Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Glycosyltransferase subfamily 4-like N-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
Bacterial bifunctional deaminase-reductase C-terminal
Pyridoxamine 5'-phosphate oxidase putative
Solute-binding protein family 3/N-terminal
Major facilitator superfamily (MFS) profile
Formamidopyrimidine-DNA glycosylase catalytic
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Threonine/serine exporter-like N-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Large ribosomal subunit protein uL15/eL18
Electron transfer flavoprotein alpha/beta-subunit N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Phosphoadenosine phosphosulphate reductase
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Polysaccharide lyase 8 N-terminal alpha-helical
RNA polymerase sigma factor 70 region 4 type 2
Mycothiol-dependent maleylpyruvate isomerase metal-binding
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
Transposase IS116/IS110/IS902 C-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
Gram-positive cocci surface proteins LPxTG domain-containing protein
ATP synthase F1 complex delta/epsilon subunit N-terminal
CobB/CobQ-like glutamine amidotransferase
S-adenosyl-L-homocysteine hydrolase NAD binding
O-(5'-phospho-DNA)-tyrosine intermediate
Alpha-D-phosphohexomutase alpha/beta/alpha
Cobalamin-independent methionine synthase MetE N-terminal
Glucose/Sorbosone dehydrogenase domain-containing protein
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
RNA 2-O ribose methyltransferase substrate binding
Peptidase S9 prolyl oligopeptidase catalytic
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
SGNH hydrolase-type esterase domain-containing protein
Lipoprotein LpqB beta-propeller domain-containing protein
Homogentisate 1,2-dioxygenase C-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Sporulation transcription regulator WhiA N-terminal
Proteinase inhibitor I42 chagasin domain-containing protein
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Right handed beta helix domain-containing protein
Ribosomal RNA adenine methylase transferase N-terminal
Solute-binding protein family 3/N-terminal domain-containing protein
Polymerase/histidinol phosphatase N-terminal
Glucosamine/galactosamine-6-phosphate isomerase
Peptide methionine sulphoxide reductase MsrA
Major facilitator superfamily (MFS) profile domain-containing protein
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
SUF system FeS cluster assembly SufBD N-terminal
Periplasmic binding protein domain-containing protein
Polysaccharide biosynthesis protein C-terminal
Glyoxalase/fosfomycin resistance/dioxygenase
Exonuclease VII large subunit C-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Nuclear transport factor 2 family protein
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
PQQ-binding-like beta-propeller repeat protein
Mandelate racemase/muconate lactonizing enzyme C-terminal
Cytochrome C biogenesis protein transmembrane
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Aminoacyl-transfer RNA synthetases class-II family profile
Beta-hexosaminidase bacterial type N-terminal
Beta-hexosaminidase bacterial type N-terminal domain-containing protein
Nitrite/Sulfite reductase ferredoxin-like
Could be important to modulate the pK values of the two catalytic cysteine residues
Translation elongation factor P/YeiP central
Neutral/alkaline non-lysosomal ceramidase C-terminal
Neutral/alkaline non-lysosomal ceramidase N-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Glycosyl transferase family 3 N-terminal
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Peptidase M1 membrane alanine aminopeptidase
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Penicillin-binding protein transpeptidase
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Heat-inducible transcription repressor HrcA C-terminal
Anthranilate synthase component I N-terminal
Alpha galactosidase C-terminal beta sandwich
Alpha galactosidase C-terminal beta sandwich domain-containing protein
N-acetylmuramoyl-L-alanine amidase domain-containing protein
Leucine-binding protein domain-containing protein
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
3-beta hydroxysteroid dehydrogenase/isomerase
Xaa-Pro dipeptidyl-peptidase C-terminal domain-containing protein
PknH-like extracellular domain-containing protein
Schiff-base intermediate with D-ribose 5-phosphate
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
PhoD-like phosphatase metallophosphatase
Beta-lactamase-related domain-containing protein
Large ribosomal subunit protein uL2 C-terminal
Prokaryotic-type class I peptide chain release factors
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Essential for prephenate dehydratase activity
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Putative Flp pilus-assembly TadG-like N-terminal
Cytochrome b/b6 N-terminal region profile
Nucleophile; cysteine thiosulfonate intermediate
FAD-dependent oxidoreductase 2 FAD binding
Tryptophan synthase beta chain-like PALP
Endoribonuclease L-PSP/chorismate mutase-like
Histidine-specific methyltransferase SAM-dependent
Fibronectin type-III domain-containing protein
Lactate utilization protein B C-terminal
NADH-rubredoxin oxidoreductase C-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
HTH-type transcriptional regulator MT1864/Rv1816-like C-terminal
Pseudouridine synthase I TruA alpha/beta
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
tRNA pseudouridine synthase II TruB subfamily 2 C-terminal
tRNA pseudouridylate synthase B C-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
NADH:ubiquinone oxidoreductase chain 4 N-terminal
YbaK/aminoacyl-tRNA synthetase-associated
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Proton acceptor; for glutaminase activity
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Mannose-6-phosphate isomerase type II C-terminal
Increases nucleophilicity of active site Cys
Small ribosomal subunit protein uS4 N-terminal
DNA-directed DNA polymerase family A palm
Alanyl-transfer RNA synthetases family profile
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Thymidylate synthase/dCMP hydroxymethylase
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Fe/B12 periplasmic-binding domain-containing protein
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
ABC-type glycine betaine transport system substrate-binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Schiff-base intermediate with substrate; via pyruvic acid
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Damage-control phosphatase ARMT1-like metal-binding
Solute-binding protein family 5 domain-containing protein
Release factor glutamine methyltransferase N-terminal
Poly-beta-hydroxybutyrate polymerase N-terminal
Bacterial type II secretion system protein E
Ribose-phosphate pyrophosphokinase N-terminal
Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Phosphomannose isomerase type I catalytic
Adaptive response protein AidB N-terminal
Methylguanine DNA methyltransferase ribonuclease-like
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Chromosomal replication initiator DnaA C-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Helix-hairpin-helix DNA-binding motif class 1
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Septum formation-related domain-containing protein
DNA replication/recombination mediator RecO N-terminal
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)
Large ribosomal subunit protein uL6 alpha-beta
Resuscitation-promoting factor core lysozyme-like
Glycine cleavage T-protein C-terminal barrel
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Transcription regulator AsnC/Lrp ligand binding
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Pyruvate dehydrogenase E1 component middle
Rv2525c-like glycoside hydrolase-like domain-containing protein
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Myo-inositol-1-phosphate synthase GAPDH-like
Important for substrate specificity; cannot use PPi as phosphoryl donor
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Polysaccharide biosynthesis protein CapD-like
Elongation factor G-binding protein C-terminal treble-clef zinc-finger
SMP-30/Gluconolactonase/LRE-like region domain-containing protein
Peptidase M14 carboxypeptidase A domain-containing protein
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Phosphatidate phosphatase APP1 catalytic
Alpha-N-acetylglucosaminidase C-terminal
Alpha-N-acetylglucosaminidase N-terminal
Alpha-N-acetylglucosaminidase tim-barrel
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
NIF system FeS cluster assembly NifU N-terminal
Peptidase C39-like domain-containing protein
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
PsbP C-terminal domain-containing protein
Removed in mature form; by autocatalysis
Acetylserotonin O-methyltransferase dimerisation
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Pyrroline-5-carboxylate reductase catalytic N-terminal
Molybdopterin cofactor biosynthesis C (MoaC)
Microcystin LR degradation protein MlrC C-terminal
Microcystin LR degradation protein MlrC N-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Pyrimidine nucleoside phosphorylase C-terminal
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Alpha-glycerophosphate oxidase C-terminal
Endonuclease/exonuclease/phosphatase domain-containing protein
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Pyrroline-5-carboxylate reductase dimerisation
Plays an important role in substrate specificity
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Glucose-methanol-choline oxidoreductase C-terminal domain-containing protein
Membrane insertase YidC/Oxa/ALB C-terminal
Gly-cisPro motif, important for rejection of L-amino acids
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal