Could play a key role in the communication between the regulatory and the substrate sites
Ribose-phosphate pyrophosphokinase N-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
tRNA pseudouridylate synthase B C-terminal
Tryptophan synthase beta chain-like PALP
RND efflux pump membrane fusion protein barrel-sandwich
Organic solvent tolerance-like N-terminal
Major facilitator superfamily (MFS) profile
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Lysidine-tRNA(Ile) synthetase C-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
DNA-binding and helicase activity, interacts with RecC
Nuclease activity, interacts with RecD and RecA
Solute-binding protein family 3/N-terminal
Glycoside hydrolase family 31 N-terminal
Domain amino terminal to FKBP-type peptidyl-prolyl isomerase
Polymerase/histidinol phosphatase N-terminal
Exonuclease VII large subunit C-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
DNA polymerase III delta subunit C-terminal
Lysozyme inhibitor LprI N-terminal domain-containing protein
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Proline utilization A proline dehydrogenase N-terminal
Neurotransmitter-gated ion-channel ligand-binding
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
NADH:ubiquinone oxidoreductase 30kDa subunit
Bacterial type II secretion system protein E
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Ribosomal RNA adenine methylase transferase N-terminal
FAD-binding PCMH-type domain-containing protein
Large ribosomal subunit protein uL2 C-terminal
Positions MEP for the nucleophilic attack
Saccharopine dehydrogenase-like C-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
Acyltransferase MbtK/IucB-like conserved
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Gly-cisPro motif, important for rejection of L-amino acids
Outer-membrane lipoprotein carrier protein
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Prokaryotic-type class I peptide chain release factors
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
O-(5'-phospho-DNA)-tyrosine intermediate
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Right handed beta helix domain-containing protein
Pseudouridine synthase I TruA alpha/beta
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Thiamin pyrophosphokinase thiamin-binding
Aminoacyl-transfer RNA synthetases class-II family profile
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Choloylglycine hydrolase/NAAA C-terminal
Organic solvent tolerance-like N-terminal domain-containing protein
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Interaction with polymerase core subunit RpoC
Phosphatidic acid phosphatase type 2/haloperoxidase
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
O-(3'-phospho-DNA)-tyrosine intermediate
Cysteine sulfenic acid (-SOH) intermediate
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Ribonucleotide reductase large subunit C-terminal
Ribonucleotide reductase large subunit N-terminal
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Glycine cleavage T-protein C-terminal barrel
Required for zinc-mediated homotetramerization and catalytic activity
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Glycosyltransferase subfamily 4-like N-terminal
Mandelate racemase/muconate lactonizing enzyme C-terminal
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Reversibly protonated during proton transport
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Probable peptidoglycan glycosyltransferase FtsW
Outer membrane protein assembly factor BamB
RNA 2-O ribose methyltransferase substrate binding
Polysaccharide biosynthesis protein CapD-like
peptide-methionine (R)-S-oxide reductase
Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with Met-247)
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-100)
Helix-hairpin-helix DNA-binding motif class 1
Large ribosomal subunit protein uL30-like ferredoxin-like fold
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Phosphoethanolamine transferase N-terminal
Peptidyl-prolyl cis-trans isomerase FKBP-type N-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Small ribosomal subunit protein uS4 N-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Prepilin type IV endopeptidase peptidase
Thymidylate synthase/dCMP hydroxymethylase
Alpha-glycerophosphate oxidase C-terminal
Important for interaction with partner proteins
Aminoacyl-tRNA synthetase class I anticodon-binding
Plays an important role in substrate specificity
Cytochrome b561 bacterial/Ni-hydrogenase
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
SUF system FeS cluster assembly SufBD N-terminal
Outer membrane protein assembly factor BamA
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Outer membrane protein assembly factor BamE
Anthranilate synthase component I N-terminal
Large ribosomal subunit protein uL6 alpha-beta
N6 adenine-specific DNA methyltransferase N-terminal
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Large ribosomal subunit protein uL15/eL18
Carbamoyl-phosphate synthase small subunit N-terminal
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
Mannose-6-phosphate isomerase type II C-terminal
Cell division protein FtsQ/DivIB C-terminal
Outer membrane protein beta-barrel domain-containing protein
Release factor glutamine methyltransferase N-terminal
Large ribosomal subunit protein bL25 L25
Interacts with tRNA; defines subfamily-specific binding signature
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Electron transfer via tryptophanyl radical
Pyruvate dehydrogenase E1 component middle
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Sec translocon accessory complex subunit YajC
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
UDP N-acetylglucosamine O-acyltransferase C-terminal
Penicillin-binding protein transpeptidase
Translation elongation factor P/YeiP central
Peptidase S9 prolyl oligopeptidase catalytic
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Schiff-base intermediate with substrate; via pyruvic acid
Chromosomal replication initiator DnaA C-terminal
Penicillin-binding protein activator LpoB
Acyl-CoA dehydrogenase C-terminal bacterial-type
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Integron-associated effector binding protein
Alanyl-transfer RNA synthetases family profile
Aconitase A/isopropylmalate dehydratase small subunit swivel
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Tetrahydrodipicolinate-N-succinyltransferase chain A
Transglycosylase SLT domain-containing protein
DNA-directed DNA polymerase family A palm
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Schiff-base intermediate with D-ribose 5-phosphate
Essential for prephenate dehydratase activity
Type I restriction modification DNA specificity
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Pyruvate phosphate dikinase AMP/ATP-binding
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity