Reversibly protonated during proton transport
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
RND efflux pump membrane fusion protein barrel-sandwich
Tryptophan synthase beta chain-like PALP
Interaction with polymerase core subunit RpoC
Aspartate/homoserine dehydrogenase NAD-binding
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Solute-binding protein family 3/N-terminal
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Glucosamine/galactosamine-6-phosphate isomerase
RNA polymerase sigma factor 70 region 4 type 2
Major facilitator superfamily (MFS) profile
Gfo/Idh/MocA-like oxidoreductase N-terminal
Aspartate carbamoyltransferase regulatory subunit C-terminal
Aspartate carbamoyltransferase regulatory subunit N-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
UDP N-acetylglucosamine O-acyltransferase C-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
Penicillin-binding protein transpeptidase
Type I restriction modification DNA specificity
Aminoacyl-transfer RNA synthetases class-II family profile
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
TRAP C4-dicarboxylate transport system permease DctM subunit
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Glycoside hydrolase family 31 N-terminal
Penicillin-binding protein activator LpoA
Important for interaction with partner proteins
Tellurite resistance methyltransferase TehB-like
Mandelate racemase/muconate lactonizing enzyme C-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Phosphatidic acid phosphatase type 2/haloperoxidase
6-phosphogluconate dehydrogenase C-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Molybdopterin cofactor biosynthesis C (MoaC)
O-(5'-phospho-DNA)-tyrosine intermediate
TonB-dependent receptor-like beta-barrel
Type I restriction enzyme R protein N-terminal
Phosphocysteine intermediate; for EIIB activity
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Appears to be important in orienting the phosphate for catalysis
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Quercetin 2,3-dioxygenase C-terminal cupin
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Cytochrome b561 bacterial/Ni-hydrogenase
RNA binding; important for wobble base 34 recognition
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Transposase IS116/IS110/IS902 C-terminal
Translation elongation factor P/YeiP central
Interacts with tRNA; defines subfamily-specific binding signature
Outer-membrane lipoprotein carrier protein
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Chromosome partition protein MukF C-terminal
Chromosome partition protein MukF middle
Chromosome partition protein MukF winged-helix
Type VI secretion system IcmF C-terminal
Membrane fusion protein biotin-lipoyl like
Gamma-glutamylcyclotransferase AIG2-like
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Exonuclease VII large subunit C-terminal
Positions MEP for the nucleophilic attack
Gfo/Idh/MocA-like oxidoreductase C-terminal
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
High-affinity branched-chain amino acid transport system permease LivHM N-terminal
Schiff-base intermediate with acetaldehyde
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Carbamoyl-phosphate synthase small subunit N-terminal
Large ribosomal subunit protein bL25 L25
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase C-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase N-terminal
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
RNA methyltransferase SpoU/TrmH type C-terminal
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Survival protein SurE-like phosphatase/nucleotidase
Chromosomal replication initiator DnaA C-terminal
ABC-type glycine betaine transport system substrate-binding
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Lipopolysaccharide export system protein LptA
Organic solvent tolerance-like N-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
DNA polymerase III subunit delta C-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Arginine decarboxylase C-terminal helical
Nucleoside-specific channel-forming protein Tsx
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Flagellar hook-length control protein-like C-terminal
Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding
Cysteine sulfenic acid (-SOH) intermediate
Outer-membrane lipoprotein Wza C-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
YbaK/aminoacyl-tRNA synthetase-associated
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
DNA polymerase III delta subunit C-terminal
Ionotropic glutamate receptor C-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
O-(phosphoribosyl dephospho-coenzyme A)serine
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Integral membrane protein YccS N-terminal
Greasy slide, important in sugar transport
Proton acceptor; for decarboxylase activity
Proton donor; for decarboxylase activity
Proton donor; for formyltransferase activity
Phosphotransferase system enzyme I N-terminal
Outer membrane protein assembly factor BamD
Plays an important role in substrate specificity
Negative modulator of initiation of replication SeqA N-terminal
Replication modulator SeqA C-terminal DNA-binding
Sugar fermentation stimulation protein C-terminal
Outer membrane protein assembly factor BamE
D-galactose/methyl-galactoside binding periplasmic protein MglB
Prepilin type IV endopeptidase peptidase
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Influences the redox potential of the prosthetic heme and FAD groups
Involved in heme-bound ligand stabilization and O-O bond activation
Large ribosomal subunit protein uL2 C-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase
Uroporphyrinogen-III C-methyltransferase
Heme-copper oxidase subunit III family profile
AraC-type arabinose-binding/dimerisation
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Pyrimidine nucleoside phosphorylase C-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
HicB-like antitoxin of toxin-antitoxin system
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Glycosyltransferase subfamily 4-like N-terminal
RNA 2-O ribose methyltransferase substrate binding
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Flagellar motor switch protein FliN N-terminal
Flagellar motor switch protein FliN-like C-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Prokaryotic-type class I peptide chain release factors
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Involved in allosteric activation by GTP
Pyruvate phosphate dikinase AMP/ATP-binding
Glyoxalase/fosfomycin resistance/dioxygenase
Periplasmic binding protein/LacI sugar binding
The binding site for the sugar molecule has not yet been established, but C-87 may be involved
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Sodium/calcium exchanger membrane region
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Glucan biosynthesis periplasmic MdoG C-terminal
Glutathionylspermidine synthase pre-ATP-grasp-like
Phosphoadenosine phosphosulphate reductase
Anthranilate synthase component I N-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Penicillin-insensitive murein endopeptidase
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Required for dimer formation and molybdate binding
High-affinity zinc uptake system protein ZnuA
Cytochrome c-type biogenesis protein CcmF C-terminal
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes
Inosine/uridine-preferring nucleoside hydrolase
Important for beta-aspartyl-AMP intermediate formation
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Polysaccharide biosynthesis protein C-terminal
SUF system FeS cluster assembly SufBD N-terminal
Serine/threonine specific protein phosphatases
Polysaccharide chain length determinant N-terminal
Type III secretion system flagellar brake protein YcgR PilZN
Polymerase/histidinol phosphatase N-terminal
Guanylate kinase/L-type calcium channel beta subunit
Peptide methionine sulphoxide reductase MsrA
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
DNA replication/recombination mediator RecO N-terminal
Beta-hexosaminidase bacterial type N-terminal
Glycosyl transferase family 3 N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Calcium/calmodulin-dependent protein kinase II association-domain
Phosphoethanolamine transferase N-terminal
Seems to be a necessary countercharge to the potassium cations
Lytic transglycosylase superhelical linker
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
NIF system FeS cluster assembly NifU C-terminal
DNA mismatch repair MutH/Type II restriction enzyme Sau3AI
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Glycine cleavage T-protein C-terminal barrel
Important for substrate binding and specificity
Flagella basal body P-ring formation protein FlgA
Cob(I)alamin adenosyltransferase N-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
DnaJ homologue subfamily C member 28 conserved
Cobalamin-independent methionine synthase MetE N-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Nitrite/Sulfite reductase ferredoxin-like
Interaction with tRNA; Important for base-flipping
Pseudouridine synthase I TruA alpha/beta
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Large ribosomal subunit protein uL15/eL18
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Non-canonical purine NTP phosphatase/PRRC1
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Ribosomal RNA adenine methylase transferase N-terminal
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Essential for prephenate dehydratase activity
Alpha-glycerophosphate oxidase C-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
Transcriptional regulator SgrR N-terminal HTH
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Helix-hairpin-helix DNA-binding motif class 1
Multiple antibiotic resistance protein MarB
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Outer membrane protein assembly factor BamA
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Essential for degradation by Lon protease
Flagellar assembly protein FliH/Type III secretion system HrpE
Antitoxin Xre/MbcA/ParS-like toxin-binding
Gly-cisPro motif, important for rejection of L-amino acids
Methylguanine DNA methyltransferase ribonuclease-like
ABC-type transport auxiliary lipoprotein component
Nucleophile; cysteine thiosulfonate intermediate
Large ribosomal subunit protein uL6 alpha-beta
Acyl-ester intermediate; for transpeptidase activity
Proton donor; for transglycosylase activity
Transglycosylase PBP1b N-terminal transmembrane
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
Small ribosomal subunit protein uS4 N-terminal
D-glutamate N-acetyltransferase-like C-terminal
D-glutamate N-acetyltransferase-like N-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Disulphide bond isomerase DsbC/G N-terminal
Pyruvate dehydrogenase E1 component middle
Could play a key role in the communication between the regulatory and the substrate sites