Cation-transporting P-type ATPase N-terminal
Important for beta-aspartyl-AMP intermediate formation
Large ribosomal subunit protein uL6 alpha-beta
Choloylglycine hydrolase/NAAA C-terminal
Nitrite/Sulfite reductase ferredoxin-like
RNA polymerase sigma factor 70 region 4 type 2
Glycosyltransferase subfamily 4-like N-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Pyridoxamine 5'-phosphate oxidase putative
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Probable transposase IS891/IS1136/IS1341
Cytochrome b/b6 C-terminal region profile
Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS
Light-independent protochlorophyllide reductase subunit B-like C-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Membrane fusion protein biotin-lipoyl like
RND efflux pump membrane fusion protein barrel-sandwich
Peptidase S9 prolyl oligopeptidase catalytic
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Heme-copper oxidase subunit III family profile
Glycosyl transferase family 28 C-terminal
Increases the nucleophilicity of the active site Cys
Major facilitator superfamily (MFS) profile
Gfo/Idh/MocA-like oxidoreductase N-terminal
Anthranilate synthase component I N-terminal
Diiron non-heme beta-hydroxylase N-terminal
Polypeptide-transport-associated ShlB-type
Hydroxymethylglutaryl-coenzyme A synthase C-terminal
Hydroxymethylglutaryl-coenzyme A synthase N-terminal
Cytochrome b/b6 N-terminal region profile
Anaphase-promoting complex subunit 4-like WD40
Protein O-mannosyl-transferase C-terminal four TM
Fatty acid synthase subunit PfaD N-terminal
Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding
L,D-transpeptidase catalytic domain-containing protein
PEP-CTERM exosortase interaction domain-containing protein
Coenzyme F420 hydrogenase/dehydrogenase beta subunit C-terminal
Coenzyme F420 hydrogenase/dehydrogenase beta subunit N-terminal
Interaction with polymerase core subunit RpoC
Prepilin type IV endopeptidase peptidase
Sulfatase-modifying factor enzyme domain-containing protein
Putative glycogen debranching enzyme N-terminal
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Tryptophan synthase beta chain-like PALP
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Cyanobacterial aminoacyl-tRNA synthetase CAAD
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Inosine/uridine-preferring nucleoside hydrolase
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Aminoacyl-transfer RNA synthetases class-II family profile
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Glycosyl transferase family 3 N-terminal
Reversibly protonated during proton transport
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Mannose-6-phosphate isomerase type II C-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Calcium-dependent cell adhesion molecule 1 membrane-binding
Calcium-dependent cell adhesion molecule N-terminal
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Gp5/Type VI secretion system Vgr protein OB-fold
Plastid lipid-associated protein/fibrillin conserved
N6 adenine-specific DNA methyltransferase N-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Thiopeptide-type bacteriocin biosynthesis
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Ribulose bisphosphate carboxylase large subunit C-terminal
Ribulose bisphosphate carboxylase large subunit ferrodoxin-like N-terminal
WGxxGxxG-CTERM domain-containing protein
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:ubiquinone/plastoquinone oxidoreductase chloroplast chain 5 C-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Large ribosomal subunit protein bL25 L25
6-phosphogluconate dehydrogenase NADP-binding
Pyruvate phosphate dikinase AMP/ATP-binding
Outer membrane protein beta-barrel domain-containing protein
Photosynthesis system II assembly factor Ycf48/Hcf136-like
ssDNA thymidine ADP-ribosyltransferase DarT
RNA binding; important for wobble base 34 recognition
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Polysaccharide chain length determinant N-terminal
Photosystem I reaction center subunit III
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Molybdopterin cofactor biosynthesis C (MoaC)
Glycosyltransferase 2-like prokaryotic type
Cytochrome b561 bacterial/Ni-hydrogenase
Phosphorylase b kinase regulatory subunit alpha/beta C-terminal
Beta-lactamase-inhibitor-like PepSY-like domain-containing protein
Bacterial bifunctional deaminase-reductase C-terminal
Cell envelope-related transcriptional attenuator
Alanyl-transfer RNA synthetases family profile
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Glycogen debranching enzyme bacterial and archaeal type N-terminal
Spore coat protein U domain-containing protein
Solute-binding protein family 3/N-terminal
Peptide methionine sulphoxide reductase MsrA
Sporulation stage II protein D amidase enhancer LytB N-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Type IV secretion system coupling protein TraD DNA-binding
SUF system FeS cluster assembly SufBD N-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Heat-inducible transcription repressor HrcA C-terminal
DNA replication/recombination mediator RecO N-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Magnesium-protoporphyrin IX methyltransferase C-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
CobB/CobQ-like glutamine amidotransferase
RlpA-like protein double-psi beta-barrel
NAD(P) transhydrogenase alpha subunit C-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Survival protein SurE-like phosphatase/nucleotidase
Glycoside hydrolase family 57 N-terminal
TonB-dependent receptor-like beta-barrel
RNA 2-O ribose methyltransferase substrate binding
Septum formation inhibitor MinC C-terminal
Cytochrome C biogenesis protein transmembrane
HicB-like antitoxin of toxin-antitoxin system
Ribulose bisphosphate carboxylase small subunit
ABC-type uncharacterised transport system
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Resolvase/invertase-type recombinase catalytic
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Photosystem II reaction center protein K
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Glycoside hydrolase family 31 N-terminal
Homocysteine biosynthesis enzyme sulfur-incorporation
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Contractile injection system tube protein N-terminal
Translation elongation factor P/YeiP central
DNA-directed DNA polymerase family A palm
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Polysaccharide biosynthesis protein CapD-like
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Photosystem II cytochrome b559 N-terminal
Photosystem II cytochrome b559 alpha subunit lumenal region
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Urease accessory protein UreH-like transmembrane
Penicillin-binding protein transpeptidase
Magnesium chelatase subunit H N-terminal
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Glycosyltransferase family 28 N-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Type II secretion system protein GspE N-terminal
Cob(I)alamin adenosyltransferase N-terminal
NIF system FeS cluster assembly NifU C-terminal
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Nicotinate phosphoribosyltransferase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Type I restriction modification DNA specificity
Involved in allosteric activation by GTP
RNA 3'-terminal phosphate cyclase insert
Schiff-base intermediate with acetaldehyde
NIF system FeS cluster assembly NifU N-terminal
P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein
Positions MEP for the nucleophilic attack
Pseudouridine synthase I TruA alpha/beta
SMODS-associated and fused to various effectors
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Rubisco accumulation factor 1 C-terminal
Rubisco accumulation factor 1 alpha helical
Rubisco accumulation factor 1 helix turn helix
Acetylserotonin O-methyltransferase dimerisation
Prokaryotic-type class I peptide chain release factors
ATP synthase F1 complex delta/epsilon subunit N-terminal
Bacterial type II secretion system protein E
NAD(P)H-quinone oxidoreductase subunit 2 N-terminal
D-glutamate N-acetyltransferase-like C-terminal
D-glutamate N-acetyltransferase-like N-terminal
Could play a key role in the communication between the regulatory and the substrate sites
S-adenosyl-L-homocysteine hydrolase NAD binding
Beta-lactamase hydrolase-like protein phosphatase-like
DNA-directed DNA polymerase family B exonuclease
DNA-directed DNA polymerase family B multifunctional
Cysteine sulfenic acid (-SOH) intermediate
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Nitrogenase molybdenum-iron protein beta chain N-terminal
Lantibiotic biosynthesis protein dehydration
Large ribosomal subunit protein uL15/eL18
Small ribosomal subunit protein uS4 N-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Inward rectifier potassium channel C-terminal
Aromatic amino acid beta-eliminating lyase/threonine aldolase
NADH:ubiquinone oxidoreductase intermediate-associated protein 30
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
DNA helicase Holliday junction RuvA type
Holliday junction DNA helicase RuvA C-terminal
CRISPR-associated protein Cas6 C-terminal
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
ADP-ribosylarginine; by dinitrogenase reductase ADP-ribosyltransferase
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
ABC transporter substrate-binding protein PnrA-like
Moybdenum cofactor oxidoreductase dimerisation
Peptidase propeptide domain-containing protein
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Important for catalytic activity and assists the phosphoryl transfer reaction to Asp8 by balancing charge and orienting the reacting groups
Exonuclease VII large subunit C-terminal
6-phosphogluconate dehydrogenase C-terminal
Gamma-glutamylcyclotransferase AIG2-like
Could be important to modulate the pK values of the two catalytic cysteine residues
SMODS-associating 2TM beta-strand rich effector
RNA-binding protein Tab2-like N-terminal
RNA-binding protein Tab2/Atab2 C-terminal
Microcin J25-processing protein McjB C-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Gly-cisPro motif, important for rejection of L-amino acids
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Glycosyl-hydrolase family 116 N-terminal
Glycosyl-hydrolase family 116 catalytic region
Glucosamine/galactosamine-6-phosphate isomerase
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Ribosomal RNA adenine methylase transferase N-terminal
Increases nucleophilicity of active site Cys
O-(5'-phospho-DNA)-tyrosine intermediate
Ribose-phosphate pyrophosphokinase N-terminal
Transposon Tn7 transposition protein TnsD C-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
glutathione gamma-glutamylcysteinyltransferase
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Schiff-base intermediate with substrate; via pyruvic acid
Mandelate racemase/muconate lactonizing enzyme C-terminal
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Schiff-base intermediate with substrate; via topaquinone
Organic solvent tolerance-like N-terminal
Organic solvent tolerance-like N-terminal domain-containing protein
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Essential for prephenate dehydratase activity
Ionotropic glutamate receptor C-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Photosystem II manganese-stabilizing polypeptide
NADH:ubiquinone oxidoreductase 30kDa subunit
Proton acceptor; for glutaminase activity
Sodium/calcium exchanger membrane region
Glycine zipper 2TM domain-containing protein
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Peptidase M1 membrane alanine aminopeptidase
Galactose oxidase-like Early set domain-containing protein
Thymidylate synthase/dCMP hydroxymethylase
1,4-alpha-glucan branching enzyme C-terminal
Intracellular proteinase inhibitor BsuPI domain-containing protein
Sodium symporter small subunit predicted
Type II restriction enzyme and methyltransferase RM.Eco57I-like
Shikimate dehydrogenase substrate binding N-terminal
General stress protein FMN-binding split barrel
Photosystem I PsaL reaction centre subunit XI
Glycosyl hydrolases family 2 sugar binding
Methionyl-tRNA synthetase anticodon-binding
Urease accessory protein UreE C-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Sugar fermentation stimulation protein C-terminal
Polymerase/histidinol phosphatase N-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Menaquinone biosynthesis protein MenD middle
Membrane insertase YidC/Oxa/ALB C-terminal
DNA mismatch repair proteins mutS family
Phosphoribosylformylglycinamidine synthase linker
Large ribosomal subunit protein uL2 C-terminal
Glycine cleavage T-protein C-terminal barrel
Plays an important role in substrate specificity
Release factor glutamine methyltransferase N-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Lysozyme inhibitor LprI N-terminal domain-containing protein
Sigma 54 modulation/S30EA ribosomal protein C-terminal
P-type conjugative transfer protein TrbJ
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Histidine-specific methyltransferase SAM-dependent
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Filamentous hemagglutinin family N-terminal domain protein
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Quercetin 2,3-dioxygenase C-terminal cupin