Essential for prephenate dehydratase activity
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
RND efflux pump membrane fusion protein barrel-sandwich
Cysteine sulfenic acid (-SOH) intermediate
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Major facilitator superfamily (MFS) profile
Phenol hydroxylase C-terminal dimerisation
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
L-seryl-tRNA selenium transferase N-terminal
Penicillin-binding protein transpeptidase
3-isopropylmalate dehydratase small subunit
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
FAD-dependent oxidoreductase 2 FAD binding
Important for substrate specificity; cannot use PPi as phosphoryl donor
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Cytochrome b/b6 N-terminal region profile
RNA polymerase sigma factor 70 region 4 type 2
ABC-type glycine betaine transport system substrate-binding
Alpha-D-phosphohexomutase alpha/beta/alpha
Important for beta-aspartyl-AMP intermediate formation
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
CobB/CobQ-like glutamine amidotransferase
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Phosphatidylglycerol lysyltransferase C-terminal
Prokaryotic-type class I peptide chain release factors
Heat-inducible transcription repressor HrcA
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Solute-binding protein family 3/N-terminal
Alpha-glycerophosphate oxidase C-terminal
Probable transcriptional regulatory protein cauri_1421
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Phosphocysteine intermediate; for EIIB activity
Membrane insertase YidC/Oxa/ALB C-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
Glycosyltransferase subfamily 4-like N-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Peptidase S9 prolyl oligopeptidase catalytic
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
Polysaccharide biosynthesis protein C-terminal
Anthranilate synthase component I N-terminal
NIF system FeS cluster assembly NifU N-terminal
Sigma 54 modulation/S30EA ribosomal protein C-terminal
ATP-dependent DNA helicase RecG C-terminal
Polymerase/histidinol phosphatase N-terminal
Isoglutamyl lysine isopeptide (Glu-Lys) (interchain with K-? in acceptor proteins)
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Bacterial bifunctional deaminase-reductase C-terminal
Resolvase/invertase-type recombinase catalytic
Threonine/serine exporter-like N-terminal
N-acetyl-gamma-glutamyl-phosphate reductase
Positions MEP for the nucleophilic attack
Ribosomal RNA small subunit methyltransferase H
Phosphoribosylformylglycinamidine synthase subunit PurL
Glucose-methanol-choline oxidoreductase N-terminal
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
ATP-dependent Clp protease ATP-binding subunit ClpX
Holliday junction branch migration complex subunit RuvB
Phosphatidate phosphatase APP1 catalytic
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Cytochrome C biogenesis protein transmembrane
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Could be important to modulate the pK values of the two catalytic cysteine residues
Glutamate-1-semialdehyde 2,1-aminomutase
Aspartate/homoserine dehydrogenase NAD-binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Tryptophan synthase beta chain-like PALP
Putative host cell surface-exposed lipoprotein Ltp-like HTH region
Cobalamin-independent methionine synthase MetE N-terminal
RNA 2-O ribose methyltransferase substrate binding
Peptide methionine sulphoxide reductase MsrA
YbaK/aminoacyl-tRNA synthetase-associated
Carbamoyl-phosphate synthase small subunit N-terminal
Pseudouridine synthase I TruA alpha/beta
AAA ATPase forming ring-shaped complexes
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Chromosomal replication initiator protein DnaA
Phosphotransferase system enzyme I N-terminal
4'-phosphopantetheinyl transferase N-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Important for autoinhibition of adenylyltransferase activity
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Peptidoglycan recognition protein family
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Ribosomal RNA adenine methylase transferase N-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Ribose-phosphate pyrophosphokinase N-terminal
Phosphomannose isomerase type I catalytic
Transposase IS116/IS110/IS902 C-terminal
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Interaction with polymerase core subunit RpoC
4-hydroxy-tetrahydrodipicolinate reductase
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Gram-positive pilin subunit D1 N-terminal
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
Inosine/uridine-preferring nucleoside hydrolase
RNA binding; important for wobble base 34 recognition
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Endoribonuclease L-PSP/chorismate mutase-like
L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase
Bifunctional purine biosynthesis protein PurH
Peptidase M1 membrane alanine aminopeptidase
Release factor glutamine methyltransferase N-terminal
Sporulation transcription regulator WhiA N-terminal
Schiff-base intermediate with D-ribose 5-phosphate
O-(5'-phospho-DNA)-tyrosine intermediate
Na+/H+ antiporter MnhB subunit-related protein
Restriction system protein Mrr-like N-terminal
Nitrite/Sulfite reductase ferredoxin-like
O-(3'-phospho-DNA)-tyrosine intermediate
HTH-type transcriptional regulator MT1864/Rv1816-like C-terminal
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Helix-hairpin-helix DNA-binding motif class 1
Schiff-base intermediate with acetaldehyde
Type I restriction modification DNA specificity
Cell wall-active antibiotics response LiaF-like C-terminal
Alanyl-transfer RNA synthetases family profile
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
ATP-dependent Clp protease adapter protein ClpS
Resuscitation-promoting factor Rpf1 C-terminal
Resuscitation-promoting factor core lysozyme-like
Reversibly protonated during proton transport
Glucosamine/galactosamine-6-phosphate isomerase
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Involved in Mg(2+) ion dislocation from EF-Tu
Phosphatidic acid phosphatase type 2/haloperoxidase
Glycerol-3-phosphate dehydrogenase [NAD(P)+]
Plays an important role in substrate specificity
Polyribonucleotide nucleotidyltransferase
5-glutamyl coenzyme A thioester intermediate
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
Holliday junction branch migration complex subunit RuvA
SUF system FeS cluster assembly SufBD N-terminal
Imidazole glycerol phosphate synthase subunit HisF
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
DNA replication/recombination mediator RecO N-terminal
Prepilin type IV endopeptidase peptidase
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
DNA-directed RNA polymerase subunit beta'
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
D-inositol 3-phosphate glycosyltransferase
6-phosphogluconate dehydrogenase C-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Arabinofuranosyltransferase AftA C-terminal
Arabinofuranosyltransferase AftA N-terminal
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C
Ionotropic glutamate receptor C-terminal
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Transcription antitermination protein NusB
Molybdopterin cofactor biosynthesis C (MoaC)
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase
Involved in ionization of N3 of dUMP, leading to its activation
4-hydroxy-tetrahydrodipicolinate synthase
tRNA N6-adenosine threonylcarbamoyltransferase