Important for substrate binding and specificity
Outer-membrane lipoprotein carrier protein
Rap1a immunity protein domain-containing protein
Heat-inducible transcription repressor HrcA C-terminal
Winged helix-turn-helix transcription repressor HrcA DNA-binding
Glycine zipper domain-containing protein
Type 4 fimbrial biogenesis protein PilX N-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Acetylserotonin O-methyltransferase dimerisation
Gamma-butyrobetaine hydroxylase-like N-terminal
Ribulose bisphosphate carboxylase small subunit 2
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Helix-hairpin-helix DNA-binding motif class 1
Solute-binding protein family 3/N-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Interaction with polymerase core subunit RpoC
Membrane insertase YidC/Oxa/ALB C-terminal
Saccharopine dehydrogenase-like C-terminal
Ribulose bisphosphate carboxylase large chain 1
Urease accessory protein UreH-like transmembrane
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
ABC-type uncharacterised transport system
TRAP C4-dicarboxylate transport system permease DctM subunit
Cysteine sulfenic acid (-SOH) intermediate
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Interchain (with Cys-211); in linked form
Interchain (with Cys-51); in linked form
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Ribulose bisphosphate carboxylase-like protein
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
ATP-dependent DNA helicase RecG C-terminal
Proton acceptor; for glutaminase activity
Ribose-phosphate pyrophosphokinase N-terminal
SUF system FeS cluster assembly SufBD N-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Aminoacyl-transfer RNA synthetases class-II family profile
Type II secretion system protein GspG C-terminal
AB hydrolase-1 domain-containing protein
Major facilitator superfamily (MFS) profile
Polysaccharide biosynthesis protein C-terminal
Penicillin-binding protein transpeptidase
Bacterial type II secretion system protein E
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Cytochrome b561 bacterial/Ni-hydrogenase
NAD(P) transhydrogenase alpha subunit C-terminal
Glycosyltransferase subfamily 4-like N-terminal
Sulfide dehydrogenase [flavocytochrome c] flavoprotein chain
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Survival protein SurE-like phosphatase/nucleotidase
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Membrane fusion protein biotin-lipoyl like
O-(5'-phospho-DNA)-tyrosine intermediate
TonB-dependent receptor-like beta-barrel
Loss of sulfur binding in the presence of thiosulfate.
Still able to bind sulfur in the presence of thiosulfate.
Lysidine-tRNA(Ile) synthetase C-terminal
Tryptophan synthase beta chain-like PALP
Ribulose bisphosphate carboxylase small subunit 1
UDP N-acetylglucosamine O-acyltransferase C-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Coenzyme F420 hydrogenase/dehydrogenase beta subunit C-terminal
Coenzyme F420 hydrogenase/dehydrogenase beta subunit N-terminal
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Na+/H+ antiporter MnhB subunit-related protein
Sulfatase-modifying factor enzyme domain-containing protein
NADH:ubiquinone oxidoreductase chain 4 N-terminal
Nucleophile; cysteine thiosulfonate intermediate
Inner membrane protein YgaP-like transmembrane
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
ABC-type transport auxiliary lipoprotein component
ABC-type transport auxiliary lipoprotein component domain-containing protein
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
CobB/CobQ-like glutamine amidotransferase
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Photosynthetic reaction center cytochrome c subunit
Loss of sulfur binding in the presence of sulfide. Loss of interaction with DsrEFH proteins.
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Large ribosomal subunit protein uL2 C-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
Could play a key role in the communication between the regulatory and the substrate sites
Required for zinc-mediated homotetramerization and catalytic activity
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Molybdopterin cofactor biosynthesis C (MoaC)
Menaquinone biosynthesis protein MenD middle
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiol:disulfide interchange protein DsbE
Cytochrome c-type biogenesis protein CcmF C-terminal
Reversibly protonated during proton transport
Phosphatidic acid phosphatase type 2/haloperoxidase
Increases the reduction potential of cluster 1 by approximately 50 mV.
No change in the reduction potential values of the clusters.
Important for beta-aspartyl-AMP intermediate formation
Light-independent protochlorophyllide reductase subunit B-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Magnesium chelatase subunit H N-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Glycosyl transferase family 3 N-terminal
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-97)
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Cation-transporting P-type ATPase N-terminal
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Dinitrogenase iron-molybdenum cofactor biosynthesis
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Ribosomal RNA adenine methylase transferase N-terminal
Phosphotransferase system enzyme I N-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Thiamine pyrophosphate enzyme TPP-binding
Ribosomal RNA large subunit methyltransferase K/L
DNA replication/recombination mediator RecO N-terminal
Type I restriction modification DNA specificity
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
NIF system FeS cluster assembly NifU C-terminal
NIF system FeS cluster assembly NifU N-terminal
Resolvase/invertase-type recombinase catalytic
Glycoside hydrolase family 57 N-terminal
Chromosomal replication initiator protein DnaA
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Small-conductance mechanosensitive channel
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Polysaccharide chain length determinant N-terminal
Mechanosensitive ion channel inner membrane
Mandelate racemase/muconate lactonizing enzyme C-terminal
Magnesium-protoporphyrin IX methyltransferase C-terminal
Plays an important role in substrate specificity
Phosphoadenosine phosphosulphate reductase
Photosynthetic reaction centre H subunit N-terminal
RND efflux pump membrane fusion protein barrel-sandwich
NADH:ubiquinone oxidoreductase 30kDa subunit
DNA-binding and helicase activity, interacts with RecC
Nuclease activity, interacts with RecD and RecA
Gly-cisPro motif, important for rejection of L-amino acids
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
400-fold decrease in PHA synthase activity.
Poly(3-hydroxyalkanoate) polymerase subunit PhaC
Glycine cleavage T-protein C-terminal barrel
DNA polymerase III subunit delta C-terminal
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Transcription factor NikR nickel binding C-terminal
Important for interaction with partner proteins
Sodium symporter small subunit predicted
ATPsynthase alpha/beta subunit N-terminal extension
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
RNA binding; important for wobble base 34 recognition
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
DNA-directed DNA polymerase family A palm
Thymidylate synthase/dCMP hydroxymethylase
Intracellular sulfur oxidation protein DsrF
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
ADP-ribosylarginine; by dinitrogenase reductase ADP-ribosyltransferase
N6 adenine-specific DNA methyltransferase N-terminal
Anthranilate synthase component I N-terminal
Ribulose bisphosphate carboxylase large chain 2
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Glycoside hydrolase family 31 N-terminal
S-adenosylmethionine-dependent methyltransferase
Acyl-ester intermediate; for transpeptidase activity
Proton donor; for transglycosylase activity
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Pyruvate dehydrogenase E1 component middle
Poly(3-hydroxyalkanoate) polymerase subunit PhaE
Probable peptidoglycan glycosyltransferase FtsW
Regulator of nucleoside diphosphate kinase N-terminal
RNA polymerase sigma factor 70 region 4 type 2
CRISPR system ring nuclease SSO1393-like
Mannose-6-phosphate isomerase type II C-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
Sulfite reductase, dissimilatory-type subunit alpha
Essential for prephenate dehydratase activity
RNA 2-O ribose methyltransferase substrate binding
Glucosamine/galactosamine-6-phosphate isomerase
Putative regulatory protein FmdB Zinc ribbon
Lysozyme inhibitor LprI N-terminal domain-containing protein
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Endolytic peptidoglycan transglycosylase RlpA
RlpA-like protein double-psi beta-barrel
L-seryl-tRNA selenium transferase N-terminal
Alanyl-transfer RNA synthetases family profile
Cytochrome subunit of sulfide dehydrogenase
Pyruvate/ketoisovalerate oxidoreductase catalytic
Carboxypeptidase regulatory-like domain-containing protein
S-adenosyl-L-homocysteine hydrolase NAD binding
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
Nitrite/Sulfite reductase ferredoxin-like
YbaK/aminoacyl-tRNA synthetase-associated
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Schiff-base intermediate with substrate; via pyruvic acid
Prepilin type IV endopeptidase peptidase
6-phosphogluconate dehydrogenase C-terminal
Glucan biosynthesis periplasmic MdoG C-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Tetrahydrodipicolinate-N-succinyltransferase chain A
Polysaccharide biosynthesis protein CapD-like
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Disulphide bond isomerase DsbC/G N-terminal
CRISPR-associated protein Cas6 C-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Small ribosomal subunit protein uS4 N-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Nitrogenase molybdenum-iron protein beta chain N-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Flagellar motor switch protein FliN-like C-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Exonuclease VII large subunit C-terminal
Ribulose bisphosphate carboxylase small subunit
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Lipopolysaccharide export system protein LptA
Organic solvent tolerance-like N-terminal
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Isocitrate dehydrogenase kinase/phosphatase (AceK) kinase
Isocitrate dehydrogenase kinase/phosphatase (AceK) regulatory
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Probable transposase IS891/IS1136/IS1341
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Alginate export domain-containing protein
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Translation elongation factor P/YeiP central
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase
Uroporphyrinogen-III C-methyltransferase
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Gfo/Idh/MocA-like oxidoreductase N-terminal
Flagellar assembly protein FliH/Type III secretion system HrpE
Polymerase/histidinol phosphatase N-terminal
Prokaryotic-type class I peptide chain release factors
Increases nucleophilicity of active site Cys
S-adenosyl-l-methionine hydroxide adenosyltransferase C-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase N-terminal
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Dinitrogenase iron-molybdenum cofactor N-terminal
Peptide methionine sulphoxide reductase MsrA
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Chromosomal replication initiator DnaA C-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
Large ribosomal subunit protein uL15/eL18
Putative beta-barrel assembly-enhancing protease
HicB-like antitoxin of toxin-antitoxin system
Positions MEP for the nucleophilic attack
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Large ribosomal subunit protein uL6 alpha-beta
Bifunctional purine biosynthesis protein PurH
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase