Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Major facilitator superfamily (MFS) profile
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Outer membrane protein beta-barrel domain-containing protein
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Alanyl-transfer RNA synthetases family profile
TRAP C4-dicarboxylate transport system permease DctM subunit
Peptidase S8/S53 domain-containing protein
Molybdopterin cofactor biosynthesis C (MoaC)
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
SUF system FeS cluster assembly SufBD N-terminal
RNA binding; important for wobble base 34 recognition
NIF system FeS cluster assembly NifU N-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
NPCBM-associated, NEW3 domain of alpha-galactosidase
Peptidase S9 prolyl oligopeptidase catalytic
Aminoacyl-transfer RNA synthetases class-II family profile
Large ribosomal subunit protein uL2 C-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Phosphomannose isomerase type I catalytic
Pyruvate phosphate dikinase AMP/ATP-binding
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Plays an important role in substrate specificity
Serine aminopeptidase S33 domain-containing protein
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Chromosomal replication initiator DnaA C-terminal
Glucosamine/galactosamine-6-phosphate isomerase
Na+/H+ antiporter MnhB subunit-related protein
ABC-type glycine betaine transport system substrate-binding
Polymerase/histidinol phosphatase N-terminal
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Glycosyltransferase subfamily 4-like N-terminal
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
DNA replication/recombination mediator RecO N-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Superoxide dismutase copper/zinc binding
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Interacts with tRNA; defines subfamily-specific binding signature
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Tetratricopeptide repeat-containing protein
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Cytochrome C biogenesis protein transmembrane
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Septum formation inhibitor MinC C-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Tryptophan synthase beta chain-like PALP
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
6-phosphogluconate dehydrogenase C-terminal
Survival protein SurE-like phosphatase/nucleotidase
Mandelate racemase/muconate lactonizing enzyme C-terminal
Type I restriction enzyme R protein N-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Membrane insertase YidC/Oxa/ALB C-terminal
S-adenosylmethionine-dependent methyltransferase
Pseudouridine synthase I TruA alpha/beta
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Activator of Hsp90 ATPase homologue 1-like C-terminal
RNA polymerase sigma factor 70 region 4 type 2
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Glycosyl transferase family 3 N-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Leucine-binding protein domain-containing protein
Phosphodiester glycosidase domain-containing protein
Small ribosomal subunit protein uS4 N-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Solute-binding protein family 3/N-terminal
Ionotropic glutamate receptor C-terminal
Schiff-base intermediate with D-ribose 5-phosphate
Pyrimidine nucleoside phosphorylase C-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Heme-copper oxidase subunit III family profile
Resolvase/invertase-type recombinase catalytic
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Peptidase C-terminal archaeal/bacterial domain-containing protein
Diacylglycerol glucosyltransferase N-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Carboxypeptidase regulatory-like domain-containing protein
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
ATPsynthase alpha/beta subunit N-terminal extension
Bacterial bifunctional deaminase-reductase C-terminal
RNA 2-O ribose methyltransferase substrate binding
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Saccharopine dehydrogenase-like C-terminal
PsbP C-terminal domain-containing protein
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
Positions MEP for the nucleophilic attack
Bacterial type II secretion system protein E
Type II secretion system protein GspE N-terminal
Exonuclease VII large subunit C-terminal
Glycine cleavage T-protein C-terminal barrel
Glycoside hydrolase family 42 N-terminal
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Nitrite/Sulfite reductase ferredoxin-like
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Influences the redox potential of the prosthetic heme and FAD groups
Involved in heme-bound ligand stabilization and O-O bond activation
Anthranilate synthase component I N-terminal
Glycosyl hydrolase family 98 putative carbohydrate-binding module
Thiamin pyrophosphokinase thiamin-binding
Trigger factor ribosome-binding bacterial
Polysaccharide biosynthesis protein CapD-like
Thymidylate synthase/dCMP hydroxymethylase
Carbamoyl-phosphate synthase small subunit N-terminal
Large ribosomal subunit protein uL6 alpha-beta
Phosphatidic acid phosphatase type 2/haloperoxidase
DR2241 4Fe-4S iron-sulfur cluster binding
O-(5'-phospho-DNA)-tyrosine intermediate
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Cell envelope-related transcriptional attenuator
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Glucose-methanol-choline oxidoreductase C-terminal
Penicillin-binding protein transpeptidase
Arginine decarboxylase C-terminal helical
Aspartate/homoserine dehydrogenase NAD-binding
Prokaryotic-type class I peptide chain release factors
NADH:ubiquinone oxidoreductase-like 20kDa subunit
RNA methyltransferase SpoU/TrmH type C-terminal
Solute-binding protein family 5 domain-containing protein
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
General stress protein FMN-binding split barrel
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Electron transfer flavoprotein alpha/beta-subunit N-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Large ribosomal subunit protein uL15/eL18
Involved in allosteric activation by GTP
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Glycoside-hydrolase family GH114 TIM-barrel
Peptidase M43 pregnancy-associated plasma-A domain-containing protein
3D (Asp-Asp-Asp) domain-containing protein
Alpha-D-phosphohexomutase alpha/beta/alpha
Ribosomal RNA adenine methylase transferase N-terminal
Transcription regulator AsnC/Lrp ligand binding
Water stress and hypersensitive response
Aromatic amino acid beta-eliminating lyase/threonine aldolase
PrcB C-terminal domain-containing protein
Glycosyl hydrolase family 79, N-terminal domain
Organic solvent tolerance-like N-terminal
Organic solvent tolerance-like N-terminal domain-containing protein
Siroheme decarboxylase AsnC-like ligand binding
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Phosphatidate phosphatase APP1 catalytic
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
DNA mismatch repair proteins mutS family
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
RND efflux pump membrane fusion protein barrel-sandwich
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Alpha-1,6-glucosidases pullulanase-type C-terminal
Glycoside hydrolase family 13 N-terminal
Pullulanase carbohydrate-binding module 41
Essential for prephenate dehydratase activity
Translation elongation factor P/YeiP central
Delta-60 repeat domain-containing protein
Pyruvate dehydrogenase E1 component middle
tRNA pseudouridylate synthase B C-terminal
ABC transporter substrate-binding protein PnrA-like
DNA topoisomerase I catalytic core eukaryotic-type
Helix-hairpin-helix DNA-binding motif class 1
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Inosine/uridine-preferring nucleoside hydrolase
Phosphoribosylformylglycinamidine synthase linker
Lipocalin-like domain-containing protein
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Important for interaction with partner proteins
Ribonucleotide reductase large subunit C-terminal
Ribonucleotide reductase large subunit N-terminal
Could play a key role in the communication between the regulatory and the substrate sites
Prepilin type IV endopeptidase peptidase