Aminoacyl-transfer RNA synthetases class-II family profile
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Tryptophan synthase beta chain-like PALP
Rubisco accumulation factor 1 C-terminal
Rubisco accumulation factor 1 alpha helical
Rubisco accumulation factor 1 helix turn helix
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Contractile injection system tube protein N-terminal
Major facilitator superfamily (MFS) profile
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Outer membrane protein beta-barrel domain-containing protein
Peptidase S9 prolyl oligopeptidase catalytic
Sodium/calcium exchanger membrane region
Cation-transporting P-type ATPase N-terminal
Important for beta-aspartyl-AMP intermediate formation
Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS
Phosphoadenosine phosphosulphate reductase
Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding
Probable transposase IS891/IS1136/IS1341
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Type I restriction modification DNA specificity
L,D-transpeptidase catalytic domain-containing protein
Glycogen debranching enzyme bacterial and archaeal type N-terminal
RND efflux pump membrane fusion protein barrel-sandwich
Glycosyltransferase subfamily 4-like N-terminal
Cytochrome b561 bacterial/Ni-hydrogenase
Bacterial bifunctional deaminase-reductase C-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
S-adenosyl-L-homocysteine hydrolase NAD binding
Ribulose bisphosphate carboxylase large subunit C-terminal
Ribulose bisphosphate carboxylase large subunit ferrodoxin-like N-terminal
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Schiff-base intermediate with acetaldehyde
Large ribosomal subunit protein uL6 alpha-beta
Light-independent protochlorophyllide reductase subunit B-like C-terminal
Important for autoinhibition of adenylyltransferase activity
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Magnesium-protoporphyrin IX methyltransferase C-terminal
Homocysteine biosynthesis enzyme sulfur-incorporation
Alpha-D-phosphohexomutase alpha/beta/alpha
Polysaccharide biosynthesis protein CapD-like
RNA polymerase sigma factor 70 region 4 type 2
Magnesium chelatase subunit H N-terminal
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Cysteine sulfenic acid (-SOH) intermediate
Polysaccharide chain length determinant N-terminal
Membrane fusion protein biotin-lipoyl like
Essential for prephenate dehydratase activity
Aconitase A/isopropylmalate dehydratase small subunit swivel
Phosphorylase b kinase regulatory subunit alpha/beta C-terminal
Bacterial OB-fold domain-containing protein
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Type II secretion system protein GspE N-terminal
Glycoside hydrolase family 57 N-terminal
Photosystem II manganese-stabilizing polypeptide
Signal transduction histidine kinase osmosensitive K+ channel sensor N-terminal
DNA-directed DNA polymerase family A palm
Ribulose bisphosphate carboxylase small subunit
Transposase IS204/IS1001/IS1096/IS1165 DDE
Transposase IS204/IS1001/IS1096/IS1165 helix-turn-helix
Transposase IS204/IS1001/IS1096/IS1165 zinc-finger
SUF system FeS cluster assembly SufBD N-terminal
CD-NTase associated protein 4-like DNA endonuclease
ABC-type glycine betaine transport system substrate-binding
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Plastid lipid-associated protein/fibrillin conserved
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Glucosamine/galactosamine-6-phosphate isomerase
Putative glycogen debranching enzyme N-terminal
Ferredoxin thioredoxin reductase alpha chain
Periplasmic copper-binding protein NosD beta helix
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Bacterial type II secretion system protein E
Photosystem I PsaL reaction centre subunit XI
Could be important to modulate the pK values of the two catalytic cysteine residues
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Sigma 54 modulation/S30EA ribosomal protein C-terminal
1,4-alpha-glucan branching enzyme C-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Resolvase/invertase-type recombinase catalytic
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
ABC-type uncharacterised transport system
CobB/CobQ-like glutamine amidotransferase
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Increases nucleophilicity of active site Cys
Penicillin-binding protein transpeptidase
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
DNA replication/recombination mediator RecO N-terminal
Glycosyl transferase family 3 N-terminal
Anthranilate synthase component I N-terminal
Large ribosomal subunit protein bL12 C-terminal
Peptide methionine sulphoxide reductase MsrA
Myo-inositol-1-phosphate synthase GAPDH-like
Aminoacyl-tRNA synthetase class I anticodon-binding
Mandelate racemase/muconate lactonizing enzyme C-terminal
RNA 3'-terminal phosphate cyclase insert
PhoD-like phosphatase metallophosphatase
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
RNA 2-O ribose methyltransferase substrate binding
Quercetin 2,3-dioxygenase C-terminal cupin
Prepilin type IV endopeptidase peptidase
Ribosomal RNA adenine methylase transferase N-terminal
Gp5/Type VI secretion system Vgr protein OB-fold
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Septum formation inhibitor MinC C-terminal
N6 adenine-specific DNA methyltransferase N-terminal
Beta-lactamase hydrolase-like protein phosphatase-like
Auto-transporter adhesin head GIN domain-containing protein
Cytochrome C biogenesis protein transmembrane
TonB-dependent receptor-like beta-barrel
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Helix-hairpin-helix DNA-binding motif class 1
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Electron transfer via tryptophanyl radical
Large ribosomal subunit protein uL2 C-terminal
Polymerase/histidinol phosphatase N-terminal
Photosystem II reaction center protein K
3-beta hydroxysteroid dehydrogenase/isomerase
Cob(I)alamin adenosyltransferase N-terminal
NIF system FeS cluster assembly NifU N-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Mannose-6-phosphate isomerase type II C-terminal
Gly-cisPro motif, important for rejection of L-amino acids
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Important for catalytic activity and assists the phosphoryl transfer reaction to Asp8 by balancing charge and orienting the reacting groups
TtsA-like Glycoside hydrolase family 108
6-phosphogluconate dehydrogenase C-terminal
Shikimate dehydrogenase substrate binding N-terminal
Cytochrome b/b6 C-terminal region profile
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Replication initiation protein-like C-terminal
Sodium symporter small subunit predicted
S-adenosyl-l-methionine hydroxide adenosyltransferase C-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase N-terminal
Large ribosomal subunit protein uL15/eL18
CRISPR-associated protein Cas6 C-terminal
Na+/H+ antiporter MnhB subunit-related protein
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Glycoside hydrolase family 31 N-terminal
Prokaryotic-type class I peptide chain release factors
Important for substrate specificity; cannot use PPi as phosphoryl donor
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
NAD(P) transhydrogenase alpha subunit C-terminal
RNA binding; important for wobble base 34 recognition
Plays an important role in substrate specificity
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
NAD(P)H-quinone oxidoreductase subunit 2 N-terminal
CRISPR system ring nuclease SSO1393-like
Inner membrane protein YgaP-like transmembrane
RNA-binding protein Tab2-like N-terminal
RNA-binding protein Tab2/Atab2 C-terminal
Alanyl-transfer RNA synthetases family profile
Nitrite/Sulfite reductase ferredoxin-like
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
D-glutamate N-acetyltransferase-like C-terminal
D-glutamate N-acetyltransferase-like N-terminal
Glycine cleavage T-protein C-terminal barrel
Photosystem I reaction center subunit III
Peptidase M1 membrane alanine aminopeptidase
Exonuclease VII large subunit C-terminal
Sporulation stage II protein D amidase enhancer LytB N-terminal
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Haem-binding uptake Tiki superfamily ChaN
Pyruvate phosphate dikinase AMP/ATP-binding
Cell envelope-related transcriptional attenuator
CRISPR-associated protein Cmr2 N-terminal
Solute-binding protein family 3/N-terminal
Large ribosomal subunit protein bL12 oligomerization
NADH:ubiquinone oxidoreductase intermediate-associated protein 30
Membrane insertase YidC/Oxa/ALB C-terminal
Menaquinone biosynthesis protein MenD middle
Bacterial Glycosyl hydrolase family 3 C-terminal
Schiff-base intermediate with substrate; via pyruvic acid
Could play a key role in the communication between the regulatory and the substrate sites
Photosystem II cytochrome b559 N-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Photosystem II cytochrome b559 alpha subunit lumenal region
Reversibly protonated during proton transport
Heme-copper oxidase subunit III family profile
Inosine/uridine-preferring nucleoside hydrolase
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Cyanobacterial aminoacyl-tRNA synthetase CAAD
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Phosphoribosylformylglycinamidine synthase linker
Type IV methyl-directed restriction enzyme EcoKMcrB subunit DNA-binding
HicB-like antitoxin of toxin-antitoxin system
Proton acceptor; for glutaminase activity
Glycosyl-hydrolase family 116 N-terminal
Glycosyl-hydrolase family 116 catalytic region
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
NADH:ubiquinone/plastoquinone oxidoreductase chloroplast chain 5 C-terminal
PEP-CTERM exosortase interaction domain-containing protein
UDP N-acetylglucosamine O-acyltransferase C-terminal
Thymidylate synthase/dCMP hydroxymethylase
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Increases the nucleophilicity of the active site Cys
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Cytochrome b/b6 N-terminal region profile
Type I restriction enzyme R protein N-terminal
Pseudouridine synthase I TruA alpha/beta
Interacts with tRNA; defines subfamily-specific binding signature
Glycosyltransferase 2-like prokaryotic type
Arsenosugar biosynthesis radical SAM protein ArsS-like C-terminal
Nicotinate phosphoribosyltransferase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Coenzyme F420 hydrogenase/dehydrogenase beta subunit C-terminal
Coenzyme F420 hydrogenase/dehydrogenase beta subunit N-terminal
NADH:ubiquinone oxidoreductase chain 4 N-terminal
Small ribosomal subunit protein uS4 N-terminal
Survival protein SurE-like phosphatase/nucleotidase
Positions MEP for the nucleophilic attack
Lantibiotic biosynthesis protein dehydration
Molybdopterin cofactor biosynthesis C (MoaC)
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Translation elongation factor P/YeiP central
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
Glucose-methanol-choline oxidoreductase C-terminal
NIF system FeS cluster assembly NifU C-terminal
Dinitrogenase iron-molybdenum cofactor biosynthesis
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Photosynthesis system II assembly factor Ycf48/Hcf136-like
Interaction with polymerase core subunit RpoC
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
ATP-dependent DNA helicase RecG C-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Organic solvent tolerance-like N-terminal