Major facilitator superfamily (MFS) profile
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Schiff-base intermediate with substrate; via pyruvic acid
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Thiamine pyrophosphate enzyme TPP-binding
Alpha-D-phosphohexomutase alpha/beta/alpha
Penicillin-binding protein transpeptidase
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Putative regulatory protein FmdB Zinc ribbon
ESX-1 secretion-associated protein EspB PE
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Glycosyltransferase subfamily 4-like N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Cytochrome C biogenesis protein transmembrane
Transposase IS116/IS110/IS902 C-terminal
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Aminoacyl-transfer RNA synthetases class-II family profile
Nitrite/Sulfite reductase ferredoxin-like
Exonuclease VII large subunit C-terminal
2,4-diaminopentanoate dehydrogenase C-terminal
Anti-sigma-D factor RsdA sigma factor binding region
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Phthiocerol/phthiodiolone dimycocerosyl transferase C-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Pyridoxamine 5'-phosphate oxidase putative
Adaptive response protein AidB N-terminal
ESX-1 secretion-associated protein EspA/EspE-like
Dihydrodipicolinate reductase N-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)
Superoxide dismutase copper/zinc binding
Transcription elongation factor GreA/GreB C-terminal
Bacterial type II secretion system protein E
Prokaryotic-type class I peptide chain release factors
N6 adenine-specific DNA methyltransferase N-terminal
Tryptophan synthase beta chain-like PALP
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Prepilin type IV endopeptidase peptidase
Could be important to modulate the pK values of the two catalytic cysteine residues
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Inosine/uridine-preferring nucleoside hydrolase
NIF system FeS cluster assembly NifU C-terminal
Resolvase/invertase-type recombinase catalytic
Mandelate racemase/muconate lactonizing enzyme C-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Heme-copper oxidase subunit III family profile
Ribose-phosphate pyrophosphokinase N-terminal
Anthranilate synthase component I N-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Resuscitation-promoting factor core lysozyme-like
Could play a key role in the communication between the regulatory and the substrate sites
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Alanyl-transfer RNA synthetases family profile
Proton acceptor; for glutaminase activity
Histidine-specific methyltransferase SAM-dependent
Translation elongation factor P/YeiP central
Type I restriction modification DNA specificity
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Alanine and valine rich exported protein
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Haemophore haem-binding domain-containing protein
Positions MEP for the nucleophilic attack
Lantibiotic biosynthesis protein dehydration
Inner membrane protein YgaP-like transmembrane
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
RNA polymerase sigma factor 70 region 4 type 2
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Sodium/calcium exchanger membrane region
Polymerase/histidinol phosphatase N-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
Essential for prephenate dehydratase activity
RNA 2-O ribose methyltransferase substrate binding
Cell envelope-related transcriptional attenuator
Small ribosomal subunit protein uS4 N-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Solute-binding protein family 3/N-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
Phosphomannose isomerase type I catalytic
Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
Ricin B lectin domain-containing protein
PknH-like extracellular domain-containing protein
Bacterial bifunctional deaminase-reductase C-terminal
Acetylserotonin O-methyltransferase dimerisation
Moybdenum cofactor oxidoreductase dimerisation
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
CobB/CobQ-like glutamine amidotransferase
Proteinase inhibitor I42 chagasin domain-containing protein
Cation-transporting P-type ATPase N-terminal
Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
Peptidase C39-like domain-containing protein
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
6-phosphogluconate dehydrogenase C-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
Involved in ionization of N3 of dUMP, leading to its activation
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Transposase IS204/IS1001/IS1096/IS1165 DDE
Polysaccharide chain length determinant N-terminal
Reversibly protonated during proton transport
Thiolase-like protein type 1 additional C-terminal
DNA topoisomerase I catalytic core eukaryotic-type
ABC-type glycine betaine transport system substrate-binding
Insecticide toxin TcdB middle/C-terminal
Insecticide toxin TcdB middle/N-terminal
Type 2A encapsulin shell protein SrpI-like
Acyltransferase MbtK/IucB-like conserved
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-113)
Arabinofuranosyltransferase AftA C-terminal
Arabinofuranosyltransferase AftA N-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Large ribosomal subunit protein uL2 C-terminal
Schiff-base intermediate with acetaldehyde
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Ribosomal RNA adenine methylase transferase N-terminal
Heat-inducible transcription repressor HrcA C-terminal
Myo-inositol-1-phosphate synthase GAPDH-like
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Polysaccharide biosynthesis protein C-terminal
Molybdopterin cofactor biosynthesis C (MoaC)
Dihydrodipicolinate reductase C-terminal
Galactofuranosyltransferase GlfT2 N-terminal
Galactofuranosyltransferase-2 C-terminal
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
Cytochrome b/b6 N-terminal region profile
Pyrimidine nucleoside phosphorylase C-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
Formamidopyrimidine-DNA glycosylase catalytic
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Mycothiol-dependent maleylpyruvate isomerase metal-binding
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
1,4-alpha-glucan branching enzyme C-terminal
Glycoside hydrolase family 57 N-terminal
Tc toxin complex TcA C-terminal TcB-binding
Release factor glutamine methyltransferase N-terminal
Pyruvate dehydrogenase E1 component middle
Putative oxidoreductase/dehydrogenase Rossmann-like
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Cytochrome b561 bacterial/Ni-hydrogenase
Solute-binding protein family 5 domain-containing protein
Shikimate dehydrogenase substrate binding N-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Aconitase A/isopropylmalate dehydratase small subunit swivel
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Glucosamine/galactosamine-6-phosphate isomerase
Antitoxin Xre/MbcA/ParS-like toxin-binding
DNA-binding and helicase activity, interacts with RecC
Nuclease activity, interacts with RecD and RecA
ABC-type glycine betaine transport system substrate-binding domain-containing protein
Peptide methionine sulphoxide reductase MsrA
Nitrile hydratase alpha /Thiocyanate hydrolase gamma
Endoribonuclease L-PSP/chorismate mutase-like
Gfo/Idh/MocA-like oxidoreductase C-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Poly-beta-hydroxybutyrate polymerase N-terminal
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
NAD(P) transhydrogenase alpha subunit C-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Phosphatidic acid phosphatase type 2/haloperoxidase
Important for substrate specificity; cannot use PPi as phosphoryl donor
Peptidase S9 prolyl oligopeptidase catalytic
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
O-(3'-phospho-DNA)-tyrosine intermediate
TetR transcriptional regulator Rv1219c-like C-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
tRNA pseudouridine synthase II TruB subfamily 2 C-terminal
tRNA pseudouridylate synthase B C-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
DNA helicase Holliday junction RuvA type
Holliday junction DNA helicase RuvA C-terminal
Alpha-glycerophosphate oxidase C-terminal
Cysteine sulfenic acid (-SOH) intermediate
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Protein O-mannosyl-transferase C-terminal four TM
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Pyruvate phosphate dikinase AMP/ATP-binding
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
L-seryl-tRNA selenium transferase N-terminal
Large ribosomal subunit protein uL15/eL18
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
Glycine cleavage T-protein C-terminal barrel
Homogentisate 1,2-dioxygenase N-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Glutathionylspermidine synthase pre-ATP-grasp-like
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Important for beta-aspartyl-AMP intermediate formation
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Increases nucleophilicity of active site Cys
Large ribosomal subunit protein uL6 alpha-beta
Plays an important role in substrate specificity
Carbamoyl-phosphate synthase small subunit N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
PsrA tetracyclin repressor-like C-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC