Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Tryptophan RNA-binding attenuator protein
Bacterial type II secretion system protein E
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Ribosomal RNA adenine methylase transferase N-terminal
Major facilitator superfamily (MFS) profile
Pyruvate/ketoisovalerate oxidoreductase catalytic
Alpha-D-phosphohexomutase alpha/beta/alpha
Ribonucleotide reductase large subunit C-terminal
Ribonucleotide reductase large subunit N-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Glycoside hydrolase family 31 N-terminal
Penicillin-binding protein transpeptidase
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
NADH:ubiquinone oxidoreductase 30kDa subunit
Phosphoribosylformylglycinamidine synthase linker
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Pesticidal crystal protein Cry22Aa Ig-like
Phosphoadenosine phosphosulphate reductase
Pyridoxamine 5'-phosphate oxidase putative
Glycoside hydrolase family 42 N-terminal
Beta-xylosidase C-terminal Concanavalin A-like
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Release factor glutamine methyltransferase N-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Glycosyl hydrolase family 98 putative carbohydrate-binding module
Phosphatidylglycerol lysyltransferase C-terminal
Tryptophan synthase beta chain-like PALP
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Helix-hairpin-helix DNA-binding motif class 1
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Putative regulatory protein FmdB Zinc ribbon
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Important for beta-aspartyl-AMP intermediate formation
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
CobB/CobQ-like glutamine amidotransferase
Diacylglycerol glucosyltransferase N-terminal
Glycosyl transferase family 28 C-terminal
Solute-binding protein family 3/N-terminal
Lysidine-tRNA(Ile) synthetase C-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Butirosin biosynthesis protein H N-terminal
Nicotinate phosphoribosyltransferase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Anthranilate synthase component I N-terminal
DNA-directed DNA polymerase family A palm
Flagellar motor switch protein FliN-like C-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Sigma 54 modulation/S30EA ribosomal protein C-terminal
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Carbamoyl-phosphate synthase small subunit N-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Ionotropic glutamate receptor C-terminal
Prokaryotic-type class I peptide chain release factors
Prepilin type IV endopeptidase peptidase
S-adenosylmethionine-dependent methyltransferase
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Sugar fermentation stimulation protein C-terminal
Resolvase/invertase-type recombinase catalytic
RNA polymerase sigma factor 70 region 4 type 2
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
DNA polymerase III delta subunit C-terminal
Large ribosomal subunit protein uL2 C-terminal
Glycosyltransferase subfamily 4-like N-terminal
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Important for interaction with partner proteins
YbaK/aminoacyl-tRNA synthetase-associated
Sporulation stage II protein D amidase enhancer LytB N-terminal
Polymerase/histidinol phosphatase N-terminal
Dinitrogenase iron-molybdenum cofactor biosynthesis
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Chromosomal replication initiator DnaA C-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Cadherin-like beta sandwich domain-containing protein
Alpha galactosidase C-terminal beta sandwich
Periplasmic binding protein domain-containing protein
Translation elongation factor P/YeiP central
Aspartate/homoserine dehydrogenase NAD-binding
NADH:flavin oxidoreductase/NADH oxidase N-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
ABC transporter substrate-binding protein PnrA-like
Thiamin pyrophosphokinase thiamin-binding
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Schiff-base intermediate with D-ribose 5-phosphate
Peptide methionine sulphoxide reductase MsrA
FAD-dependent oxidoreductase 2 FAD binding
Cation-transporting P-type ATPase N-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Type I restriction modification DNA specificity
ATP synthase F1 complex delta/epsilon subunit N-terminal
Dipicolinate synthase subunit A N-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Schiff-base intermediate with acetaldehyde
Plays an important role in discriminating NADH against NADPH
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
RDXXRA motif of the pArg binding pocket involved in allosteric regulation
Exonuclease VII large subunit C-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
DNA mismatch repair proteins mutS family
Cytochrome c-type biogenesis protein CcmF C-terminal
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Proton acceptor; for glutaminase activity
Flagellar hook-length control protein-like C-terminal
RNA 2-O ribose methyltransferase substrate binding
Transposon Tn7 transposition protein TnsD C-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Cell envelope-related transcriptional attenuator
Terminase large subunit-like endonuclease
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Large ribosomal subunit protein bL9 C-terminal
Mandelate racemase/muconate lactonizing enzyme C-terminal
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Glycoside hydrolase GH146 substrate-binding
Interaction with polymerase core subunit RpoC
NIF system FeS cluster assembly NifU N-terminal
Signal transduction histidine kinase internal region
Phosphomannose isomerase type I catalytic
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Type III secretion system flagellar brake protein YcgR PilZN
Phage conserved hypothetical protein C-terminal
Large ribosomal subunit protein uL6 alpha-beta
Glutamate synthase alpha subunit C-terminal
Glycogen debranching enzyme bacterial and archaeal type N-terminal
Arginine decarboxylase C-terminal helical
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
RNA binding; important for wobble base 34 recognition
Flagellar assembly protein FliH/Type III secretion system HrpE
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Gly-cisPro motif, important for rejection of L-amino acids
Meso-diaminopimelate D-dehydrogenase C-terminal
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Glycosyl transferase family 3 N-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Could be important to modulate the pK values of the two catalytic cysteine residues
Shikimate dehydrogenase substrate binding N-terminal
Large ribosomal subunit protein uL15/eL18
Membrane iron-sulfur containing protein FtrD-like
Phosphatidic acid phosphatase type 2/haloperoxidase
Involved in allosteric activation by GTP
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Type I restriction enzyme R protein N-terminal
Glycosyltransferase family 28 N-terminal
Iron dependent repressor metal binding and dimerisation
Glycosyl hydrolases family 2 sugar binding
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
N6 adenine-specific DNA methyltransferase N-terminal
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
Membrane fusion protein biotin-lipoyl like
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Transcriptional coactivator p15 (PC4) C-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Formylmethanofuran dehydrogenase subunit E
Membrane insertase YidC/Oxa/ALB C-terminal
Flagellar Assembly Protein A N-terminal region
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
Sporulation transcription regulator WhiA N-terminal
Gamma-glutamylcyclotransferase AIG2-like
SAM-dependent methyltransferase TRM5/TYW2-type
Carboxypeptidase regulatory-like domain-containing protein
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Hydroxymethylglutaryl-coenzyme A synthase C-terminal
Hydroxymethylglutaryl-coenzyme A synthase N-terminal
Important for autoinhibition of adenylyltransferase activity
N(4)-bis(aminopropyl)spermidine synthase C-terminal
Heat-inducible transcription repressor HrcA C-terminal
Winged helix-turn-helix transcription repressor HrcA DNA-binding
Pyrimidine nucleoside phosphorylase C-terminal
Putative amidase domain-containing protein
Protein O-mannosyl-transferase C-terminal four TM
Could play a key role in the communication between the regulatory and the substrate sites
Threonine/serine exporter-like N-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Transcription regulator AsnC/Lrp ligand binding
Nucleophile; cysteine thiosulfonate intermediate
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Integron-associated effector binding protein
Small ribosomal subunit protein uS4 N-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Translation elongation factor EFTs/EF1B dimerisation
ADP-ribosylarginine; by dinitrogenase reductase ADP-ribosyltransferase
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Polysaccharide biosynthesis protein C-terminal
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Signal transduction histidine kinase osmosensitive K+ channel sensor N-terminal
Peptidase S9 prolyl oligopeptidase catalytic
Copper amine oxidase-like domain-containing protein
Putative oxidoreductase/dehydrogenase Rossmann-like
Pseudouridine synthase I TruA alpha/beta
Alanyl-transfer RNA synthetases family profile
Saccharopine dehydrogenase-like C-terminal
Reversibly protonated during proton transport
tRNA pseudouridylate synthase B C-terminal
Plays an important role in substrate specificity
Ribose-phosphate pyrophosphokinase N-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
Peptidase C45 acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase
Alpha-(1,6)-fucosyltransferase N- and catalytic