Aromatic amino acid beta-eliminating lyase/threonine aldolase
Bacterial bifunctional deaminase-reductase C-terminal
Alanyl-transfer RNA synthetases family profile
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Activator of Hsp90 ATPase homologue 1-like C-terminal
Major facilitator superfamily (MFS) profile
SMODS-associated and fused to various effectors
Large ribosomal subunit protein uL15/eL18
Anthranilate synthase component I N-terminal
Signal transduction histidine kinase internal region
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Glutathionylspermidine synthase pre-ATP-grasp-like
Haem-binding uptake Tiki superfamily ChaN
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
DNA-directed DNA polymerase family A palm
Polymerase/histidinol phosphatase N-terminal
Membrane fusion protein biotin-lipoyl like
RND efflux pump membrane fusion protein barrel-sandwich
Anaphase-promoting complex subunit 4-like WD40
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Glycosyltransferase RgtA/B/C/D-like domain-containing protein
Penicillin-binding protein transpeptidase
TonB-dependent receptor-like beta-barrel
Hydroxymethylglutaryl-coenzyme A synthase C-terminal
Hydroxymethylglutaryl-coenzyme A synthase N-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Tetrahydrodipicolinate-N-succinyltransferase chain A
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Peptidase M17 leucyl aminopeptidase N-terminal
RNA polymerase sigma factor 70 region 4 type 2
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Cytochrome c-type biogenesis protein CcmF C-terminal
Molybdopterin cofactor biosynthesis C (MoaC)
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Iron/zinc purple acid phosphatase-like C-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Neutral/alkaline non-lysosomal ceramidase N-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Gp5/Type VI secretion system Vgr protein OB-fold
Type II secretion system protein GspE N-terminal
DNA topoisomerase I catalytic core eukaryotic-type
Menaquinone biosynthesis protein MenD middle
Polysaccharide biosynthesis protein C-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Schiff-base intermediate with dihydroxyacetone-P
Glycosyltransferase subfamily 4-like N-terminal
N-end rule aminoacyl transferase C-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Bacterial type II secretion system protein E
Could play a key role in the communication between the regulatory and the substrate sites
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Flagellar motor switch protein FliN-like C-terminal
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Type I restriction modification DNA specificity
tRNA pseudouridylate synthase B C-terminal
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Biopterin-dependent aromatic amino acid hydroxylase family profile
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
DNA polymerase III delta subunit C-terminal
Aspartate/homoserine dehydrogenase NAD-binding
Putative auto-transporter adhesin head GIN
Transcription elongation factor GreA/GreB C-terminal
Heat-inducible transcription repressor HrcA C-terminal
Peptidase M1 membrane alanine aminopeptidase
Electron transfer flavoprotein alpha/beta-subunit N-terminal
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
PHA accumulation regulator DNA-binding N-terminal
Thiopeptide-type bacteriocin biosynthesis
Survival protein SurE-like phosphatase/nucleotidase
Release factor glutamine methyltransferase N-terminal
NIF system FeS cluster assembly NifU N-terminal
Cation-transporting P-type ATPase N-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Diiron non-heme beta-hydroxylase N-terminal
Water stress and hypersensitive response
PhoD-like phosphatase metallophosphatase
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Peptidase S9 prolyl oligopeptidase catalytic
Outer membrane protein beta-barrel domain-containing protein
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Adaptive response protein AidB N-terminal
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase
Putative regulatory protein FmdB Zinc ribbon
Proton acceptor; for glutaminase activity
Styrene monooxygenase StyA putative substrate binding
S-adenosyl-l-methionine hydroxide adenosyltransferase C-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase N-terminal
Contractile injection system tube protein N-terminal
Sporulation stage II protein D amidase enhancer LytB N-terminal
YbaK/aminoacyl-tRNA synthetase-associated
Flagellar assembly protein FliH/Type III secretion system HrpE
Quercetin 2,3-dioxygenase C-terminal cupin
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
RlpA-like protein double-psi beta-barrel
RsbT co-antagonist protein RsbRD N-terminal
Predicted DNA-binding protein ribbon-helix-helix
Cytochrome oxidase subunit II copper A binding
Phosphatidate phosphatase APP1 catalytic
Sigma 54 modulation/S30EA ribosomal protein C-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
AraC-type arabinose-binding/dimerisation
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
SUF system FeS cluster assembly SufBD N-terminal
Regulator of nucleoside diphosphate kinase N-terminal
Nitrile hydratase alpha /Thiocyanate hydrolase gamma
Large ribosomal subunit protein uL6 alpha-beta
Acetylserotonin O-methyltransferase dimerisation
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Schiff-base intermediate with substrate; via pyruvic acid
Prokaryotic-type class I peptide chain release factors
Trigger factor ribosome-binding bacterial
Nitrite/Sulfite reductase ferredoxin-like
Glycine cleavage T-protein C-terminal barrel
Exonuclease VII large subunit C-terminal
Pyridoxamine 5'-phosphate oxidase putative
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
O-(5'-phospho-DNA)-tyrosine intermediate
S-adenosylmethionine-dependent methyltransferase
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Pyrimidine nucleoside phosphorylase C-terminal
ABC-type uncharacterised transport system
Abnormal spindle-like microcephaly-associated protein ASH
Phosphatidic acid phosphatase type 2/haloperoxidase
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
6-phosphogluconate dehydrogenase NADP-binding
Type VII secretion system protein EssD-like
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Mandelate racemase/muconate lactonizing enzyme C-terminal
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Large ribosomal subunit protein uL2 C-terminal
Transcription elongation factor GreA/GreB N-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Tryptophan synthase beta chain-like PALP
Type VI secretion system IcmF C-terminal
N,N-dimethylformamidase beta subunit-like C-terminal
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
Gamma-butyrobetaine hydroxylase-like N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Ribose-phosphate pyrophosphokinase N-terminal
Methylguanine DNA methyltransferase ribonuclease-like
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Transcriptional regulator TetR C-terminal Proteobacteria type
vWA-MoxR associated protein middle region 1
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Outer membrane beta-barrel porin/alpha-amylase
Pesticidal crystal protein Cry22Aa Ig-like
Chromosomal replication initiator DnaA C-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Polysaccharide chain length determinant N-terminal
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Type I restriction enzyme R protein N-terminal
2-oxoacid dehydrogenase acyltransferase catalytic
Glucosamine/galactosamine-6-phosphate isomerase
DNA replication/recombination mediator RecO N-terminal
Phosphotransferase system enzyme I N-terminal
Endonuclease/exonuclease/phosphatase family protein
S-adenosyl-L-homocysteine hydrolase NAD binding
Heme-copper oxidase subunit III family profile
Ribosomal RNA adenine methylase transferase N-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Cysteine sulfenic acid (-SOH) intermediate
Glyoxalase/fosfomycin resistance/dioxygenase
O-(3'-phospho-DNA)-tyrosine intermediate
Elongation factor G-binding protein C-terminal treble-clef zinc-finger
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Important for interaction with partner proteins
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Peptidase M43 pregnancy-associated plasma-A
Thymidylate synthase/dCMP hydroxymethylase
ABC transporter substrate-binding protein PnrA-like
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
Plays an important role in substrate specificity
Nicotinate/nicotinamide phosphoribosyltransferase
1,4-alpha-glucan branching enzyme C-terminal
Glycoside hydrolase family 57 N-terminal
Transcription regulator AsnC/Lrp ligand binding
NADH:ubiquinone oxidoreductase chain 4 N-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Outer membrane protein with beta-barrel domain
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Putative Flp pilus-assembly TadG-like N-terminal
Mannose-6-phosphate isomerase type II C-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Membrane insertase YidC/Oxa/ALB C-terminal
RNA 3'-terminal phosphate cyclase insert
NADH:ubiquinone oxidoreductase-like 20kDa subunit
General stress protein FMN-binding split barrel
Translation elongation factor P/YeiP central
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Solute-binding protein family 3/N-terminal
Superoxide dismutase copper/zinc binding
Glycosyltransferase family 28 N-terminal
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Peptidase C-terminal archaeal/bacterial domain-containing protein
Arginine decarboxylase C-terminal helical
Pseudouridine synthase I TruA alpha/beta
Penicillin-binding protein activator LpoB
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Lysidine-tRNA(Ile) synthetase C-terminal
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Prepilin type IV endopeptidase peptidase
Flagellar hook-length control protein-like C-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Sphingolipid delta4-desaturase N-terminal
Non-canonical purine NTP phosphatase/PRRC1
ATP synthase F1 complex delta/epsilon subunit N-terminal
Organic solvent tolerance-like N-terminal
Glycosyl transferase family 28 C-terminal
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Important for substrate specificity; cannot use PPi as phosphoryl donor
Peptidoglycan recognition protein family
Interaction with polymerase core subunit RpoC
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
6-phosphogluconate dehydrogenase C-terminal
Glycogen debranching enzyme bacterial and archaeal type N-terminal
3-keto-disaccharide hydrolase domain-containing protein
RNA binding; important for wobble base 34 recognition
Glycosyl transferase family 3 N-terminal
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
2,4-diaminopentanoate dehydrogenase C-terminal
Peptidase M61 catalytic domain-containing protein
N6 adenine-specific DNA methyltransferase N-terminal
DNA helicase Holliday junction RuvA type
Holliday junction DNA helicase RuvA C-terminal
Type II secretion system protein GspG C-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Reversibly protonated during proton transport
Small ribosomal subunit protein uS4 N-terminal
Lantibiotic biosynthesis protein dehydration
Could be important to modulate the pK values of the two catalytic cysteine residues
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Inner membrane protein YgaP-like transmembrane
UDP N-acetylglucosamine O-acyltransferase C-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Gly-cisPro motif, important for rejection of L-amino acids
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Glycoside hydrolase family 31 N-terminal
3-beta hydroxysteroid dehydrogenase/isomerase
tRNA pseudouridine synthase II TruB subfamily 2 C-terminal