Large ribosomal subunit protein uL2 C-terminal
Gram-positive cocci surface proteins LPxTG
Anthranilate synthase component I N-terminal
Putative amidase domain-containing protein
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Sporulation stage II protein D amidase enhancer LytB N-terminal
N(4)-bis(aminopropyl)spermidine synthase C-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Membrane fusion protein biotin-lipoyl like
Signal transduction histidine kinase internal region
Could play a key role in the communication between the regulatory and the substrate sites
Lantibiotic biosynthesis protein dehydration
6-hydroxymethylpterin diphosphokinase MptE-like
Membrane insertase YidC/Oxa/ALB C-terminal
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Carbamoyl-phosphate synthase small subunit N-terminal
Prokaryotic-type class I peptide chain release factors
Alanyl-transfer RNA synthetases family profile
Threonine/serine exporter-like N-terminal
Peptidase M15C domain-containing protein
O-(5'-phospho-DNA)-tyrosine intermediate
Resolvase/invertase-type recombinase catalytic
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
Glycoside hydrolase family 42 N-terminal
Sodium/calcium exchanger membrane region
DNA glycosylase/AP lyase H2TH DNA-binding
Phosphocysteine intermediate; for EIIB activity
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Inner membrane protein YgaP-like transmembrane
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Tryptophan synthase beta chain-like PALP
Nicotinamide phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Aromatic amino acid beta-eliminating lyase/threonine aldolase
NIF system FeS cluster assembly NifU N-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
FAD-dependent oxidoreductase 2 FAD binding
ADP-ribosylarginine; by dinitrogenase reductase ADP-ribosyltransferase
Polysaccharide biosynthesis protein C-terminal
Intein C-terminal splicing domain-containing protein
Terminase large subunit-like endonuclease
Solute-binding protein family 3/N-terminal
Plays an important role in substrate specificity
Pseudouridine synthase I TruA alpha/beta
Exonuclease VII large subunit C-terminal
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Schiff-base intermediate with acetaldehyde
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
DNA primase/polymerase bifunctional N-terminal
Major facilitator superfamily (MFS) profile
SGNH hydrolase-type esterase domain-containing protein
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Polymerase/histidinol phosphatase N-terminal
ABC transporter substrate-binding protein PnrA-like
Cation-transporting P-type ATPase N-terminal
General stress protein FMN-binding split barrel
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
A-kinase anchor protein 7-like phosphoesterase
RNA polymerase sigma factor 70 region 4 type 2
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
CobB/CobQ-like glutamine amidotransferase
Phosphomannose isomerase type I catalytic
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Pyridoxamine 5'-phosphate oxidase putative
Transcriptional regulator TetR C-terminal Firmicutes type
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
Cellulosome anchoring protein cohesin region
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Carbohydrate binding module family 17/28
Glycosyltransferase subfamily 4-like N-terminal
DNA mismatch repair proteins mutS family
Positions MEP for the nucleophilic attack
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
Reversibly protonated during proton transport
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Alpha-D-phosphohexomutase alpha/beta/alpha
D-galactose/methyl-galactoside binding periplasmic protein MglB
1-phosphatidylinositol phosphodiesterase
Phosphatidylinositol-specific phospholipase C X
Chromosomal replication initiator DnaA C-terminal
Flagellar hook-length control protein-like C-terminal
DNA-directed DNA polymerase family A palm
Arabinogalactan endo-beta-1,4-galactanase
Diacylglycerol glucosyltransferase N-terminal
Glycosyl transferase family 28 C-terminal
Bacterial transcription activator effector binding
Na+-translocating membrane potential-generating system MpsC
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Stage III sporulation protein AA AAA+ ATPase
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Ribosomal RNA adenine methylase transferase N-terminal
tRNA pseudouridylate synthase B C-terminal
Polysaccharide chain length determinant N-terminal
Penicillin-binding protein transpeptidase
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Heat-inducible transcription repressor HrcA C-terminal
Thymidylate synthase/dCMP hydroxymethylase
Type I restriction modification DNA specificity
Replication initiation protein-like C-terminal
Rolling Circle replication initiation protein N-terminal
Quercetin 2,3-dioxygenase C-terminal cupin
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
Phosphoadenosine phosphosulphate reductase
Gly-cisPro motif, important for rejection of L-amino acids
RNA binding; important for wobble base 34 recognition
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Electron transfer flavoprotein alpha subunit C-terminal
Essential for prephenate dehydratase activity
Nicotinate phosphoribosyltransferase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Glycosyl transferase family 3 N-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
1,4-alpha-glucan branching enzyme C-terminal
Glycoside hydrolase family 57 N-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
Thiopeptide-type bacteriocin biosynthesis
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
DNA polymerase III delta subunit C-terminal
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Cell envelope-related transcriptional attenuator
Sugar fermentation stimulation protein C-terminal
Sporulation stage IV protein A C-terminal
Bacterial type II secretion system protein E
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Phosphotransferase system enzyme I N-terminal
Glycoside hydrolase family 31 N-terminal
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Periplasmic copper-binding protein NosD beta helix
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Peptidase C39-like domain-containing protein
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Large ribosomal subunit protein uL6 alpha-beta
Lysozyme inhibitor LprI N-terminal domain-containing protein
N6 adenine-specific DNA methyltransferase N-terminal
Survival protein SurE-like phosphatase/nucleotidase
Extracellular endo-alpha-(1->5)-L-arabinanase C-terminal
Glycosyltransferase family 28 N-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Schiff-base intermediate with D-ribose 5-phosphate
Thiamin pyrophosphokinase thiamin-binding
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Shikimate dehydrogenase substrate binding N-terminal
Pyrimidine nucleoside phosphorylase C-terminal
Flagellar motor switch protein FliN-like C-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Phosphatidic acid phosphatase type 2/haloperoxidase
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
RNA 2-O ribose methyltransferase substrate binding
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Important for substrate specificity; cannot use PPi as phosphoryl donor
Methionyl-tRNA synthetase anticodon-binding
Small ribosomal subunit protein uS4 N-terminal
Important for beta-aspartyl-AMP intermediate formation
HNH/Endo VII superfamily nuclease toxins
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Important for autoinhibition of adenylyltransferase activity
Septum formation inhibitor MinC C-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Prepilin type IV endopeptidase peptidase
Phosphoribosylformylglycinamidine synthase linker
Peptide methionine sulphoxide reductase MsrA
Involved in allosteric activation by GTP
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Helix-hairpin-helix DNA-binding motif class 1
Lysidine-tRNA(Ile) synthetase C-terminal
Large ribosomal subunit protein uL15/eL18
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
Polysaccharide biosynthesis protein CapD-like
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase N-terminal
Schiff-base intermediate with substrate; via pyruvic acid
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Global transcriptional regulator CodY C-terminal
Global transcriptional regulator CodY N-terminal
Damage-control phosphatase ARMT1-like metal-binding
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
YbaK/aminoacyl-tRNA synthetase-associated
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Integron-associated effector binding protein
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
ABC transporter substrate binding protein
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Beta-xylosidase C-terminal Concanavalin A-like
Translation elongation factor P/YeiP central
Glutathionylspermidine synthase pre-ATP-grasp-like
Sporulation transcription regulator WhiA N-terminal
Ionotropic glutamate receptor C-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Important for interaction with partner proteins
Proton acceptor; for glutaminase activity
Dinitrogenase iron-molybdenum cofactor biosynthesis
Type III secretion system flagellar brake protein YcgR PilZN
NADH-rubredoxin oxidoreductase C-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Flagellar assembly protein FliH/Type III secretion system HrpE
Increases nucleophilicity of active site Cys
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Pyruvate/ketoisovalerate oxidoreductase catalytic
Release factor glutamine methyltransferase N-terminal
Major facilitator superfamily associated
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation