Glucosamine/galactosamine-6-phosphate isomerase
Aminoacyl-transfer RNA synthetases class-II family profile
Major facilitator superfamily (MFS) profile
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Large ribosomal subunit protein uL6 alpha-beta
PHA accumulation regulator DNA-binding N-terminal
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Prokaryotic-type class I peptide chain release factors
Outer membrane protein assembly factor BamD
Tryptophan synthase beta chain-like PALP
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
TonB-dependent receptor-like beta-barrel
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Alanyl-transfer RNA synthetases family profile
Alpha-glutamyl/putrescinyl thymine pyrophosphorylase clade 3
Polysaccharide biosynthesis protein C-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
DNA mismatch repair proteins mutS family
N6 adenine-specific DNA methyltransferase N-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Thiol:disulfide interchange protein DsbD N-terminal
Glycosyltransferase subfamily 4-like N-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Important for beta-aspartyl-AMP intermediate formation
Peptidase S9 prolyl oligopeptidase catalytic
Transition state stabilizer; via amide nitrogen
Cysteine sulfenic acid (-SOH) intermediate
Phosphatidate phosphatase APP1 catalytic
Chromosomal replication initiator DnaA C-terminal
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Nitrite/Sulfite reductase ferredoxin-like
Cobaltochelatase subunit CobS N-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
2-oxoisovalerate dehydrogenase E1 alpha subunit N-terminal
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
NAD(P) transhydrogenase alpha subunit C-terminal
Penicillin-binding protein transpeptidase
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Resolvase/invertase-type recombinase catalytic
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Heat-inducible transcription repressor HrcA C-terminal
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Tail specific protease domain-containing protein
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
Membrane fusion protein biotin-lipoyl like
C-type lysozyme inhibitor domain-containing protein
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Outer membrane protein beta-barrel domain-containing protein
Carbamoyl-phosphate synthase small subunit N-terminal
peptide-methionine (R)-S-oxide reductase
Biopterin-dependent aromatic amino acid hydroxylase family profile
Plays an important role in substrate specificity
Phosphoadenosine phosphosulphate reductase
Large ribosomal subunit protein uL15/eL18
Molybdopterin cofactor biosynthesis C (MoaC)
Quercetin 2,3-dioxygenase C-terminal cupin
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
RNA binding; important for wobble base 34 recognition
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Positions MEP for the nucleophilic attack
S-adenosylmethionine-dependent methyltransferase
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Anthranilate synthase component I N-terminal
Electron transfer via tryptophanyl radical
Trimeric autotransporter adhesin YadA-like C-terminal membrane anchor
Thymidylate synthase/dCMP hydroxymethylase
Essential for prephenate dehydratase activity
Carboxypeptidase regulatory-like domain-containing protein
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Exonuclease VII large subunit C-terminal
Outer membrane protein assembly factor BamA
Interaction with polymerase core subunit RpoC
Polysaccharide chain length determinant N-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Pseudouridine synthase I TruA alpha/beta
Mandelate racemase/muconate lactonizing enzyme C-terminal
SUF system FeS cluster assembly SufBD N-terminal
Protein O-mannosyl-transferase C-terminal four TM
Transferrin-binding protein B C-lobe/N-lobe beta barrel domain-containing protein
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Cytochrome c-type biogenesis protein CcmF C-terminal
Ribonucleotide reductase large subunit C-terminal
Ribonucleotide reductase large subunit N-terminal
Signal recognition particle SRP54 helical bundle
RND efflux pump membrane fusion protein barrel-sandwich
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Heme-copper oxidase subunit III family profile
tRNA pseudouridylate synthase B C-terminal
Translation elongation factor P/YeiP central
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding
Glycosyl transferase family 3 N-terminal
Required for zinc-mediated homotetramerization and catalytic activity
Membrane insertase YidC/Oxa/ALB C-terminal
Bacterial type II secretion system protein E
Peptide methionine sulfoxide reductase MsrA
Peptide methionine sulphoxide reductase MsrA
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
General stress protein FMN-binding split barrel
O-(3'-phospho-DNA)-tyrosine intermediate
Phosphoribosylformylglycinamidine synthase linker
Proline utilization A proline dehydrogenase N-terminal
Poly-beta-hydroxybutyrate polymerase N-terminal
Helix-hairpin-helix DNA-binding motif class 1
Microcystin LR degradation protein MlrC C-terminal
Microcystin LR degradation protein MlrC N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Prepilin type IV endopeptidase peptidase
Sodium/calcium exchanger membrane region
Amidohydrolase-related domain-containing protein
Small ribosomal subunit protein uS4 N-terminal
Bacterial DNA polymerase III alpha subunit NTPase
DNA polymerase helix-hairpin-helix motif
ATP synthase F1 complex delta/epsilon subunit N-terminal
Type I restriction modification DNA specificity
RNA polymerase sigma factor 70 region 4 type 2
Could be important to modulate the pK values of the two catalytic cysteine residues
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
Ribose-phosphate pyrophosphokinase N-terminal
RNA 2-O ribose methyltransferase substrate binding
Shikimate dehydrogenase substrate binding N-terminal
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein
PhoD-like phosphatase metallophosphatase
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Proton acceptor; for glutaminase activity
Polymerase/histidinol phosphatase N-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Sodium symporter small subunit predicted
Signal transduction histidine kinase dimerisation/phosphoacceptor
Aconitase A/isopropylmalate dehydratase small subunit swivel
Histidine-specific methyltransferase SAM-dependent
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
S-adenosyl-L-homocysteine hydrolase NAD binding
Terminase large subunit gp17-like C-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Important for interaction with partner proteins
Pyridoxamine 5'-phosphate oxidase putative
N-end rule aminoacyl transferase C-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Reversibly protonated during proton transport
DNA replication/recombination mediator RecO N-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Fungal lipase-like domain-containing protein
Outer membrane lipoprotein-sorting protein
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Schiff-base intermediate with substrate; via pyruvic acid
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Methionyl-tRNA synthetase anticodon-binding
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Signal transduction histidine kinase internal region
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Superoxide dismutase copper/zinc binding
Glycine cleavage T-protein C-terminal barrel
Cytochrome b561 bacterial/Ni-hydrogenase
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
NADH:ubiquinone oxidoreductase chain 4 N-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Nucleophile; cysteine thiosulfonate intermediate
DNA topoisomerase I catalytic core eukaryotic-type
Solute-binding protein family 5 domain-containing protein
DNA-directed DNA polymerase family A palm
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
TRAP C4-dicarboxylate transport system permease DctM subunit
TonB C-terminal domain-containing protein
Survival protein SurE-like phosphatase/nucleotidase
Beta-lactamase hydrolase-like protein phosphatase-like
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-99)
Beta-barrel assembly machine subunit BamF
Ribosomal RNA adenine methylase transferase N-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
CagE TrbE VirB component of type IV transporter system central
Histidine phosphotransferase ChpT C-terminal
Large ribosomal subunit protein uL2 C-terminal
Tetrahydrodipicolinate-N-succinyltransferase chain A
Chromosomal replication initiator protein DnaA
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
PEP-CTERM protein-sorting domain-containing protein
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
Release factor glutamine methyltransferase N-terminal
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase