PhoD-like phosphatase metallophosphatase
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Tryptophan synthase beta chain-like PALP
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Excalibur calcium-binding domain-containing protein
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Large ribosomal subunit protein uL6 alpha-beta
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Acyl-CoA dehydrogenase/oxidase N-terminal
Large ribosomal subunit protein uL15/eL18
Molybdopterin cofactor biosynthesis C (MoaC)
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Citrate transporter-like domain-containing protein
Reversibly protonated during proton transport
Glycine cleavage T-protein C-terminal barrel
Thiamine pyrophosphate enzyme N-terminal TPP-binding
O-(3'-phospho-DNA)-tyrosine intermediate
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Major facilitator superfamily (MFS) profile
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
ABC transporter substrate-binding protein
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
RNA polymerase sigma factor 70 region 4 type 2
Thiamine pyrophosphate enzyme TPP-binding
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Na+/H+ antiporter MnhB subunit-related protein
Could play a key role in the communication between the regulatory and the substrate sites
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Glycosyltransferase subfamily 4-like N-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Solute-binding protein family 5 domain-containing protein
CobB/CobQ-like glutamine amidotransferase
FAD-dependent oxidoreductase 2 FAD binding
Nitrite/Sulfite reductase ferredoxin-like
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Solute-binding protein family 3/N-terminal
Ribosomal RNA adenine methylase transferase N-terminal
Cysteine sulfenic acid (-SOH) intermediate
Resolvase/invertase-type recombinase catalytic
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
NADH:flavin oxidoreductase/NADH oxidase N-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Positions MEP for the nucleophilic attack
5-glutamyl coenzyme A thioester intermediate
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
Cytochrome C biogenesis protein transmembrane
Type II restriction enzyme and methyltransferase RM.Eco57I-like
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Ribose-phosphate pyrophosphokinase N-terminal
N6 adenine-specific DNA methyltransferase N-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Phosphocysteine intermediate; for EIIB activity
Sodium/calcium exchanger membrane region
RNA binding; important for wobble base 34 recognition
Aminoacyl-transfer RNA synthetases class-II family profile
Bacterial bifunctional deaminase-reductase C-terminal
ABC-type glycine betaine transport system substrate-binding
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Heat-inducible transcription repressor HrcA C-terminal
Essential for prephenate dehydratase activity
ATP synthase F1 complex delta/epsilon subunit N-terminal
Plays an important role in substrate specificity
O-(5'-phospho-DNA)-tyrosine intermediate
Cytochrome b561 bacterial/Ni-hydrogenase
S-adenosyl-L-homocysteine hydrolase NAD binding
Resuscitation-promoting factor Rpf1 C-terminal
Resuscitation-promoting factor core lysozyme-like
RNA 2-O ribose methyltransferase substrate binding
Putative host cell surface-exposed lipoprotein Ltp-like HTH region
Polymerase/histidinol phosphatase N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Activator of Hsp90 ATPase homologue 1-like C-terminal
DNA replication/recombination mediator RecO N-terminal
Pyruvate dehydrogenase E1 component middle
Chromosomal replication initiator DnaA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Prokaryotic-type class I peptide chain release factors
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Transposase IS204/IS1001/IS1096/IS1165 DDE
Schiff-base intermediate with D-ribose 5-phosphate
Aconitase A/isopropylmalate dehydratase small subunit swivel
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Alanyl-transfer RNA synthetases family profile
Exonuclease VII large subunit C-terminal
Peptidase S9 prolyl oligopeptidase catalytic
Phosphatidate phosphatase APP1 catalytic
Glucosamine/galactosamine-6-phosphate isomerase
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Inosine/uridine-preferring nucleoside hydrolase
Bacterial type II secretion system protein E
Large ribosomal subunit protein uL2 C-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Alpha-D-phosphohexomutase alpha/beta/alpha
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Phosphotransferase system enzyme I N-terminal
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
Ribosome maturation factor RimP N-terminal
Penicillin-binding protein transpeptidase
Cobalamin-independent methionine synthase MetE N-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Endoribonuclease L-PSP/chorismate mutase-like
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Pyridoxamine 5'-phosphate oxidase putative
DNA-directed DNA polymerase family A palm
Glycosyl transferase family 3 N-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Phosphoribosylformylglycinamidine synthase linker
Peptide methionine sulphoxide reductase MsrA
Septum formation-related domain-containing protein
Protocatechuate 3,4-dioxygenase beta subunit N-terminal
Prepilin type IV endopeptidase peptidase
Peptidase M1 membrane alanine aminopeptidase
Important for substrate specificity; cannot use PPi as phosphoryl donor
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Cell envelope-related transcriptional attenuator
NIF system FeS cluster assembly NifU N-terminal
Methionyl-tRNA synthetase anticodon-binding
Phosphatidic acid phosphatase type 2/haloperoxidase
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
SGNH hydrolase-type esterase domain-containing protein
tRNA pseudouridine synthase II TruB subfamily 2 C-terminal
tRNA pseudouridylate synthase B C-terminal
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
Putative oxidoreductase/dehydrogenase Rossmann-like
SUF system FeS cluster assembly SufBD N-terminal
Thymidylate synthase/dCMP hydroxymethylase
4'-phosphopantetheinyl transferase N-terminal
Small ribosomal subunit protein uS4 N-terminal
6-phosphogluconate dehydrogenase C-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Membrane insertase YidC/Oxa/ALB C-terminal
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Phosphomannose isomerase type I catalytic
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Could be important to modulate the pK values of the two catalytic cysteine residues
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Involved in ionization of N3 of dUMP, leading to its activation
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Rv2525c-like glycoside hydrolase-like domain-containing protein
Helix-hairpin-helix DNA-binding motif class 1
Anthranilate synthase component I N-terminal
DNA helicase Holliday junction RuvA type
Holliday junction DNA helicase RuvA C-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Translation elongation factor P/YeiP central
Glucose-methanol-choline oxidoreductase N-terminal
Gly-cisPro motif, important for rejection of L-amino acids
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Important for beta-aspartyl-AMP intermediate formation
Shikimate dehydrogenase substrate binding N-terminal