Saccharopine dehydrogenase-like C-terminal
DNA replication/recombination mediator RecO N-terminal
Penicillin-binding protein transpeptidase
Cation-transporting P-type ATPase C-terminal
Cation-transporting P-type ATPase N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Polysaccharide biosynthesis protein C-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
ABC transporter substrate-binding protein PnrA-like
Shikimate dehydrogenase substrate binding N-terminal
Alanyl-transfer RNA synthetases family profile
Defence against restriction A C-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Probable transposase IS891/IS1136/IS1341
Aminoacyl-transfer RNA synthetases class-II family profile
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Resolvase/invertase-type recombinase catalytic
Meso-diaminopimelate D-dehydrogenase C-terminal
Lysidine-tRNA(Ile) synthetase C-terminal
Pseudouridine synthase I TruA alpha/beta
Plays an important role in discriminating NADH against NADPH
Cell envelope-related transcriptional attenuator
Large ribosomal subunit protein uL30-like ferredoxin-like fold
CobB/CobQ-like glutamine amidotransferase
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Membrane fusion protein biotin-lipoyl like
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Lantibiotic biosynthesis protein dehydration
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Tryptophan synthase beta chain-like PALP
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Schiff-base intermediate with dihydroxyacetone-P
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Terminase large subunit-like endonuclease
Transposase IS204/IS1001/IS1096/IS1165 DDE
Transposase IS204/IS1001/IS1096/IS1165 zinc-finger
Positions MEP for the nucleophilic attack
Phosphatidic acid phosphatase type 2/haloperoxidase
Type I restriction modification DNA specificity
N-sulphoglucosamine sulphohydrolase C-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
ATPsynthase alpha/beta subunit N-terminal extension
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Phosphoribosylformylglycinamidine synthase linker
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Release factor glutamine methyltransferase N-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Formiminotransferase C-terminal subdomain
Formiminotransferase N-terminal subdomain
Aconitase A/isopropylmalate dehydratase small subunit swivel
S-adenosylmethionine-dependent methyltransferase
Signal transduction histidine kinase osmosensitive K+ channel sensor N-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
Aspartate carbamoyltransferase regulatory subunit C-terminal
Aspartate carbamoyltransferase regulatory subunit N-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
LPXTG-motif cell wall anchor domain protein
Could be important to modulate the pK values of the two catalytic cysteine residues
Solute-binding protein family 3/N-terminal
Gram-positive pilin backbone subunit 2 Cna-B-like
Sporulation stage IV protein A C-terminal
NADH-rubredoxin oxidoreductase C-terminal
Sugar fermentation stimulation protein C-terminal
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Bacterial alpha-L-rhamnosidase N-terminal
Could play a key role in the communication between the regulatory and the substrate sites
Helix-hairpin-helix DNA-binding motif class 1
Integrase Tn916-type N-terminal DNA binding
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
DNA-directed RNA polymerase RpoA/D/Rpb3-type
RNA 2-O ribose methyltransferase substrate binding
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
O-(phosphoribosyl dephospho-coenzyme A)serine
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Thymidylate synthase/dCMP hydroxymethylase
Important for substrate specificity; cannot use PPi as phosphoryl donor
TRAP C4-dicarboxylate transport system permease DctM subunit
Polymerase/histidinol phosphatase N-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
Proton acceptor; for glutaminase activity
Anthranilate synthase component I N-terminal
Exonuclease VII large subunit C-terminal
Phosphomannose isomerase type I catalytic
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Sporulation transcription regulator WhiA N-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Large ribosomal subunit protein bL9 C-terminal
Gram-positive pilin subunit D1 N-terminal
Gram-positive pilin subunit D1 N-terminal domain-containing protein
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Bacterial type II secretion system protein E
Polysaccharide chain length determinant N-terminal
Beta-xylosidase C-terminal Concanavalin A-like
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
CO dehydrogenase/acetyl-CoA synthase complex beta subunit C-terminal
Carbon monoxide dehydrogenase subunit alpha ,N-terminal
Sporulation stage II protein D amidase enhancer LytB N-terminal
Solute-binding protein family 3/N-terminal domain-containing protein
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Glycosyl transferase family 28 C-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
DNA polymerase helix-hairpin-helix motif
Important for beta-aspartyl-AMP intermediate formation
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
RNA polymerase sigma factor 70 region 4 type 2
HicB-like antitoxin of toxin-antitoxin system
Methylaspartate ammonia-lyase C-terminal
Methylaspartate ammonia-lyase N-terminal
Transcriptional coactivator p15 (PC4) C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
Major facilitator superfamily (MFS) profile
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
Magnesium transporter MgtE intracellular
Helix-turn-helix conjugative transposon-like
YbaK/aminoacyl-tRNA synthetase-associated
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Pyrimidine nucleoside phosphorylase C-terminal
Gram-positive signal peptide protein, YSIRK family
Periplasmic copper-binding protein NosD beta helix
RND efflux pump membrane fusion protein barrel-sandwich
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Diacylglycerol glucosyltransferase N-terminal
Carbohydrate-binding domain-containing protein
N6 adenine-specific DNA methyltransferase N-terminal
DNA-directed DNA polymerase family A palm
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Inosine monophosphate cyclohydrolase-like
Prokaryotic-type class I peptide chain release factors
Heat-inducible transcription repressor HrcA C-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Essential for prephenate dehydratase activity
Reversibly protonated during proton transport
Thiamin pyrophosphokinase thiamin-binding
Arabinogalactan endo-beta-1,4-galactanase
Large ribosomal subunit protein uL15/eL18
Replicative helicase inhibitor G39P N-terminal
Prenyltransferase and squalene oxidase repeat protein
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Ribonucleotide reductase large subunit C-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Glucosamine/galactosamine-6-phosphate isomerase
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Glycosyltransferase family 28 N-terminal
Glutamate synthase alpha subunit C-terminal
FAD-dependent oxidoreductase 2 FAD binding
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
ATP-dependent DNA helicase RecG C-terminal
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Lacto-N-biose phosphorylase-like N-terminal TIM barrel
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Dipicolinate synthase subunit A N-terminal
DNA mismatch repair proteins mutS family
Carbamoyl-phosphate synthase small subunit N-terminal
Small ribosomal subunit protein uS4 N-terminal
Ribosomal RNA adenine methylase transferase N-terminal
Inosine/uridine-preferring nucleoside hydrolase
Large ribosomal subunit protein uL6 alpha-beta
SsuA/THI5-like domain-containing protein
Stage III sporulation protein AA AAA+ ATPase
Glycosyltransferase subfamily 4-like N-terminal
ABC-type uncharacterised transport system
Gly-cisPro motif, important for rejection of L-amino acids
Phage terminase large subunit GpA ATPase
Terminase large subunit GpA endonuclease
tRNA pseudouridylate synthase B C-terminal
NIF system FeS cluster assembly NifU N-terminal
CO dehydrogenase/acetyl-CoA synthase delta subunit TIM barrel
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal