Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Major facilitator superfamily (MFS) profile
6-phosphogluconate dehydrogenase C-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Bacterial bifunctional deaminase-reductase C-terminal
Tricarboxylic transport membrane protein
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Acyl-CoA dehydrogenase/oxidase C-terminal
SGNH hydrolase-type esterase domain-containing protein
Penicillin-binding protein transpeptidase
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Phosphotransferase system enzyme I N-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
Mycothiol-dependent maleylpyruvate isomerase metal-binding
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Phosphatidic acid phosphatase type 2/haloperoxidase
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Polysaccharide chain length determinant N-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Positions MEP for the nucleophilic attack
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Peptidase M43 pregnancy-associated plasma-A
YbaK/aminoacyl-tRNA synthetase-associated
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Plays an important role in substrate specificity
DNA replication/recombination mediator RecO N-terminal
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase
Small ribosomal subunit protein uS4 N-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Histidine-specific methyltransferase SAM-dependent
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Acetylserotonin O-methyltransferase dimerisation
Gly-cisPro motif, important for rejection of L-amino acids
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Formamidopyrimidine-DNA glycosylase catalytic
ATP synthase F1 complex delta/epsilon subunit N-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Na+/H+ antiporter MnhB subunit-related protein
Putative regulatory protein FmdB Zinc ribbon
Glycosyl transferase family 3 N-terminal
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
Tryptophan synthase beta chain-like PALP
Nitrite/Sulfite reductase ferredoxin-like
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
RNA polymerase sigma factor 70 region 4 type 2
Large ribosomal subunit protein uL15/eL18
Prepilin type IV endopeptidase peptidase
Glycosyltransferase subfamily 4-like N-terminal
Peptidase S9 prolyl oligopeptidase catalytic
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Transposase IS116/IS110/IS902 C-terminal
Methionyl-tRNA synthetase anticodon-binding
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase
Putative Flp pilus-assembly TadG-like N-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Peptidoglycan recognition protein family
Schiff-base intermediate with D-ribose 5-phosphate
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Heat-inducible transcription repressor HrcA C-terminal
Peptidase M1 membrane alanine aminopeptidase
Important for substrate specificity; cannot use PPi as phosphoryl donor
TrbL/VirB6 plasmid conjugal transfer protein
Pyruvate phosphate dikinase AMP/ATP-binding
Important for beta-aspartyl-AMP intermediate formation
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Bacterial type II secretion system protein E
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
L-seryl-tRNA selenium transferase N-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Poly-beta-hydroxybutyrate polymerase N-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Cell envelope-related transcriptional attenuator
O-(3'-phospho-DNA)-tyrosine intermediate
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
DNA-directed DNA polymerase family A palm
Putative oxidoreductase/dehydrogenase Rossmann-like
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Mandelate racemase/muconate lactonizing enzyme C-terminal
Phosphatidate phosphatase APP1 catalytic
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
Essential for prephenate dehydratase activity
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
D-inositol 3-phosphate glycosyltransferase
ABC-type glycine betaine transport system substrate-binding
Homogentisate 1,2-dioxygenase C-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
Transcription regulator AsnC/Lrp ligand binding
Phosphoadenosine phosphosulphate reductase
Glycine cleavage T-protein C-terminal barrel
Carbonic anhydrase or acetyltransferase, isoleucine patch superfamily
Restriction system protein Mrr-like N-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Tripartite-type tricarboxylate transporter, receptor component TctC
Membrane insertase YidC/Oxa/ALB C-terminal
LPXTG-motif cell wall anchor domain-containing protein
Pyruvate dehydrogenase E1 component middle
Chromosomal replication initiator DnaA C-terminal
Phosphogluconate dehydrogenase NAD-binding putative C-terminal
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Tat (Twin-arginine translocation) pathway signal sequence
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
NADH:ubiquinone oxidoreductase 30kDa subunit
Inosine/uridine-preferring nucleoside hydrolase
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Ribulose bisphosphate carboxylase large subunit C-terminal
Ribulose bisphosphate carboxylase large subunit ferrodoxin-like N-terminal
Schiff-base intermediate with substrate; via topaquinone
Glycosyl hydrolases family 2 sugar binding
Bifunctional glucose-6-phosphate/mannose-6-phosphate isomerase C-terminal
Could play a key role in the communication between the regulatory and the substrate sites
Superoxide dismutase copper/zinc binding
Cytochrome b/b6 N-terminal region profile
Resolvase/invertase-type recombinase catalytic
tRNA pseudouridine synthase II TruB subfamily 2 C-terminal
tRNA pseudouridylate synthase B C-terminal
FAD-dependent oxidoreductase 2 FAD binding
Large ribosomal subunit protein uL2 C-terminal
Lactate utilization protein B C-terminal
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
Reversibly protonated during proton transport
Endoribonuclease L-PSP/chorismate mutase-like
PhoD-like phosphatase metallophosphatase
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Cytochrome oxidase subunit II copper A binding
Ribose-phosphate pyrophosphokinase N-terminal
Ribosomal RNA adenine methylase transferase N-terminal
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
Myo-inositol-1-phosphate synthase GAPDH-like
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Helix-hairpin-helix DNA-binding motif class 1
Polysaccharide biosynthesis protein C-terminal
Flagellar motor switch protein FliN-like C-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
RNA 2-O ribose methyltransferase substrate binding
Cell wall-active antibiotics response LiaF-like C-terminal
Sporulation transcription regulator WhiA N-terminal
Polymerase/histidinol phosphatase N-terminal
Prokaryotic-type class I peptide chain release factors
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Glucosamine/galactosamine-6-phosphate isomerase
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Elongation factor G-binding protein C-terminal treble-clef zinc-finger
Sodium/calcium exchanger membrane region
3-beta hydroxysteroid dehydrogenase/isomerase
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)
Threonine/serine exporter-like N-terminal
Alpha-glycerophosphate oxidase C-terminal
Cytochrome C biogenesis protein transmembrane
Phosphomannose isomerase type I catalytic
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Transposase IS204/IS1001/IS1096/IS1165 DDE
Electron transfer flavoprotein alpha/beta-subunit N-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Solute-binding protein family 3/N-terminal
Nicotinate phosphoribosyltransferase N-terminal
6-phosphogluconate dehydrogenase NADP-binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Galactofuranosyltransferase GlfT2 N-terminal
Galactofuranosyltransferase-2 C-terminal
Translation elongation factor P/YeiP central
Alanyl-transfer RNA synthetases family profile
Nucleophile; cysteine thiosulfonate intermediate
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Peptide methionine sulphoxide reductase MsrA
Release factor glutamine methyltransferase N-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Flagellar hook-length control protein-like C-terminal
Nitrile hydratase alpha /Thiocyanate hydrolase gamma
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
SUF system FeS cluster assembly SufBD N-terminal
Protein O-mannosyl-transferase C-terminal four TM
Pyrimidine nucleoside phosphorylase C-terminal
Flagellar assembly protein FliH/Type III secretion system HrpE
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Exonuclease VII large subunit C-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Large ribosomal subunit protein uL6 alpha-beta