Major facilitator superfamily (MFS) profile
G-protein coupled receptors family 1 profile
TATA box binding protein associated factor (TAF) histone-like fold
Biopterin-dependent aromatic amino acid hydroxylase family profile
Small ribosomal subunit protein uS2 C-terminal
Ionotropic glutamate receptor C-terminal
Ionotropic glutamate receptor L-glutamate and glycine-binding
Sphingolipid delta4-desaturase N-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Translation elongation factor EFTs/EF1B dimerisation
Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term
Interaction with phosphoserine on interacting protein
G-protein coupled receptors family 2 profile 2
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Voltage-dependent calcium channel alpha-1 subunit IQ
Histone deacetylase complex subunit SAP30 Sin3 binding
Histone deacetylase complex subunit SAP30 zinc-finger
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Alpha galactosidase A C-terminal beta-sandwich
CCR4-NOT transcription complex subunit 1
CCR4-NOT transcription complex subunit 1 CAF1-binding
CCR4-NOT transcription complex subunit 1 HEAT repeat
CCR4-NOT transcription complex subunit 1 TTP binding
CCR4-Not complex component Not1 C-terminal
Phosphatidylinositol-specific phospholipase C X
RNA 3'-terminal phosphate cyclase insert
Cytoskeleton-associated protein 2 C-terminal
Tumor necrosis factor receptor superfamily member 11B
Sodium/calcium exchanger membrane region
Vacuolar protein 14 C-terminal Fig4-binding
Nucleolar complex-associated protein 3 N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Ubiquitin-activating enzyme E1 C-terminal
NADH:ubiquinone oxidoreductase intermediate-associated protein 30
Ribosomal RNA methyltransferase SPB1-like C-terminal
Large ribosomal subunit protein uL10-like insertion
Tryptophan synthase beta chain-like PALP
Lipid-binding serum glycoprotein N-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
C4-type zinc-finger of DNA polymerase delta
DNA-directed DNA polymerase family B exonuclease
DNA-directed DNA polymerase family B multifunctional
Endoplasmic reticulum resident protein 29
Endoplasmic reticulum resident protein 29 C-terminal
U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein
Inward rectifier potassium channel C-terminal
Potassium channel inwardly rectifying transmembrane
Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium
Histone RNA hairpin-binding protein RNA-binding
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Phosphatidylserine amidated glycine; alternate
Serine/threonine specific protein phosphatases
Bicarbonate transporter-like transmembrane
Elongation factor 1 beta central acidic region eukaryote
Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange
Mitochondrial cytochrome c oxidase subunit VIc/VIIs
Large ribosomal subunit protein uL15/eL18
Pseudouridine synthase I TruA alpha/beta
Pyrroline-5-carboxylate reductase catalytic N-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
Serine/threonine-protein kinase receptor
Potassium voltage-gated channel subfamily D member 2
Plays an important role in the conformation switch to the active conformation
Neurotransmitter-gated ion-channel ligand-binding
Neurotransmitter-gated ion-channel transmembrane
Dendritic cell-specific transmembrane protein-like
Critical for TLR4-TLR6 dimerization and signaling
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Anaphase-promoting complex subunit 4-like WD40
6-phosphogluconate dehydrogenase C-terminal
Corticotropin-releasing factor receptor 1
G-protein coupled receptors family 2 profile 1
Aminoacyl-transfer RNA synthetases class-II family profile
Pre-rRNA-processing protein RIX1 N-terminal
Non-canonical purine NTP phosphatase/PRRC1
Peptide methionine sulphoxide reductase MsrA
Insulin-like growth factor-binding protein 1
DNA polymerase alpha subunit B N-terminal
DNA polymerase alpha/delta/epsilon subunit B
G-protein coupled receptors family 3 profile
Beta-1,3-galactosyltransferase 2 N-terminal
Cysteine persulfide intermediate; for sulfurtransferase activity
Glycyl thioester intermediate; for adenylyltransferase activity
ER membrane protein complex subunit 7 beta-sandwich
Calcium-activated potassium channel BK alpha subunit
tRNA-splicing endonuclease subunit Sen15
Heme-copper oxidase subunit III family profile
Spermatid maturation protein 1 N-terminal
Vacuolar protein sorting-associated protein 54 C-terminal
Vacuolar protein sorting-associated protein 54 N-terminal
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein
Arginine vasopressin-induced protein 1/transcriptional and immune response regulator
Potassium channel tetramerisation-type BTB
Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
S100/CaBP-9k-type calcium binding subdomain
NADH-rubredoxin oxidoreductase C-terminal
Homologous-pairing protein 2 winged helix
Major intrinsically disordered Notch2-binding receptor 1-like C-terminal
Low-density lipoprotein receptor-related protein
Gamma-butyrobetaine hydroxylase-like N-terminal
Nuclear receptor-interacting protein 1 repression
U2A'/phosphoprotein 32 family A C-terminal
Lipid-binding serum glycoprotein C-terminal
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Signal recognition particle SRP72 subunit RNA-binding
Glycine cleavage T-protein C-terminal barrel
Phosphomannose isomerase type I C-terminal
Phosphomannose isomerase type I catalytic
Phosphomannose isomerase type I helical insertion
Microsomal triglyceride transfer protein large subunit
Transcriptional coactivator p15 (PC4) C-terminal
Glycosyl-hydrolase family 116 N-terminal
Glycosyl-hydrolase family 116 catalytic region
Important for autoinhibition of adenylyltransferase activity
26S proteasome non-ATPase regulatory subunit RPN1 C-terminal
Translocon-associated protein subunit delta
Alpha-2-macroglobulin receptor-associated protein
Potassium channel inwardly rectifying Kir N-terminal
Dynein regulatory complex protein 1/2 N-terminal
Chromosome segregation protein Spc25 C-terminal
DET1- and DDB1-associated protein 1 N-terminal
CBF1-interacting co-repressor CIR N-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)
Interferon regulatory factor 2-binding protein 1 & 2 zinc finger
Release factor glutamine methyltransferase N-terminal
Glycosyltransferase subfamily 4-like N-terminal
RNA-polymerase II-associated protein 3-like C-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Nicotinamide phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Janus kinase and microtubule-interacting protein C-terminal
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
receptor protein serine/threonine kinase
Protein phosphatase 1 regulatory subunit 21 N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Cysteine/serine-rich nuclear protein N-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Platelet-derived growth factor receptor-like protein
Transcription factor CBF/NF-Y/archaeal histone
Histone deacetylase glutamine rich N-terminal
Histone-binding protein RBBP4 N-terminal
Hyaluronan-mediated motility receptor C-terminal
Exocyst complex component EXOC2/Sec5 N-terminal
tRNA-splicing endonuclease subunit Sen54 N-terminal
Essential for stabilizing binding to COTL1
HAUS augmin-like complex subunit 3 N-terminal
Gamma-aminobutyric acid receptor subunit gamma-2
Vacuolar protein sorting-associated protein 13 DH-like
Vacuolar protein sorting-associated protein 13 VPS13 adaptor binding
ER membrane protein complex subunit 1 C-terminal
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal
RNase L inhibitor RLI-like possible metal-binding
Pentacotripeptide-repeat region of PRORP
Tartrate-resistant acid phosphatase type 5
Sodium/hydrogen exchanger regulatory region
Gamma-aminobutyric acid receptor subunit alpha-1
Activator of Hsp90 ATPase AHSA1-like N-terminal
Transducer of regulated CREB activity C-terminal
Transducer of regulated CREB activity N-terminal
Transducer of regulated CREB activity middle
Clathrin/coatomer adaptor adaptin-like N-terminal
Coatomer beta subunit appendage platform
For hydroxyacyl-coenzyme A dehydrogenase activity
Important for hydroxyacyl-coenzyme A dehydrogenase activity
Important for long-chain enoyl-CoA hydratase activity
CCR4-Not complex component Not N-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Neurogenic locus notch homolog protein 1
Small ribosomal subunit protein uS17 N-terminal
Ribosomal RNA-processing protein 7 C-terminal
Cationic amino acid transporter C-terminal
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
Sodium:neurotransmitter symporter serotonin N-terminal
Deubiquitinating enzyme MINDY-3/4 conserved
Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain
Corticotropin-releasing factor-binding protein
Schwannomin interacting protein 1 C-terminal
Ribosome maturation protein SDO1/SBDS C-terminal
Ribosome maturation protein SDO1/SBDS N-terminal
Ribosome maturation protein SDO1/SBDS central
Pre-mRNA processing factor 4 (PRP4)-like
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
T-cell surface glycoprotein CD3 gamma chain
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Nicotinate phosphoribosyltransferase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Interferon-related developmental regulator C-terminal
Interferon-related developmental regulator N-terminal
DNA endonuclease activator Ctp1 C-terminal
Beta-adaptin appendage C-terminal subdomain
GPI ethanolamine phosphate transferase 2 C-terminal
Large ribosomal subunit protein uL6 N-terminal
Cation-transporting P-type ATPase N-terminal
Carnitine O-palmitoyltransferase N-terminal
High affinity immunoglobulin epsilon receptor subunit gamma
Intercellular adhesion molecule N-terminal
Ubiquitin carboxyl-terminal hydrolase family 1 cysteine active-site
DNA-directed RNA polymerase RBP11-like dimerisation
Gamma tubulin complex component C-terminal
Gamma tubulin complex component protein N-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Peptidase M1 membrane alanine aminopeptidase
TATA-binding protein interacting (TIP20)
Glucose-methanol-choline oxidoreductase N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Bridge-like lipid transfer protein family member 1 C-terminal
18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23 C-terminal
Prokaryotic-type class I peptide chain release factors
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
MHC class I-like antigen recognition-like
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
FGFR1 oncogene partner (FOP) N-terminal dimerisation
Protein inscuteable homologue C-terminal
Protein inscuteable homologue LGN-binding
Insulin-like growth factor-binding protein 4
FXYD domain-containing ion transport regulator
Vacuolar protein sorting-associated protein 13 extended chorein
Neutral/alkaline non-lysosomal ceramidase C-terminal
Neutral/alkaline non-lysosomal ceramidase N-terminal
3-beta hydroxysteroid dehydrogenase/isomerase
Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central
Alpha-ketoglutarate-dependent dioxygenase FTO catalytic
Immediate early response 3-interacting protein 1
Platelet-derived growth factor (PDGF) family profile
Exocyst complex component Sec8 N-terminal
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter C-terminal
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter N-terminal
Pro-opiomelanocortin/corticotropin ACTH central region
Histone deacetylase complex subunit SAP130 C-terminal
Large ribosomal subunit protein uL23 N-terminal
Bactericidal permeability-increasing protein
Glucosamine/galactosamine-6-phosphate isomerase
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity
Interaction with galactose moiety of substrate glycoprotein
Cation channel complex component UNC80 N-terminal
NF-kappa-B-activating protein C-terminal
Transcription factor IIIC subunit Tfc1/Sfc1 triple barrel
Eukaryotic glycogen debranching enzyme N-terminal
Glycogen debranching enzyme glucanotransferase
Polyribonucleotide 5'-hydroxyl-kinase Clp1 P-loop
Pre-mRNA cleavage complex subunit Clp1 C-terminal
Helix-hairpin-helix DNA-binding motif class 1
GDP-fucose protein O-fucosyltransferase 1
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Protein-arginine deiminase (PAD) N-terminal
Protein-arginine deiminase (PAD) central
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Small ribosomal subunit protein uS15 N-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
N-acetylglucosaminylphosphatidylinositol deacetylase
Nucleoporin Nup133/Nup155-like C-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
DNA replication complex GINS protein SLD5 C-terminal
Transcription initiation factor TFIID subunit 12
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
SNARE-complex protein Syntaxin-18 N-terminal
NPC intracellular cholesterol transporter 2
Ribosomal RNA adenine methylase transferase N-terminal
Exocyst complex subunit Exo70 C-terminal
GDP-fucose protein O-fucosyltransferase 2
Peptidase S9 prolyl oligopeptidase catalytic
Large ribosomal subunit protein uL30 N-terminal eukaryotes
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Resistance to inhibitors of cholinesterase protein 3 N-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Insulin-like growth factor-binding protein 5
Centriolar and ciliogenesis-associated protein HYLS1 C-terminal
Zinc finger protein 750-like zinc finger
Harmonin-binding protein USHBP1 PDZ-binding
Dolichol-phosphate mannosyltransferase subunit 3
Interaction with APS and STAT5, and activation
Pyrroline-5-carboxylate reductase dimerisation
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate
Formiminotransferase C-terminal subdomain
Formiminotransferase N-terminal subdomain
NADH:ubiquinone oxidoreductase chain 4 N-terminal
Phosphorylase b kinase regulatory subunit alpha/beta C-terminal
SAPK-interacting protein 1 Pleckstrin-homology
Tetratricopeptide repeat protein 5 OB fold
Origin recognition complex subunit 5 C-terminal
Cleavage/polyadenylation specificity factor A subunit C-terminal
Cleavage/polyadenylation specificity factor A subunit N-terminal
BMP and activin membrane-bound inhibitor C-terminal
BMP and activin membrane-bound inhibitor N-terminal
BMP and activin membrane-bound inhibitor homolog
Enhancer of mRNA-decapping protein 4 WD40 repeat region
GPI ethanolamine phosphate transferase 1 C-terminal
Cleavage stimulation factor subunit 1 dimerisation
YbaK/aminoacyl-tRNA synthetase-associated
Mon2/Sec7/BIG1-like dimerisation and cyclophilin-binding
DNA-directed RNA polymerase subunit 2 hybrid-binding
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Telomerase activating protein Est1-like N-terminal
Multiple myeloma tumor-associated protein 2-like N-terminal
Voltage-gated Na+ ion channel cytoplasmic
Translation elongation factor IF5A C-terminal
Alpha-N-acetylglucosaminidase C-terminal
Alpha-N-acetylglucosaminidase N-terminal
Alpha-N-acetylglucosaminidase tim-barrel
Important for obstruction of the ion pore in the closed conformation
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
NIF system FeS cluster assembly NifU N-terminal
RNA 2-O ribose methyltransferase substrate binding
Histone-arginine methyltransferase CARM1 N-terminal
Cyclic nucleotide phosphodiesterase catalytic
Acylamino-acid-releasing enzyme N-terminal
May act as a substrate filter by repelling compounds with a negatively charged alpha-carboxylate
WD repeat-containing protein 18 C-terminal
Large ribosomal subunit protein uL2 C-terminal
Domain of unknown function with conserved HDNR motif
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Glycoside hydrolase family 31 N-terminal
Gamma-tubulin complex component 6 N-terminal
Centrosomal protein Cep63/Deup1 N-terminal
Endoplasmic reticulum vesicle transporter C-terminal
Endoplasmic reticulum vesicle transporter N-terminal
N-sulphoglucosamine sulphohydrolase C-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
DDB1- and CUL4-associated factor 15 WD40 repeat-containing
E3 ubiquitin-protein ligase Arkadia N-terminal
GATOR complex protein MIO zinc-ribbon like
Nuclear respiratory factor 1 NLS/DNA-binding dimerisation
Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal
Granulocyte-macrophage colony-stimulating factor
UDP-glucuronate decarboxylase N-terminal
Inositol polyphosphate-related phosphatase
Myo-inositol-1-phosphate synthase GAPDH-like
NADH:ubiquinone oxidoreductase 30kDa subunit
Activity-regulated cytoskeleton-associated protein C-terminal
Activity-regulated cytoskeleton-associated protein N-terminal
Cell division control protein 73 C-terminal
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Aspartate/homoserine dehydrogenase NAD-binding
Spermatogenesis-associated protein 6 N-terminal
A-kinase anchor protein 7 RI-RII subunit-binding
Post-GPI attachment to proteins factor 3
RNA polymerase subunit H/Rpb5 C-terminal
Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase
BAAT/Acyl-CoA thioester hydrolase C-terminal
Transmembrane protein 127 transmembrane region
Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal
Rad21/Rec8-like protein C-terminal eukaryotic
RNA binding; important for wobble base 34 recognition
Cocaine- and amphetamine-regulated transcript protein
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
U3 small nucleolar RNA-associated protein 13 C-terminal