Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Important for substrate specificity; cannot use PPi as phosphoryl donor
Major facilitator superfamily (MFS) profile
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Tryptophan synthase beta chain-like PALP
ABC transporter substrate-binding protein PnrA-like
TRAP C4-dicarboxylate transport system permease DctM subunit
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
YbaK/aminoacyl-tRNA synthetase-associated
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Cell envelope-related transcriptional attenuator
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Gram-positive cocci surface proteins LPxTG
DNA-directed DNA polymerase family A palm
Inosine/uridine-preferring nucleoside hydrolase
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
RNA polymerase sigma factor 70 region 4 type 2
Glycosyl transferase family 3 N-terminal
ABC transporter substrate-binding protein
Resolvase/invertase-type recombinase catalytic
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Lysidine-tRNA(Ile) synthetase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Important for beta-aspartyl-AMP intermediate formation
Ionotropic glutamate receptor C-terminal
Solute-binding protein family 3/N-terminal
Meso-diaminopimelate D-dehydrogenase C-terminal
Large ribosomal subunit protein bL9 C-terminal
Membrane fusion protein biotin-lipoyl like
Molybdopterin cofactor biosynthesis C (MoaC)
Sporulation stage IV protein A C-terminal
tRNA pseudouridylate synthase B C-terminal
Polymerase/histidinol phosphatase N-terminal
Cysteine sulfenic acid (-SOH) intermediate
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Interchain (with Cys-207); in linked form
Interchain (with Cys-44); in linked form
Penicillin-binding protein transpeptidase
Choloylglycine hydrolase/NAAA C-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
ATPsynthase alpha/beta subunit N-terminal extension
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Aminoacyl-transfer RNA synthetases class-II family profile
Pyruvate phosphate dikinase AMP/ATP-binding
Microcystin LR degradation protein MlrC C-terminal
Microcystin LR degradation protein MlrC N-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Glycosyltransferase subfamily 4-like N-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Na+-translocating membrane potential-generating system MpsC
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Proton acceptor; for glutaminase activity
Bacterial type II secretion system protein E
Could be important to modulate the pK values of the two catalytic cysteine residues
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Phosphatidylglycerol lysyltransferase C-terminal
Pseudouridine synthase I TruA alpha/beta
Phosphomannose isomerase type I catalytic
NIF system FeS cluster assembly NifU N-terminal
Periplasmic binding protein domain-containing protein
Dinitrogenase iron-molybdenum cofactor biosynthesis
Schiff-base intermediate with acetaldehyde
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Glycoside hydrolase family 38 N-terminal
Sporulation transcription regulator WhiA N-terminal
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Could play a key role in the communication between the regulatory and the substrate sites
Small ribosomal subunit protein uS4 N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Essential for prephenate dehydratase activity
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Glycosyl hydrolases family 2 sugar binding
Transposase IS116/IS110/IS902 C-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
RNA 2-O ribose methyltransferase substrate binding
PsbP C-terminal domain-containing protein
O-(5'-phospho-DNA)-tyrosine intermediate
Flagellar motor switch protein FliN-like C-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Large ribosomal subunit protein uL15/eL18
Membrane iron-sulfur containing protein FtrD-like
Membrane iron-sulfur containing protein FtrD-like domain-containing protein
Alpha-L-rhamnosidase six-hairpin glycosidase
Bacterial alpha-L-rhamnosidase N-terminal
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Flagellar basal body rod protein N-terminal
Septum formation inhibitor MinC C-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Aspartate/homoserine dehydrogenase NAD-binding
Signal transduction histidine kinase internal region
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Phosphocysteine intermediate; for EIIB activity
Ribosomal RNA adenine methylase transferase N-terminal
Flagellar hook-length control protein-like C-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Helix-hairpin-helix DNA-binding motif class 1
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Polysaccharide biosynthesis protein C-terminal
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Saccharopine dehydrogenase-like C-terminal
Reversibly protonated during proton transport
Flagellar basal-body/hook protein C-terminal
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Shikimate dehydrogenase substrate binding N-terminal
Lacto-N-biose phosphorylase-like N-terminal TIM barrel
Type II restriction enzyme and methyltransferase RM.Eco57I-like
Gamma-glutamylcyclotransferase AIG2-like
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
D-galactose/methyl-galactoside binding periplasmic protein MglB
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
ABC-type uncharacterised transport system
Glucosamine/galactosamine-6-phosphate isomerase
Thiamin pyrophosphokinase thiamin-binding
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Prepilin type IV endopeptidase peptidase
Pyrimidine nucleoside phosphorylase C-terminal
Ribose-phosphate pyrophosphokinase N-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Chromosomal replication initiator DnaA C-terminal
Bypass of forespore C C-terminal domain-containing protein
RND efflux pump membrane fusion protein barrel-sandwich
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Inosine monophosphate cyclohydrolase-like
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Cation-transporting P-type ATPase N-terminal
Positions MEP for the nucleophilic attack
Gly-cisPro motif, important for rejection of L-amino acids
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
Defence against restriction A C-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Mandelate racemase/muconate lactonizing enzyme C-terminal
Glucose-6-phosphate isomerase prokaryote
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Carbamoyl-phosphate synthase small subunit N-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Damage-control phosphatase ARMT1-like metal-binding
Interaction with polymerase core subunit RpoC
Sugar fermentation stimulation protein C-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Important for catalytic activity and assists the phosphoryl transfer reaction to Asp8 by balancing charge and orienting the reacting groups
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Aspartate carbamoyltransferase regulatory subunit C-terminal
Aspartate carbamoyltransferase regulatory subunit N-terminal
DNA mismatch repair proteins mutS family
The binding site for the sugar molecule has not yet been established, but C-87 may be involved
Bacterial bifunctional deaminase-reductase C-terminal
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Endoribonuclease L-PSP/chorismate mutase-like
Global transcriptional regulator CodY C-terminal
Global transcriptional regulator CodY N-terminal
Flagellar Assembly Protein A N-terminal region
O-(3'-phospho-DNA)-tyrosine intermediate
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
Phosphoribosylformylglycinamidine synthase linker
BREX system Lon protease-like BrxL N-terminal
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Heat-inducible transcription repressor HrcA C-terminal
Anthranilate synthase component I N-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Gram-positive cocci surface proteins LPxTG domain-containing protein
Phage terminase large subunit C-terminal
Phage terminase large subunit N-terminal
Plays an important role in substrate specificity
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Transcription regulator AsnC/Lrp ligand binding
Phosphotransferase system enzyme I N-terminal
Threonine/serine exporter-like N-terminal
Terminase large subunit-like endonuclease
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Aconitase A/isopropylmalate dehydratase small subunit swivel
Translation elongation factor P/YeiP central
Viral replication-associated protein N-terminal
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Cyclic nucleotide phosphodiesterase C-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
ATP synthase F1 complex delta/epsilon subunit N-terminal
DNA replication/recombination mediator RecO N-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Large ribosomal subunit protein uL6 alpha-beta
Dipicolinate synthase subunit A N-terminal
Large ribosomal subunit protein uL2 C-terminal
2,4-diaminopentanoate dehydrogenase C-terminal
Dihydrodipicolinate reductase N-terminal
Nicotinate phosphoribosyltransferase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Glycine cleavage T-protein C-terminal barrel
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
6-hydroxymethylpterin diphosphokinase MptE-like
Prokaryotic-type class I peptide chain release factors
Sporulation stage II protein D amidase enhancer LytB N-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Methylguanine DNA methyltransferase ribonuclease-like
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Exonuclease VII large subunit C-terminal
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Alanyl-transfer RNA synthetases family profile