Cytochrome b561 bacterial/Ni-hydrogenase
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Pyruvate dehydrogenase E1 component middle
Aminoacyl-transfer RNA synthetases class-II family profile
Interacts with tRNA; defines subfamily-specific binding signature
Electron transfer via tryptophanyl radical
TRAP C4-dicarboxylate transport system permease DctM subunit
Positions MEP for the nucleophilic attack
Flagellar hook-length control protein-like C-terminal
Involved in allosteric activation by GTP
TonB-dependent receptor-like beta-barrel
Beta-lactamase-related domain-containing protein
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Interaction with polymerase core subunit RpoC
Bacterial type II secretion system protein E
Two-component system QseEF-associated lipoprotein QseG
AraC-type arabinose-binding/dimerisation
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Anthranilate synthase component I N-terminal
RND efflux pump membrane fusion protein barrel-sandwich
HupH hydrogenase expression protein C-terminal
High potential iron-sulfur proteins family profile
Outer membrane protein beta-barrel domain-containing protein
Prokaryotic-type class I peptide chain release factors
Chromosomal replication initiator DnaA C-terminal
Flagellar Assembly Protein A N-terminal region
Phosphodiester glycosidase domain-containing protein
O-(3'-phospho-DNA)-tyrosine intermediate
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
RNA polymerase sigma factor 70 region 4 type 2
N6 adenine-specific DNA methyltransferase N-terminal
FAD-dependent cmnm(5)s(2)U34 oxidoreductase
NIF system FeS cluster assembly NifU C-terminal
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-102)
Glycosyltransferase subfamily 4-like N-terminal
Penicillin-binding protein transpeptidase
Major facilitator superfamily (MFS) profile
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Heme-copper oxidase subunit III family profile
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Peptide methionine sulphoxide reductase MsrA
Release factor glutamine methyltransferase N-terminal
NAD(P) transhydrogenase alpha subunit C-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
DNA-directed DNA polymerase family A palm
Toxin-antitoxin system YwqK family antitoxin
Survival protein SurE-like phosphatase/nucleotidase
Capsule biosynthesis GfcC-like C-terminal
Capsule biosynthesis GfcC-like N-terminal
Cysteine sulfenic acid (-SOH) intermediate
Acyl-CoA dehydrogenase/oxidase C-terminal
Adaptive response protein AidB N-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Isocitrate dehydrogenase kinase/phosphatase (AceK) kinase
Isocitrate dehydrogenase kinase/phosphatase (AceK) regulatory
Important for beta-aspartyl-AMP intermediate formation
Translation initiation factor beta propellor-like
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Moybdenum cofactor oxidoreductase dimerisation
Exonuclease VII large subunit C-terminal
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Outer membrane protein assembly factor BamC
Disulphide bond isomerase DsbC/G N-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Solute-binding protein family 3/N-terminal
RNA 2-O ribose methyltransferase substrate binding
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Sodium symporter small subunit predicted
Type 4 fimbrial biogenesis protein PilX N-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Cytochrome c-type biogenesis protein CcmF C-terminal
Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
Cell wall-active antibiotics response LiaF-like C-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Acyl-CoA dehydrogenase/oxidase N-terminal
Superoxide dismutase copper/zinc binding
Transposase IS116/IS110/IS902 C-terminal
DNA polymerase III subunit delta C-terminal
SUF system FeS cluster assembly SufBD N-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Bacterial virulence factor lipase N-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Mannose-6-phosphate isomerase type II C-terminal
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
N-end rule aminoacyl transferase C-terminal
Organic solvent tolerance-like N-terminal
GlyGly-CTERM sorting domain-containing protein
RNA methyltransferase SpoU/TrmH type C-terminal
Choice-of-anchor E domain-containing protein
Plays an important role in discriminating NADH against NADPH
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Glyoxalase/fosfomycin resistance/dioxygenase
Ysc84 actin-binding domain-containing protein
Type II secretion system protein GspC N-terminal
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Molybdopterin cofactor biosynthesis C (MoaC)
Peptidase M1 membrane alanine aminopeptidase
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
6-phosphogluconate dehydrogenase C-terminal
TIGR04219 family outer membrane beta-barrel protein
Gly-cisPro motif, important for rejection of L-amino acids
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
UDP N-acetylglucosamine O-acyltransferase C-terminal
PEP-CTERM sorting domain-containing protein
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Erythronate-4-phosphate dehydrogenase dimerisation
Outer-membrane lipoprotein carrier protein
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Acyl-CoA dehydrogenase C-terminal bacterial-type
Phosphatidic acid phosphatase type 2/haloperoxidase
Alpha-1,6-glucosidases pullulanase-type C-terminal
Glycoside hydrolase family 13 N-terminal
Pullulanase carbohydrate-binding module 41
Glycine cleavage T-protein C-terminal barrel
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Aconitase A/isopropylmalate dehydratase small subunit swivel
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-122)
Threonine/serine exporter-like N-terminal
Type I restriction modification DNA specificity
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Tryptophan synthase beta chain-like PALP
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Outer membrane protein assembly factor BamD
Arginine decarboxylase C-terminal helical
PEP-CTERM protein-sorting domain-containing protein
Could play a key role in the communication between the regulatory and the substrate sites
DNA-directed RNA polymerase RpoA/D/Rpb3-type
YbaK/aminoacyl-tRNA synthetase-associated
Translation elongation factor P/YeiP central
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
O-(5'-phospho-DNA)-tyrosine intermediate
Membrane fusion protein biotin-lipoyl like
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Pseudouridine synthase I TruA alpha/beta
Flagellar motor switch protein FliN-like C-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Mandelate racemase/muconate lactonizing enzyme C-terminal
Outer membrane protein assembly factor BamA
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Peptidase S9 prolyl oligopeptidase catalytic
TonB-dependent receptor plug domain-containing protein
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Biopterin-dependent aromatic amino acid hydroxylase family profile
Signal transduction histidine kinase internal region
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
ATP synthase F1 complex delta/epsilon subunit N-terminal
Large ribosomal subunit protein uL6 alpha-beta
Type II secretion system protein GspG C-terminal
Magnesium transporter MgtE intracellular
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Polymerase/histidinol phosphatase N-terminal
Glucosamine/galactosamine-6-phosphate isomerase
Pectinesterase catalytic domain-containing protein
Alginate export domain-containing protein
Thiol:disulfide interchange protein DsbD
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Secretin/TonB short N-terminal domain-containing protein
Pyruvate phosphate dikinase AMP/ATP-binding
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Flagellar assembly protein FliH/Type III secretion system HrpE
Glutathionylspermidine synthase pre-ATP-grasp-like
Lipopolysaccharide export system protein LptA
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
General stress protein FMN-binding split barrel
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase C-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase N-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase
Uroporphyrinogen-III C-methyltransferase
TIGR03016 family PEP-CTERM system-associated outer membrane protein
Negative modulator of initiation of replication SeqA N-terminal
Replication modulator SeqA C-terminal DNA-binding
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Helix-hairpin-helix DNA-binding motif class 1
NADH-rubredoxin oxidoreductase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Could be important to modulate the pK values of the two catalytic cysteine residues
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Inner membrane protein YgaP-like transmembrane
S-adenosyl-L-homocysteine hydrolase NAD binding
Large ribosomal subunit protein uL15/eL18
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
Tetrahydrodipicolinate-N-succinyltransferase chain A
Membrane-bound lytic murein transglycosylase F
Large ribosomal subunit protein uL2 C-terminal
Important for substrate binding and specificity
Inosine/uridine-preferring nucleoside hydrolase
Curli production assembly/transport component CsgG
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Urease accessory protein UreH-like transmembrane
Thymidylate synthase/dCMP hydroxymethylase
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Serine aminopeptidase S33 domain-containing protein
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Glycoside hydrolase family 31 N-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Putative beta-barrel assembly-enhancing protease
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Reversibly protonated during proton transport
Type III secretion system flagellar brake protein YcgR PilZN
Important for interaction with partner proteins
t-SNARE coiled-coil homology domain-containing protein
Glycosyl transferase family 3 N-terminal
Peptide methionine sulfoxide reductase MsrA
DNA mismatch repair proteins mutS family
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Non-canonical purine NTP phosphatase/PRRC1
Activator of Hsp90 ATPase homologue 1-like C-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Saccharopine dehydrogenase-like C-terminal
Toxin co-regulated pilus biosynthesis protein Q C-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Appears to be important in orienting the phosphate for catalysis
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Sodium/calcium exchanger membrane region
Alanyl-transfer RNA synthetases family profile
Polysaccharide chain length determinant N-terminal
Sugar fermentation stimulation protein C-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
DNA replication/recombination mediator RecO N-terminal
Proline utilization A proline dehydrogenase N-terminal
Type II secretion system protein GspI C-terminal
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
DNA-directed DNA polymerase family B exonuclease
DNA-directed DNA polymerase family B multifunctional
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
PhoD-like phosphatase metallophosphatase
Prepilin type IV endopeptidase peptidase
RNA binding; important for wobble base 34 recognition
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Quercetin 2,3-dioxygenase C-terminal cupin
Membrane insertase YidC/Oxa/ALB C-terminal
Plays an important role in substrate specificity
Lipid/polyisoprenoid-binding YceI-like domain-containing protein
Polysaccharide biosynthesis protein CapD-like
Conserved virulence factor B-like winged helix
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Ribosomal RNA adenine methylase transferase N-terminal
Required for zinc-mediated homotetramerization and catalytic activity
Na(+)-translocating NADH-quinone reductase subunit A C-terminal
Small ribosomal subunit protein uS4 N-terminal