic phosphodiesterase pde-3
In ev520; mild uncoordinated phenotype. Causes no axon guidance defects or distal tip cell migrations and gonad morphology defects. Enhances the distal tip cell migration defects of unc-5 ev585, unc-5 e53 or unc-6 ev400 mutants. Suppresses the anterior touch neuron axon guidance defects in an unc-5 over-expression mutant background.
In ev529; causes no distal tip cell migrations and gonad morphology defects. Enhances the distal tip cell migration defects of the unc-5 ev585, unc-5 e53 or unc-6 ev400 mutants.
In isoform a, isoform b, isoform c and isoform e.
Does not interact with unc-64. Does not rescue the uncoordinated locomotion defect of the unc-18 e81 mutant.
Does not interact with unc-64. Increases sensitivity to ethanol. Mildly resistant to acetylcholine esterase inhibitor Aldicarb. Rescues the uncoordinated locomotion defect of the unc-18 e81 mutant.
In b403; uncoordinated with slow growth rate. Defects in synaptic vesicle docking and tethering. Accumulation of the neurotransmitter acetylcholine. Resistant to acetylcholine esterase inhibitor trichlorfon. Reduces binding to unc-64 and unc-13.
In e234; uncoordinated with slow growth rate. Vesicle docking defects with an accumulation of synaptic vesicles at presynaptic nerve terminals, but a decreased number of vesicle fusion events as a result of a reduction in the number of vesicles primed for release. Accumulation of the neurotransmitter acetylcholine. Resistant to acetylcholine esterase inhibitor trichlorfon. Defective anterograde transport of unc-64 out of neuronal cell bodies characterized by an accumulation of unc-64 in neuronal cell bodies. Abnormal accumulation of unc-6 in muscle cells.
In e81; locomotion and motility defects resulting in paralysis. Uncoordinated with slow growth rate. Vesicle docking defects with an accumulation of synaptic vesicles at presynaptic nerve terminals, but a decreased number of vesicle fusion events as a result of a reduction in the number of vesicles primed for release. Accumulation of the neurotransmitter acetylcholine. Resistant to acetylcholine esterase inhibitors trichlorfon and Aldicarb. Reduces unc-64 levels by 50%. Defective anterograde transport of unc-64 out of neuronal cell bodies characterized by an accumulation of unc-64 in neuronal cell bodies.
In md1401; uncoordinated with slow growth rate. Reduces locomotion. Accumulation of the neurotransmitter acetylcholine. Resistant to acetylcholine esterase inhibitor trichlorfon. Resistant to sedatory and stimulatory effects of ethanol.
In md1412; uncoordinated with slow growth rate. Accumulation of the neurotransmitter acetylcholine. Resistant to acetylcholine esterase inhibitor trichlorfon.
In sk2; gain of function mutation. Reduces body size. Increases motility. Increases release of the neurotransmitter acetylcholine from excitatory motor neurons. Increases sensitivity to acetylcholine esterase inhibitor Aldicarb.
Increases rate of locomotion. Resistant to sedatory and stimulatory effects of ethanol. Rescues the uncoordinated locomotion defect of the unc-18 e81 mutant.
Reduces binding to unc-64. Rescues the uncoordinated locomotion defect and sensitivity to acetylcholine esterase inhibitor Aldicarb defects of the unc-18 e81 mutant.
Rescues the uncoordinated locomotion defect and sensitivity to acetylcholine esterase inhibitor Aldicarb defects of the unc-18 e81 mutant. Impairs temperature sensitivity, tolerating higher temperatures compared to wild-type.
Uncharacterized calcium-binding protein B0563.7
In e262; movement defects, fertile. Abnormal, ectopic expression of ceh-12 in VA motor neurons. Inability to move backward is partially restored in an unc-12 mutant background. Ectopic expression of innexin unc-7 in puncta adjacent to VA motor neurons and DA class motor neurons, probably as a result of miswiring of gap junctions.
Putative UDP-glucuronosyltransferase ugt-56
Nitric oxide synthase-interacting protein homolog
CRAL-TRIO domain-containing protein T23G5.2
Probable small nuclear ribonucleoprotein-associated protein B
Reduces the touch responsiveness of the worm.
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
In n3376; defective programmed cell death.
Nuclear hormone receptor family member nhr-133
Phosphatidate cytidylyltransferase, mitochondrial
BTB and MATH domain-containing protein 45
Breast cancer type 1 susceptibility protein homolog
Microtubule-associated protein homolog maph-1.1
Abolished ability to hydrolyze ufm-1 bound to a target protein. No significant effect on GPCR localization in AWA cilia or odorant chemotaxis.
No significant effect on GPCR localization in AWA cilia.
Reduced ability to hydrolyze ufm-1 bound to a target protein.
Strongly reduced ability to hydrolyze ufm-1 bound to a target protein.
Tetratricopeptide repeat protein 30 homolog
Zinc finger E-box-binding homeobox protein zag-1
In gk567379; increased sensitivity to the neurotoxin 6-hydroxydopamine (6-OHDA) during the first three larval stages resulting in the degeneration of dopaminergic head neurons.
In gt1983; increased sensitivity to the neurotoxin 6-hydroxydopamine (6-OHDA) during the first three larval stages resulting in the degeneration of dopaminergic head neurons. Reduced survival and developmental defects in response to oxidative stress-induced by paraquat. No defects in the rate of axonal regrowth, reconnection or fusion after injury. No degeneration of dopaminergic head neurons in a dat-1 (ok157) mutant background in response to 6-OHDA. Dopaminergic neurodegeneration is partially suppressed in a ced-6 (n1813) or ced-10 (n3246) mutant background in response to 6-OHDA.
Probable 5-formyltetrahydrofolate cyclo-ligase
In e204; uncoordinated. In AIY, ASI, D-type neurons, impairs axonal guidance and outgrowth and in some cases causes ectopic axonal branching. In VD neurons, increases growth cone filopodial protrusion associated with a loss of F-actin polarity and an accumulation of plus-end microtubule in the growth cone. Causes mislocalization of several axonal and dendrite proteins. In the PLM neuron axon, increases the number of unc-9 puncta close to the two original gap junctions and the length of the first gap junction. Causes unc-33 mislocalization to the perikaryon. Reduces its expression, homodimerization and heterodimerization; in isoform b. Prevents homodimerization and heterodimerization; in isoform c.
In ky869; axonal proteins are mislocalized to dendrites.
In ky880; axonal proteins including unc-104 and synaptic proteins are mislocalized to dendrites. Increases tubulin levels in dendrites while decreasing tubulin levels in axons.
In yad26; in the PLM neuron axon, increases the number of unc-9 puncta close to the two original gap junctions and the length of the first gap junction, also causes mis-localization of unc-1, loss of unc-1-unc-9 co-localization and a reduction in the number of unc-9 leaving the gap junction; when associated with D-328.
In yad26; in the PLM neuron axon, increases the number of unc-9 puncta close to the two original gap junctions and the length of the first gap junction, also causes mis-localization of unc-1, loss of unc-1-unc-9 co-localization and a reduction in the number of unc-9 leaving the gap junction; when associated with K-168.
In n5117; fail to exit the molting cycle and inappropriately initiate an adult molt; effect more common in males than in hermaphrodites.
In n5118; fail to exit the molting cycle and inappropriately initiate an adult molt; effect more common in males than in hermaphrodites.
Abolished interaction with shc-1. Probable loss of kinase activity. Loss of phosphorylation at Y-890. Impaired axon regeneration following injury.
Abolishes phosphorylation. Impaired axon regeneration following injury.
In cim16; restores the locomotory speed defects and aldicarb sensitivity in the slo-1 (ky399gf) gain of function mutant.
Probable ergosterol biosynthetic protein 28 homolog
In qj1: Causes transgene silencing in hypodermal and intestinal cells but does not appear to markedly affect transgenes expressed in muscles or neurons. Abolishes A-to-IRNA editing of known substrates. Reduced nuclear localization of adr-2. Does not affect fertility.
Guanine nucleotide-binding protein alpha-15 subunit
In ust117; lack of cold-warm shock-induced translocation of exosome components from the nucleolus to the nucleoplasm.
Probable NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
In ct350; temperature-sensitive allele. Induces aberrant centrosome attachment and nuclear positioning when transferred to nonpermissive temperature.
In or577; temperature-sensitive allele. Induces aberrant centrosome attachment and nuclear positioning when transferred to nonpermissive temperature. Abolishes homodimerization.
Nuclear hormone receptor family member nhr-55
In e53; Disregulates axon guidance and migration. Distal tip cell migration defects. On an unc-129 mutant background, does not contribute to an increase in axonal guidance defects. The distal tip cell migration defects are enhanced in seu-1 ev520 or seu-1 ev529 mutants.
In ev585; temperature-sensitive allele leading to distal tip cells migration defects. The distal tip cell migration defects are enhanced in seu-1 ev520 or seu-1 ev529 mutants.
Induces a strong decrease in tyrosine phosphorylation but only weakly affects function in vivo; when associated with F-415; F-416; F-445; F-467 and F-566.
Induces a strong decrease in tyrosine phosphorylation but only weakly affects function in vivo; when associated with F-415; F-416; F-445; F-467 and F-719.
Induces a strong decrease in tyrosine phosphorylation but only weakly affects function in vivo; when associated with F-415; F-416; F-445; F-566 and F-719.
Induces a strong decrease in tyrosine phosphorylation but only weakly affects function in vivo; when associated with F-415; F-416; F-467; F-566 and F-719.
Induces a strong decrease in tyrosine phosphorylation but only weakly affects function in vivo; when associated with F-445; F-467; F-566 and F-719.
Loss of function and induces a strong decrease in tyrosine phosphorylation.
In ky707; reduced association with lim-4 resulting in AWB olfactory neurons adopting an AWC olfactory neuron cell identity.
Drastically reduces phosphorylation in vitro.
In e2809, e2889 and e2896; abnormal left-twisted body.
In e2888, e2890 and sc8; abnormal left-twisted body. At the restrictive temperature of 25 degrees Celsius, lethal in a dpy-31 (ju345) mutant background.
In e2906; temperature sensitive mutant. At the restrictive temperature of 15 degrees Celsius, lethal at the embryonic or early larval stages. At the permissive temperature of 25 degrees Celsius, slightly shorter and stouter.
Signal recognition particle subunit SRP68
Clumping behavior; behavior more similar to many wild-isolated strains of C. elegans than the laboratory reference Bristol N2 strain. Binds GLGPRPLRF-amide flp-21 peptide with lower affinity, in vitro. Not activated by EMPGVLRF-amide flp-18 peptide, in vitro.
In ad609; clumping behavior; when associated with A-144.
In ad609; clumping behavior; when associated with I-83.
In ky13; clumping behavior. Abnormally active during the sleep-like state called lethargus, which occurs during molting between larval and adult stages; normal quiescence restored in FMRFamide peptide receptor frpr-18 mutant background.
Ribonucleases P/MRP protein subunit popl-1
Nuclear hormone receptor family member nhr-199
In it13; defective meiotic chromosomal segregation.
In it23; defective meiotic chromosomal segregation.
In it44; induces temperature sensitivity; defective meiotic chromosomal segregation.
In me15; defective meiotic chromosomal segregation.
Glycosyltransferase family 92 protein C35A5.5
Eukaryotic translation initiation factor 3 subunit C
A disintegrin and metalloproteinase with thrombospondin motifs adt-2
In wk156; reduced seam cell size, lifespan and reduced adult body length with increased body width.
Mitochondrial import inner membrane translocase subunit tim-13
Guanine nucleotide-binding protein alpha-7 subunit
High zinc activated nuclear receptor protein
In am285; gain of function. The mutant protein accumulates in nucleus and increases transcription of zinc-activated genes in the absence of excess dietary zinc.
Phosphatidylinositol-binding clathrin assembly protein unc-11
Probable N-acetylgalactosaminyltransferase 9
Probable mitochondrial import inner membrane translocase subunit tin-44
Disruption of GABA(A) receptor clustering.
Sigma non-opioid intracellular receptor 1
Vacuolar protein sorting-associated protein 39 homolog
Centriolar and ciliogenesis-associated protein hyls-1
Does not alter centriole localization; Does not alter cilium localization; Partial rescue cilia assembly in the hyls-1 deletion mutants.
In db1039; defective aggregation behavior.
Interleukin cytokine-related protein 17.1
In yc20; enhances the hypodermal P-cell nuclear migration defect in unc-84 mutants.
Transducer of Cdc42-dependent actin assembly protein 1 homolog
In ot721; Induces ectopic expression of unc-129, unc-53, acr-16 and unc-8 in ventral nerve cord motor neurons (MNs) VA and VB. In an unc-3 mutant background, both normal and ectopic expression of unc-129 in ventral nerve cord MNs is abolished.
In ot763; Induces ectopic expression of unc-129 and unc-53 in ventral nerve cord motor neurons (MNs).
Probable 3-hydroxyacyl-CoA dehydrogenase B0272.3
In ns770; Viable. Inappropriate survival of male gonadal linker cell; exacerbated on a heat shock transcription factor hsf-1 mutant background. Simultaneous RNAi-mediated knockdown of cul-3 causes a synergistic increase in linker cell survival.
In s1132; hermaphrodites arrest during the early stages of larval stages.
In av77; temperature sensitive mutant. At nonpermissive temperature, fails to localize to chromosome axes in pachytene nuclei in hermaphrodite and male germlines and is absent from nuclei in the male meiotic division zone. Leads to cell cycle arrest in male and hermaphrodite germlines.
In it7; temperature sensitive mutant. At nonpermissive temperature, leads to embryonic lethality due to failure in sperm chromosome segregation during anaphase I of meiosis resulting in anucleate sperm.
In strain: CB4856; increased sensitivity to etoposide, teniposide and slightly increased sensitivity to XK469 and increased resistance to dactinomycin.
Integrin-linked protein kinase homolog pat-4
No effect on the interaction with unc-112 or pat-6.
Restores the interaction with unc-112 when mutated at 'Asp-382' and the localization of mutated unc-112 to integrin adhesion sites in body wall muscles.
Lysine-specific histone demethylase 1B homolog
Probable G-protein coupled receptor tkr-1
Phosphomimetic mutant which may allow for association with cebp-1.
18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23 C-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Actin interacting protein 3-like C-terminal
Probable insulin-like peptide alpha-type 2
Abolishes kinase activity and abolishes autophosphorylation. Does not rescue the axon regeneration defect in the svh-4 loss of function mutant (ok564) following injury to D-type motor neurons.
Discoidin domain-containing receptor tyrosine kinase B
Does not rescue the axon regeneration defect in the svh-4 loss of function mutant (ok564) following injury to D-type motor neurons.
Loss of N-glycosylation. Impairs axon regeneration following axon injury. No effect on axon localization and kinase activity.
No effect on axon regeneration following axon injury.
Partially impairs axon regeneration following axon injury.
Histidine triad nucleotide-binding protein 1
In sb26; no effect on thick filament organization in body wall muscles. Partially restores thick filament organization in a mel-26 (ct61sb4) mutant background.
Partial reduction in ced-3-mediated cleavage; when associated with E-404 and E-417.
Partial reduction in ced-3-mediated cleavage; when associated with E-404 and E-435.
Partial reduction in ced-3-mediated cleavage; when associated with E-417 and E-435.
Does not impair axon regeneration after injury.
Glycosyltransferase subfamily 4-like N-terminal
In rh152; causes ectopic muscle membrane extensions.
Abolishes phosphorylation; causes significant down-regulation of chemoreceptor str-1 expression.
In oy59; Suppresses reduced chemoreceptor gene expression phenotype in a Ser/Thr kinase kin-29 mutant background.
Localizes to cytoplasm; does not affect chemoreceptor str-1 expression; when associated with A-416.
Localizes to cytoplasm; does not affect chemoreceptor str-1 expression; when associated with A-515.
Probable small nuclear ribonucleoprotein G
Ethanolamine-phosphate phospho-lyase homolog 1
Heterogeneous nuclear ribonucleoprotein K homolog
Embryonic or larval lethality. The few surviving adults are uncoordinated and have severely reduced fertility.
Probable RNA 3'-terminal phosphate cyclase-like protein
Complete inhibition of the interaction with gyg-1. Loss of function.
Partially inhibits the interaction with gyg-1. Loss of function.
Slight reduction in the interaction with gyg-1. Partial loss of function in absence of glycogen branching enzyme.
Impaired alae formation. Animals are shorter and dumpier. Accumulation of multivesicular bodies in the epidermis. Impaired secretion of Hedgehog-related peptides such as wrt-2 in the epidermis.
Impaired alae formation. Animals are shorter and dumpier. Accumulation of multivesicular bodies in the epidermis. Impaired secretion of Hedgehog-related peptides such as wrt-2 in the epidermis. Accumulates together with che-14 and rdy-2 in multivesicular bodies but not in amphid sheath cells.
Impaired alae formation. Animals are shorter and dumpier. Accumulation of multivesicular bodies in the epidermis. No defect in collagen secretion.
Section of excretory canal is increased with multiple lumens and abnormal whorls.
Section of excretory canal is increased with multiple lumens and abnormal whorls. Impaired alae formation. Accumulation of multivesicular bodies in the epidermis. Animals are shorter and dumpier.
Section of excretory canal is increased with multiple lumens and abnormal whorls. No defect in collagen secretion.
V-type proton ATPase 116 kDa subunit a 2
Probable loss of catalytic activity. Failed epidermal enclosure during embryogenesis.
E3 ubiquitin-protein ligase hrd-like protein 1
In dy51; temperature sensitive mutant which at the restrictive temperature of 25 degrees Celsius displays uncoordinated movements, reduced pharyngeal pumping rate, prolonged defecation cycle, an egg-laying defect and embryonic lethality of the progeny. Accumulates of apoptotic cell corpses in abnormally enlarged early phagosomes prior to rab-5 recruitment. Decreases rab-5 recruitment to phagosomes. Impaired coelomocyte endocytosis.
In n4039; loss of apoptotic cell engulfment. Embryos fail to hatch. Loss of piki-1 recruitment to the nascent phagosome during apoptotic cell corpse engulfment.
In h1960; results in decreased brood size and a high incidence of males (Him) phenotype.
Suppressor of spindle checkpoint defect 1
In by105; increased expression of presenilin hop-1. Increased ROS levels and reduced survival upon paraquat treatment to induce oxidative stress.
Leucine-rich repeat serine/threonine-protein kinase 1
Loss of ability to correctly sort SV proteins. No loss of ability to correctly sort SV proteins; when associated with T-1877.
No loss of ability to correctly sort SV proteins; when associated with A-1726.
Ubiquitin-like modifier-activating enzyme Atg7 N-terminal
Calcium/calmodulin-dependent protein kinase kinase
Branched-chain-amino-acid aminotransferase, cytosolic
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D 1
Guanine nucleotide-binding protein alpha-12 subunit
Probably constitutively active. Constitutive expression of nlp-29, nlp-31, nlp-34, cnc-2, cnc-4 and cnc-1 in absence of infection.
Putative sodium-dependent excitatory amino acid transporter glt-3
Phosphomannose isomerase type I catalytic
Phosphomannose isomerase type I helical insertion
In wa22; Impaired synaptic vesicle recycling characterized by a partially diffused localization of synaptic vesicle protein snb-1 along the dorsal nerve cord and the formation of enlarged synaptic vesicles. snb-1 diffused localization is increased in a unc-57 (ok310) mutant background but not in a unc-26 (s1710) mutant background. Severe depletion of unc-26 at release sites in the dorsal nerve cord and increased phosphatidylinositol 4,5-bisphosphate levels at release sites and at the axonal plasma membrane. Impaired locomotion.
Probable ribosome biogenesis protein RLP24
Tyrosine-protein phosphatase non-receptor type eak-6
DNA polymerase epsilon catalytic subunit A C-terminal
Embryonic lethal and inhibits NDC80 complex binding to microtubules; when associated with A-100 and A-144.
Embryonic lethal and inhibits NDC80 complex binding to microtubules; when associated with A-100 and A-155.
Embryonic lethal and inhibits NDC80 complex binding to microtubules; when associated with A-144 and A-155.
Rescues embryonic lethality and chromosome segregation defects in single knockdown mutant; when associated with A-18, A-44 and A-51.
Rescues embryonic lethality and chromosome segregation defects in single knockdown mutant; when associated with A-8, A-18 and A-44.
Rescues embryonic lethality and chromosome segregation defects in single knockdown mutant; when associated with A-8, A-18 and A-51.
Rescues embryonic lethality and chromosome segregation defects in single knockdown mutant; when associated with A-8, A-44 and A-51.
In e1112; spontaneously induces activation of the crh-1/CREB1 transcription factor in cholinergic SIA neurons in the absence and presence of food. Reduces swimming-induced paralysis in response to amphetamine. Defective male mating behavior.
Beta-catenin/armadillo-related protein 1
In ep451; interferes with neuroblast Q migration.
In ep460 and mu63; suppresses ectopic expression of mab-5.
In ep461; interferes with neuroblast Q migration.
In ep466; interferes with neuroblast Q migration.
In ep484; interferes with neuroblast Q migration; in association with Asn-281.
In ep484; interferes with neuroblast Q migration; in association with Gly-278.
In ep485; interferes with neuroblast Q migration.
In ep486; interferes with neuroblast Q migration.
In ep487/ep478; variable interference with neuroblast Q migration.
In ga80; reduces survival. Abnormal Pn.p cell fate specification leading to defective vulval induction and a protruding vulval phenotype. Reduces sod-3 expression.
In mu349; suppresses ectopic expression of mab-5 and interferes with neuroblast Q migration.
BAG family molecular chaperone regulator 1
RNA 2-O ribose methyltransferase substrate binding
Dauer formation above 20 degrees Celsius.
Dauer formation above 25 degrees Celsius.
Dauer formation above 26 degrees Celsius.
Dauer formation; when associated with L-470.
Dauer formation; when associated with Y-401.
In e1368; dauer formation above 25 degrees Celsius. Enhances dauer formation in a tatn-1 RNAi mutant background.
In e1370; extended lifespan. Accumulates fat and undergoes dauer formation with a developmentally arrested germline at 25 degrees Celsius and above. Pigmented intestine and increased resistance to bacterial pathogens, UV, high temperature and paraquat treatment. At 22 degrees Celsius, under constant darkness conditions only 41% of animals enter the dauer diapause phase, while under constant white light exposure, 100% of animals enter the dauer diapause phase and lifepan increases. Under standard day light conditions 87% of animals lived longer as compared to wild-type. Reduced number of germline progenitors during larval development and proliferation of germline stem cells. Fails to avoid NaCl after exposure to NaCl under starvation conditions. Increases the number of muscle membrane extensions during larval development. Overextension of PML neuron axons. Reduces nucleoli size in hypodermal and pharyngeal muscle cells. Enhances the defective seam cell development and delayed terminal differentiation phenotype of the sea-2 bp283 mutant.
In e1391; dauer formation above 20 degrees Celsius and increased lifespan. Increases the number of muscle membrane extensions during larval development.
In m41; temperature-sensitive. No visible change in dauer formation and adult lifepspan at 15 degrees Celsius, but undergoes dauer formation at 25 degrees Celsius and has increased lifespan. Slight decrease in NaCl avoidance behavior after exposure to NaCl under starvation conditions. Normal number of muscle membrane extensions.
In m577; normal number of muscle membrane extensions.
In m596; increases the number of muscle membrane extensions during larval development.
In sa219; dauer formation above 20 degrees Celsius. Normal NaCl avoidance behavior after exposure to NaCl under starvation conditions.
Probable loss of kinase activity. Increased apoptosis during embryonic development in an akt-1 tm399 mutant background.
Aryl hydrocarbon receptor nuclear translocator homolog
Glycosyltransferase family 92 protein F59C6.8
Probable 26S proteasome regulatory subunit rpn-6.1
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Rab3 GTPase-activating protein regulatory subunit
Abolishes ligand binding; when associated with Q-625.
Abolishes ligand binding; when associated with Q-628.
In isoform e, isoform f, isoform g and isoform h.
In n2559; slow developmental rate to adulthood, absence of ovulation, sterility, absence of defecation cycle and intestinal calcium oscillations.
In sa73; slow developmental rate to adulthood, reduced brood size, slow intestinal calcium oscillations, slower pharyngeal pumping, longer defecation cycle, defective ovulation, reduced myoepithelial sheath contractility and reduced efficiency of sperm transfer. Causes gross mitochondrial morphological changes, consistent with enhanced mitochondrial fusion. Elevated levels of phosphorylation of AMP-activated protein kinase. At semi-permissive temperature of 20 degrees Celsius, suppresses longevity in an atf-6 mutant background.
In sy290; gain of function. 2-fold increase in ligand affinity. Increased velocity of posterior-to-anterior calcium wave. Reduced fertility, hyperactive spermathecal dilation leading to decreased brood size. Extended lifespan.
In sy327; gain of function. Increased velocity of posterior-to-anterior calcium wave and enhanced sheath contractile activity.
In sy328; reduced fertility and brood size.
In sy331; reduced fertility and brood size.
Inositol 1,4,5-trisphosphate receptor itr-1
Conserved oligomeric Golgi complex subunit 6
Ribosomal RNA methyltransferase SPB1-like C-terminal
In isoform a, isoform b, isoform c, isoform d, isoform e, isoform f, isoform g, isoform h, isoform i, isoform j, isoform k, isoform l and isoform u.
In isoform a, isoform b, isoform c, isoform d, isoform e, isoform f, isoform m, isoform p, isoform q and isoform t.
In isoform a, isoform b, isoform c, isoform g, isoform h, isoform i, isoform m, isoform r, isoform s and isoform t.
In isoform b, isoform e, isoform h, isoform k, isoform o, isoform q, isoform s and isoform t.
In isoform c, isoform f, isoform i and isoform l.
No catalytic activity. Arrest at L2 larval stage and abnormal formation of the excretory canal.
No defect in the formation of the excretory canal.
Severe loss of interaction with gck-3 and abnormal formation of the excretory canal; when associated with A-1133.
Severe loss of interaction with gck-3 and abnormal formation of the excretory canal; when associated with A-1222.
Probable S-adenosylmethionine synthase 5
Gamma-aminobutyric acid type B receptor subunit 2
No change in protein function; when associated with A-572.
No change in protein function; when associated with V-484.
Doublesex- and mab-3-related transcription factor dmd-3
In mg477; suppresses defect in vitellogenesis on sgk-1 mutant background.
Up-regulates expression of stress-response genes which may also be ceh-60 targets.
Galactoside 2-alpha-L-fucosyltransferase
Intraflagellar transport protein 20 homolog
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Alpha N-terminal protein methyltransferase 1
Loss of ribonuclease activity; when associated with A-313, A-314 and A-332.
Loss of ribonuclease activity; when associated with N-231; A-313 and A-314.
Loss of ribonuclease activity; when associated with N-231; A-313, and A-332.
Loss of ribonuclease activity; when associated with N-231; A-314 and A-332.
Potential E3 ubiquitin-protein ligase ariadne-2
In tm2443; chromosome segregation defects during meiosis and mitosis.
Abolishes phosphorylation by max-2. Loss of kinase activity. No effect on the interaction with max-2. Loss of resistance to heavy metal ions such as Cu(2+). Impaired axon regeneration after injury.
In km701; rescues growth arrest at larval L2-L3 stages in vhp-1 km20 mutant.
Loss of kinase activity. No effect on the interaction with max-2. No effect on phosphorylation of Ser-355 by max-2.
May abolish interaction with shc-2. Severe loss of resistance to heavy metal ions such as Cu(2+).
Mitogen-activated protein kinase kinase kinase mlk-1
Phosphomimetic mutant which probably causes constitutive kinase activation and results in mek-1 phosphorylation. Resistance to arachidonoyl ethanolamide (AEA)-mediated inhibition of axon regeneration after injury.
In he110; lack of postembryonic blast cell division.
Loss of activity. Arrest at an early larval stage associated with a lack of cell division in several postembryonic blast cells.
In n6219; many mutants fail to undergo developmental arrest in response to osmotic stress.
In n6228; many mutants fail to undergo developmental arrest in response to osmotic stress.
In n6231; many mutants fail to undergo developmental arrest in response to osmotic stress.
In n6242; many mutants fail to undergo developmental arrest in response to osmotic stress; exacerbated on insulin-like receptor daf-2 mutant background.
Nuclear hormone receptor family member nhr-1
Mitochondrial prohibitin complex protein 1
In isoform e, isoform f, isoform h and isoform i.
Abolishes phosphorylation by mbk-2. Abolishes interaction with mel-26. Prevents mei-1 degradation during the transition from meiosis to mitosis; when associated with C-36.
In ct46; gain of function. Embryonic lethal. Abolishes interaction with mel-26 and probably mel-26-mediated degradation. Simultaneous RNAi-mediated knockdown of ppfr-1, pph-4.1 or ppfr-4, partially rescues embryonic lethality. Myosin thick filaments are disorganized in body wall muscles in an unc-29 (e1072) mutant background.
In ct46ct101; null. Formation of an abnormally large polar body during oocyte meiosis II. Myosin thick filaments are disorganized in body wall muscles in an unc-29 (e1072) mutant background.
In ct46ct103; dominant negative. Formation of an abnormally large polar body during oocyte meiosis II. Increased in metaphase and anaphase meiotic spindle length, failure of chromosomes to align on the metaphase plate persistence of spindle poles during anaphase resulting in their mis-positioning and delay in anaphase meiotic spindle disassembly.
In ct46ct99; loss of function. Does not affect mei-1 degradation. Prevents mei-1 degradation during the transition from meiosis to mitosis; when associated with A-92.
In ct46sb9 and ct46sb17; gain of function.
Phosphomimetic mutant. No effect on the interaction with mel-26.
Severe loss of ATPase activity and complete loss of microtubule severing activity.
Non-specific lipid-transfer protein-like 1
In gu22; abnormal tail in males. Almost normal egg-laying by hermaphrodites. Mostly normal morphology in vulval cell vulF. Reduced expression of lin-48 in hindgut cells. Reduces DNA binding ability in vitro.
In n578; almost normal male tail. Abnormal egg-laying by hermaphrodites, as a result of defects in the vulva and the uterus, and their subsequent connection during the larval L4 stage. Abnormal morphology in vulval cell vulF. Fail to express lin-3 in the vulF cells in the vulva and lacks uv1 cells in the uterus; absence of uvl cells is suppressed in a let-23 mutant background. Increased germline cell apoptosis. Almost normal expression of lin-48 in hindgut cells. Reduces DNA binding ability in vitro. Abolishes expression of nlp-7. Significantly reduces expression of nlp-2.
In sy287; abnormal tail in males. Normal egg-laying by hermaphrodites when grown at 15 degrees Celsius, but defective at 25 degrees. Mostly normal morphology in vulval cell vulF. Reduced expression of lin-48 in hindgut cells. Reduces DNA binding ability in vitro.
In sy294; abnormal tail in males, due to variable cell lineage defects affecting the cells U, B and F, which would normally develop into the posterior rectal epithelium. Abnormal egg-laying by hermaphrodites. Mostly normal morphology in vulval cell vulF. Abolishes expression of lin-48 in hindgut cells, although expression in other cell types is maintained. Reduces DNA binding ability in vitro. Defects in excretory duct. Abolishes expression of nlp-7. Significantly reduces expression of nlp-2.
Uncharacterized integrin beta-like protein C05D9.3
Probable methylthioribulose-1-phosphate dehydratase
Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
Abolishes PIP2 binding, impairs trimerization, reduces potassium current and calcium-sensitivity; when associated with A-129.
Abolishes PIP2 binding, impairs trimerization, reduces potassium current and calcium-sensitivity; when associated with L-133.
Trimeric intracellular cation channel type 1B.1
Nuclear hormone receptor family member nhr-67
32 kDa beta-galactoside-binding lectin lec-3
Defective nuclear localization; when associated with A-195 or A-196.
Defective nuclear localization; when associated with A-198.
In m116 and m423; no transcriptional activity in vitro. Defective dauer formation.
In m420; no transcriptional activity in vitro. Defective dauer formation.
In m421; no transcriptional activity in vitro. Defective dauer formation.
In m424; reduced DNA binding affinity and transcriptional activity in vitro. Defective dauer formation.
In rh273; dauer-constitutive phenotype with gonadal heterochrony.
In rh284; temperature sensitive mutation that prevents transcriptional activity and with gonadal heterochrony.
In rh62 and rh274; dauer-constitutive phenotype with gonadal heterochrony.
In sa156; no transcriptional activity in vitro. Defective dauer formation.
Nuclear hormone receptor family member daf-12
Severely reduced DNA binding and reduced transcriptional activity in vitro.
Small reduction in DNA binding in vitro.
Probable splicing factor, arginine/serine-rich 5
Conserved oligomeric Golgi complex subunit 2
In or598; embryonic lethal. Defects in mitotic spindle formation and reduced paa-1 levels at mitotic centrosomes with normal rsa-1 centrosome localization. May prevent interaction with paa-1.
Serine/threonine-protein phosphatase 2A regulatory subunit rsa-1
Calponin homology domain-containing protein
In xd27; probable loss-of-function mutation. Reduced cell protrusions on both BDU and PLM neurons. Partial embryonic lethality. Weak egg laying. Distal tip cell migration defects.
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
Does not rescue the extended lifespan phenotype observed in ctbp-1 deletion mutants.
Rescues the extended lifespan phenotype observed in ctbp-1 deletion mutants.
Small ribosomal subunit protein mS35 mitochondrial conserved
Nuclear hormone receptor family member nhr-12
Voltage-dependent calcium channel alpha-1 subunit IQ
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial
CRAL-TRIO domain-containing protein C34C12.6
Serine/threonine-protein phosphatase 4 regulatory subunit 1
Cytochrome c oxidase assembly factor 7 homolog
MAP kinase-activated protein kinase mak-1
Glyceraldehyde-3-phosphate dehydrogenase 4
Acetylcholine receptor subunit beta-type lev-1
Probable UDP-N-acetylglucosamine pyrophosphorylase
Abolishes RNA-binding; when associated with G-638; L-650; G-661; G-665 and G-690.
Abolishes RNA-binding; when associated with L-634; G-638; G-661; G-665 and G-690.
Abolishes RNA-binding; when associated with L-634; G-638; L-650; G-661 and G-665.
Abolishes RNA-binding; when associated with L-634; G-638; L-650; G-661 and G-690.
Abolishes RNA-binding; when associated with L-634; G-638; L-650; G-665 and G-690.
Abolishes RNA-binding; when associated with L-634; L-650; G-661; G-665 and G-690.
Globular cytoplasmic granules form, but do not contain the P-granule components such as pos-1.
No effect on methylation of the RNA-binding RGG-box.
Reduces methylation of the RNA-binding RGG-box. Abolishes methylation of the RNA-binding RGG-box; when associated with A-641; A-650; A-658; A-661; A-665; A-668; A-676 and A-682.
Reduces methylation of the RNA-binding RGG-box. Abolishes methylation of the RNA-binding RGG-box; when associated with A-641; A-650; A-658; A-661; A-665; A-668; A-676 and A-690.
Reduces methylation of the RNA-binding RGG-box. Abolishes methylation of the RNA-binding RGG-box; when associated with A-641; A-650; A-658; A-661; A-665; A-668; A-682 and A-690.
Reduces methylation of the RNA-binding RGG-box. Abolishes methylation of the RNA-binding RGG-box; when associated with A-641; A-650; A-658; A-661; A-665; A-676; A-682 and A-690.
Reduces methylation of the RNA-binding RGG-box. Abolishes methylation of the RNA-binding RGG-box; when associated with A-641; A-650; A-658; A-661; A-668; A-676; A-682 and A-690.
Reduces methylation of the RNA-binding RGG-box. Abolishes methylation of the RNA-binding RGG-box; when associated with A-641; A-650; A-658; A-665; A-668; A-676; A-682 and A-690.
Reduces methylation of the RNA-binding RGG-box. Abolishes methylation of the RNA-binding RGG-box; when associated with A-641; A-650; A-661; A-665; A-668; A-676; A-682 and A-690.
Reduces methylation of the RNA-binding RGG-box. Abolishes methylation of the RNA-binding RGG-box; when associated with A-641; A-658; A-661; A-665; A-668; A-676; A-682 and A-690.
Reduces methylation of the RNA-binding RGG-box. Abolishes methylation of the RNA-binding RGG-box; when associated with A-650; A-658; A-661; A-665; A-668; A-676; A-682 and A-690.
Probable 3',5'-cyclic phosphodiesterase pde-2
Putative endoplasmic reticulum metallopeptidase 1-B
In bx142; reduced mate searching behavior.
Ribosomal RNA processing protein 1 homolog
Zinc finger DHHC domain-containing protein 4
Eukaryotic translation initiation factor 4E-2
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Phosphatidylserine decarboxylase proenzyme, mitochondrial
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Translation machinery-associated protein 7 homolog
Grinder formation defects are rescued in 1.6% of animals in an eat-17 ad707 mutant background.
Grinder formation defects are rescued in 4.1% of animals in an eat-17 ad707 mutant background.
In ad707; defective grinder formation characterized by disorganized cuticle ridges in the grinder and the absence of grinder plates resulting in ineffective grinding of bacteria.
Defecation defect; when associated with N-247.
Defecation defect; when associated with N-253.
Increases lifespan. Prevents interaction with mpz-1.
Transcription factor TFIIIC triple barrel
Does not impair binding to aat-6. Abolishes binding to aat-6; when associated with A-154 and A-155.
Highly reduces binding to aat-6. Abolishes binding to aat-6; when associated with A-26 and A-27.
Na(+)/H(+) exchange regulatory cofactor-like protein nrfl-1
Guanine nucleotide-binding protein alpha-5 subunit
In mh17; pointed tail tip in males, also known as leptoderan (Lep) tail. Loss of asymmetry in the divisions of the T cell lineage daughter cells, T.p and T.ap, often resulting in loss of neural cell fates. Gross morphologies of the tail tips of hermaphrodites unaffected, but both males and hermaphrodites have defects in tail tip cell fusion. On lin-44 mutant background, polarity of the T cell division is reversed. On a lin-17 mutant background, there is a loss of cell polarity in the T cell lineages, resulting in the generation of only hypodermal cell fates.
Does not rescue the AIY axon guidance defects of the unc-6 ev400 mutant.
In ev400; reduces synapse formation between the PHB and AVA neurons. Defective guidance of the AIY axon into the nerve ring, which impairs nerve ring assembly. Anterior touch neuron axons fail to extend in a dorsal direction. The axons of DA and DB motorneurons do not grow to their targets in the dorsal cord and instead extend along subdorsal longitudinal paths. Distal tip cell migration defects. The distal tip cell migration defects are enhanced in seu-1 ev520 or seu-1 ev529 mutants.
Partially rescues the AIY axon guidance defects of the unc-6 ev400 mutant.
Defective S-adenosyl-L-methionine binding and reduces methylation of daf-16.
In bp292; reduces methylation and impairs degradation of P-granule components pgl-1 and pgl-3 in somatic cells during embryogenesis. Reduces lifespan.
RNA polymerase II-associated protein 1 N-terminal
Actin-depolymerizing factor 1, isoforms a/b
For hydroxyacyl-coenzyme A dehydrogenase activity
Important for hydroxyacyl-coenzyme A dehydrogenase activity
Important for long-chain enoyl-CoA hydratase activity
Disrupts the attraction of the muscle arm extensions.
In zc12; strongly blocks hsp-4 mRNA induction. Severely attenuates larval development and growth, and causes disruption of ER homeostasis, when exposed to Gram-negative bacterium P.aeruginosa PA14; this effect is abrogated in a pmk-1 mutant background. Disrupts ER homeostasis and larval development, in the absence of pathogenic bacteria, when combined with RNAi-mediated knockdown of vhp-1, in a pmk-1-dependent manner. Increases constitutive ire-1 splicing activity, in a smg-2 mutant background. Positively modulates pek-1-mediated phosphorylation of the alpha subunit of eukaryotic translation-initiation factor 2 (eIF2alpha). Increases longevity by oleic acid (OA) dietary supplementation.
Baculoviral IAP repeat-containing protein bir-2
Putative RNA polymerase II transcriptional coactivator
Queuine tRNA-ribosyltransferase catalytic subunit
RNA binding; important for wobble base 34 recognition
Little or no effect, suggesting that it acts as an beta-like subunit.
Loss of function, suggesting that it acts as an beta-like subunit.
Cell cycle checkpoint protein RAD1 homolog mrt-2
Nuclear hormone receptor family member nhr-268
Nuclear hormone receptor family member nhr-85
Gamma-butyrobetaine hydroxylase-like N-terminal
Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-4
Loss of interaction with mpk-1 (isoform a).
Probable loss of activity. Truncated excretory canals; when associated with A-188.
Probable loss of activity. Truncated excretory canals; when associated with R-63.
Severe loss of interaction with mpk-1 (isoform a).
Disintegrin and metalloproteinase domain-containing protein 10 homolog
In n1258; reduced body length. Vulva precursor cells P(5-7).p fail to acquire a secondary cell fate. Males have severe tail patterning defects including shortened and fused rays, smaller fans and crumpled spicules. 13 percent of animals display a twisted pharynx. In a sma-9 (cc604) mutant background, partially restores the production of the 2 M lineage-derived coelomocytes. In a glp-1 (e2141) mutant background, results in 22 percent embryonic lethality and sterility in 30 percent of surviving adults. In a lin-12 (n137) mutant background, prevents the formation of an ectopic pseudovulva. In a lin-12 (ar170) mutant background, enhances the number of adults with 2 anchor cells. In a adm-4 (ok265) mutant background, causes sterility with abnormal oocytes containing endoreduplicated DNA and impaired spermatheca function, and production of 2 anchor cells. In a tsp-12 (ok239) mutant background, causes lethality at various developmental stages.
In n316; reduced body length. Reduced axon migration of SDQL neuron. No pharyngeal defects. In a sma-9 (cc604) mutant background, partially restores the production of the 2 M lineage-derived coelomocytes. In a lin-12 (n952) mutant background, restores egg-laying functions. In a glp-1 (e2141) mutant background, results in sterility in 18 percent adults.
In y414; hermaphrodites are viable as in wild-type.
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial
Abolishes the interaction with fem-3 but not with fem-1.
Loss of catalytic activity. Prevents male development. No effect on the interaction with fem-3.
No effect on the interaction with fem-3 and fem-1.
Severe reduction in the interaction with fem-1 and fem-3.
In mg158; thermotaxis defects with animals displaying cryophilic behavior.
Abolishes ability to demethylate m6ADNA in vitro. Reduces fertility and results in a high proportion of male progeny (also known as a Him phenotype). Defective DNA replication and aberrant rad-51 expression in germline nuclei indicative of defective DNA damage repair mechanisms. No change in phosphorylation levels of histone H3 'Ser-10'.
In mac397; increases survival in excess iodide.
In transgene rescue experiments with csnk-1 loss-of-function mutant, results in reduced capacity of the transgene to revert increased survival in excess iodide, an oxidative stressor.
Putative tyrosine-protein phosphatase B0280.11
Probable small nuclear ribonucleoprotein E
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in lgg-3/ATG12)
In bp546; results in defective degradation of protein aggregates by autophagy.
Coiled-coil domain-containing protein 130 homolog
Nuclear hormone receptor family member nhr-150
Glutamate-gated chloride channel subunit beta
Putative UDP-glucuronosyltransferase ugt-48
Mitochondrial 2-oxoglutarate/malate carrier protein
ADP-ribosylation factor-like protein 13B
Abolishes palmitoylation and localization to the cilium membrane.
Amphid cilia are abnormally dispersed and mis-positioned. Defects in intraflagellar transport.
Decreaed sumoylation. Abolishes sumoylation; when associated with R-239.
Decreased sumoylation. Abolishes sumoylation; when associated with R-331.
Loss of auto-glucosylation. No effect on interaction with gsy-1 but loss of gsy-1 function.
Loss of interaction with gsy-1. Complete loss of gsy-1 function.
Loss of interaction with gsy-1. Partial loss of gsy-1 function.
Protein phosphatase 1 regulatory subunit SDS22 homolog
Proton myo-inositol cotransporter hmit-1.3
Probable citrate synthase, mitochondrial
Set1/Ash2 histone methyltransferase complex subunit ash-2
Uncharacterized RING finger protein C02B8.6
N-acetyltransferase ESCO acetyl-transferase
Probable type I inositol 1,4,5-trisphosphate 5-phosphatase
In isoform a, isoform c, isoform d and isoform f.
In isoform c, isoform d, isoform g and isoform i.
In ot154; Reduces expression of lim-6 in the sensory ASEL neuron; exacerbated in a lin-49 mutant background.
In n1654; lethal at the restrictive temperature of 25 degrees Celsius. Protruding vulva phenotype observed in 26% of animals and abnormal folding and/or overmigration of the gonad arms in 18% and 47%, respectively. Abnormal migration and axonal pathfinding of hermaphrodite specific neurons (HSN) during embryogenesis and reduced expression of several genes encoding components of the serotonin synthesis and transport pathways. Germ lines are smaller. Expression of sem-4 and ham-2 is severely affected in the HSNs, while unc-86 expression is barely affected.
SWI/SNF chromatin-remodeling accessory subunit 1
Thioredoxin reductase-like selenoprotein T homolog selt-1.1
Eukaryotic translation initiation factor 3 subunit D
Alpha-ketoglutarate-dependent dioxygenase AlkB-like
Hypersensitivity to quinine which may be due to loss of phosphorylation at this site.
Hypomorphic allele which is overexpressed relative to wild-type. Progressive germline mortality, resistant to nuclear RNAi and displays defective RNAi inheritance.
Nuclear hormone receptor family member nhr-61
In emb-27(g48); temperature sensitive mutant. Embryos arrest at the one-cell stage of embryogenesis.
Signal recognition particle 14 kDa protein
In zc14; loss of adaptive protection conferred by non-lethal hypoxia treatment. Prevents transcriptional up-regulation of apy-1 upon ER stress. Reduced UDPase activity upon ER stress.
Serine/threonine-protein kinase/endoribonuclease ire-1
UDP-glucose:glycoprotein glucosyltransferase thioredoxin-like
Ribosome biogenesis protein BRX1 homolog
Lysophosphatidylinositol acyltransferase 10
Processed sterol regulatory element binding protein sbp-1
Sterol regulatory element binding protein sbp-1
V-type proton ATPase 16 kDa proteolipid subunit c 1
Probable 26S proteasome regulatory subunit 4
In tm4059; loss of tubulin glutamylation in male CEM and CEP cilia. Defects in cilia axoneme structure. Release of extracellular vesicles via cilia is reduced. Abnormal accumulation of pkd-2 in cilia and dendrites of male CEM, HOB and RnB neurons. Decreases kinesin klp-6 velocity in male CEM cilia. Normal klp-6 and osm-3 velocity is restored in a ccpp-1 mutant background. No defect in polar spindle formation in dividing embryonic cells, cilia-dependent osmotic avoidance and in male mating efficiency.
6-phosphogluconate dehydrogenase, decarboxylating
Eukaryotic translation initiation factor 3 subunit F
Putative pterin-4-alpha-carbinolamine dehydratase
Abolishes sequestration in endosomes by plr-1; when associated with R-343; R-430; R-442; R-445 and R541.
Abolishes sequestration in endosomes by plr-1; when associated with R-343; R-430; R-442; R-445 and R548.
Abolishes sequestration in endosomes by plr-1; when associated with R-343; R-430; R-442; R-541 and R548.
Abolishes sequestration in endosomes by plr-1; when associated with R-343; R-430; R-445; R-541 and R548.
Abolishes sequestration in endosomes by plr-1; when associated with R-343; R-442; R-445; R-541 and R548.
Abolishes sequestration in endosomes by plr-1; when associated with R-430; R-442; R-445; R-541 and R548.
Myo-inositol-1-phosphate synthase GAPDH-like
DNA/pantothenate metabolism flavoprotein C-terminal
Reticulon-4-interacting protein 1, mitochondrial
Nuclear speckle splicing regulatory protein 1 homolog
TWiK family of potassium channels protein 9
Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial
Solute carrier family 12 protein B0303.11
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 2
C-type lectin domain-containing protein 161
Resistance to inhibitors of cholinesterase protein 3
Sufficient for function in acetylcholine receptor folding
Nucleosome-remodeling factor subunit NURF301-like
In fr4; Susceptibility to fungal infection characterized by a severe loss of nlp-29 and nlp-31 expression and a decrease in survival. Susceptibility to bacterial pathogens P.aeruginosa or E.faecalis is characterized by a decrease in survival rate; this phenotype is abrogated in a cebp-1 mutant background. Drastic reduction in transcription of gst-4 and gcs-1 mRNAs during infection by P.aeruginosa or P.faecalis; this phenotype is abrogated in a cebp-1 mutant background. Increased level of vhp-1 mRNA during P.aeruginosa or E.faecalis infection. Level of pmk-1 phosphorylation reduced during E.faecalis infection, despite almost normal overall level of pmk-1 protein. Animals have a temperature-sensitive reduction in size. In absence of infection, reduced survival rate. Dramatically reduced lifespan in response to ToxA from Gram-negative bacterium P.aeruginosa. Reduced viability in response to translational inhibitor, G418.
In gm300; production of an additional HSN/PHB precursor cell.
In gm301; production of an additional HSN/PHB precursor cell and an additional PVM precursor cell.
In n4780; production of an additional M4 motor neuron.
Maternal embryonic leucine zipper kinase
May be constitutively active. Promotes cell shedding during embryogenesis. In some mutants, production of an additional PVM neuron.
May be inactive. Prevents cell shedding during embryogenesis. Additional production of PVM neuron.
Biogenesis of lysosome-related organelles complex 1 subunit 4
Required for maintaining the overall integrity of the AHR:ARNT heterodimer and its transcriptional activity
In e1500; confers 'rubber band' muscle contraction.
In n200; confers 'rubber band' muscle contraction; when associated with V-49.
In n200; confers 'rubber band' muscle contraction; when associated with V-562.
Putative potassium channel regulatory protein unc-93
Pre-mRNA cleavage complex subunit Clp1 C-terminal
Alpha-N-acetylglucosaminidase C-terminal
Alpha-N-acetylglucosaminidase tim-barrel
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
JmjC domain-containing histone demethylation protein 1
Defective degradation of sepa-1-containing protein aggregates in embryos.
Diffuse cytosolic localization in 500-cell embryos with no punctate pattern of distribution which is in contrast to wild-type. Not cleaved by atg-4.1 and atg-4.2. Does not rescue the protein degradation defect in the atg-4.1 bp501 mutant. Reduces lgg-2 lipidation and the accumulation of sqst-1-containing aggregates. Abolishes the interaction with atg-3.
Does not rescue the degradation defect in the lgg-1 bp500 mutant.
Does not rescue the protein aggregate degradation defect in the lgg-1 bp500 mutant.
Impaired membrane tethering activity and fusion in vitro.
Impairs interaction with atg-3. Rescues the protein degradation defect in the atg-4.1 bp501 and atg-4.2 tm3948 single mutants. Does not rescue the lethal phenotype of the atg-4.1 bp501 and atg-4.2 tm3948 double mutant, but partially rescues the protein degradation defect.
In bp500; defective degradation of sepa-1-containing protein aggregates in comma stage embryos. Suppresses the lysosomal accumulation of ribosomal RNA and ribosomal proteins in the rnst-2 qx245 mutant.
In bp523; abolishes interaction with sqst-1 and impairs the interaction with epg-7, sepa-1 and unc-51. Defective degradation of sepa-1- and sqst-1-containing aggregates in embryos. No defects in lipidation or puncta formation.
Mildly impaired membrane tethering activity and fusion in vitro.
Required for the interaction with unc-51
Severely impaired membrane tethering activity and fusion in vitro. Does not rescue the degradation defect in the lgg-1 bp500 mutant.
In mg375; defective avoidance behavior in response to P.aeruginosa.
Loss of cleavage by ced-3. Loss of deoxyribonuclease (DNase) activity. Reduced number of cell corpses in embryos.
Loss of dsRNA dicing and DNase activities, bursting and protruding vulva and reduction in the number of cell corpses in embryos; when associated with A-1794 and A-1682.
Severe reduction in both dsRNA dicing and DNase activities; when associated with A-1682. Loss of dsRNA dicing and DNase activities, bursting and protruding vulva and reduction in the number of cell corpses in embryos; when associated with A-1682 and A-1686.
Severe reduction in both dsRNA dicing and DNase activities; when associated with A-1794. Loss of dsRNA dicing and DNase activities, bursting and protruding vulva and reduction in the number of cell corpses in embryos; when associated with A-1794 and A-1686.
Guanine nucleotide exchange factor subunit R06F6.8
BTB and MATH domain-containing protein 36
Reduced binding to microtubules. Severely truncated cilium. Accumulates in truncated cilium and does not undergo intraflagellar retrograde transport.
Reduced frequency of intraflagellar retrograde transport of mutant protein.
Shorter cilium, and reduced speed and frequency of intraflagellar retrograde transport of mutant protein.
Shorter cilium, and severely reduced speed and reduced frequency of intraflagellar retrograde transport of mutant protein.
Critical for specifying symmetric addition of methyl groups
Significantly elevates methylase activity, and converts PRMT5 to an enzyme catalyzing both symmetric and asymmetric arginine dimethylation.
BTB and MATH domain-containing protein 42
Mitochondrial import inner membrane translocase subunit tim-16
U3 small nucleolar RNA-associated protein 15 C-terminal
Zinc finger transcription factor family protein 1
In ga97; lethality with 18% surviving animals. Reduces expression of lin-39 in the embryo. Suppresses an increase in seam cell number caused by simultaneous RNAi-mediated knockdown of pop-1 at the L1 larval stage.
In n162; lethality with 43% surviving animals. Reduces expression of lin-39 in the embryo. Suppresses an increase in seam cell number caused by simultaneous RNAi-mediated knockdown of pop-1 at the L1 larval stage. Reduces the average number of seam cells per side; reduced further either by simultaneous RNAi-mediated knockdown of elt-6, or egl-18, at the L1 stage.
In n475; lethality with 45% surviving animals. L1 larvae have breaks in alae and a twisted body. L4 larvae have defective vulval openings, which may go on to develop into the protruding vulva (Pvl) phenotype in surviving adults.
Does not rescue the elevated expression of the ER stress response protein hsp-4 in the dma1 mutant.
In dma1; results in up-regulation of ER stress response protein hsp-4 in the intestine and pharyngeal epithelium. Elevated expression of hsp-4 is suppressed in xbp-1 or ire-1 RNAi-mediated knockdown animals.
Mesencephalic astrocyte-derived neurotrophic factor homolog
In isoform b, isoform c, isoform d and isoform h.
In jg1; 80 percent reduction in uridine and thymidine phosphorylase activity. Reduced lifespan. Resistance to 5-fluorouracil (5-FU) or 5-deoxy-5-fluorouridine (5dFUR)-mediated toxicity.
In jg2; 80 percent reduction in uridine and thymidine phosphorylase activity. Reduced lifespan. Resistance to 5-fluorouracil (5-FU)-mediated toxicity.
In cs41; temperature sensitive mutant in which G1 cell fails to delaminate during the excretory system development.
In sy262; restores normal vulva induction in let-23 sy-1 mutant.
In ks86; defective chemotaxis response to sodium acetate and reduced expression of tax-2. About 55% of animals arrest as larvae.
In ky640; about 1% lethality of embryos and 78% reach larval stage 4 (L4) by 6 days. Expression of the transcription factor mls-2 is abolished after the L1 stage in the AWC neurons.
In ky646; many cells in embryos have defects in both cell cycle timing and cell position, or fail to undergo programmed cell death when expected. About 10% lethality of embryos and 59% reach larval stage 4 (L4) by 6 days.
Elongation of long chain fatty acids protein 1
In fc73, gk266317 and n5888; defects in developmental arrest in response to osmotic stress. Suppresses volatile anesthetic sensitivity and uncoordinated locomotion phenotype on stomatin-like unc-1 mutant background.
In gk319712; defects in developmental arrest in response to osmotic stress.
In gk747222; defects in developmental arrest in response to osmotic stress.
In gk876992; defects in developmental arrest in response to osmotic stress.
Abolishes histone methyltransferase activity.
Impairs histone methyltransferase activity.
Strongly impairs histone methyltransferase activity.
Putative sodium-dependent excitatory amino acid transporter glt-4
In am88; extends lifespan, increases pharyngeal pumping, and causes faster body movements. Also increases dauer formation.
In hx546; increases lifespan. Increases dauer formation. Fails to avoid NaCl after exposure to NaCl under starvation conditions. Defective in aversive olfactory learning. Reduces nuclear enrichment of egl-4 in the AWC neurons after odor conditioning.
In n1924; 5% larval lethal, no effect on vulval development.
In n2018; 76% larval lethal, 24% abnormal vulval development.
In n2506; 86% larval lethal, 93% abnormal vulval development.
In oz178 and oz201; 55% larval lethal, 100% abnormal vulval development.
Probably abolishes phosphorylation. Multivulva formation. Multivulva formation; when associated with A-453.
Probably abolishes phosphorylation. Multivulva formation; when associated with A-312.
Raf homolog serine/threonine-protein kinase
In pk2295; viable with reduced brood size. Reduces methyltransferase activity. Reduces methylation of 26G-siRNAs and 21U-piRNAs. Reduces levels of 22G-siRNAs (which are formed from 21U-piRNAs and 26G-siRNAs) in embryos. Suppresses RNAi-mediated silencing by siR-1, which are 22G-siRNAs. Reduces levels of 21U-piRNAs in embryos and modestly reduces levels of 21U-piRNAs in adults, but 21U-piRNAs levels are unaffected at the L4 larval stage. Mixed exoRNAi defects with enhanced RNAi (Eri phenotype) in somatic cells in a dpy-13 RNAi-mediated knockdown background, and defective RNAi (Rde phenotype) in somatic cells in a pos-1 RNAi-mediated knockdown background.
In pk2452; viable with reduced brood size. Reduces methyltransferase activity. Reduces methylation of 26G-siRNAs and 21U-piRNAs.
Putative serine/threonine-protein phosphatase C06A1.3
Intraflagellar transport protein 56 homolog
In n983; gain of function, uncoordinated rubber band response.
Putative potassium channel regulatory protein sup-10
Aminoacyl-tRNA synthetase class I anticodon-binding
Immunoglobulin domain-containing protein oig-1
Myelin regulatory factor homolog 2, C-terminal
Myelin regulatory factor homolog 2, N-terminal
Probable very-long-chain enoyl-CoA reductase art-1
C-type lectin domain-containing protein 180
V-type proton ATPase 116 kDa subunit a 4
Cytochrome c oxidase subunit 5A, mitochondrial
Pre-rRNA-processing protein Ipi1 N-terminal
In n732; defects in programmed cell death in the sister cells of the serotoninergic neurosecretory motor (NSM) neurons. Morphological defects in excretory duct cells. Reduced expression of transcription factor lin-48.
Putative transmembrane ascorbate-dependent reductase CYB561 homolog
Heparan sulfate 2-O-sulfotransferase hst-2
Immunoglobulin domain and leucine-rich repeat-containing protein 2
26S rRNA (cytosine-C(5))-methyltransferase nsun-5
Intraflagellar transport protein 43 homolog
5-demethoxyubiquinone hydroxylase, mitochondrial
Enhances nuclear localization. Unable to contribute to the mitochondrial role in ubiquinone biosynthesis. Modulates lifespan.
In e2519; Extension of life-span, longer and more irregular defecation period.
Guanine nucleotide-binding protein alpha-13 subunit
In n545; many defects in reproductive organs; egg-laying defect, sterile, protruding vulva, vulvaless and male mating defect.
Guanine nucleotide-binding protein alpha-1 subunit
In ox423; egg-laying defects, dumpy and uncoordinated phenotypes, and progressive paralysis. Highly disorganized nervous system due to axon sprouting defects in late larval stage and adult animals whereby VD and DD motor neurons exhibit extra commissures, misrouted or branched axons, persistent growth cones, and spindly axons. Axon defects accumulate with age. No defects in axon guidance or synapse formation, but there is failure to repress the emergence of new growth cones after they have reached their target. Regeneration of cut axons at the L4 larval stage is improved compared to wild-type. Reduces expression of the long isoform of unc-44 in embryos. Locomotion defects are restored in a ssup-72 mutant background.
In n1046; multivulva phenotype. The multivulval phenotype is enhanced in a chp-1 tm2277 mutant background. The multivula phenotype is suppressed in a rsf-1 tm5002 mutant background. RNAi-mediated knockdown of let-765 suppresses the multivulva phenotype.
In e2322ts; unable to crawl backwards. Phenotype is exacerbated in a lin-17 mutant background. Backward movement is restored in an egl-20 mutant background. Significant restoration of backward movement in a mig-1 mutant background, or by RNAi-mediated knockdown of mom-5.
In e2323; unable to crawl backwards. Abolishes interaction with unc-37. Backward movement is restored in an egl-20 mutant background.
In e26/e2307; unable to crawl backwards. Abolishes interaction with unc-37.
In wdEx65; unable to crawl backwards. Abolishes interaction with unc-37.
Almost completely eliminates localization to cell cortex.
Essential for association with cell cortex
In gm279; embryos have no detectable ham-1 protein. Some daughter cells of neuroblasts which would normally undergo programmed cell death have abnormally large corpses. Daughter cell size asymmetry is reduced or lost.
In n1810; defects in the hermaphrodite-specific neurons (HSN); abnormal migration, reduced levels of serotonin, also egg-laying defects. Localized inappropriately to the cytoplasm.
Modest reduction in localization to nucleus. Results in localization exclusively to the cell cortex with little or no nuclear localization; when associated with 286-K--R-290.
Modest reduction in localization to nucleus. Results in localization exclusively to the cell cortex with little or no nuclear localization; when associated with 321-P--R-327 del.
Significantly reduces localization to the cell cortex.
Putative G-protein coupled receptor-like protein B0244.6
In b1; induces an arrest in cell division at all stages of development.
In it25; temperature-sensitive mutant. At 20 degrees Celsius, nearly 100% of progeny are viable. At 24 degrees Celsius, over 90% of progeny are embryonic lethal. Embryonic lethality arises due to failure to duplicate the sperm-derived centriolar pair, failure to assemble the bipolar spindle, and failure of the embryo to develop beyond the two-cell stage. The embryonic lethality phenotype is rescued in a szy-20 (bs52) loss of function mutant background at 24 degrees Celsius, due to suppression of the centrosome duplication defect (in the zyg-2 single mutant) and successful assembly of the bipolar spindle.
In it4; induces an arrest in cell division at all stages of development.
Probable serine/threonine-protein kinase zyg-1
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase
Coiled-coil domain-containing protein mdt-28
Probable medium-chain specific acyl-CoA dehydrogenase 10, mitochondrial
G patch domain and ankyrin repeat-containing protein 1 homolog
Nuclear hormone receptor family member nhr-103
Zinc metalloproteinase-like protein nas-21
Putative sphingolipid delta(4)-desaturase
In e1430; defects in dorsal pathfinding. The axons of DA and DB motorneurons do not grow to their targets in the dorsal cord and instead extend along subdorsal longitudinal paths.
In jj59; significantly smaller body size; suppression of the mesodermal M lineage phenotype on a sma-9 mutant background.
In cy2; probable loss of activity. Partial sensitivity to the heavy metal Cu(2+). During development, DD and DV motoneuron axons fail to reach the dorsal cord. Axonal growth is not affected. Mild defect in locomotion. In pak-1 mutants, causes lateral displacement of the VD neuron. In mig-10 mutants, failure of HSN axons to migrate to the ventral nerve cord.
Probable loss of activity. Partial sensitivity to the heavy metal Cu(2+) and loss of kgb-1 phosphorylation upon Cu(2+) treatment. Does not affect interaction with mlk-1.
Putative UDP-glucuronosyltransferase ugt-60
About 100% of cells have irregular mitochondria.
About 80% of cells have irregular mitochondria. Worst affected cells have mitochondria consisting of large blebs with irregular shapes and sizes. Causes the inappropriate survival of 2 or 3 of the 16 cells destined to die during the development of the anterior pharynx.
About 95% of cells have irregular mitochondria. Worst affected cells have mitochondria consisting of large blebs with irregular shapes and sizes.
Interaction with caspase ced-9 is no longer enhanced by GTP.
Loss of ced-3-mediated cleavage. Normal mitochondrial fission.
Spindle and kinetochore-associated protein 1
Calcium/calmodulin-dependent protein kinase II association-domain
Calcium/calmodulin-dependent protein kinase type II
Constitutively activate kinase activity, increase in translocation to the neurites.
In e408; males display locomotor and muscle seizure defects and egg laying defects.
In n498gf; slight increase in calcium independent kinase activity, no effect on translocation to the neurite. Nuclear translocation of daf-16 resulting in lifespan extension.
In sy574; abnormal spicule protraction; when associated with E-170.
In sy574; abnormal spicule protraction; when associated with V-665.
Increase in calcium independent kinase activity and translocation to an unlocalized pool in the neurite. Small decrease in glr-1 trafficking.
Increase in calcium independent kinase activity, loss of translocation to neurites and glr-1 trafficking.
Increase in calcium independent kinase activity, no effect on translocation to the neurite.
Loss of autoinhibition and increase in binding of Ca2+/calmodulin.
Loss of cooperative activation of adjacent holoenzyme subunits.
Slight increase in calcium independent kinase activity, no effect on translocation to the neurite.
In lq56; irregular accumulation of snb-1-positive synaptic vesicles along the axons of ventral D-type GABAergic motorneurons.
In lq83; ventral D-type GABAergic axon guidance and extension defects. Irregular accumulation of snb-1-positive synaptic vesicles along the axons of ventral D-type GABAergic motorneurons.
In e2706; lack of tail swelling and mild constipation following M.nematophilium infection. Hyperinduction of vulval epidermal cells.
Mediator of RNA polymerase II transcription subunit 23
Zinc finger CCCH domain-containing protein 14
Double-strand break repair protein mre-11
In mre-11-ME41; defective in meiotic chromosome degradation.
In ye4; resistant to Bacillus thuringiensis crystal5B toxin and reduced brood size. Resistant to C.cinerea galectin Cgl2.
Mon2/Sec7/BIG1-like dimerisation and cyclophilin-binding
Ras association domain-containing protein 1 homolog
In hh2; loss of degradation of ubiquitinated proteins; when associated with 1304-W--N-2648 DEL.
In hh2; loss of degradation of ubiquitinated proteins; when associated with T-977.
In hh3; loss of degradation of ubiquitinated proteins.
In hh4; loss of degradation of ubiquitinated proteins.
Guanine nucleotide-binding protein alpha-14 subunit
Abolishes interaction with mxt; when associated with A-74.
Eukaryotic translation initiation factor 4E-3
cGMP-dependent protein kinase interacting
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
Acetylcholine-gated chloride channel subunit acc-3
Eukaryotic translation initiation factor 4E-1
Proteasomal ubiquitin receptor ADRM1 homolog
ATP synthase F(0) complex subunit B1, mitochondrial
Abolishes binding to the NGFI-B response element (NBRE) 5'-AAAGGTCA-3'. Fails to activate transcription. Abnormal spermatheca development with abnormal egg morphology, lack of the spermatheca-uterine valve and lack of distal constriction.
Nuclear hormone receptor family member nhr-6
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial
DNA replication complex GINS protein SLD5 C-terminal
Phosphorylase b kinase regulatory subunit alpha/beta C-terminal
WD repeat and FYVE domain-containing protein 2
In qd22; increases level of activated MAP kinase pmk-1 compared to wild-type. Simultaneous RNA-imediated knockdown of atf-7 confers increased resistance to Gram-negative bacterium P.aeruginosa.
Regulator of telomere elongation helicase 1 homolog
Cysteine/serine-rich nuclear protein N-terminal
Disrupts efficient nucleus localization and transcriptional repression in germline blastomeres.
Pharynx and intestine in excess protein 1
Required for inhibition of Ser-2 phosphorylation
In su33; loss of localization to muscle-muscle cell boundaries. Aberrant sarcomeric structure in the muscle with disorganized actin-containing filaments (I band), myosin-containing filaments (A band), M-lines and disorganized dense bodies, indicating a failure to assemble normal muscle adhesion structures. Loss of recruitment of deb-1/vinculin to nascent muscle attachments during embryogenesis.
In wy1048; defective morphology of the active zone region of the synapse, and abnormal clustering and localization of synaptic vesicles at presynaptic terminals of serotonergic NSM neurons. Defective synaptic transmission at neuromuscular junctions with increased sensitivity to the acetylcholinesterase inhibitor Aldicarb, and a 46% reduction in the frequency of spontaneous postsynaptic currents in postsynaptic muscle cells.
In kq1461; increased swimming/thrashing behavior and increased hyper-contraction/overbending. Hypersensitivity to levamisole. Significant non-responsiveness to gentle touches.
In kq1464; increased swimming/thrashing behavior and increased hyper-contraction/overbending. Resistance to levamisole. Significant non-responsiveness to gentle touches.
Glyceraldehyde-3-phosphate dehydrogenase 3
Does not rescue the egg-laying defect of the egl-26 ku211 mutant.
In ku211; vulval morphology defects displaying a connection of gonad defective (Cog) phenotype where there is failure to make a proper connection between the vulval and uterine lumens. This is caused by thick disorganized tissue at the apex of the vulva which blocks the exit to the vulva from the uterus. Abnormal vulF cell morphology and irregular positioning of vulF nuclei at the apex of the vulva. These defects most likely cause an egg-laying defective (Egl) phenotype where progeny hatch in the uterus killing the mother. No anchor cell invasion or fusion defects during the L3 and L4 larval stages.
In ku228 and e1952; vulval morphology defects displaying a connection of gonad defective (Cog) phenotype where there is failure to make a proper connection between the vulval and uterine lumens. This is caused by thick disorganized tissue at the apex of the vulva which blocks the exit to the vulva from the uterus. Abnormal vulF cell morphology and irregular positioning of vulF nuclei at the apex of the vulva. These defects most likely cause an egg-laying defective (Egl) phenotype where progeny hatch in the uterus killing the mother.
In n481; vulval morphology defects displaying a connection of gonad defective (Cog) phenotype where there is failure to make a proper connection between the vulval and uterine lumens. This is caused by thick disorganized tissue at the apex of the vulva which blocks the exit to the vulva from the uterus. Abnormal vulF cell morphology and irregular positioning of vulF nuclei at the apex of the vulva. These defects most likely cause an egg-laying defective (Egl) phenotype where progeny hatch in the uterus killing the mother. Localizes to the cytoplasm rather than to the apical cell membrane. Rescues the egg-laying defect of the egl-26 ku211 mutant.
Localizes to the apical cell membrane, but is abundant in the cytoplasm. Rescues the egg-laying defect of the egl-26 ku211 mutant.
Localizes to the cytoplasm rather than to the apical cell membrane. Does not rescue the egg-laying defect of the egl-26 ku211 mutant.
Rescues the egg-laying defect of the egl-26 ku211 mutant.
ATPase family AAA domain-containing protein 3
Increased incidence of embryonic lethality and reduced fertility as compared to wild-type.
Nuclear protein localization protein 4 homolog 2
Eukaryotic translation initiation factor 3 subunit E
In isoform c, isoform e, isoform f and isoform g.
Abolishes phosphorylation by wnk-1. No effect on activity.
Loss of catalytic activity without affecting oligomerization; when associated with A-256.
Loss of catalytic activity without affecting oligomerization; when associated with A-529.
Transitional endoplasmic reticulum ATPase homolog 2
Probable elongation factor 1-beta/1-delta 2
Skn-1 dependent zygotic transcript 15 protein
In ot406; significantly more pronounced defect in the expression of dopamine pathway genes in adults compared with young larvae. Progressive loss of expression of the dopamine transporter dat-1 in the ADE and CEPD neurons; effect is exacerbated, either in the ast-1 mutant background or, in a combined ceh-20 and ceh-40 mutant background.
10-fold reduction in catalytic efficiency for ATP.
Linear activity for only a short time, suggesting a role in maintaining enzyme conformation.
Linear activity for only a short time, suggesting a role in maintaining enzyme conformation. Substantial decrease in the affinity for ATP.
Moderate decrease in catalytic efficiency with a 3-fold decrease in the affinity for ATP and for Mg(2+). Activated by low concentrations of Ca(2+) and inhibited by high concentrations of Ca(2+).
Moderate decrease in catalytic efficiency.
Severe decrease in catalytic efficiency but no effect on the affinity for ATP and choline. No inhibition at high Mg(2+) concentrations.
Severe decrease in catalytic efficiency with a 3-fold decrease in the affinity for ATP and for Mg(2+). No inhibition at high Mg(2+) concentrations. Activated by low concentrations of Ca(2+) and inhibited by high concentrations of Ca(2+).
Severe decrease in catalytic efficiency with a 5-fold decrease in the affinity for choline.
Severe decrease in catalytic efficiency with a decreased affinity for Mg(2+). No inhibition at high Mg(2+) concentrations. Activated by low concentrations of Ca(2+) and inhibited by high concentrations of Ca(2+).
Severe decrease in catalytic efficiency.
Nuclear hormone receptor family member nhr-22
Uncharacterized RING finger protein T02C1.1
5'-AMP-activated protein kinase catalytic subunit alpha-2
Chromosomal passenger complex protein bir-1
Hypersensitive to pore-forming toxin protein 40
Reduces ability to stimulate elongation by rat RNA polymerase II.
Stimulates elongation by rat RNA polymerase II with the same activity as wild-type.
Transcription elongation factor B polypeptide 3
Important for interaction with histone H3
Peroxisome membrane anchor protein Pex14p N-terminal
Prion-like-(Q/N-rich) domain-bearing protein 96
Probable mitochondrial pyruvate carrier 2
Probable N-acetylgalactosaminyltransferase 7
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2
Decreased phosphorylation by kgb-1. Loss of phosphorylation by kgb-1; when associated with A-452 and A-454.
Loss of phosphorylation by kgb-1; when associated with A-440 and A-452.
Loss of phosphorylation by kgb-1; when associated with A-440 and A-454.
Serine/threonine-protein phosphatase 6 catalytic subunit
Probable voltage-dependent anion-selective channel
Nuclear hormone receptor family member nhr-164
Aspartyl/Glutamyl-tRNA(Gln) amidotransferase subunit B/E catalytic
In or204ts; temperature sensitive mutant. During EMS blastomere cell division, loss of nuclear rotation resulting in the transversal localization of the mitotic spindle; when associated with H-409.
In or204ts; temperature sensitive mutant. During EMS blastomere cell division, loss of nuclear rotation resulting in the transversal localization of the mitotic spindle; when associated with H-515.
Binds significantly less of the PLP cofactor. Altered fluorescence-based tryptophan spectra.
Trafficking protein particle complex subunit 3 homolog
Nuclear hormone receptor family member nhr-19
In h755a: Impaired larval growth. No defect in axon regeneration following injury.
Probably prevents secretion. Impaired axon regeneration following injury. Impaired larval growth.
In kr302; substrate-trapping mutant. Reduced sensitivity to the nicotinic acetylcholine receptor (nAChR) agonist levamisole.
Signal transducer and activator of transcription 1
Eukaryotic translation initiation factor 3 subunit A
In cc571; increased number of vulval cells.
Activator of Hsp90 ATPase AHSA1-like N-terminal
Mediator of RNA polymerase II transcription subunit 19
Uncharacterized RING finger protein ZK637.14
In gk116531; RIA interneurons fail to acquire a number of features of RIA identity, including expression of eat-4, glr-3 and dop-2.
In qx57; results in defective degradation of sqst-1, pgl-1 and sepa-1 protein aggregates.
Solute-binding protein family 3/N-terminal
Mannosyl-oligosaccharide 1,2-alpha-mannosidase C52E4.5
Probable ubiquitin carboxyl-terminal hydrolase K02C4.3
Ig-like and fibronectin type-III domain-containing protein 1
Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase
In b285; induces defects in dosage compensation. Defects in diakinesis bivalent formation. Blocks precocious homolog and sister chromatid separation in a RNAi-mediated rec-8 knockdown background.
In mn29; induces defects in dosage compensation. Defects in mitotic chromosome segregation and in germline formation.
Mitotic chromosome and X-chromosome-associated protein mix-1
Connector enhancer of kinase suppressor of ras
tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit
Gamma-aminobutyric acid type B receptor subunit 1
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Abolishes DNA binding. Becomes localized to both cytoplasm and nucleus.
FLYWCH-type zinc finger-containing protein peb-1
Guanine nucleotide-binding protein alpha-9 subunit
In q385; die as L1 larvae with cell transformations that result in the loss of the excretory cell, loss of the rectum and a twisted nose.
Probable tyrosine-protein phosphatase F54C8.4
Results in aggregate formation within nucleoli.
In sam3 and sam6; enlarged P-granules in the germline and accumulation of RNA transcripts in the central rachis and around the nuclear periphery of germ cells. Enhances the sterility and RNAi defective phenotypes of the drh-3 (sam27) mutant.
Transcription initiation factor TFIID subunit 10
Leads to a dominant hypercontracted and uncoordinated phenotype. Leads to a dominant hypercontracted and uncoordinated phenotype; when associated with Y-183 and Y-200.
Leads to a dominant hypercontracted and uncoordinated phenotype; when associated with Y-183 and Y-217.
Leads to a dominant hypercontracted and uncoordinated phenotype; when associated with Y-200 and Y-217.
NAD-dependent protein deacetylase sir-2.4
Putative extracellular sulfatase Sulf-1 homolog
Vacuolar protein sorting-associated protein 53 homolog
cAMP-dependent protein kinase, catalytic subunit-like
Uncharacterized WD repeat-containing protein F47D12.9
AT-rich interactive domain-containing protein cfi-1
In ot786; Glutamate receptor (GluR) gene glr-4 is ectopically expressed in DA and DB motor neurons.
In n111; multivulva phenotype in a lin-15B n2245, lin-52 n771, lin-9 n112, lin-35 n745 or lin-37 n758 mutant background. Increased lin-3 mRNA levels in a lin-35 n745 mutant background as compared to wild-type.
In n2376; temperature-sensitive multivulva phenotype in a lin-15B n2245 or lin-52 n771 mutant background.
In n2378; multivulva phenotype in a lin-15B n2245, lin-52 n771 or lin-36 n766 mutant background.
In n2403; temperature-sensitive multivulva phenotype in a lin-15B n2245 or lin-52 n771 mutant background.
In n2741; temperature-sensitive multivulva phenotype in a lin-15B n2245 or lin-52 n771 mutant background.
Guanine nucleotide-binding protein alpha-10 subunit
In me66; severe reduction in male fertility caused by a premature activation of spermatids and impaired sperm transfer into the hermaphrodite. Seminal fluid transfer and trans-activation of hermaphrodite sperm are normal. In a tyr-5(jn21) mutant background, suppresses premature sperm activation in males.
In me86; severe reduction in male fertility caused by a premature activation of spermatids and impaired sperm transfer into the hermaphrodite. Seminal fluid transfer and trans-activation of hermaphrodite sperm are normal. Does not affect hermaphrodite self-fertility. In a tyr-5(jn21) mutant background, suppresses premature sperm activation in males.
In mu220; fails to downregulate lin-12 on the left of the E8 primordium. Nearly all embryos lack the characteristic intestinal twist. Affects the pattern of Pn.p cell fusion in larval development in hermaphrodites; frequently has between one and three ectopic pseudovulvae in the posterior body region. Occasionally has misshapen heads in larvae of either sex. Ectopic expression of multiple markers of an entire neuronal sublineage only on the right side of the animal. In a mab-5 mutant background, P1.p and P2.p cells often remain unfused.
In oy40; ectopic expression of multiple markers of an entire neuronal sublineage only on the right side of the animal.
In my13; results in cilia with structural defects and increased accumulation of the mechanosensory receptor, pkd-2. Mutants may have slightly altered chemotactic tendencies and have vacuoles in amphid sheath cells.
In n1606; results in defective avoidance of nitric oxide and P.aeruginosa.
Patronin (microtubule-binding protein) homolog