RND efflux pump membrane fusion protein barrel-sandwich
Interacts with tRNA; defines subfamily-specific binding signature
Major facilitator superfamily (MFS) profile
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Penicillin-binding protein transpeptidase
Flagellar hook-length control protein-like C-terminal
Peptide methionine sulphoxide reductase MsrA
Malonate/sodium symporter MadM subunit N-terminal
Disulphide bond isomerase DsbC/G N-terminal
TonB-dependent receptor-like beta-barrel
Bacterial type II secretion system protein E
Ribosomal RNA adenine methylase transferase N-terminal
Bacterial transcription activator effector binding
Type III secretion system flagellar brake protein YcgR PilZN
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Lysozyme inhibitor LprI N-terminal domain-containing protein
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Type II secretion system protein GspG C-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
ABC-type glycine betaine transport system substrate-binding
RNA polymerase sigma factor 70 region 4 type 2
High-affinity branched-chain amino acid transport system permease LivHM N-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
For 3-hydroxyacyl-CoA dehydrogenase activity
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Gamma-butyrobetaine hydroxylase-like N-terminal
Guanylate kinase/L-type calcium channel beta subunit
Membrane fusion protein biotin-lipoyl like
Aminoacyl-transfer RNA synthetases class-II family profile
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase C-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase N-terminal
Glucose-methanol-choline oxidoreductase N-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Polymerase/histidinol phosphatase N-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
CD-NTase associated protein 4-like DNA endonuclease
Flagellar motor switch protein FliN-like C-terminal
Tryptophan synthase beta chain-like PALP
Lipoprotein YgdI/YgdR-like SH3-like domain-containing protein
Quercetin 2,3-dioxygenase C-terminal cupin
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Solute-binding protein family 3/N-terminal
Glucosamine/galactosamine-6-phosphate isomerase
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Inner membrane protein YgaP-like transmembrane
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Putative Flp pilus-assembly TadG-like N-terminal
Glutamate synthase alpha subunit C-terminal
Mannose-6-phosphate isomerase type II C-terminal
Lytic transglycosylase superhelical linker
Poly-beta-hydroxybutyrate polymerase N-terminal
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Glycosyltransferase subfamily 4-like N-terminal
Integral membrane protein YccS N-terminal
Putative beta-barrel assembly-enhancing protease
Endoribonuclease L-PSP/chorismate mutase-like
Ionotropic glutamate receptor C-terminal
Gp5/Type VI secretion system Vgr protein OB-fold
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Glucose-methanol-choline oxidoreductase C-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Thymidylate synthase/dCMP hydroxymethylase
Alkaline proteinase inhibitor/ Outer membrane lipoprotein Omp19
Required for dimer formation and molybdate binding
Water stress and hypersensitive response
Large ribosomal subunit protein uL15/eL18
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
DNA polymerase III subunit delta C-terminal
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
Organic solvent tolerance-like N-terminal
Important for interaction with partner proteins
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Cation-transporting P-type ATPase N-terminal
Glucan biosynthesis periplasmic MdoG C-terminal
Translation elongation factor P/YeiP central
Electron transfer via tryptophanyl radical
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Twin-arginine translocation pathway signal protein
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
O-(phosphoribosyl dephospho-coenzyme A)serine
Periplasmic binding protein/LacI sugar binding
The binding site for the sugar molecule has not yet been established, but C-87 may be involved
Nitrile hydratase alpha /Thiocyanate hydrolase gamma
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Plays an important role in discriminating NADH against NADPH
Shikimate dehydrogenase substrate binding N-terminal
ABC-type transport auxiliary lipoprotein component
Endolytic peptidoglycan transglycosylase RlpA
RlpA-like protein double-psi beta-barrel
Interaction with polymerase core subunit RpoC
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Translocation and assembly module subunit TamA
Flagella basal body P-ring formation protein FlgA
Important for substrate binding and specificity
Flagellar assembly protein FliH/Type III secretion system HrpE
Peptidase S9 prolyl oligopeptidase catalytic
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Biopterin-dependent aromatic amino acid hydroxylase family profile
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Signal transduction histidine kinase internal region
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
6-hydroxymethylpterin diphosphokinase MptE-like
Cytochrome b561 bacterial/Ni-hydrogenase
Outer membrane assembly lipoprotein YfiO
Beta-barrel assembly machine subunit BamE
Styrene monooxygenase StyA putative substrate binding
N6 adenine-specific DNA methyltransferase N-terminal
Pyruvate dehydrogenase E1 component middle
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
Mechanosensitive ion channel inner membrane
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Urease accessory protein UreH-like transmembrane
Chromosomal replication initiator DnaA C-terminal
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Ribose-phosphate pyrophosphokinase N-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Chromosomal replication initiator protein DnaA
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Lysidine-tRNA(Ile) synthetase C-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase
Uroporphyrinogen-III C-methyltransferase
Proline utilization A proline dehydrogenase N-terminal
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Prepilin type IV endopeptidase peptidase
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
YbaK/aminoacyl-tRNA synthetase-associated
Photosynthesis system II assembly factor Ycf48/Hcf136-like
Photosynthesis system II assembly factor Ycf48/Hcf136-like domain-containing protein
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Essential for prephenate dehydratase activity
Alginate biosynthesis protein AlgX C-terminal carbohydrate-binding module
Ribosomal RNA small subunit methyltransferase E methyltransferase
Positions MEP for the nucleophilic attack
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Type VI secretion system IcmF C-terminal
4'-phosphopantetheinyl transferase N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
Large ribosomal subunit protein uL2 C-terminal
Anthranilate synthase component I N-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
NAD(P) transhydrogenase alpha subunit C-terminal
Heme-copper oxidase subunit III family profile
Plays an important role in substrate specificity
Glycine cleavage T-protein C-terminal barrel
Pyruvate phosphate dikinase AMP/ATP-binding
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Adaptive response protein AidB N-terminal
FAD-dependent cmnm(5)s(2)U34 oxidoreductase
Prokaryotic-type class I peptide chain release factors
DNA-directed DNA polymerase family A palm
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Tetratricopeptide repeat-containing protein
Large ribosomal subunit protein uL30-like ferredoxin-like fold
NIF system FeS cluster assembly NifU C-terminal
Transposase IS204/IS1001/IS1096/IS1165 DDE
Phosphocysteine intermediate; for EIIB activity
Probable periplasmic serine endoprotease DegP-like
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Calcium/calmodulin-dependent protein kinase II association-domain
Calcium/calmodulin-dependent protein kinase II association-domain domain-containing protein
Antitoxin Xre/MbcA/ParS-like toxin-binding
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Terminase large subunit gp17-like C-terminal
N-end rule aminoacyl transferase C-terminal
Sodium/calcium exchanger membrane region
Carbamoyl-phosphate synthase small subunit N-terminal
Ion-translocating oxidoreductase complex subunit G
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
O-(3'-phospho-DNA)-tyrosine intermediate
Could be important to modulate the pK values of the two catalytic cysteine residues
Mandelate racemase/muconate lactonizing enzyme C-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Glycosyl transferase family 3 N-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Putative regulatory protein FmdB Zinc ribbon
NADH:ubiquinone oxidoreductase 30kDa subunit
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Anti-bacteriophage protein A/HamA C-terminal
Putative conjugal transfer nickase/helicase TraI C-terminal
Arginine decarboxylase C-terminal helical
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Aconitase A/isopropylmalate dehydratase small subunit swivel
Holliday junction resolvasome, helicase subunit
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Membrane insertase YidC/Oxa/ALB C-terminal
DNA-binding beta-propeller fold protein YncE
Transglycosylase SLT domain-containing protein
Alanyl-transfer RNA synthetases family profile
O-(5'-phospho-DNA)-tyrosine intermediate
Polysaccharide biosynthesis protein CapD-like
DNA polymerase III delta subunit C-terminal
Penicillin-binding protein activator LpoB
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Cob(I)alamin adenosyltransferase N-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Alginate export domain-containing protein
Molybdenum cofactor biosynthesis protein F N-terminal
Survival protein SurE-like phosphatase/nucleotidase
Inosine/uridine-preferring nucleoside hydrolase
Methylene-tetrahydrofolate reductase C-terminal
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
RNA 2-O ribose methyltransferase substrate binding
6-phosphogluconate dehydrogenase C-terminal
Exonuclease VII large subunit C-terminal
Outer membrane protein assembly factor BamA
Cysteine sulfenic acid (-SOH) intermediate
TRAP C4-dicarboxylate transport system permease DctM subunit
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Large ribosomal subunit protein uL6 alpha-beta
Alpha-D-phosphohexomutase alpha/beta/alpha
Nitrite/Sulfite reductase ferredoxin-like
Important for beta-aspartyl-AMP intermediate formation
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
DNA-binding and helicase activity, interacts with RecC
Nuclease activity, interacts with RecD and RecA
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Membrane-bound lytic murein transglycosylase A
Sugar fermentation stimulation protein C-terminal
Protein activator of alkane oxidation PraB
Gly-cisPro motif, important for rejection of L-amino acids
NIF system FeS cluster assembly NifU N-terminal
Glutathionylspermidine synthase pre-ATP-grasp-like
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Sporulation stage II protein D amidase enhancer LytB N-terminal
DNA replication/recombination mediator RecO N-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Serine aminopeptidase S33 domain-containing protein
Small ribosomal subunit protein uS4 N-terminal
Peptidase M61 catalytic domain-containing protein
Beta-barrel assembly machine subunit BamC
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Isocitrate dehydrogenase kinase/phosphatase (AceK) kinase
Isocitrate dehydrogenase kinase/phosphatase (AceK) regulatory
Proton acceptor; for decarboxylase activity
Proton donor; for decarboxylase activity
Proton donor; for formyltransferase activity
Reversibly protonated during proton transport
Lipopolysaccharide export system protein LptA
S-adenosylmethionine-dependent methyltransferase
S-adenosyl-L-homocysteine hydrolase NAD binding
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Cytochrome c-type biogenesis protein CcmF C-terminal
Phosphatidylglycerol lysyltransferase C-terminal
Erythronate-4-phosphate dehydrogenase dimerisation
Phosphatidic acid phosphatase type 2/haloperoxidase
Helix-hairpin-helix DNA-binding motif class 1
5-glutamyl coenzyme A thioester intermediate
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
Seems to be a necessary countercharge to the potassium cations
Molybdopterin cofactor biosynthesis C (MoaC)
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
DNA topoisomerase I catalytic core eukaryotic-type
7 transmembrane helices usually fused to an inactive transglutaminase
Inactive transglutaminase fused to 7 transmembrane helices
DNA-directed RNA polymerase RpoA/D/Rpb3-type
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Outer membrane lipoprotein-sorting protein
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
HicB-like antitoxin of toxin-antitoxin system
Type I restriction modification DNA specificity
N-sulphoglucosamine sulphohydrolase C-terminal
Phospholipid-binding protein, PBP family
Outer-membrane lipoprotein carrier protein
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
UDP N-acetylglucosamine O-acyltransferase C-terminal
Glycoside hydrolase family 42 N-terminal
Regulator of nucleoside diphosphate kinase N-terminal