Major facilitator superfamily (MFS) profile
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Type VI secretion system IcmF C-terminal
Type II secretion system protein GspI C-terminal
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Acyl-CoA dehydrogenase/oxidase N-terminal
Membrane fusion protein biotin-lipoyl like
Tle cognate immunity protein 4 C-terminal
Tle cognate immunity protein 4 N-terminal
Large ribosomal subunit protein uL2 C-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Solute-binding protein family 3/N-terminal
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Glycosyltransferase subfamily 4-like N-terminal
Trimeric autotransporter adhesin YadA-like C-terminal membrane anchor
Trimeric autotransporter adhesin YadA-like head
Trimeric autotransporter adhesin YadA-like stalk
Translation elongation factor P/YeiP central
Pyridoxamine 5'-phosphate oxidase putative
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Flagellar assembly protein FliH/Type III secretion system HrpE
O-(3'-phospho-DNA)-tyrosine intermediate
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
PHA accumulation regulator DNA-binding N-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
DNA-directed DNA polymerase family B exonuclease
DNA-directed DNA polymerase family B multifunctional
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Heme-copper oxidase subunit III family profile
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Acyl-CoA dehydrogenase/oxidase C-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Phosphatidylglycerol lysyltransferase C-terminal
Gamma-butyrobetaine hydroxylase-like N-terminal
Carboxypeptidase regulatory-like domain-containing protein
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Alpha-D-phosphohexomutase alpha/beta/alpha
RND efflux pump membrane fusion protein barrel-sandwich
Phosphatidic acid phosphatase type 2/haloperoxidase
Aldehyde oxidase/xanthine dehydrogenase first molybdopterin binding
Aldehyde oxidase/xanthine dehydrogenase second molybdopterin binding
Proton acceptor; for glutaminase activity
Putative type VI secretion system Rhs element associated Vgr
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Interaction with polymerase core subunit RpoC
Seems to be a necessary countercharge to the potassium cations
Spore coat protein U domain-containing protein
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
FAD-dependent oxidoreductase 2 FAD binding
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
D-(-)-3-hydroxybutyrate oligomer hydrolase
TonB-dependent receptor-like beta-barrel
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Outer membrane protein assembly factor BamA
Mandelate racemase/muconate lactonizing enzyme C-terminal
Pyruvate/ketoisovalerate oxidoreductase catalytic
DNA-directed DNA polymerase family A palm
O-(5'-phospho-DNA)-tyrosine intermediate
PliI/PliC-like inhibitor of I-type lysozyme
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Penicillin-binding protein transpeptidase
Cysteine sulfenic acid (-SOH) intermediate
Gp5/Type VI secretion system Vgr protein OB-fold
Ribose-phosphate pyrophosphokinase N-terminal
Helix-hairpin-helix DNA-binding motif class 1
Probable transposase IS891/IS1136/IS1341
Activator of Hsp90 ATPase homologue 1-like C-terminal
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Aminoacyl-tRNA synthetase class I anticodon-binding
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Alginate export domain-containing protein
Glucose-methanol-choline oxidoreductase N-terminal
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Organic solvent tolerance-like N-terminal
Integral membrane protein YccS N-terminal
Adaptive response protein AidB N-terminal
Styrene monooxygenase StyA putative substrate binding
Gfo/Idh/MocA-like oxidoreductase N-terminal
General stress protein FMN-binding split barrel
Peptide methionine sulphoxide reductase MsrA
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Tryptophan synthase beta chain-like PALP
RNA polymerase sigma factor 70 region 4 type 2
NADH-rubredoxin oxidoreductase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
ABC-type glycine betaine transport system substrate-binding
Cytochrome b561 bacterial/Ni-hydrogenase
Bacterial type II secretion system protein E
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
2-oxoisovalerate dehydrogenase E1 alpha subunit N-terminal
Polymerase/histidinol phosphatase N-terminal
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-91)
Peptidase S9 prolyl oligopeptidase catalytic
FAD-dependent cmnm(5)s(2)U34 oxidoreductase
Pyrimidine nucleoside phosphorylase C-terminal
MalT-like TPR region domain-containing protein
Ionotropic glutamate receptor C-terminal
Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Type IV secretion system coupling protein TraD DNA-binding
DNA-3-methyladenine glycosylase AlkA N-terminal
YaiO family beta-barrel domain-containing protein
CobB/CobQ-like glutamine amidotransferase
NIF system FeS cluster assembly NifU N-terminal
TRAP C4-dicarboxylate transport system permease DctM subunit
Gfo/Idh/MocA-like oxidoreductase C-terminal
YbaK/aminoacyl-tRNA synthetase-associated
Microcystin LR degradation protein MlrC C-terminal
Microcystin LR degradation protein MlrC N-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Positions MEP for the nucleophilic attack
Type 2A encapsulin shell protein SrpI-like
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Flagellar motor switch protein FliN-like C-terminal
Saccharopine dehydrogenase-like C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
EfeO-type cupredoxin-like domain-containing protein
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Serine/threonine specific protein phosphatases
Glycine cleavage T-protein C-terminal barrel
Important for autoinhibition of adenylyltransferase activity
Water stress and hypersensitive response
Mannose-6-phosphate isomerase type II C-terminal
Bacterial collagen-like protein middle domain-containing protein
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Pseudouridine synthase I TruA alpha/beta
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
ATP synthase F1 complex delta/epsilon subunit N-terminal
Lysozyme inhibitor LprI N-terminal domain-containing protein
Malonate/sodium symporter MadM subunit N-terminal
Type II secretion system protein GspG C-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Transposase IS204/IS1001/IS1096/IS1165 DDE
Periplasmic binding protein/LacI sugar binding
The binding site for the sugar molecule has not yet been established, but C-87 may be involved
Survival protein SurE-like phosphatase/nucleotidase
Transposase IS116/IS110/IS902 C-terminal
Tetrahydrodipicolinate-N-succinyltransferase chain A
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Sodium symporter small subunit predicted
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Glucosamine/galactosamine-6-phosphate isomerase
Beta-lactamase hydrolase-like protein phosphatase-like
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Outer membrane assembly lipoprotein YfiO
O-(phosphoribosyl dephospho-coenzyme A)serine
Glycoside hydrolase family 42 N-terminal
Outer-membrane lipoprotein carrier protein
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Polysaccharide chain length determinant N-terminal
Prepilin type IV endopeptidase peptidase
5-glutamyl coenzyme A thioester intermediate
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Diacylglycerol glucosyltransferase N-terminal
Prokaryotic-type class I peptide chain release factors
Isocitrate dehydrogenase kinase/phosphatase (AceK) kinase
Isocitrate dehydrogenase kinase/phosphatase (AceK) regulatory
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Type III secretion system flagellar brake protein YcgR PilZN
Putative Flp pilus-assembly TadG-like N-terminal
6-phosphogluconate dehydrogenase C-terminal
DNA mismatch repair proteins mutS family
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Ricin B lectin domain-containing protein
Glycosyl transferase family 3 N-terminal
DNA polymerase III subunit delta C-terminal
Plastocyanin-like domain-containing protein
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
High potential iron-sulfur proteins family profile
Superoxide dismutase copper/zinc binding
L-seryl-tRNA selenium transferase N-terminal
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Essential for prephenate dehydratase activity
Important for beta-aspartyl-AMP intermediate formation
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
Pyruvate dehydrogenase E1 component middle
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Inward rectifier potassium channel C-terminal
Bacterial transglutaminase-like N-terminal
Increases nucleophilicity of active site Cys
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Required for dimer formation and molybdate binding
Endoribonuclease L-PSP/chorismate mutase-like
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Important for interaction with partner proteins
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Large ribosomal subunit protein uL6 alpha-beta
Blue (type 1) copper domain-containing protein
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
ABC-type transport auxiliary lipoprotein component
ABC-type transport auxiliary lipoprotein component domain-containing protein
Sodium/calcium exchanger membrane region
Glucose-methanol-choline oxidoreductase C-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
RNA binding; important for wobble base 34 recognition
Plays an important role in substrate specificity
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Resolvase/invertase-type recombinase catalytic
Glycoside hydrolase family 13 N-terminal
HicB-like antitoxin of toxin-antitoxin system
Phosphocysteine intermediate; for EIIB activity
Polysaccharide biosynthesis protein CapD-like
Could be important to modulate the pK values of the two catalytic cysteine residues
Carbamoyl-phosphate synthase small subunit N-terminal
Histidine-specific methyltransferase SAM-dependent
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Alanyl-transfer RNA synthetases family profile
Molybdenum cofactor biosynthesis protein F N-terminal
Type II restriction enzyme and methyltransferase RM.Eco57I-like
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Polypeptide-transport-associated ShlB-type
Alpha-glycerophosphate oxidase C-terminal
Involved in tetramerization or stability of the tetramer
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Interacts with tRNA; defines subfamily-specific binding signature
Ribosomal RNA adenine methylase transferase N-terminal
Shikimate dehydrogenase substrate binding N-terminal
Release factor glutamine methyltransferase N-terminal
High-affinity branched-chain amino acid transport system permease LivHM N-terminal
C-type lysozyme inhibitor domain-containing protein
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
AB hydrolase-1 domain-containing protein
Acyltransferase MbtK/IucB-like conserved
Quercetin 2,3-dioxygenase C-terminal cupin
Signal recognition particle SRP54 helical bundle
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Disulphide bond isomerase DsbC/G N-terminal
Major facilitator superfamily associated
Hydroquinone 1,2-dioxygenase large subunit N-terminal
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Chitobiase/beta-hexosaminidases N-terminal
Nicotinamide phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Phospholipase D-like domain-containing protein
RNA 2-O ribose methyltransferase substrate binding
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
UDP N-acetylglucosamine O-acyltransferase C-terminal
Schiff-base intermediate with acetaldehyde
Molybdopterin cofactor biosynthesis C (MoaC)
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
Small ribosomal subunit protein uS4 N-terminal
DNA replication/recombination mediator RecO N-terminal
Endolytic peptidoglycan transglycosylase RlpA
RlpA-like protein double-psi beta-barrel
Aminoacyl-transfer RNA synthetases class-II family profile
Cation-transporting P-type ATPase N-terminal
Flagellar hook-length control protein-like C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Putative glycogen debranching enzyme N-terminal
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Phosphotransferase system enzyme I N-terminal
Outer membrane lipoprotein-sorting protein
NADH:ubiquinone oxidoreductase chain 4 N-terminal
Antitoxin Xre/MbcA/ParS-like toxin-binding
Putative oxidoreductase/dehydrogenase Rossmann-like
Proline utilization A proline dehydrogenase N-terminal
Putative regulatory protein FmdB Zinc ribbon
Photosynthesis system II assembly factor Ycf48/Hcf136-like
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Poly-beta-hydroxybutyrate polymerase N-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Type III restriction enzyme C-terminal endonuclease
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Bacterial OB-fold domain-containing protein
Gly-cisPro motif, important for rejection of L-amino acids
Outer membrane protein assembly factor BamB
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Gamma-glutamylcyclotransferase AIG2-like
Rap1a immunity protein domain-containing protein
Type IV pilus biogenesis and competence protein PilQ
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Virulence factor membrane-bound polymerase C-terminal
HTH-type transcriptional regulator AraC-type N-terminal
Thymidylate synthase/dCMP hydroxymethylase
DNA-binding and helicase activity, interacts with RecC
Nuclease activity, interacts with RecD and RecA
Aspartate/homoserine dehydrogenase NAD-binding
Schiff-base intermediate with substrate; via pyruvic acid
Nicotinate phosphoribosyltransferase N-terminal
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Electron transfer flavoprotein alpha subunit C-terminal
Moves into active site upon enzyme activation, plays a role in electron transfer
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Nucleophile; methyl group acceptor from either O6-methylguanine or O4-methylthymine
Nucleophile; methyl group acceptor from methylphosphotriester
N-end rule aminoacyl transferase C-terminal
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Chromosomal replication initiator DnaA C-terminal
Lysidine-tRNA(Ile) synthetase C-terminal
DnaJ homologue subfamily C member 28 conserved
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Plays an important role in discriminating NADH against NADPH
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Chromosomal replication initiator protein DnaA
Glyoxalase/fosfomycin resistance/dioxygenase
Glycoside hydrolase family 31 N-terminal
Electron transfer via tryptophanyl radical
Required for zinc-mediated homotetramerization and catalytic activity
NADH:ubiquinone oxidoreductase 30kDa subunit
Pectate lyase superfamily protein domain-containing protein
Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein
NAD(P) transhydrogenase alpha subunit C-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
Outer membrane protein assembly factor BamD
Anthranilate synthase component I N-terminal
3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold
Exonuclease VII large subunit C-terminal
Schiff-base intermediate with acetoacetate
Heat-inducible transcription repressor HrcA C-terminal
Winged helix-turn-helix transcription repressor HrcA DNA-binding
Surface antigen domain-containing protein
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
Alginate lyase domain-containing protein
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
Reversibly protonated during proton transport
Large ribosomal subunit protein uL15/eL18
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal