D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Release factor glutamine methyltransferase N-terminal
RNA 2-O ribose methyltransferase substrate binding
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Major facilitator superfamily (MFS) profile
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Transcriptional regulator SgrR N-terminal HTH
Phosphatidic acid phosphatase type 2/haloperoxidase
Membrane insertase YidC/Oxa/ALB C-terminal
Gp5/Type VI secretion system Vgr protein OB-fold
Translation elongation factor P/YeiP central
Glycoside hydrolase family 31 N-terminal
Ionotropic glutamate receptor C-terminal
Solute-binding protein family 3/N-terminal
Glycosyltransferase subfamily 4-like N-terminal
Flagellar assembly protein FliH/Type III secretion system HrpE
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
TRAP C4-dicarboxylate transport system permease DctM subunit
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
ABC-type glycine betaine transport system substrate-binding
Chromosome partition protein MukF C-terminal
Chromosome partition protein MukF middle
Chromosome partition protein MukF winged-helix
Chromosomal replication initiator DnaA C-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Prepilin type IV endopeptidase peptidase
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Tryptophan synthase beta chain-like PALP
Polymerase/histidinol phosphatase N-terminal
Penicillin-binding protein transpeptidase
FAD-dependent cmnm(5)s(2)U34 oxidoreductase
Major facilitator superfamily associated
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
6-phosphogluconate dehydrogenase C-terminal
Flagellar hook-associated protein 2 C-terminal domain-containing protein
Common pilus major fimbrillin subunit EcpA
YbaK/aminoacyl-tRNA synthetase-associated
Membrane fusion protein biotin-lipoyl like
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Disulphide bond isomerase DsbC/G N-terminal
Inosine/uridine-preferring nucleoside hydrolase
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Lipoprotein YgdI/YgdR-like SH3-like domain-containing protein
SUF system FeS cluster assembly SufBD N-terminal
RND efflux pump membrane fusion protein barrel-sandwich
Prokaryotic-type class I peptide chain release factors
ABC-type transport auxiliary lipoprotein component
ABC-type transport auxiliary lipoprotein component domain-containing protein
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Penicillin-insensitive murein endopeptidase
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Pyrimidine nucleoside phosphorylase C-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Mannose-6-phosphate isomerase type II C-terminal
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
DNA-3-methyladenine glycosylase AlkA N-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
DNA-binding and helicase activity, interacts with RecC
Nuclease activity, interacts with RecD and RecA
Divergent polysaccharide deacetylase family protein
Mandelate racemase/muconate lactonizing enzyme C-terminal
O-(phosphoribosyl dephospho-coenzyme A)serine
Important for interaction with partner proteins
L-seryl-tRNA selenium transferase N-terminal
Nitrite/Sulfite reductase ferredoxin-like
Outer membrane protein assembly factor BamD
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Outer-membrane lipoprotein carrier protein
Cytochrome C biogenesis protein transmembrane
NIF system FeS cluster assembly NifU N-terminal
Flagellar motor switch protein FliN-like C-terminal
Dinitrogenase iron-molybdenum cofactor biosynthesis
NADH:ubiquinone oxidoreductase 30kDa subunit
High-affinity branched-chain amino acid transport system permease LivHM N-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
RNA methyltransferase SpoU/TrmH type C-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Phosphocysteine intermediate; for EIIB activity
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Ribosomal RNA adenine methylase transferase N-terminal
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Polysaccharide chain length determinant N-terminal
TonB-dependent receptor-like beta-barrel
Appears to be important in orienting the phosphate for catalysis
O-(5'-phospho-DNA)-tyrosine intermediate
YdgH/BhsA/McbA-like domain-containing protein
Gamma-glutamylcyclotransferase AIG2-like
Aromatic amino acid beta-eliminating lyase/threonine aldolase
DNA mismatch repair proteins mutS family
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
RNA polymerase sigma factor 70 region 4 type 2
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Pyruvate phosphate dikinase AMP/ATP-binding
For 3-hydroxyacyl-CoA dehydrogenase activity
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Flagella basal body P-ring formation protein FlgA
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Prepilin peptidase dependent protein C-like C-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Lipopolysaccharide export system protein LptA
Organic solvent tolerance-like N-terminal
Cytochrome b561 bacterial/Ni-hydrogenase
HicB-like antitoxin of toxin-antitoxin system
Interaction with polymerase core subunit RpoC
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Transglycosylase PBP1b N-terminal transmembrane
DNA polymerase III subunit delta C-terminal
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Sodium/calcium exchanger membrane region
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Integral membrane protein YccS N-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Abortive infection protein-like C-terminal
Glycine cleavage T-protein C-terminal barrel
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Arabinogalactan endo-beta-1,4-galactanase
Plays an important role in discriminating NADH against NADPH
Flagellar motor switch protein FliN N-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
DnaJ homologue subfamily C member 28 conserved
Type VI secretion system-associated protein
Aminoacyl-transfer RNA synthetases class-II family profile
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Phage terminase large subunit GpA ATPase
Terminase large subunit GpA endonuclease
Phosphotransferase system enzyme I N-terminal
Influences the redox potential of the prosthetic heme and FAD groups
Involved in heme-bound ligand stabilization and O-O bond activation
Bacteriophage tail tape measure C-terminal
Bacteriophage tail tape measure N-terminal
Mechanosensitive ion channel inner membrane
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Ion-translocating oxidoreductase complex subunit G
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Acyl-CoA dehydrogenase C-terminal bacterial-type
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Superoxide dismutase copper/zinc binding
Greasy slide, important in sugar transport
Molybdopterin cofactor biosynthesis C (MoaC)
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
Outer-membrane lipoprotein Wza C-terminal
Phosphomannose isomerase type I C-terminal
Phosphomannose isomerase type I catalytic
Phosphomannose isomerase type I helical insertion
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Peptide methionine sulphoxide reductase MsrA
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Glycosyl transferase family 3 N-terminal
Cation-transporting P-type ATPase N-terminal
Essential for degradation by Lon protease
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Outer membrane protein assembly factor BamE
Nitrogenase molybdenum-iron protein beta chain N-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
4'-phosphopantetheinyl transferase N-terminal
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Survival protein SurE-like phosphatase/nucleotidase
Large ribosomal subunit protein bL25 L25
Plays an important role in substrate specificity
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Reversibly protonated during proton transport
Tetrahydrodipicolinate-N-succinyltransferase chain A
Cysteine sulfenic acid (-SOH) intermediate
Alpha-D-phosphohexomutase alpha/beta/alpha
Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS
Periplasmic binding protein/LacI sugar binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
D-galactose/methyl-galactoside binding periplasmic protein MglB
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Schiff-base intermediate with acetaldehyde
Glucosamine/galactosamine-6-phosphate isomerase
DNA polymerase III delta subunit C-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Regulator of nucleoside diphosphate kinase N-terminal
ADP-ribosylarginine; by dinitrogenase reductase ADP-ribosyltransferase
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
O-(3'-phospho-DNA)-tyrosine intermediate
Gly-cisPro motif, important for rejection of L-amino acids
NIF system FeS cluster assembly NifU C-terminal
Schiff-base intermediate with substrate; via pyruvic acid
Important for substrate binding and specificity
Quercetin 2,3-dioxygenase C-terminal cupin
Peptidase S9 prolyl oligopeptidase catalytic
Chitobiase/beta-hexosaminidases N-terminal
DNA mismatch repair MutH/Type II restriction enzyme Sau3AI
Type II secretion system protein GspG C-terminal
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Menaquinone biosynthesis protein MenD middle
Bacterial type II secretion system protein E
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Glutathionylspermidine synthase pre-ATP-grasp-like
Type III secretion system flagellar brake protein YcgR PilZN
Membrane-bound lytic murein transglycosylase A
Phosphoethanolamine transferase N-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
RNA binding; important for wobble base 34 recognition
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Proline utilization A proline dehydrogenase N-terminal
Negative modulator of initiation of replication SeqA N-terminal
Replication modulator SeqA C-terminal DNA-binding
Putative type VI secretion system Rhs element associated Vgr
Outer membrane protein assembly factor BamB
Transcription factor NikR nickel binding C-terminal
YbhB/YbcL family Raf kinase inhibitor-like protein
Required for zinc-mediated homotetramerization and catalytic activity
Large ribosomal subunit protein uL15/eL18
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Cob(I)alamin adenosyltransferase N-terminal
Lysozyme inhibitor LprI N-terminal domain-containing protein
Arginine decarboxylase C-terminal helical
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Large ribosomal subunit protein uL2 C-terminal
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Thymidylate synthase/dCMP hydroxymethylase
Aspartate carbamoyltransferase regulatory subunit C-terminal
Aspartate carbamoyltransferase regulatory subunit N-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Glycoside hydrolase family 42 N-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Anthranilate synthase component I N-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
Type VI secretion system IcmF C-terminal
Aspartate/homoserine dehydrogenase NAD-binding
Exonuclease VII large subunit C-terminal
Small ribosomal subunit protein uS4 N-terminal
Translocation and assembly module subunit TamA
Threonine/serine exporter-like N-terminal
Non-canonical purine NTP phosphatase/PRRC1
NADH-rubredoxin oxidoreductase C-terminal
Polypeptide-transport-associated ShlB-type
Could play a key role in the communication between the regulatory and the substrate sites
Nucleoside-specific channel-forming protein Tsx
Proton acceptor; for decarboxylase activity
Proton donor; for decarboxylase activity
Proton donor; for formyltransferase activity
Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with Met-252)
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-105)
Endoribonuclease L-PSP/chorismate mutase-like
Positions MEP for the nucleophilic attack
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Flagellar hook-length control protein-like C-terminal
Pseudouridine synthase I TruA alpha/beta
Helix-hairpin-helix DNA-binding motif class 1
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
Antitoxin Xre/MbcA/ParS-like toxin-binding
Interacts with tRNA; defines subfamily-specific binding signature
Heme-copper oxidase subunit III family profile
Lysidine-tRNA(Ile) synthetase C-terminal
Lytic transglycosylase superhelical linker
Moves into active site upon enzyme activation, plays a role in electron transfer
UDP N-acetylglucosamine O-acyltransferase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Mediates proton transfer from the outer aqueous phase to the interior of the protein; involved in linking H(+) and Cl(-) transport
Mediates proton transfer from the protein to the inner aqueous phase
Capsule biosynthesis GfcC-like C-terminal
Capsule biosynthesis GfcC-like N-terminal
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Bacterial transcription activator effector binding
Isocitrate dehydrogenase kinase/phosphatase (AceK) kinase
Isocitrate dehydrogenase kinase/phosphatase (AceK) regulatory
Outer membrane protein assembly factor BamA
Adaptive response protein AidB N-terminal
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Cobalamin-independent methionine synthase MetE N-terminal
D-glutamate N-acetyltransferase-like C-terminal
D-glutamate N-acetyltransferase-like N-terminal
Alpha-glycerophosphate oxidase C-terminal
Hypersensitivity response secretion-like HrpJ
Involved in allosteric activation by GTP
Glycoside hydrolase family 13 N-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase C-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase N-terminal
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Penicillin-binding protein activator LpoA
Pyruvate dehydrogenase E1 component middle
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes
Penicillin-binding protein activator LpoB
Precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase
Uroporphyrinogen-III C-methyltransferase
Thiol:disulfide interchange protein DsbD
CobB/CobQ-like glutamine amidotransferase
Involved in tetramerization or stability of the tetramer
BREX system Lon protease-like BrxL N-terminal
Serine/threonine specific protein phosphatases
EcpB C-terminal domain-containing protein
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Carbamoyl-phosphate synthase small subunit N-terminal
Putative exodeoxyribonuclease 8 PDDEXK-like
DNA-directed DNA polymerase family A palm
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Large ribosomal subunit protein uL6 alpha-beta
Alanyl-transfer RNA synthetases family profile
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
DNA-directed DNA polymerase family B exonuclease
DNA-directed DNA polymerase family B multifunctional
DNA replication/recombination mediator RecO N-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type