Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Thiamine pyrophosphate enzyme TPP-binding
Release factor glutamine methyltransferase N-terminal
Phosphatidylglycerol lysyltransferase C-terminal
Inosine/uridine-preferring nucleoside hydrolase
DNA replication/recombination mediator RecO N-terminal
CagE TrbE VirB component of type IV transporter system central
Polymerase/histidinol phosphatase N-terminal
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Type II restriction enzyme and methyltransferase RM.Eco57I-like
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Resolvase/invertase-type recombinase catalytic
Glucosamine/galactosamine-6-phosphate isomerase
Aminoacyl-transfer RNA synthetases class-II family profile
Penicillin-binding protein transpeptidase
Anthranilate synthase component I N-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
HicB-like antitoxin of toxin-antitoxin system
Mannose-6-phosphate isomerase type II C-terminal
TRAP C4-dicarboxylate transport system permease DctM subunit
O-(5'-phospho-DNA)-tyrosine intermediate
Methylaspartate ammonia-lyase C-terminal
Methylaspartate ammonia-lyase N-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Survival protein SurE-like phosphatase/nucleotidase
Putative oxidoreductase/dehydrogenase Rossmann-like
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Cytochrome oxidase subunit II copper A binding
Alpha-D-phosphohexomutase alpha/beta/alpha
N6 adenine-specific DNA methyltransferase N-terminal
Major facilitator superfamily (MFS) profile
Lysidine-tRNA(Ile) synthetase C-terminal
Nicotinate phosphoribosyltransferase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
UDP N-acetylglucosamine O-acyltransferase C-terminal
Solute-binding protein family 3/N-terminal
D-galactarate/Altronate dehydratase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Bacterial type II secretion system protein E
RND efflux pump membrane fusion protein barrel-sandwich
Ionotropic glutamate receptor C-terminal
F420-non-reducing hydrogenase iron-sulfur subunit D
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Pyrimidine nucleoside phosphorylase C-terminal
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Phosphomannose isomerase type I catalytic
Glycosyltransferase subfamily 4-like N-terminal
RNA 2-O ribose methyltransferase substrate binding
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Glyoxalase/fosfomycin resistance/dioxygenase
Pyridoxamine 5'-phosphate oxidase putative
CobB/CobQ-like glutamine amidotransferase
Polysaccharide biosynthesis protein C-terminal
Sodium/calcium exchanger membrane region
Thiamine pyrophosphate enzyme N-terminal TPP-binding
NIF system FeS cluster assembly NifU N-terminal
YbaK/aminoacyl-tRNA synthetase-associated
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Phosphocysteine intermediate; for EIIB activity
Could play a key role in the communication between the regulatory and the substrate sites
Tryptophan synthase beta chain-like PALP
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
Outer membrane protein beta-barrel domain-containing protein
Gfo/Idh/MocA-like oxidoreductase N-terminal
Type I restriction modification DNA specificity
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Important for beta-aspartyl-AMP intermediate formation
Threonine/serine exporter-like N-terminal
tRNA (guanine-N(1)-)-methyltransferase C-terminal
Prepilin type IV endopeptidase peptidase
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Ribosomal RNA adenine methylase transferase N-terminal
Polysaccharide chain length determinant N-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Phosphoribosylformylglycinamidine synthase linker
RNA polymerase sigma factor 70 region 4 type 2
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
O-(phosphoribosyl dephospho-coenzyme A)serine
Dinitrogenase iron-molybdenum cofactor biosynthesis
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
FAD-dependent oxidoreductase 2 FAD binding
Alanyl-transfer RNA synthetases family profile
Peptide methionine sulphoxide reductase MsrA
DNA-directed DNA polymerase family A palm
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Carboxypeptidase regulatory-like domain-containing protein
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Small ribosomal subunit protein uS4 N-terminal
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Membrane insertase YidC/Oxa/ALB C-terminal
Thiamin/hydroxymethyl pyrimidine-binding YkoF putative
Pyruvate/ketoisovalerate oxidoreductase catalytic
Prokaryotic-type class I peptide chain release factors
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Large ribosomal subunit protein uL15/eL18
tRNA pseudouridylate synthase B C-terminal
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
ADP-ribosylarginine; by dinitrogenase reductase ADP-ribosyltransferase
Important for guanine/8-oxoguanine distinction
5-glutamyl coenzyme A thioester intermediate
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Ribonucleotide reductase large subunit C-terminal
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase N-terminal
Bacterial transcription activator effector binding
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Glycosyl transferase family 3 N-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
ABC transporter substrate-binding protein PnrA-like
Translation elongation factor P/YeiP central
Phage terminase large subunit GpA ATPase
Terminase large subunit GpA endonuclease
Gly-cisPro motif, important for rejection of L-amino acids
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Pyruvate phosphate dikinase AMP/ATP-binding
DNA mismatch repair proteins mutS family
RNA binding; important for wobble base 34 recognition
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
ABC-type glycine betaine transport system substrate-binding
Carbamoyl-phosphate synthase small subunit N-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
NADH-rubredoxin oxidoreductase C-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Interaction with polymerase core subunit RpoC
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Could be important to modulate the pK values of the two catalytic cysteine residues
Tripartite tricarboxylate transporter substrate binding protein
Large ribosomal subunit protein uL6 alpha-beta
Aconitase A/isopropylmalate dehydratase small subunit swivel
RlpA-like protein double-psi beta-barrel
Heat-inducible transcription repressor HrcA C-terminal
Peptide methionine sulfoxide reductase MsrA
Cysteine sulfenic acid (-SOH) intermediate
Signal transduction histidine kinase 5TM receptor LytS transmembrane region
Signal transduction histidine kinase internal region
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Phosphotransferase system enzyme I N-terminal
Helix-hairpin-helix DNA-binding motif class 1
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Large ribosomal subunit protein uL2 C-terminal
Pseudouridine synthase I TruA alpha/beta
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
ssDNA thymidine ADP-ribosyltransferase DarT
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Phosphoadenosine phosphosulphate reductase
Exonuclease VII large subunit C-terminal
Malonyl-[acyl-carrier protein] O-methyltransferase 2
Type III restriction enzyme C-terminal endonuclease
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Schiff-base intermediate with D-ribose 5-phosphate
Aspartate/homoserine dehydrogenase NAD-binding
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Molybdopterin cofactor biosynthesis C (MoaC)
Transcription factor NikR nickel binding C-terminal
Rubrerythrin diiron-binding domain-containing protein
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
6-phosphogluconate dehydrogenase C-terminal
Schiff-base intermediate with acetaldehyde
Aspartate carbamoyltransferase regulatory subunit C-terminal
Aspartate carbamoyltransferase regulatory subunit N-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Plays an important role in discriminating NADH against NADPH
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Increases nucleophilicity of active site Cys
Gfo/Idh/MocA-like oxidoreductase C-terminal
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Sporulation transcription regulator WhiA N-terminal
Essential for prephenate dehydratase activity
Malonyl-[acyl-carrier protein] O-methyltransferase 1
Glycoside-hydrolase family GH114 TIM-barrel
Reversibly protonated during proton transport