DNA-directed DNA polymerase family A palm
Phosphatidic acid phosphatase type 2/haloperoxidase
Secretion system C-terminal sorting domain-containing protein
Aminoacyl-transfer RNA synthetases class-II family profile
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
RNA 2-O ribose methyltransferase substrate binding
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
FAD-dependent oxidoreductase 2 FAD binding
Fibrobacter succinogenes major paralogous
Por secretion system C-terminal sorting domain-containing protein
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Outer membrane protein beta-barrel domain-containing protein
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Saccharopine dehydrogenase-like C-terminal
Glycosyltransferase subfamily 4-like N-terminal
Shikimate dehydrogenase substrate binding N-terminal
Phospholipid transport system substrate-binding protein
Glycosyl hydrolase family 98 putative carbohydrate-binding module
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Insecticide toxin TcdB middle/C-terminal
Insecticide toxin TcdB middle/N-terminal
UDP N-acetylglucosamine O-acyltransferase C-terminal
AMP-activated protein kinase glycogen-binding
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Type 2A encapsulin shell protein SrpI-like
Gliding motility protein SprA N-terminal
Gliding motility protein SprA N-terminal domain-containing protein
Alanyl-transfer RNA synthetases family profile
Polymerase/histidinol phosphatase N-terminal
Large ribosomal subunit protein uL15/eL18
Penicillin-binding protein transpeptidase
Anthranilate synthase component I N-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Tryptophan synthase beta chain-like PALP
Periplasmic copper-binding protein NosD beta helix
Periplasmic copper-binding protein NosD beta helix domain-containing protein
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
O-(3'-phospho-DNA)-tyrosine intermediate
Positions MEP for the nucleophilic attack
Chromosomal replication initiator DnaA C-terminal
Gamma-butyrobetaine hydroxylase-like N-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
ADP-ribosylarginine; by dinitrogenase reductase ADP-ribosyltransferase
Type I restriction modification DNA specificity
Glycoside hydrolase GH146 substrate-binding
Small ribosomal subunit protein uS4 N-terminal
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Polysaccharide biosynthesis protein C-terminal
Type I restriction enzyme R protein N-terminal
1,4-alpha-glucan branching enzyme C-terminal
Glycoside hydrolase family 57 N-terminal
Proton acceptor; for glutaminase activity
Signal recognition particle SRP54 helical bundle
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Glycosyl hydrolase family 30 beta sandwich
Solute-binding protein family 3/N-terminal
RlpA-like protein double-psi beta-barrel
Type II restriction enzyme and methyltransferase RM.Eco57I-like
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Bacterial type II secretion system protein E
Gly-cisPro motif, important for rejection of L-amino acids
NADH:ubiquinone oxidoreductase 30kDa subunit
NADH:ubiquinone oxidoreductase-like 20kDa subunit
ATP-dependent DNA helicase RecG C-terminal
Large ribosomal subunit protein uL6 alpha-beta
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Plays an important role in discriminating NADH against NADPH
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Arginine decarboxylase C-terminal helical
S-adenosylmethionine-dependent methyltransferase
Prepilin type IV endopeptidase peptidase
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Trigger factor ribosome-binding bacterial
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Large ribosomal subunit protein bL9 C-terminal
Glycosyl-hydrolase family 116 N-terminal
Glycosyl-hydrolase family 116 catalytic region
NIF system FeS cluster assembly NifU C-terminal
NIF system FeS cluster assembly NifU N-terminal
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Interacts with tRNA; defines subfamily-specific binding signature
Major facilitator superfamily (MFS) profile
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
RNA polymerase sigma factor 70 region 4 type 2
Glycosyl hydrolases family 45 active site
Polysaccharide biosynthesis protein CapD-like
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
N6 adenine-specific DNA methyltransferase N-terminal
Peptidase S9 prolyl oligopeptidase catalytic
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Endoribonuclease L-PSP/chorismate mutase-like
Could play a key role in the communication between the regulatory and the substrate sites
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Glycosyl hydrolases family 2 sugar binding
Polysaccharide chain length determinant N-terminal
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Type III restriction enzyme C-terminal endonuclease
Peptidase S8/S53 domain-containing protein
SsuA/THI5-like domain-containing protein
5 X 7 AA tandem repeats of P-X-S-S-S-S-X
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Thymidylate synthase/dCMP hydroxymethylase
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Mannose-6-phosphate isomerase type II C-terminal
Pseudouridine synthase I TruA alpha/beta
Listeria/Bacterioides repeat-containing protein
Could be important to modulate the pK values of the two catalytic cysteine residues
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
RND efflux pump membrane fusion protein barrel-sandwich
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Glycyl cysteine dithioester (Cys-Gly) (interchain with G-Cter in ThiS)
Siroheme decarboxylase AsnC-like ligand binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Exonuclease VII large subunit C-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
YbaK/aminoacyl-tRNA synthetase-associated
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Ribosomal RNA adenine methylase transferase N-terminal
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Prokaryotic-type class I peptide chain release factors
ATP-dependent RNA helicase HrpB C-terminal
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Glycosyl transferase family 3 N-terminal
ATPsynthase alpha/beta subunit N-terminal extension
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
Meso-diaminopimelate D-dehydrogenase C-terminal
RNA binding; important for wobble base 34 recognition
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Alpha-D-phosphohexomutase alpha/beta/alpha
Translation elongation factor P/YeiP central
S-adenosyl-L-homocysteine hydrolase NAD binding
Histidine phosphatase superfamily (Branch 2)
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
CRISPR-associated protein Cas6 C-terminal
SUF system FeS cluster assembly SufBD N-terminal
Phosphotransferase system enzyme I N-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
DNA replication/recombination mediator RecO N-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Pyridoxamine 5'-phosphate oxidase putative
Large ribosomal subunit protein bL12 C-terminal
Involved in allosteric activation by GTP
Outer membrane lipoprotein-sorting protein
Plays an important role in substrate specificity
ABC-type transport auxiliary lipoprotein component
Membrane insertase YidC/Oxa/ALB C-terminal
Large ribosomal subunit protein uL2 C-terminal
Phosphoadenosine phosphosulphate reductase
Schiff-base intermediate with substrate; via pyruvic acid
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Schiff-base intermediate with D-ribose 5-phosphate
Gfo/Idh/MocA-like oxidoreductase N-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
O-(5'-phospho-DNA)-tyrosine intermediate
TonB-dependent receptor-like beta-barrel
Dinitrogenase iron-molybdenum cofactor biosynthesis
Tc toxin complex TcA C-terminal TcB-binding
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Sodium/calcium exchanger membrane region
Aminoacyl-tRNA synthetase class I anticodon-binding
Outer membrane lipoprotein carrier protein
AlgX/AlgJ SGNH hydrolase-like domain-containing protein
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Translation elongation factor EFTs/EF1B dimerisation
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase