Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Aminoacyl-transfer RNA synthetases class-II family profile
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Survival protein SurE-like phosphatase/nucleotidase
Penicillin-binding protein transpeptidase
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Important for beta-aspartyl-AMP intermediate formation
Glycosyltransferase subfamily 4-like N-terminal
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Large ribosomal subunit protein uL6 alpha-beta
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Flagellar motor switch protein FliN-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Septum formation inhibitor MinC C-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Pyruvate/ketoisovalerate oxidoreductase catalytic
Pseudouridine synthase I TruA alpha/beta
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
RND efflux pump membrane fusion protein barrel-sandwich
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Ribosomal RNA small subunit methyltransferase E methyltransferase
Aldehyde ferredoxin oxidoreductase N-terminal
Peptide methionine sulphoxide reductase MsrA
6-hydroxymethylpterin diphosphokinase MptE-like
Large ribosomal subunit protein uL2 C-terminal
FAD-dependent oxidoreductase 2 FAD binding
ABC-type transport auxiliary lipoprotein component
Mannose-6-phosphate isomerase type II C-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Major facilitator superfamily (MFS) profile
YbaK/aminoacyl-tRNA synthetase-associated
Dinitrogenase iron-molybdenum cofactor biosynthesis
Fibronectin type-III domain-containing protein
Magnesium transporter MgtE intracellular
Involved in ionization of N3 of dUMP, leading to its activation
Molybdopterin cofactor biosynthesis C (MoaC)
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Formylmethanofuran dehydrogenase subunit E
Exonuclease VII large subunit C-terminal
Flagellar Assembly Protein A N-terminal region
Solute-binding protein family 3/N-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Large ribosomal subunit protein uL15/eL18
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Nickel transport complex, NikM subunit, transmembrane
Flagellar assembly protein FliH/Type III secretion system HrpE
Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein
O-(3'-phospho-DNA)-tyrosine intermediate
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Restriction system protein Mrr-like N-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Phosphoethanolamine transferase N-terminal
Ribosomal RNA adenine methylase transferase N-terminal
Small ribosomal subunit protein uS4 N-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
NIF system FeS cluster assembly NifU C-terminal
NIF system FeS cluster assembly NifU N-terminal
Organic solvent tolerance-like N-terminal
Important for interaction with partner proteins
TRAP C4-dicarboxylate transport system permease DctM subunit
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
DNA mismatch repair proteins mutS family
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Damage-control phosphatase ARMT1-like metal-binding
Restriction endonuclease type I HsdR N-terminal
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Cysteine sulfenic acid (-SOH) intermediate
Bacterial type II secretion system protein E
Thiamine pyrophosphate enzyme TPP-binding
Polymerase/histidinol phosphatase N-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Positions MEP for the nucleophilic attack
RNA polymerase sigma factor 70 region 4 type 2
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Cytochrome b561 bacterial/Ni-hydrogenase
UDP N-acetylglucosamine O-acyltransferase C-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Shikimate dehydrogenase substrate binding N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
DNA replication/recombination mediator RecO N-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Flagellar hook-length control protein-like C-terminal
Anthranilate synthase component I N-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Essential for prephenate dehydratase activity
UDP-N-acetylenolpyruvoylglucosamine reductase C-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
TonB-dependent receptor-like beta-barrel
Nucleic acid binding OB-fold tRNA/helicase-type
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Inner membrane protein YgaP-like transmembrane
Polysaccharide biosynthesis protein CapD-like
Plays an important role in substrate specificity
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Translation elongation factor P/YeiP central
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Saccharopine dehydrogenase-like C-terminal
Ysc84 actin-binding domain-containing protein
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Resolvase/invertase-type recombinase catalytic
Aconitase A/isopropylmalate dehydratase small subunit swivel
Reversibly protonated during proton transport
Involved in allosteric activation by GTP
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Membrane fusion protein biotin-lipoyl like
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Glutathionylspermidine synthase pre-ATP-grasp-like
N-end rule aminoacyl transferase C-terminal
Carbohydrate binding module xylan-binding
ATP synthase F1 complex delta/epsilon subunit N-terminal
Schiff-base intermediate with substrate; via pyruvic acid
Chromosomal replication initiator DnaA C-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Plasminogen-binding protein PgbA N-terminal
Plasminogen-binding protein PgbA N-terminal domain-containing protein
Peptidase S9 prolyl oligopeptidase catalytic
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Ionotropic glutamate receptor C-terminal
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Transcription factor NikR nickel binding C-terminal
Tryptophan synthase beta chain-like PALP
STT3 subunit PglB C-terminal beta-barrel
Carbamoyl-phosphate synthase small subunit N-terminal
Arginine decarboxylase C-terminal helical
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Release factor glutamine methyltransferase N-terminal
Glycosyl transferase family 3 N-terminal
Polysaccharide chain length determinant N-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Prokaryotic-type class I peptide chain release factors
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Interaction with polymerase core subunit RpoC
Polypeptide-transport-associated ShlB-type
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Alanyl-transfer RNA synthetases family profile
Pyruvate phosphate dikinase AMP/ATP-binding
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
DNA-directed DNA polymerase family A palm
Succinate dehydogenase/fumarate reductase N-terminal
Important for autoinhibition of adenylyltransferase activity
Gamma-glutamylcyclotransferase AIG2-like
Helix-hairpin-helix DNA-binding motif class 1
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
RNA 2-O ribose methyltransferase substrate binding
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
RNA binding; important for wobble base 34 recognition
Phosphoribosylformylglycinamidine synthase linker
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Could be important to modulate the pK values of the two catalytic cysteine residues