Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Major facilitator superfamily (MFS) profile
Phosphatidic acid phosphatase type 2/haloperoxidase
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Solute-binding protein family 3/N-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Pyridine nucleotide-disulphide oxidoreductase dimerisation
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Penicillin-binding protein transpeptidase
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Chromosomal replication initiator DnaA C-terminal
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
TRAP C4-dicarboxylate transport system permease DctM subunit
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Plays an important role in discriminating NADH against NADPH
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
ABC-type glycine betaine transport system substrate-binding
Mandelate racemase/muconate lactonizing enzyme C-terminal
Prepilin peptidase dependent protein C-like C-terminal
TonB-dependent receptor-like beta-barrel
Cytochrome b561 bacterial/Ni-hydrogenase
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Influences the redox potential of the prosthetic heme and FAD groups
Involved in heme-bound ligand stabilization and O-O bond activation
Nitrite/Sulfite reductase ferredoxin-like
Transcriptional regulator SgrR N-terminal HTH
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Phosphomannose isomerase type I C-terminal
Phosphomannose isomerase type I catalytic
Phosphomannose isomerase type I helical insertion
Ionotropic glutamate receptor C-terminal
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
High-affinity zinc uptake system protein ZnuA
O-(5'-phospho-DNA)-tyrosine intermediate
Outer-membrane lipoprotein carrier protein
Cytochrome c-type biogenesis protein CcmF C-terminal
Greasy slide, important in sugar transport
Electron transfer via tryptophanyl radical
Tryptophan synthase beta chain-like PALP
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold
Outer membrane protein assembly factor BamA
FAD-dependent oxidoreductase 2 FAD binding
NIF system FeS cluster assembly NifU N-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
Involved in allosteric activation by GTP
DNA-directed RNA polymerase RpoA/D/Rpb3-type
NADH:ubiquinone oxidoreductase 30kDa subunit
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
O-(phosphoribosyl dephospho-coenzyme A)serine
Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Phosphocysteine intermediate; for EIIB activity
Anthranilate synthase component I N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Moves into active site upon enzyme activation, plays a role in electron transfer
Translation elongation factor P/YeiP central
Plays an important role in substrate specificity
Tellurite resistance methyltransferase TehB-like
Acyl-CoA dehydrogenase/oxidase C-terminal
Adaptive response protein AidB N-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
Exonuclease VII large subunit C-terminal
Type I restriction modification DNA specificity
Large ribosomal subunit protein uL6 alpha-beta
Heme-copper oxidase subunit III family profile
Negative modulator of initiation of replication SeqA N-terminal
Replication modulator SeqA C-terminal DNA-binding
Signal transduction histidine kinase 5TM receptor LytS transmembrane region
Signal transduction histidine kinase internal region
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Menaquinone biosynthesis protein MenD middle
Phosphogluconate dehydrogenase NAD-binding putative C-terminal
RND efflux pump membrane fusion protein barrel-sandwich
RNA polymerase sigma factor 70 region 4 type 2
Bacterial bifunctional deaminase-reductase C-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
RNA methyltransferase SpoU/TrmH type C-terminal
Gly-cisPro motif, important for rejection of L-amino acids
Involved in tetramerization or stability of the tetramer
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Cysteine sulfenic acid (-SOH) intermediate
Tetrahydrodipicolinate-N-succinyltransferase chain A
Schiff-base intermediate with substrate; via pyruvic acid
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Gfo/Idh/MocA-like oxidoreductase N-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
DNA polymerase III subunit delta C-terminal
DNA polymerase III delta subunit C-terminal
NIF system FeS cluster assembly NifU C-terminal
DNA-binding and helicase activity, interacts with RecC
Nuclease activity, interacts with RecD and RecA
Flagellar motor switch protein FliN N-terminal
Flagellar motor switch protein FliN-like C-terminal
Pyruvate dehydrogenase E1 component middle
Glycine cleavage T-protein C-terminal barrel
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Sodium/calcium exchanger membrane region
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Beta-xylosidase C-terminal Concanavalin A-like
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Cob(I)alamin adenosyltransferase N-terminal
Important for substrate binding and specificity
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Schiff-base intermediate with acetaldehyde
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Prokaryotic-type class I peptide chain release factors
Large ribosomal subunit protein uL2 C-terminal
Seems to be a necessary countercharge to the potassium cations
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase C-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase N-terminal
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
DNA replication/recombination mediator RecO N-terminal
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Essential for prephenate dehydratase activity
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Extradiol ring-cleavage dioxygenase LigAB LigA subunit
Essential for degradation by Lon protease
Glutathionylspermidine synthase pre-ATP-grasp-like
6-phosphogluconate dehydrogenase C-terminal
Penicillin-binding protein activator LpoA
RNA binding; important for wobble base 34 recognition
Aconitase A/isopropylmalate dehydratase small subunit swivel
Molybdopterin cofactor biosynthesis C (MoaC)
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Gamma-glutamylcyclotransferase AIG2-like
Peptidase S9 prolyl oligopeptidase catalytic
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Alpha-glycerophosphate oxidase C-terminal
L-seryl-tRNA selenium transferase N-terminal
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
DnaJ homologue subfamily C member 28 conserved
Superoxide dismutase copper/zinc binding
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Reversibly protonated during proton transport
Gp5/Type VI secretion system Vgr protein OB-fold
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Phosphotransferase system enzyme I N-terminal
Cobalamin-independent methionine synthase MetE N-terminal
Phage terminase large subunit GpA ATPase
Terminase large subunit GpA endonuclease
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Quercetin 2,3-dioxygenase C-terminal cupin
Major facilitator superfamily associated
Glycosyltransferase subfamily 4-like N-terminal
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Ribosomal RNA adenine methylase transferase N-terminal
Endolytic peptidoglycan transglycosylase RlpA
YbaK/aminoacyl-tRNA synthetase-associated
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Erythronate-4-phosphate dehydrogenase dimerisation
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Guanylate kinase/L-type calcium channel beta subunit
Thymidylate synthase/dCMP hydroxymethylase
Outer membrane protein assembly factor BamE
Periplasmic nitrate reductase, electron transfer subunit
Proton acceptor; for decarboxylase activity
Proton donor; for decarboxylase activity
Proton donor; for formyltransferase activity
Important for interaction with partner proteins
ABC-type transport auxiliary lipoprotein component
Outer membrane protein assembly factor BamD
Appears to be important in orienting the phosphate for catalysis
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Could be important to modulate the pK values of the two catalytic cysteine residues
Outer-membrane lipoprotein Wza C-terminal
Thiol:disulfide interchange protein DsbD
Curli production assembly/transport component CsgG
Gfo/Idh/MocA-like oxidoreductase C-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Membrane-bound lytic murein transglycosylase C
Pilus (Caulobacter type) biogenesis lipoprotein CpaD
Type VI secretion system-associated protein
Interaction with polymerase core subunit RpoC
Survival protein SurE-like phosphatase/nucleotidase
Flagellar assembly protein FliH/Type III secretion system HrpE
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Aspartate carbamoyltransferase regulatory subunit C-terminal
Aspartate carbamoyltransferase regulatory subunit N-terminal
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Glycosyl transferase family 3 N-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Nicotinamide phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Cytochrome C biogenesis protein transmembrane
Thiol:disulfide interchange protein DsbD N-terminal
RNA 2-O ribose methyltransferase substrate binding
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
UDP N-acetylglucosamine O-acyltransferase C-terminal
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Translocation and assembly module subunit TamA
Chromosomal replication initiator protein DnaA
Integral membrane protein YccS N-terminal
Large ribosomal subunit protein bL25 L25
Polymerase/histidinol phosphatase N-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Aspartate/homoserine dehydrogenase NAD-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Na(+)-translocating NADH-quinone reductase subunit A C-terminal
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Proton acceptor; for glutaminase activity
Flagellar hook-length control protein-like C-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Lipopolysaccharide export system protein LptA
Organic solvent tolerance-like N-terminal
Nicotinate phosphoribosyltransferase N-terminal
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Periplasmic binding protein/LacI sugar binding
The binding site for the sugar molecule has not yet been established, but C-87 may be involved
Activator of Hsp90 ATPase homologue 1-like C-terminal
Phosphoethanolamine transferase N-terminal
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Non-canonical purine NTP phosphatase/PRRC1
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with Met-252)
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-105)
Cation-transporting P-type ATPase N-terminal
Helix-hairpin-helix DNA-binding motif class 1
Bacterial type II secretion system protein E
Polysaccharide biosynthesis protein C-terminal
Regulator of nucleoside diphosphate kinase N-terminal
Small ribosomal subunit protein uS4 N-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Glycoprotein-polysaccharide metabolism protein
Chromosome partition protein MukF C-terminal
Chromosome partition protein MukF middle
Chromosome partition protein MukF winged-helix
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Type III secretion system flagellar brake protein YcgR PilZN
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Choloylglycine hydrolase/NAAA C-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Chitobiase/beta-hexosaminidases N-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Flagella basal body P-ring formation protein FlgA
Important for beta-aspartyl-AMP intermediate formation
Large ribosomal subunit protein uL15/eL18
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Shikimate dehydrogenase substrate binding N-terminal
Rap1a immunity protein domain-containing protein
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Acyl-ester intermediate; for transpeptidase activity
Proton donor; for transglycosylase activity
Transglycosylase PBP1b N-terminal transmembrane
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Glucosamine/galactosamine-6-phosphate isomerase
Mediates proton transfer from the outer aqueous phase to the interior of the protein; involved in linking H(+) and Cl(-) transport
Mediates proton transfer from the protein to the inner aqueous phase
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
DNA mismatch repair proteins mutS family
Hypersensitivity response secretion-like HrpJ
Inosine/uridine-preferring nucleoside hydrolase
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Type VI secretion system IcmF C-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
HicB-like antitoxin of toxin-antitoxin system
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal