Important for beta-aspartyl-AMP intermediate formation
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Plays an important role in substrate specificity
Major facilitator superfamily (MFS) profile
ATP synthase F1 complex delta/epsilon subunit N-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
Alanine and proline-rich secreted protein Apa
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Prokaryotic-type class I peptide chain release factors
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
1,4-alpha-glucan branching enzyme C-terminal
Glycoside hydrolase family 57 N-terminal
Cell envelope-related transcriptional attenuator
Polymerase/histidinol phosphatase N-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Rv2525c-like glycoside hydrolase-like domain-containing protein
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Alpha-D-phosphohexomutase alpha/beta/alpha
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Resuscitation-promoting factor core lysozyme-like
Schiff-base intermediate with acetaldehyde
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Arabinofuranosyltransferase AftA C-terminal
Arabinofuranosyltransferase AftA N-terminal
Small ribosomal subunit protein uS4 N-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
Heat-inducible transcription repressor HrcA C-terminal
Pyridoxamine 5'-phosphate oxidase putative
Endoribonuclease L-PSP/chorismate mutase-like
Alanyl-transfer RNA synthetases family profile
Putative oxidoreductase/dehydrogenase Rossmann-like
Large ribosomal subunit protein uL2 C-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
S-adenosyl-L-homocysteine hydrolase NAD binding
Could play a key role in the communication between the regulatory and the substrate sites
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Positions MEP for the nucleophilic attack
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Phosphoribosylformylglycinamidine synthase linker
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Glycine cleavage T-protein C-terminal barrel
ESX-1 secretion-associated protein EspA/EspE-like
6-phosphogluconate dehydrogenase C-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Carbamoyl-phosphate synthase small subunit N-terminal
Helix-hairpin-helix DNA-binding motif class 1
Involved in ionization of N3 of dUMP, leading to its activation
Peptidase S9 prolyl oligopeptidase catalytic
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Galactofuranosyltransferase GlfT2 N-terminal
Galactofuranosyltransferase-2 C-terminal
Glycosyl transferase family 3 N-terminal
Glycosyltransferase subfamily 4-like N-terminal
Alpha-glycerophosphate oxidase C-terminal
Proton acceptor; for glutaminase activity
Anthranilate synthase component I N-terminal
Cytochrome oxidase subunit II copper A binding
Cation-transporting P-type ATPase C-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Glucosamine/galactosamine-6-phosphate isomerase
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
Putative regulatory protein FmdB Zinc ribbon
Release factor glutamine methyltransferase N-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Schiff-base intermediate with D-ribose 5-phosphate
Glucose-methanol-choline oxidoreductase C-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Important for substrate specificity; cannot use PPi as phosphoryl donor
Thymidylate synthase/dCMP hydroxymethylase
Membrane insertase YidC/Oxa/ALB C-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
RNA polymerase sigma factor 70 region 4 type 2
Type 2A encapsulin shell protein SrpI-like
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)
Sodium/calcium exchanger membrane region
4'-phosphopantetheinyl transferase N-terminal
Phthiocerol/phthiodiolone dimycocerosyl transferase C-terminal
Methionyl-tRNA synthetase anticodon-binding
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Superoxide dismutase copper/zinc binding
Mandelate racemase/muconate lactonizing enzyme C-terminal
Large ribosomal subunit protein uL6 alpha-beta
Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
Tryptophan synthase beta chain-like PALP
Removed in mature form; by autocatalysis
Phosphatidic acid phosphatase type 2/haloperoxidase
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
3-beta hydroxysteroid dehydrogenase/isomerase
RNA 2-O ribose methyltransferase substrate binding
Penicillin-binding protein transpeptidase
Large ribosomal subunit protein uL15/eL18
Aconitase A/isopropylmalate dehydratase small subunit swivel
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Translation elongation factor P/YeiP central
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Cytochrome b/b6 N-terminal region profile
Bacterial bifunctional deaminase-reductase C-terminal
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Phosphomannose isomerase type I catalytic
Reversibly protonated during proton transport
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
tRNA pseudouridine synthase II TruB subfamily 2 C-terminal
tRNA pseudouridylate synthase B C-terminal
Chromosomal replication initiator DnaA C-terminal
ABC-type glycine betaine transport system substrate-binding
Gly-cisPro motif, important for rejection of L-amino acids
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
NAD(P) transhydrogenase alpha subunit C-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Cytochrome C biogenesis protein transmembrane
DNA replication/recombination mediator RecO N-terminal
Heme-copper oxidase subunit III family profile
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Exonuclease VII large subunit C-terminal
NIF system FeS cluster assembly NifU N-terminal
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta