Large ribosomal subunit protein uL6 alpha-beta
PEP-CTERM protein-sorting domain-containing protein
Acetylserotonin O-methyltransferase dimerisation
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
S-adenosyl-L-homocysteine hydrolase NAD binding
Glycosyltransferase subfamily 4-like N-terminal
Large ribosomal subunit protein uL2 C-terminal
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
CobB/CobQ-like glutamine amidotransferase
ADP-ribosylarginine; by dinitrogenase reductase ADP-ribosyltransferase
Polypeptide-transport-associated ShlB-type
Heme-copper oxidase subunit III family profile
Electron transfer via tryptophanyl radical
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Anthranilate synthase component I N-terminal
Choice-of-anchor D domain-containing protein
HicB-like antitoxin of toxin-antitoxin system
CD-NTase associated protein 4-like DNA endonuclease
Mandelate racemase/muconate lactonizing enzyme C-terminal
Major facilitator superfamily (MFS) profile
Putative glycogen debranching enzyme N-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Penicillin-binding protein transpeptidase
Alpha-D-phosphohexomutase alpha/beta/alpha
Aminoacyl-transfer RNA synthetases class-II family profile
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Na+-translocating membrane potential-generating system MpsC
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
O-(5'-phospho-DNA)-tyrosine intermediate
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
RNA polymerase sigma factor 70 region 4 type 2
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
DNA primase/polymerase bifunctional N-terminal
Magnesium-protoporphyrin IX methyltransferase C-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Bacterial type II secretion system protein E
Type II secretion system protein GspE N-terminal
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
PEP-CTERM sorting domain-containing protein
Phosphatidic acid phosphatase type 2/haloperoxidase
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Cytochrome b561 bacterial/Ni-hydrogenase
Cation-transporting P-type ATPase N-terminal
Terminase large subunit gp17-like C-terminal
Resolvase/invertase-type recombinase catalytic
Bacterial bifunctional deaminase-reductase C-terminal
Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS
Probable transposase IS891/IS1136/IS1341
Transposase IS204/IS1001/IS1096/IS1165 DDE
Transposase IS204/IS1001/IS1096/IS1165 zinc-finger
Cytochrome b/b6 N-terminal region profile
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Could be important to modulate the pK values of the two catalytic cysteine residues
Membrane fusion protein biotin-lipoyl like
RND efflux pump membrane fusion protein barrel-sandwich
Photosystem I reaction center subunit III
Peptide methionine sulphoxide reductase MsrA
Beta-lactamase hydrolase-like protein phosphatase-like
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Photosystem II cytochrome b559 N-terminal
Opioid growth factor receptor (OGFr) conserved
Sporulation stage II protein D amidase enhancer LytB N-terminal
Shikimate dehydrogenase substrate binding N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Sulfatase-modifying factor enzyme domain-containing protein
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Antitoxin Xre/MbcA/ParS-like toxin-binding
Ribulose bisphosphate carboxylase large subunit C-terminal
Ribulose bisphosphate carboxylase large subunit ferrodoxin-like N-terminal
Glycosyl transferase family 28 C-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Involved in allosteric activation by GTP
Damage-control phosphatase ARMT1-like metal-binding
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Polymerase/histidinol phosphatase N-terminal
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Tryptophan synthase beta chain-like PALP
Magnesium chelatase subunit H N-terminal
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Glucosamine/galactosamine-6-phosphate isomerase
Signal transduction histidine kinase osmosensitive K+ channel sensor N-terminal
Glycosyl transferase family 3 N-terminal
Glycosyltransferase family 28 N-terminal
Positions MEP for the nucleophilic attack
N,N-dimethylformamidase beta subunit-like C-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Peptidase S9 prolyl oligopeptidase catalytic
LPXTG-motif cell wall anchor domain protein
NADH:ubiquinone oxidoreductase 30kDa subunit
Pyruvate phosphate dikinase AMP/ATP-binding
Prepilin type IV endopeptidase peptidase
Carbamoyl-phosphate synthase small subunit N-terminal
RNA-binding protein Tab2-like N-terminal
RNA-binding protein Tab2/Atab2 C-terminal
Solute-binding protein family 3/N-terminal
Nitrite/Sulfite reductase ferredoxin-like
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
SUF system FeS cluster assembly SufBD N-terminal
RNA 2-O ribose methyltransferase substrate binding
Type I restriction modification DNA specificity
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Ribosomal RNA adenine methylase transferase N-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase C-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase N-terminal
Histidine-specific methyltransferase SAM-dependent
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Diacylglycerol glucosyltransferase N-terminal
Polysaccharide chain length determinant N-terminal
Helix-hairpin-helix DNA-binding motif class 1
Plastid lipid-associated protein/fibrillin conserved
Phosphoribosylformylglycinamidine synthase linker
N6 adenine-specific DNA methyltransferase N-terminal
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Important for catalytic activity and assists the phosphoryl transfer reaction to Asp8 by balancing charge and orienting the reacting groups
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Homogentisate 1,2-dioxygenase N-terminal
NIF system FeS cluster assembly NifU C-terminal
NIF system FeS cluster assembly NifU N-terminal
Molybdopterin cofactor biosynthesis C (MoaC)
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
DNA replication/recombination mediator RecO N-terminal
Cyanobacterial aminoacyl-tRNA synthetase CAAD
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Type IV secretion system coupling protein TraD DNA-binding
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Sodium/calcium exchanger membrane region
Inward rectifier potassium channel C-terminal
CRISPR-associated protein Cas6 C-terminal
Glycine cleavage T-protein C-terminal barrel
RNA binding; important for wobble base 34 recognition
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Proton acceptor; for glutaminase activity
ATP synthase F1 complex delta/epsilon subunit N-terminal
Gp5/Type VI secretion system Vgr protein OB-fold
Quercetin 2,3-dioxygenase C-terminal cupin
Dinitrogenase iron-molybdenum cofactor biosynthesis
Homocysteine biosynthesis enzyme sulfur-incorporation
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Photosystem I PsaL reaction centre subunit XI
Photosystem II manganese-stabilizing polypeptide
Choloylglycine hydrolase/NAAA C-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
NAD(P)H-quinone oxidoreductase subunit 2 N-terminal
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Glycogen debranching enzyme bacterial and archaeal type N-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
CRISPR-associated protein Cmr2 N-terminal
Alanyl-transfer RNA synthetases family profile
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Thymidylate synthase/dCMP hydroxymethylase
Glycoside hydrolase family 57 N-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Important for substrate specificity; cannot use PPi as phosphoryl donor
Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding
Abortive infection protein-like C-terminal
Contractile injection system tube protein N-terminal
Interaction with polymerase core subunit RpoC
Glycine-zipper-containing OmpA-like membrane
UDP N-acetylglucosamine O-acyltransferase C-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Ribulose bisphosphate carboxylase small subunit
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Schiff-base intermediate with acetaldehyde
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
NADH:ubiquinone oxidoreductase chain 4 N-terminal
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Transglycosylase SLT domain-containing protein
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
NADH:ubiquinone oxidoreductase-like 20kDa subunit
SAM-dependent methyltransferase TRM5/TYW2-type
Could play a key role in the communication between the regulatory and the substrate sites
Survival protein SurE-like phosphatase/nucleotidase
Cysteine sulfenic acid (-SOH) intermediate
Gly-cisPro motif, important for rejection of L-amino acids
Ferrous iron transport protein B C-terminal
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
NADH:ubiquinone oxidoreductase intermediate-associated protein 30
Restriction endonuclease type I HsdR N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Arsenosugar biosynthesis radical SAM protein ArsS-like C-terminal
ssDNA thymidine ADP-ribosyltransferase DarT
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
NADH:ubiquinone/plastoquinone oxidoreductase chloroplast chain 5 C-terminal
Methionyl-tRNA synthetase anticodon-binding
Large ribosomal subunit protein uL15/eL18
NAD(P) transhydrogenase alpha subunit C-terminal
DNA-directed DNA polymerase family A palm
Nitrogenase molybdenum-iron protein beta chain N-terminal
Coenzyme F420 hydrogenase/dehydrogenase beta subunit C-terminal
Coenzyme F420 hydrogenase/dehydrogenase beta subunit N-terminal
Rubisco accumulation factor 1 C-terminal
Rubisco accumulation factor 1 alpha helical
Rubisco accumulation factor 1 helix turn helix
Glycosyl-hydrolase family 116 N-terminal
Glycosyl-hydrolase family 116 catalytic region
May play a role in transmitting local conformational changes
Restriction endonuclease type II DpnII-like
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Small ribosomal subunit protein uS4 N-terminal
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Gamma-glutamylcyclotransferase AIG2-like
Peptidase M1 membrane alanine aminopeptidase
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Cytochrome C biogenesis protein transmembrane
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
Inosine/uridine-preferring nucleoside hydrolase
Arginine decarboxylase C-terminal helical
6-phosphogluconate dehydrogenase C-terminal
Important for beta-aspartyl-AMP intermediate formation
Heat-inducible transcription repressor HrcA C-terminal
Sugar fermentation stimulation protein C-terminal
Reversibly protonated during proton transport
Translation elongation factor P/YeiP central
Ferredoxin thioredoxin reductase alpha chain
Cell envelope-related transcriptional attenuator
Nicotinate phosphoribosyltransferase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Carboxypeptidase regulatory-like domain-containing protein
Prokaryotic-type class I peptide chain release factors
Light-independent protochlorophyllide reductase subunit B-like C-terminal
Ionotropic glutamate receptor C-terminal
Cob(I)alamin adenosyltransferase N-terminal
Phosphatidylglycerol lysyltransferase C-terminal
Transposase IS204/IS1001/IS1096/IS1165 helix-turn-helix
Photosystem II cytochrome b559 alpha subunit lumenal region
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Essential for prephenate dehydratase activity
Chromosomal replication initiator DnaA C-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
1,4-alpha-glucan branching enzyme C-terminal
Plays an important role in substrate specificity
Cytochrome b/b6 C-terminal region profile
Menaquinone biosynthesis protein MenD middle
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Mannose-6-phosphate isomerase type II C-terminal
Septum formation inhibitor MinC C-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Type I restriction enzyme R protein N-terminal
DNA mismatch repair proteins mutS family
ABC-type uncharacterised transport system
Glycoside hydrolase family 31 N-terminal
Exonuclease VII large subunit C-terminal
Pseudouridine synthase I TruA alpha/beta