Major facilitator superfamily (MFS) profile
Peptidase M1 membrane alanine aminopeptidase
Aminoacyl-transfer RNA synthetases class-II family profile
DNA-directed RNA polymerase RpoA/D/Rpb3-type
RND efflux pump membrane fusion protein barrel-sandwich
Proline utilization A proline dehydrogenase N-terminal
Polysaccharide chain length determinant N-terminal
Transcriptional regulator AbiEi antitoxin N-terminal
Survival protein SurE-like phosphatase/nucleotidase
TonB-dependent receptor-like beta-barrel
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
TIGR04219 family outer membrane beta-barrel protein
Important for interaction with partner proteins
RNA binding; important for wobble base 34 recognition
S-adenosyl-L-homocysteine hydrolase NAD binding
Tetrahydrodipicolinate-N-succinyltransferase chain A
Plays an important role in substrate specificity
Outer membrane protein assembly factor BamB
O-(3'-phospho-DNA)-tyrosine intermediate
CD-NTase-associated protein 12/Pycsar effector protein TIR
Outer membrane protein beta-barrel domain-containing protein
Organic solvent tolerance-like N-terminal
Anthranilate synthase component I N-terminal
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
DNA-directed DNA polymerase family A palm
Cytochrome c-type biogenesis protein CcmF C-terminal
Intracellular proteinase inhibitor BsuPI
Intracellular proteinase inhibitor BsuPI domain-containing protein
DNA mismatch repair MutH/Type II restriction enzyme Sau3AI
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
Outer-membrane lipoprotein carrier protein
Cation-transporting P-type ATPase N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Peptide methionine sulphoxide reductase MsrA
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
RNA polymerase sigma factor 70 region 4 type 2
Threonine/serine exporter-like N-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
DNA polymerase III delta subunit C-terminal
Fibronectin type-III domain-containing protein
Translation elongation factor P/YeiP central
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Erythronate-4-phosphate dehydrogenase dimerisation
Carbohydrate-binding domain-containing protein
O-(5'-phospho-DNA)-tyrosine intermediate
Peptidase S9 prolyl oligopeptidase catalytic
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Solute-binding protein family 3/N-terminal
Nitrite/Sulfite reductase ferredoxin-like
Glucose-methanol-choline oxidoreductase C-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Pseudouridine synthase I TruA alpha/beta
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Type II secretion system protein GspG C-terminal
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Regulator of nucleoside diphosphate kinase N-terminal
Transcription elongation factor GreA/GreB C-terminal
Reversibly protonated during proton transport
Important for beta-aspartyl-AMP intermediate formation
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Biopterin-dependent aromatic amino acid hydroxylase family profile
RNA methyltransferase SpoU/TrmH type C-terminal
Bacterial type II secretion system protein E
Positions MEP for the nucleophilic attack
Arginine decarboxylase C-terminal helical
Tryptophan synthase beta chain-like PALP
Helix-hairpin-helix DNA-binding motif class 1
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Bacterial virulence factor lipase N-terminal
Bacterial virulence factor lipase N-terminal domain-containing protein
Penicillin-binding protein transpeptidase
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
DNA replication/recombination mediator RecO N-terminal
Activator of Hsp90 ATPase 1 family protein
Exonuclease VII large subunit C-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Endolytic peptidoglycan transglycosylase RlpA
RNA 2-O ribose methyltransferase substrate binding
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Heat-inducible transcription repressor HrcA C-terminal
Winged helix-turn-helix transcription repressor HrcA DNA-binding
Protein glutaminase domain-containing protein
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Large ribosomal subunit protein uL6 alpha-beta
Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Glyoxalase/fosfomycin resistance/dioxygenase
Type VI secretion system effector, Hcp1 family
Metallo-beta-lactamase domain-containing protein
Prokaryotic-type class I peptide chain release factors
Histidine-specific methyltransferase SAM-dependent
Activator of Hsp90 ATPase homologue 1-like C-terminal
Aspartate/homoserine dehydrogenase NAD-binding
Type 4 fimbrial biogenesis protein PilX N-terminal
Photosynthesis system II assembly factor Ycf48/Hcf136-like
Photosynthesis system II assembly factor Ycf48/Hcf136-like domain-containing protein
Signal transduction histidine kinase internal region
Essential for prephenate dehydratase activity
Outer membrane protein assembly factor BamC
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Cytochrome b561 bacterial/Ni-hydrogenase
NIF system FeS cluster assembly NifU N-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
DNA polymerase III subunit delta C-terminal
Important for substrate binding and specificity
Large ribosomal subunit protein uL15/eL18
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Acyl-CoA dehydrogenase C-terminal bacterial-type
Type II secretion system protein GspI C-terminal
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Interaction with polymerase core subunit RpoC
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Urease accessory protein UreH-like transmembrane
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Transcription elongation factor GreA/GreB N-terminal
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Pyruvate phosphate dikinase AMP/ATP-binding
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Interacts with tRNA; defines subfamily-specific binding signature
Large ribosomal subunit protein uL2 C-terminal
Chromosomal replication initiator DnaA C-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Small ribosomal subunit protein uS4 N-terminal
Membrane fusion protein biotin-lipoyl like
Molybdopterin cofactor biosynthesis C (MoaC)
Na(+)-translocating NADH-quinone reductase subunit A C-terminal
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
UDP N-acetylglucosamine O-acyltransferase C-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
GlyGly-CTERM sorting domain-containing protein
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Outer membrane protein assembly factor BamA
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-108)
Glucose-methanol-choline oxidoreductase N-terminal
Gly-cisPro motif, important for rejection of L-amino acids
Membrane insertase YidC/Oxa/ALB C-terminal
Cysteine sulfenic acid (-SOH) intermediate
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
TRAP C4-dicarboxylate transport system permease DctM subunit
Sodium/calcium exchanger membrane region
Release factor glutamine methyltransferase N-terminal
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Chromosomal replication initiator protein DnaA
Methylguanine DNA methyltransferase ribonuclease-like
NlpE C-terminal OB domain-containing protein
Gamma-butyrobetaine hydroxylase-like N-terminal
Heme-copper oxidase subunit III family profile
Glycosyltransferase subfamily 4-like N-terminal
Glycine cleavage T-protein C-terminal barrel
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Type VI secretion system IcmF C-terminal
Electron transfer via tryptophanyl radical
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Putative adhesin domain-containing protein
Polymerase/histidinol phosphatase N-terminal
Prepilin type IV endopeptidase peptidase
N-end rule aminoacyl transferase C-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
NIF system FeS cluster assembly NifU C-terminal
Saccharopine dehydrogenase-like C-terminal
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
ATP synthase F1 complex delta/epsilon subunit N-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-92)
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Acyl-ester intermediate; for transpeptidase activity
Proton donor; for transglycosylase activity
Disulphide bond isomerase DsbC/G N-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Plays an important role in discriminating NADH against NADPH
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Lysidine-tRNA(Ile) synthetase C-terminal
Lipocalin-like domain-containing protein
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Lytic transglycosylase superhelical linker
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Sulfatase-modifying factor enzyme domain-containing protein
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Outer membrane lipoprotein-sorting protein
NADH:flavin oxidoreductase/NADH oxidase N-terminal
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Sugar fermentation stimulation protein C-terminal
Quercetin 2,3-dioxygenase C-terminal cupin
Outer membrane protein assembly factor BamE
Pyrimidine nucleoside phosphorylase C-terminal
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase
Uroporphyrinogen-III C-methyltransferase
Ribosomal RNA adenine methylase transferase N-terminal
Required for zinc-mediated homotetramerization and catalytic activity
Thymidylate synthase/dCMP hydroxymethylase
Virulence factor membrane-bound polymerase C-terminal
Outer membrane lipoprotein carrier protein LolA
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase C-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase N-terminal
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Homogentisate 1,2-dioxygenase N-terminal
Methyltransferase type 11 domain-containing protein
Type II secretion system protein GspC N-terminal
DNA mismatch repair proteins mutS family