Molybdopterin cofactor biosynthesis C (MoaC)
Threonine/serine exporter-like N-terminal
Prepilin peptidase dependent protein C-like C-terminal
Putative conjugal transfer nickase/helicase TraI C-terminal
O-(phosphoribosyl dephospho-coenzyme A)serine
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
Phosphocysteine intermediate; for EIIB activity
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
NIF system FeS cluster assembly NifU C-terminal
Chromosomal replication initiator protein DnaA
Mandelate racemase/muconate lactonizing enzyme C-terminal
UDP N-acetylglucosamine O-acyltransferase C-terminal
Polymerase/histidinol phosphatase N-terminal
Solute-binding protein family 3/N-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Major facilitator superfamily (MFS) profile
Alpha-D-phosphohexomutase alpha/beta/alpha
Glycine cleavage T-protein C-terminal barrel
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Outer membrane protein assembly factor BamA
Cytochrome b561 bacterial/Ni-hydrogenase
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
NADH:ubiquinone oxidoreductase-like 20kDa subunit
ssDNA thymidine ADP-ribosyltransferase DarT
Glucosamine/galactosamine-6-phosphate isomerase
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Peptidase S9 prolyl oligopeptidase catalytic
Penicillin-binding protein activator LpoA
Cysteine sulfenic acid (-SOH) intermediate
Glycosyltransferase subfamily 4-like N-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Tryptophan synthase beta chain-like PALP
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Negative modulator of initiation of replication SeqA N-terminal
Replication modulator SeqA C-terminal DNA-binding
Type II secretion system protein GspG C-terminal
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Peptide methionine sulphoxide reductase MsrA
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
TonB-dependent receptor-like beta-barrel
Mechanosensitive ion channel inner membrane
RNA binding; important for wobble base 34 recognition
Serine/threonine specific protein phosphatases
FAD-dependent cmnm(5)s(2)U34 oxidoreductase
Calcium/calmodulin-dependent protein kinase II association-domain
Acyl-ester intermediate; for transpeptidase activity
Penicillin-binding protein transpeptidase
Proton donor; for transglycosylase activity
Transglycosylase PBP1b N-terminal transmembrane
Type IV secretion system coupling protein TraD DNA-binding
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
RNA methyltransferase SpoU/TrmH type C-terminal
6-phosphogluconate dehydrogenase C-terminal
Type II secretion system protein GspI C-terminal
Type III restriction enzyme C-terminal endonuclease
Gp5/Type VI secretion system Vgr protein OB-fold
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase C-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase N-terminal
Nitrite/Sulfite reductase ferredoxin-like
D-galactose/methyl-galactoside binding periplasmic protein MglB
Proton acceptor; for decarboxylase activity
Proton donor; for decarboxylase activity
Proton donor; for formyltransferase activity
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Ionotropic glutamate receptor C-terminal
Interacts with tRNA; defines subfamily-specific binding signature
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Membrane fusion protein biotin-lipoyl like
Schiff-base intermediate with substrate; via pyruvic acid
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Putative auto-transporter adhesin head GIN
Putative auto-transporter adhesin head GIN domain-containing protein
Methylguanine DNA methyltransferase ribonuclease-like
Bacterial type II secretion system protein E
Large ribosomal subunit protein uL6 alpha-beta
Peptidase C-terminal archaeal/bacterial domain-containing protein
Interaction with polymerase core subunit RpoC
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Could play a key role in the communication between the regulatory and the substrate sites
Glutathionylspermidine synthase pre-ATP-grasp-like
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Superoxide dismutase copper/zinc binding
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Thiol:disulfide interchange protein DsbD
DNA replication/recombination mediator RecO N-terminal
Lysidine-tRNA(Ile) synthetase C-terminal
Isocitrate dehydrogenase kinase/phosphatase (AceK) kinase
Isocitrate dehydrogenase kinase/phosphatase (AceK) regulatory
Outer membrane protein assembly factor BamD
Phosphatidic acid phosphatase type 2/haloperoxidase
Outer-membrane lipoprotein Wza C-terminal
Large ribosomal subunit protein uL2 C-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
O-(5'-phospho-DNA)-tyrosine intermediate
Toxin co-regulated pilus biosynthesis protein Q C-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Major facilitator superfamily associated
Transposase IS116/IS110/IS902 C-terminal
Translation elongation factor P/YeiP central
Mannose-6-phosphate isomerase type II C-terminal
Nucleoside-specific channel-forming protein Tsx
Sugar fermentation stimulation protein C-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Ribosomal RNA adenine methylase transferase N-terminal
RND efflux pump membrane fusion protein barrel-sandwich
Release factor glutamine methyltransferase N-terminal
4'-phosphopantetheinyl transferase N-terminal
Phosphomannose isomerase type I C-terminal
Phosphomannose isomerase type I catalytic
Phosphomannose isomerase type I helical insertion
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
DnaJ homologue subfamily C member 28 conserved
Pyrimidine nucleoside phosphorylase C-terminal
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Flagellar hook-length control protein-like C-terminal
Aspartate/homoserine dehydrogenase NAD-binding
RNA polymerase sigma factor 70 region 4 type 2
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Non-canonical purine NTP phosphatase/PRRC1
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Transcription factor NikR nickel binding C-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Involved in allosteric activation by GTP
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
RNA 2-O ribose methyltransferase substrate binding
Small ribosomal subunit protein uS4 N-terminal
Polysaccharide chain length determinant N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
O-(3'-phospho-DNA)-tyrosine intermediate
Pyruvate phosphate dikinase AMP/ATP-binding
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Capsule biosynthesis GfcC-like C-terminal
Capsule biosynthesis GfcC-like N-terminal
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
N6 adenine-specific DNA methyltransferase N-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Exonuclease VII large subunit C-terminal
Helix-hairpin-helix DNA-binding motif class 1
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Type I restriction modification DNA specificity
Appears to be important in orienting the phosphate for catalysis
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Proline utilization A proline dehydrogenase N-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
FAD-dependent oxidoreductase 2 FAD binding
Glycoside hydrolase family 13 N-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Quercetin 2,3-dioxygenase C-terminal cupin
Large ribosomal subunit protein uL15/eL18
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Flagellar motor switch protein FliN N-terminal
Flagellar motor switch protein FliN-like C-terminal
Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase
Sodium/calcium exchanger membrane region
NADH:flavin oxidoreductase/NADH oxidase N-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Tetrahydrodipicolinate-N-succinyltransferase chain A
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Required for dimer formation and molybdate binding
Glycoside hydrolase family 31 N-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Membrane insertase YidC/Oxa/ALB C-terminal
Bacteriophage T7 Gp4 DNA primase/helicase N-terminal
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Periplasmic binding protein/LacI sugar binding
The binding site for the sugar molecule has not yet been established, but C-87 may be involved
D-glutamate N-acetyltransferase-like C-terminal
D-glutamate N-acetyltransferase-like N-terminal
Bacteriophage lambda Replication protein O N-terminal
Terminase large subunit gp17-like C-terminal
Phage terminase large subunit C-terminal
Phage terminase large subunit N-terminal
Important for substrate binding and specificity
Electron transfer via tryptophanyl radical
Penicillin-insensitive murein endopeptidase
DNA mismatch repair MutH/Type II restriction enzyme Sau3AI
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Essential for degradation by Lon protease
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Cob(I)alamin adenosyltransferase N-terminal
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Chromosome partition protein MukF C-terminal
Chromosome partition protein MukF middle
Chromosome partition protein MukF winged-helix
Lipopolysaccharide export system protein LptA
Organic solvent tolerance-like N-terminal
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Gamma-glutamylcyclotransferase AIG2-like
Acyl-CoA dehydrogenase/oxidase C-terminal
DNA polymerase III subunit delta C-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Shikimate dehydrogenase substrate binding N-terminal
High-affinity branched-chain amino acid transport system permease LivHM N-terminal
Heme-copper oxidase subunit III family profile
Pseudouridine synthase I TruA alpha/beta
ABC-type glycine betaine transport system substrate-binding
NIF system FeS cluster assembly NifU N-terminal
Important for interaction with partner proteins
Inosine/uridine-preferring nucleoside hydrolase
Resolvase/invertase-type recombinase catalytic
Glycoside hydrolase family 42 N-terminal
Anthranilate synthase component I N-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
DNA-directed DNA polymerase family B exonuclease
DNA-directed DNA polymerase family B multifunctional
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Schiff-base intermediate with acetaldehyde
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Prokaryotic-type class I peptide chain release factors
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Reversibly protonated during proton transport
Important for beta-aspartyl-AMP intermediate formation
Phosphotransferase system enzyme I N-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Thymidylate synthase/dCMP hydroxymethylase
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Essential for prephenate dehydratase activity
Flagellar assembly protein FliH/Type III secretion system HrpE
DNA polymerase III delta subunit C-terminal
Precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase
Uroporphyrinogen-III C-methyltransferase
Could be important to modulate the pK values of the two catalytic cysteine residues
Transcriptional regulator SgrR N-terminal HTH
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Pyruvate dehydrogenase E1 component middle
Integral membrane protein YccS N-terminal
Membrane-bound lytic murein transglycosylase C
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Guanylate kinase/L-type calcium channel beta subunit
Plays an important role in substrate specificity
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Cobalamin-independent methionine synthase MetE N-terminal
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-95)
YbaK/aminoacyl-tRNA synthetase-associated
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Erythronate-4-phosphate dehydrogenase dimerisation
Large ribosomal subunit protein bL25 L25
Gly-cisPro motif, important for rejection of L-amino acids
Prepilin type IV endopeptidase peptidase
Tellurite resistance methyltransferase TehB-like
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Arginine decarboxylase C-terminal helical