ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Ionotropic glutamate receptor C-terminal
Solute-binding protein family 3/N-terminal
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Small ribosomal subunit protein uS4 N-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Peptidase S9 prolyl oligopeptidase catalytic
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
Probable transposase IS891/IS1136/IS1341
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
Outer membrane protein beta-barrel domain-containing protein
Major facilitator superfamily (MFS) profile
Phosphatidic acid phosphatase type 2/haloperoxidase
Polymerase/histidinol phosphatase N-terminal
Type IV methyl-directed restriction enzyme EcoKMcrB subunit DNA-binding
PsbP C-terminal domain-containing protein
Bacterial transcription activator effector binding
ABC transporter substrate-binding protein PnrA-like
Aminoacyl-transfer RNA synthetases class-II family profile
Important for autoinhibition of adenylyltransferase activity
Exonuclease VII large subunit C-terminal
Flavodoxin-like domain-containing protein
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Large ribosomal subunit protein uL30-like ferredoxin-like fold
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase N-terminal
OMP85-like membrane spanning beta barrel
Phosphotransferase system enzyme I N-terminal
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Aspartate/homoserine dehydrogenase NAD-binding
Peptidase S8/S53 domain-containing protein
Prepilin type IV endopeptidase peptidase
RNA binding; important for wobble base 34 recognition
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
DNA mismatch repair proteins mutS family
AB hydrolase-1 domain-containing protein
Plays an important role in substrate specificity
DNA replication/recombination mediator RecO N-terminal
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
PTS system alpha-glucoside-specific EIICB component
Phosphocysteine intermediate; for EIIB activity
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Glycosyltransferase subfamily 4-like N-terminal
Glucosamine/galactosamine-6-phosphate isomerase
Release factor glutamine methyltransferase N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
ABC transporter substrate binding protein
Alpha-D-phosphohexomutase alpha/beta/alpha
Large ribosomal subunit protein uL2 C-terminal
C-type lysozyme inhibitor domain-containing protein
Schiff-base intermediate with D-ribose 5-phosphate
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Thymidylate synthase/dCMP hydroxymethylase
Alanyl-transfer RNA synthetases family profile
Nicotinamide phosphoribosyltransferase N-terminal
Lysozyme inhibitor LprI N-terminal domain-containing protein
Sugar fermentation stimulation protein C-terminal
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Aspartate carbamoyltransferase regulatory subunit C-terminal
Aspartate carbamoyltransferase regulatory subunit N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Translation elongation factor P/YeiP central
TtsA-like Glycoside hydrolase family 108
Large ribosomal subunit protein uL15/eL18
Cysteine sulfenic acid (-SOH) intermediate
Pyrimidine nucleoside phosphorylase C-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Heat-inducible transcription repressor HrcA C-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
FAD-dependent oxidoreductase 2 FAD binding
Polysaccharide biosynthesis protein C-terminal
Penicillin-binding protein transpeptidase
Phosphomannose isomerase type I catalytic
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
RNA 2-O ribose methyltransferase substrate binding
UDP N-acetylglucosamine O-acyltransferase C-terminal
Peptide methionine sulphoxide reductase MsrA
Tryptophan synthase beta chain-like PALP
Pyridoxamine 5'-phosphate oxidase putative
Interaction with polymerase core subunit RpoC
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Esterase Ig-like N-terminal domain-containing protein
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Could play a key role in the communication between the regulatory and the substrate sites
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Large ribosomal subunit protein uL6 alpha-beta
Carbamoyl-phosphate synthase small subunit N-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
YbaK/aminoacyl-tRNA synthetase-associated
Saccharopine dehydrogenase-like C-terminal
TonB-dependent receptor-like beta-barrel
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Type I restriction modification DNA specificity
Essential for prephenate dehydratase activity
Cytochrome C biogenesis protein transmembrane
Organic solvent tolerance-like N-terminal
Type II restriction enzyme and methyltransferase RM.Eco57I-like
CagE TrbE VirB component of type IV transporter system central
Aromatic amino acid beta-eliminating lyase/threonine aldolase
ATP synthase F1 complex delta/epsilon subunit N-terminal
Cell envelope-related transcriptional attenuator
Lysidine-tRNA(Ile) synthetase C-terminal
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Schiff-base intermediate with dihydroxyacetone-P
Barely detectable pre-crRNA cleavage, retains target RNA cleavage.
Binds 3' nucleotide of the target RNA PFS
Binds 3'-end of target RNA, in adjacent protein
CRISPR-associated endoribonuclease Cas13a
Complete loss of pre-crRNA cleavage, retains target RNA cleavage. Decreased ability to activate non-specific RNA degradation when tested with a 6-spacer CRISPR array.
Dramatically decreased cleavage of target RNA.
No cleavage of target RNA, retains pre-crRNA cleavage. Still no effect on pre-crRNA cleavage; when associated with 1048-A--A-1053.
No cleavage of target RNA, retains pre-crRNA cleavage. Still no effect on pre-crRNA cleavage; when associated with 427-A--A-477.
Could be important to modulate the pK values of the two catalytic cysteine residues
tRNA pseudouridylate synthase B C-terminal
Bacterial type II secretion system protein E
Large ribosomal subunit protein bL9 C-terminal
Phosphoadenosine phosphosulphate reductase
HicB-like antitoxin of toxin-antitoxin system
Phosphoribosylformylglycinamidine synthase linker
Inosine/uridine-preferring nucleoside hydrolase
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
1,4-alpha-glucan branching enzyme C-terminal
Glycoside hydrolase family 57 N-terminal
Sel1 domain protein repeat-containing protein
Reversibly protonated during proton transport
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Pseudouridine synthase I TruA alpha/beta
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Cation-transporting P-type ATPase N-terminal
Chromosomal replication initiator DnaA C-terminal
DNA-directed DNA polymerase family A palm
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Helix-hairpin-helix DNA-binding motif class 1
tRNA (guanine-N(1)-)-methyltransferase C-terminal
Gly-cisPro motif, important for rejection of L-amino acids
NIF system FeS cluster assembly NifU N-terminal
Shikimate dehydrogenase substrate binding N-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
ATP-dependent DNA helicase RecG C-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
O-(5'-phospho-DNA)-tyrosine intermediate
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Gp5/Type VI secretion system Vgr protein OB-fold
Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Aconitase A/isopropylmalate dehydratase small subunit swivel
Prokaryotic-type class I peptide chain release factors
Thiamin pyrophosphokinase thiamin-binding
Nitrite/Sulfite reductase ferredoxin-like
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Plays an important role in discriminating NADH against NADPH
Mannose-6-phosphate isomerase type II C-terminal
Glycosyl hydrolase-like 10 domain-containing protein
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation